Higher constitutive IL15Rα expression and lower IL-15 response threshold in coeliac disease patients

Clinical and Experimental Immunology

Volumn 154, Issue 1, 2008, Pages 64-73

  Bernardo, D ^a   Garrote, J A ^a,b   Allegretti, Y ^c   Leon A ^a   Gomez E ^a   Bermejo Martin, J F ^a   Calvo, C ^a,b   Riestra, S ^d   Fernandez Salazar L ^b   Blanco Quiros A ^a   Chirdo, F ^c   Arranz, E ^a  

^a UNIVERSITY OF VALLADOLID   (Spain)

^b HOSPITAL CLÍNICO UNIVERSITARIO DE VALLADOLID   (Spain)

^c FACULTAD DE CIENCIAS EXACTAS   (Argentina)

^d HOSPITAL UNIVERSITARIO CENTRAL DE ASTURIAS   (Spain)

Author keywords

Coeliac disease; IL 15; IL15R; Immune threshold

Indexed keywords

INTERLEUKIN 15; INTERLEUKIN 15 RECEPTOR ALPHA; MESSENGER RNA;

ADOLESCENT; ADULT; AGED; ARTICLE; CELIAC DISEASE; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; FEMALE; GLUTEN FREE DIET; HUMAN; HUMAN TISSUE; IMMUNE RESPONSE; IMMUNOFLUORESCENCE; IN VITRO STUDY; INTESTINE BIOPSY; MALE; NUCLEOTIDE SEQUENCE; ORGAN CULTURE; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ADOLESCENT; ADULT; AGED; BLOTTING, WESTERN; CASE-CONTROL STUDIES; CELIAC DISEASE; CHILD; CHILD, PRESCHOOL; DUODENUM; FEMALE; GLUTENS; HUMANS; INTERLEUKIN-15; MALE; MIDDLE AGED; RECEPTORS, INTERLEUKIN-15; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 51349136306     PISSN: 00099104     EISSN: 13652249     Source Type: Journal    
DOI: 10.1111/j.1365-2249.2008.03743.x     Document Type: Article

References (48)

