Secretory expression of biologically active human Herpes virus interleukin-10 analogues in Escherichia coli via a modified Sec-dependent transporter construct

BMC Biotechnology

Volumn 13, Issue , 2013, Pages

  Förster, Sarah ^a   Brandt, Manuela ^a   Mottok, Dorothea S ^a,b   Zschüttig, Anke ^a   Zimmermann, Kurt ^c   Blattner, Frederick R ^d,e   Gunzer, Florian ^a   Pöhlmann, Christoph ^a,f  

^a DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

^b QIAGEN GMBH   (Germany)

^c SymbioPharm GmbH   (Germany)

^d Scarab Genomics LLC   (United States)

^e UNIVERSITY OF WISCONSIN MADISON   (United States)

^f ROBERT BOSCH HOSPITAL   (Germany)

Author keywords

Bacterial transport system; Escherichia coli; Inflammatory bowel disease; Interleukin 10; Outer membrane protein F

Indexed keywords

BACTERIAL TRANSPORT; BIOLOGICAL CHARACTERISTIC; INFLAMMATORY BOWEL DISEASE; INTERLEUKIN-10; OUTER-MEMBRANE PROTEIN F; THERAPEUTIC APPLICATION; THERAPEUTIC MOLECULES; TUMOR NECROSIS FACTORS;

BIOACTIVITY; BIOLOGICAL MEMBRANES; CELL CULTURE; CHASSIS; CHEMICAL ACTIVATION; MACROPHAGES; PATIENT TREATMENT; RECOMBINANT PROTEINS; SIGNAL TRANSDUCTION; TRANSCRIPTION; VIRUSES;

ESCHERICHIA COLI;

EPSTEIN BARR VIRUS INTERLEUKIN 10; HERPES SIMPLEX VIRUS INTERLEUKIN 10; HUMAN CYTOMEGALOVIRUS INTERLEUKIN 10; INTERLEUKIN 10; INTERLEUKIN 10 RECEPTOR; LIPOPOLYSACCHARIDE; OUTER MEMBRANE PROTEIN F; RECOMBINANT CYTOKINE; RECOMBINANT VIRUS INTERLEUKIN 10 PROTEIN; SIGNAL PEPTIDE; STAT3 PROTEIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; VIRUS PROTEIN;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; BACTERIAL CELL; BACTERIUM CARRIER; BIOLOGICAL ACTIVITY; BURKITT LYMPHOMA; CELL MEMBRANE; CODON; CONTROLLED STUDY; CYTOKINE RELEASE; CYTOPLASM; DAUDI CELL; DRUG DELIVERY SYSTEM; ENTERITIS; ENZYME LINKED IMMUNOSORBENT ASSAY; EPSTEIN BARR VIRUS; ESCHERICHIA COLI; EXPRESSION VECTOR; HUMAN; HUMAN CELL; HUMAN CYTOMEGALOVIRUS; IMMUNOBLOTTING; IN VITRO STUDY; MACROPHAGE; NONHUMAN; NUCLEOTIDE SEQUENCE; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; HERPESVIRIDAE; HUMAN HERPESVIRUS 4; HUMAN HERPESVIRUS 5; MAMMALIA; SIMPLEXVIRUS;

ANIMALS; CELL LINE; CYTOMEGALOVIRUS; ESCHERICHIA COLI; GENETIC VECTORS; HERPESVIRUS 4, HUMAN; HUMANS; INFLAMMATORY BOWEL DISEASES; INTERLEUKIN-10; MICE; PERIPLASM; PHOSPHORYLATION; PORINS; PROTEIN SORTING SIGNALS; RECOMBINANT PROTEINS; SEQUENCE ANALYSIS, DNA; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR; TUMOR NECROSIS FACTOR-ALPHA; VIRAL PROTEINS;

EID: 84884962114     PISSN: None     EISSN: 14726750     Source Type: Journal    
DOI: 10.1186/1472-6750-13-82     Document Type: Article

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