Cardiac sympathetic dysfunction in the prehypertensive spontaneously hypertensive rat

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 305, Issue 7, 2013, Pages

  Shanks, Julia ^a   Manou Stathopoulou, Sotiria ^a   Lu, Chieh Ju ^a   Li, Dan ^a   Paterson, David J ^a   Herring, Neil ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Autonomic neurotransmission; Cardiac; Hypertension; Spontaneously hypertensive rat; Sympathetic; Vagal

Indexed keywords

CALCIUM; NEUROPEPTIDE Y; NORADRENALIN TRANSPORTER; YOHIMBINE;

ADRENERGIC TRANSMISSION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERIAL PRESSURE; ARTICLE; BLOOD LEVEL; CALCIUM TRANSPORT; CARDIAC SYMPATHETIC DYSFUNCTION; CONTROLLED STUDY; HEART RATE; IN VIVO STUDY; MEASUREMENT; NONHUMAN; PREHYPERTENSION; PRIORITY JOURNAL; RAT; SPONTANEOUSLY HYPERTENSIVE RAT; STELLATE CELL; TACHYCARDIA; VAGUS NERVE STIMULATION;

AUTONOMIC NEUROTRANSMISSION; CARDIAC; HYPERTENSION; SPONTANEOUSLY HYPERTENSIVE RAT; SYMPATHETIC; VAGAL;

ADRENERGIC ALPHA-2 RECEPTOR ANTAGONISTS; ADRENERGIC UPTAKE INHIBITORS; ANIMALS; ARTERIAL PRESSURE; CALCIUM SIGNALING; DISEASE MODELS, ANIMAL; ELECTRIC STIMULATION; HEART; HEART RATE; HYPERTENSION; MALE; NEUROPEPTIDE Y; NOREPINEPHRINE; PREHYPERTENSION; RATS; RATS, INBRED SHR; RATS, INBRED WKY; STELLATE GANGLION; SYMPATHETIC NERVOUS SYSTEM; TIME FACTORS; VAGUS NERVE;

EID: 84884957187     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00255.2013     Document Type: Article

References (36)