1. Maki M, Collin P. Coeliac disease. Lancet 1997 349 : 1755 9.
2. Sollid LM. Coeliac disease: dissecting a complex inflammatory disorder. Nat Rev Immunol 2002 2 : 647 55.
3. Shan L, Molberg O, Parrot I et al. Structural basis for gluten intolerance in celiac sprue. Science 2002 297 : 2275 9.
4. van de Wal Y, Kooy Y, van Veelen P et al. Selective deamidation by tissue transglutaminase strongly enhances gliadin-specific T cell reactivity. J Immunol 1998 161 : 1585 8.
5. Qiao SW, Bergseng E, Molberg O et al. Antigen presentation to celiac lesion-derived T cells of a 33-mer gliadin peptide naturally formed by gastrointestinal digestion. J Immunol 2004 173 : 1757 62.
6. Raki M, Tollefsen S, Molberg O, Lundin KE, Sollid LM, Jahnsen FL. A unique dendritic cell subset accumulates in the celiac lesion and efficiently activates gluten-reactive T cells. Gastroenterology 2006 131 : 428 38.
7. Brandtzaeg P. The changing immunological paradigm in coeliac disease. Immunol Lett 2006 105 : 127 39.
8. Londei M, Ciacci C, Ricciardelli I, Vacca L, Quaratino S, Maiuri L. Gliadin as a stimulator of innate responses in celiac disease. Mol Immunol 2005 42 : 913 18.
9. Jabri B, Sollid LM. Mechanisms of disease: immunopathogenesis of celiac disease. Nat Clin Pract Gastroenterol Hepatol 2006 3 : 516 25.
10. Maiuri L, Ciacci C, Ricciardelli I et al. Association between innate response to gliadin and activation of pathogenic T cells in coeliac disease. Lancet 2003 362 : 30 7.
11. Di Sabatino A, Ciccocioppo R, Cupelli F et al. Epithelium derived interleukin 15 regulates intraepithelial lymphocyte Th1 cytokine production, cytotoxicity, and survival in coeliac disease. Gut 2006 55 : 469 77.
12. Matysiak-Budnik T, Candalh C, Dugave C et al. Alterations of the intestinal transport and processing of gliadin peptides in celiac disease. Gastroenterology 2003 125 : 696 707.
13. Clemente MG, De Virgiliis S, Kang JS et al. Early effects of gliadin on enterocyte intracellular signalling involved in intestinal barrier function. Gut 2003 52 : 218 23.
14. Maiuri L, Ciacci C, Auricchio S, Brown V, Quaratino S, Londei M. Interleukin 15 mediates epithelial changes in celiac disease. Gastroenterology 2000 119 : 996 1006.
15. Meresse B, Chen Z, Ciszewski C et al. Coordinated induction by IL15 of a TCR-independent NKG2D signaling pathway converts CTL into lymphokine-activated killer cells in celiac disease. Immunity 2004 21 : 357 66.
16. Hue S, Mention JJ, Monteiro RC et al. A direct role for NKG2D/MICA interaction in villous atrophy during celiac disease. Immunity 2004 21 : 367 77.
17. Ebert EC. IL-15 converts human intestinal intraepithelial lymphocytes to CD94 producers of IFN-gamma and IL-10, the latter promoting Fas ligand-mediated cytotoxicity. Immunology 2005 115 : 118 26.
18. Nilsen EM, Lundin KE, Krajci P et al. T cells from coeliac mucosa produce cytokines with Th1 or Th0 profile dominated by interferon gamma. Gut 1995 37 : 766 76.
19. Rossi M, Young JW. Human dendritic cells: potent antigen-presenting cells at the crossroads of innate and adaptive immunity. J Immunol 2005 175 : 1373 81.
20. Bernardo D, Garrote JA, Fernandez-Salazar L, Riestra S, Arranz E. Is gliadin really safe for non-coeliac individuals? Production of interleukin 15 in biopsy culture from non-coeliac individuals challenged with gliadin peptides. Gut 2007 56 : 889 90.
21. Fais S, Maiuri L, Pallone F et al. Gliadin induced changes in the expression of MHC-class II antigens by human small intestinal epithelium. Organ culture studies with coeliac disease mucosa. Gut 1992 33 : 472 5.
22. Budagian V, Bulanova E, Paus R, Bulfone-Paus S. IL-15/IL-15 receptor biology: a guided tour through an expanding universe. Cytokine Growth Factor Rev 2006 17 : 259 80.
23. Bongers M, Liehl E, Barsig J. One-step RT-PCR to detect cytokine/chemokine induction in macrophages. Focus 2003 21 : 66 8.
24. Tejman-Yarden N, Zlotnik M, Lewis E, Etzion O, Chaimovitz C, Douvdevani A. Renal cells express a functional interleukin-15 receptor. Nephrol Dial Transplant 2005 20 : 516 23.
25. Ohtsuki M, Nomura T, Morimoto S et al. Suppressed expression of GTP cyclohydrolase I mRNA and accelerated expression of inducible nitric oxide synthase mRNA in endomyocardial biopsy specimens from patients with dilated cardiomyopathy. Clin Chim Acta 2005 353 : 103 7.
