Proinflammatory effects of IL-10 during human endotoxemia

Journal of Immunology

Volumn 165, Issue 5, 2000, Pages 2783-2789

  Lauw, F N ^a   Pajkrt, D ^a   Hack, C E ^a   Kurimoto, M ^a   Van Deventer, S J H ^a   Van der Poll, T ^a  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; ESCHERICHIA COLI LIPOPOLYSACCHARIDE; GAMMA INTERFERON; PLACEBO; RECOMBINANT INTERLEUKIN 10;

ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; CYTOTOXIC T LYMPHOCYTE; DOUBLE BLIND PROCEDURE; ENDOTOXEMIA; ESCHERICHIA COLI; EXPERIMENTAL MODEL; HUMAN; IMMUNOSTIMULATION; INFLAMMATION; NATURAL KILLER CELL; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL;

EID: 0034284243     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.165.5.2783     Document Type: Article

References (54)

1. Interleukin-10
2. Biological properties of IL-10
3. Interleukin 10 (IL-10) and viral IL-10 strongly reduce antigen-specific human T cell proliferation by diminishing the antigen-presenting capacity of monocytes via down-regulation of class II major histocompatibility complex expression
4. Interleukin 10 (IL-10) inhibits cytokine synthesis by human monocytes: An autoregulatory role of IL-10 produced by monocytes
5. + T cell clones and resting T cells. Specific inhibition of IL-2 production and proliferation
6. Interleukin 10 reduces the release of tumor necrosis factor and prevents lethality in experimental endotoxemia
7. Interleukin 10 protects mice from lethal endotoxemia
8. Interleukin 10 protects mice against staphylococcal enterotoxin B-induced lethal shock
9. Effects of IL-10 on systemic inflammatory responses during sublethal primate endotoxemia
10. Attenuation of proinflammatory response by recombinant human IL-10 in human endotoxemia: Effect of timing of recombinant human IL-10 administration
11. Interlenkin 10 is a potent growth and differentiation factor for activated human B lymphocytes
12. Preincubation of human resting T cell clones with interleukin 10 strongly enhances their ability to produce cytokines after stimulation
13. + T cells
14. Immunoregulatory roles of IL-10 in innate immunity: IL-10 inhibits macrophage production of IFN-γ-inducing factors but enhances NK cell production of IFN-γ
15. Interleukin-10 administration decreases survival in murine recipients of major histocompatibility complex disparate donor bone marrow grafts
16. Multiple doses of intravenous interleuldn 10 in steroid-refractory, Crohn's disease
17. IL-10 as a therapeutic strategy in the treatment of rheumatoid arthritis
18. Interleuldn-10 inhibits activation of coagulation and fibrinolysis during human endotoxemia
19. Erythromycin inhibits tumor necrosis factor alpha and interleukin 6 production induced by heat-killed Streptococcus pneumoniae in whole blood
20. Characterization of anti-human interleukin-18 (IL-18)/interferon-γ-inducing factor (IGIF) monoclonal antibodies and their application in the measurement of human IL-18 by ELISA
21. Extracellular granzymes A and B in man: Detection of native species during CTL responses in vitro and in vivo
22. Cellular responses to interferon-γ
23. Interleukin-12: A cytokine produced by antigen-presenting cells with immunoregulatory functions in the generation of T-helper cells type I and cytotoxic lymphocytes
24. Cloning of a new cytokine that induces IFN-γ production by T cells
25. Interferon-γ-inducing factor enhances T helper cytokine production by stimulated human T cells: Synergism with interleukin-12 for interferon-γ production
26. Endogenous production of interleukin 15 by activated human monocytes is critical for optimal production of interferon-γ by natural killer cells in vitro
27. Interleukin 12 and tumor necrosis factor α are costimulators of interferon T production by natural killer cells in severe combined immunodeficiency mice with listeriosis, and interleukin 10 is a physiologic antagonist
28. Mig and IP-10: CXC chemokines that target lymphocytes
29. Granzymes: Exogenous proteinases that induce target cell apoptosis
30. Diurnal rhythmicity of human cytokine production: A dynamic disequilibrium in T helper cell type 1/T helper cell type 2 balance?
31. IL-12 up-regulates IL-18 receptor expression on T cells, Th1 cells, and B cells: Synergism with IL-18 for IFN-γ production
32. Release of interleukin-12 in experimental Escherichia coli septic shock in baboons: Relation to plasma levels of interleukin-10 and interferon-γ
33. In vivo production and function of IL-12 p40 homodimers
34. Human IL-12 p40 homodimer binds to the IL-12 receptor but does not mediate biologic activity
35. Mouse interleukin-12 (IL-12) p40 homodimer: A potent IL-12 antagonist
36. + IFN-γ-producing cells
37. A randomized, controlled trial of IL-10 in humans: Inhibition of inflammatory cytokine production and immune responses
38. Clinical, hematologic, and immunologic effects of interleukin-10 in humans
39. IL-10 enhances NK cell proliferation, cytotoxicity and production of IFN-γ when combined with IL-18
40. A transgenic model to analyze the immunoregulatory role of IL-10 secreted by antigen-presenting cells
41. Unlocking the secrets of CTL and NK cells
42. Lymphocyte granule-mediated apoptosis: Matters of viral mimicry and deadly proteases
43. Expression of granzyme B during primary cytomegalovirus infection after renal transplantation
44. Gene expression and production of the monokine induced by IFN-γ (MIG), IFN-inducible T cell a chemoattractant (I-TAC), and IFN-γ-inducible protein-10 (IP-10) chemokines by human neutrophils
45. Biphasic production of IL-8 in lipopolysaccharide (LPS)-stimulated human whole blood
46. Genetic influence on cytokine production and fatal meningococcal disease
47. Interleukin-1 β (IL-1β), IL-1 receptor antagonist, and TNF a production in whole blood
48. Down-regulation of proinflammatory cytokine release in whole blood from septic patients
49. Reduced Th1, but not Th2, cytokine production by lymphocytes after in vivo exposure of healthy subjects to endotoxin
50. Interleukin 10 (IL-10) inhibits human lymphocyte interferon γ-production by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cells
51. Differential effects of anti-tumor necrosis factor monoclonal antibodies on systemic inflammatory responses in experimental endotoxemia in chimpanzees
52. Antibodies to cachectin/tumor-necrosis factor reduce interleukin 1 β and interleukin 6 appearance during lethal bacteremia
53. Interleukin 10 inhibits the release of CC chemokines during human endotoxemia
54. Anti- and proinflammatory effects of interleukin-10 in mild to moderate Crohn's disease