Chromatographic resolution of closely related species: Separation of warfarin and hydroxylated isomers

Journal of Chromatography A

Volumn 1314, Issue , 2013, Pages 266-275

  Regalado, Erik L ^a   Schafer, Wes ^a   McClain, Ray ^a   Welch, Christopher J ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Chiral screening; Complex mixtures; High throughput experimentation; Method development; SFC; UPLC

Indexed keywords

CHIRAL SCREENING; COMPLEX MIXTURE; HIGH THROUGHPUT EXPERIMENTATION; METHOD DEVELOPMENT; SFC; UPLC;

CHROMATOGRAPHIC ANALYSIS; DRUG PRODUCTS; GAS CHROMATOGRAPHY; ISOMERS; LIQUID CHROMATOGRAPHY; MIXTURES; STEREOCHEMISTRY; TOOLS;

SEPARATION;

10 HYDROXYWARFARIN; 4 HYDROXYWARFARIN; 6 HYDROXYWARFARIN; 7 HYDROXYWARFARIN; 8 HYDROXYWARFARIN; UNCLASSIFIED DRUG; WARFARIN; WARFARIN DERIVATIVE;

ACHIRAL CHROMATOGRAPHY; ANALYTICAL EQUIPMENT; ARTICLE; CHIRAL CHROMATOGRAPHY; CHROMATOGRAPHY; CONTROLLED STUDY; DRUG STRUCTURE; INTERMETHOD COMPARISON; ISOMER; MULTIDIMENSIONAL CHROMATOGRAPHY; PERFORMANCE; PRIORITY JOURNAL; SUPERCRITICAL FLUID CHROMATOGRAPHY; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY;

CHIRAL SCREENING; COMPLEX MIXTURES; HIGH-THROUGHPUT EXPERIMENTATION; METHOD DEVELOPMENT; SFC; UPLC;

ANTICOAGULANTS; CHROMATOGRAPHY, LIQUID; HYDROXYLATION; ISOMERISM; WARFARIN;

EID: 84884985795     PISSN: 00219673     EISSN: 18733778     Source Type: Journal    
DOI: 10.1016/j.chroma.2013.07.092     Document Type: Article

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