26. Karlsson MG, Ludvigsson J. Determination of mRNA expression for IFN-gamma and IL-4 in lymphocytes from children with IDDM by RT-PCR technique. Diabetes Res Clin Pract 1998 40 : 21 30.
27. Atkins GJ, Haynes DR, Geary SM, Loric M, Crotti TN, Findlay DM. Coordinated cytokine expression by stromal and hematopoietic cells during human osteoclast formation. Bone 2000 26 : 653 61.
28. Dubois S, Magrangeas F, Lehours P et al. Natural splicing of exon 2 of human interleukin-15 receptor alpha-chain mRNA results in a shortened form with a distinct pattern of expression. J Biol Chem 1999 274 : 26978 84.
29. Mention JJ, Ben Ahmed M, Begue B et al. Interleukin 15: a key to disrupted intraepithelial lymphocyte homeostasis and lymphomagenesis in celiac disease. Gastroenterology 2003 125 : 730 45.
30. Leon AJ, Garrote JA, Blanco-Quiros A et al. Interleukin 18 maintains a long-standing inflammation in coeliac disease patients. Clin Exp Immunol 2006 146 : 479 85.
31. Olaussen RW, Johansen FE, Lundin KE, Jahnsen J, Brandtzaeg P, Farstad IN. Interferon-gamma-secreting T cells localize to the epithelium in coeliac disease. Scand J Immunol 2002 56 : 652 64.
32. Forsberg G, Hernell O, Melgar S, Israelsson A, Hammarstrom S, Hammarstrom ML. Paradoxical coexpression of proinflammatory and down-regulatory cytokines in intestinal T cells in childhood celiac disease. Gastroenterology 2002 123 : 667 78.
33. Maiuri MC, De Stefano D, Mele G et al. Gliadin increases iNOS gene expression in interferon-gamma-stimulated RAW 264.7 cells through a mechanism involving NF-kappa B. Naunyn Schmiedebergs Arch Pharmacol 2003 368 : 63 71.
34. Sander GR, Cummins AG, Henshall T, Powell BC. Rapid disruption of intestinal barrier function by gliadin involves altered expression of apical junctional proteins. FEBS Lett 2005 579 : 4851 5.
35. Drago S, El Asmar R, Di Pierro M et al. Gliadin, zonulin and gut permeability: effects on celiac and non-celiac intestinal mucosa and intestinal cell lines. Scand J Gastroenterol 2006 41 : 408 19.
36. Jelinkova L, Tuckova L, Cinova J, Flegelova Z, Tlaskalova-Hogenova H. Gliadin stimulates human monocytes to production of IL-8 and TNF-alpha through a mechanism involving NF-kappaB. FEBS Lett 2004 571 : 81 5.
37. Dolfini E, Elli L, Roncoroni L et al. Damaging effects of gliadin on three-dimensional cell culture model. World J Gastroenterol 2005 11 : 5973 7.
38. Nikulina M, Habich C, Flohe SB, Scott FW, Kolb H. Wheat gluten causes dendritic cell maturation and chemokine secretion. J Immunol 2004 173 : 1925 33.
39. Thomas KE, Sapone A, Fasano A, Vogel SN. Gliadin stimulation of murine macrophage inflammatory gene expression and intestinal permeability are MyD88-dependent: role of the innate immune response in Celiac disease. J Immunol 2006 176 : 2512 21.
40. Cinova J, Palova-Jelinkova L, Smythies LE et al. Gliadin peptides activate blood monocytes from patients with celiac disease. J Clin Immunol 2007 27 : 201 9.
41. Hudson DA, Cornell HJ, Purdham DR, Rolles CJ. Non-specific cytotoxicity of wheat gliadin components towards cultured human cells. Lancet 1976 1 : 339 41.
42. Rocca E, Paganuzzi Stammati A, Zampaglioni F, Zucco F. Effects of gliadin-derived peptides from bread and durum wheats on in vitro cultures of human cell lines. Implications for coeliac disease pathogenesis. Toxicol Lett 1983 16 : 331 8.
43. Dolfini E, Elli L, Dasdia T et al. In vitro cytotoxic effect of bread wheat gliadin on the LoVo human adenocarcinoma cell line. Toxicol In Vitro 2002 16 : 331 7.
44. Giovannini C, Mancini E, De Vincenzi M. Inhibition of the cellular metabolism of Caco-2 cells by prolamin peptides from cereals toxic for coeliacs. Toxicol In Vitro 1996 533 8.
45. Giovannini C, Lechetti R, De Vincenzi M. The activities of peptides '31 43', '44-55' and '56-68' of A-gliadin on in vitro cultures of CaCo-2 cells. ATLA 1997 25 : 437 43.
46. Giovannini C, Sanchez M, Straface E, Scazzocchio B, Silano M, De Vincenzi M. Induction of apoptosis in caco-2 cells by wheat gliadin peptides. Toxicology 2000 145 : 63 71.
47. Giovannini C, Matarrese P, Scazzocchio B et al. Wheat gliadin induces apoptosis of intestinal cells via an autocrine mechanism involving Fas-Fas ligand pathway. FEBS Lett 2003 540 : 117 24.
48. Sato N, Patel HJ, Waldmann TA, Tagaya Y. The IL-15/IL-15Ralpha on cell surfaces enables sustained IL-15 activity and contributes to the long survival of CD8 memory T cells. Proc Natl Acad Sci USA 2007 104 : 588 93.