High throughput screening of active pharmaceutical ingredients by UPLC

Journal of Separation Science

Volumn 31, Issue 12, 2008, Pages 2167-2172

  Al Sayah, Mohammad A ^a   Rizos, Panagiota ^a   Antonucci, Vincent ^a   Wu, Naijun ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Active pharmaceutical ingredient; High efficiency; High throughput screening; Sub 2 micron particles; Ultra performance LC

Indexed keywords

ARSENIC COMPOUNDS; CHEMOTHERAPY; CHROMATOGRAPHIC ANALYSIS; DRUG DELIVERY; DRUG DOSAGE; DRUG PRODUCTS; ELECTRON BEAM LITHOGRAPHY; GRADIENT METHODS; PLATES (STRUCTURAL COMPONENTS); THROUGHPUT;

ACTIVE PHARMACEUTICAL INGREDIENT (API); ACTIVE PHARMACEUTICAL INGREDIENTS (APIS); COLUMN DIMENSIONS; DRUG CANDIDATES; DRUG DEVELOPMENTS; EARLY STAGES; HIGH EFFICIENCY; HIGH THROUGHPUT SCREENING (HTS); METHOD DEVELOPMENT; MULTIPARAMETRIC; PARTICLE COLUMN; PEAK CAPACITY; PHASE GRADIENTS; SCREENING APPROACHES; SCREENING EXPERIMENTS; STATION ARY PHASES; TRIAL AND ERROR; ULTRA PERFORMANCE LC;

COLUMNS (STRUCTURAL);

ALKYLBENZENE; PHOSPHORIC ACID;

ANALYTICAL ERROR; ARTICLE; CHEMICAL ANALYSIS; CHEMICAL COMPOSITION; CHEMICAL STRUCTURE; CONTROLLED STUDY; DRUG MIXTURE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIGH THROUGHPUT SCREENING; INTERMETHOD COMPARISON; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PARTICLE SIZE; PHASE SEPARATION; PRIORITY JOURNAL; PROCESS OPTIMIZATION; SCREENING TEST; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CHROMATOGRAPHY, LIQUID; DRUG CONTAMINATION; DRUG EVALUATION, PRECLINICAL; DRUG INDUSTRY; MASS SPECTROMETRY; PHARMACEUTICAL PREPARATIONS;

APIS;

EID: 48049116222     PISSN: 16159306     EISSN: 16159314     Source Type: Journal    
DOI: 10.1002/jssc.200700594     Document Type: Article

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