1. Abdala AP, McBryde FD, Marina N, Hendy EB, Engelman ZJ, Fudim M, Sobotka PA, Gourine AV, Paton JF. Hypertension is critically dependent on the carotid body input in the spontaneously hypertensive rat. J Physiol 590: 4269-4277, 2012.
2. Anderson EA, Sinkey CA, Lawton WJ, Mark AL. Elevated sympathetic nerve activity in borderline hypertensive humans: Evidence from direct intraneural recordings. Hypertension 14: 177-183, 1989.
3. Carlson DE, Gann DS. Alpha-adrenergic input in the locus coeruleus modulates plasma adrenocorticotropin in cats. Endocrinology 130: 2795-2803, 1992.
4. Cuculi F, Herring N, De Caterina AR, Banning AP, Prendergast BD, Forfar JC, Choudhury RP, Channon KM, Kharbanda RK. Relationship of plasma neuropeptide Y with angiographic, electrocardiographic and coronary physiology indices of reperfusion during ST elevation myocardial infarction. Heart 99: 1198-1203, 2013.
5. Davrath LR, Goren Y, Pinhas E, Toledo E, Akselrod S. Early automoic malfunction in normotensive individuals with a genetic predisposition to essential hypertension. Am J Physiol Heart Circ Physiol 285: H1697-H1704, 2003.
6. Dyke AC, Angus JA, Korner PI. A functional study of the development of the cardiac sympathetic neuroeffector junction in the SHR. Hypertension 7: 345-353, 1989.
7. Esler MD, Krum H, Sobotka PA, Schlaich MP, Schmieder RE, Bohm M. Renal sympathetic denervation in patients with treatment-resistant hypertension (The Symplicity HTN-2 Trial): a randomised controlled trial. Lancet 376: 1903-1909, 2010.
8. Fisher JP, Paton JF. The sympathetic nervous system and blood pressure in humans: implications for hypertension. J Hum Hypertens 26: 463-475, 2012.
9. Flaa A, Mundal HH, Eide I, Kjeldsen S, Rostrup M. Sympathetic activity and cardiovascular risk factors in young men in the low, normal, and high blood pressure ranges. Hypertension 47: 396-402, 2006.
10. Greenwood JP, Stoker JB, Mary DASG. Single-unit sympathetic discharge: quantitative assessment in human hypertensive disease. Circ Res 100: 1305-1310, 1999.
11. Heaton DA, Li D, Almond SC, Dawson TA, Wang L, Channon KM, Paterson DJ. Gene transfer of neuronal nitric oxide synthase into intracardiac ganglia reverses vagal impairment in hypertensive rats. Hypertension 49: 380-388, 2007.
12. Herring N, Cranley J, Lokale MN, Li D, Shanks J, Alston EN, Girard BM, Carter E, Parsons RL, Habecker BA, Paterson DJ. The cardiac sympathetic co-transmitter galanin reduces acetylcholine release and vagal bradycardia: implications for neural control of cardiac excitability. J Mol Cell Cardiol 52: 667-676, 2012.
13. Herring N, Lee CW, Sunderland N, Wright K, Paterson DJ. Pravastatin normalises peripheral cardiac sympathetic hyperactivity in the spontaneously hypertensive rat. J Mol Cell Cardiol 50: 99-106, 2011.
14. Herring N, Lokale MN, Danson EJ, Heaton DA, Paterson DJ. Neuropeptide Y reduces acetylcholine release and vagal bradycardia via a Y2 receptor-mediated, protein kinase C-dependent pathway. J Mol Cell Cardiol 44: 477-485, 2008.
15. Kokubo M, Uemura A, Matsubara T, Murohara T. Noninvasive evaluation of the time course of change in cardiac function in spontaneously hypertensive rats by echocardiography. Hypertens Res 28: 601-609, 2005.
16. Komolova M, Friberg P, Adams MA. Altered vascular resistance properties and acute pressure-natriuresis mechanism in neonatal and weaning spontaneously hypertensive rats. Hypertension 59: 979-984, 2012.
17. Kondo K, Matsubara T, Nakamura J, Hotta N. Characteristic patterns of circadian variation in plasma catecholamine levels, blood pressure and heart rate variability in Type 2 diabetic patients. Diabet Med 19: 359-365, 2002.
18. Kondo M, Fujiwara T, Tabei R. Noradrenergic hyperinnervation in the heart of stroke-prone spontaneously hypertensive rats (SHRSP). Hypertens Res 19: 69-73, 1996.
19. Lee CW, Li D, Channon KM, Paterson DJ. L-arginine supplementation reduces cardiac noradrenergic neurotransmission in spontaneously hypertensive rats. J Mol Cell Cardiol 47: 149-155, 2009.
20. Li D, Lee CW, Buckler KJ, Parekh A, Herring N, Paterson DJ. Abnormal intracellular calcium homeostasis in sympathetic neurons from young prehypertensive rats. Hypertension 59: 642-649, 2012.
21. Li D, Wang L, Lee CW, Dawson TA, Paterson DJ. Noradrenergic cell specific gene transfer with neuronal nitric oxide synthase reduces cardiac sympathetic neurotransmission in hypertensive rats. Hypertension 50: 1-6, 2007.
22. Lockinger A, Koberle D, Konig PS, Saria A, Herold M, Cornelissen G, Halberg F. Neuropeptide chronomics in clinically healthy young adults: circaoctohoran and circadian patterns. Peptides 25: 533-542, 2004.
23. Malliani A, Pagani M, Bergamaschi M. Positive feedback sympathetic reflexes and hypertension. Am J Cardiol 44: 860-865, 1979.
24. Minami N, Head GA. Cardiac vagal responsiveness during development in spontaneously hypertensive rats. Auton Neurosci 82: 115-122, 2000.
25. Mohan RM, Golding S, Paterson DJ. Intermittent hypoxia modulates nNOS expression and heart rate response to sympathetic nerve stimulation. Am J Physiol Heart Circ Physiol 281: H132-H138, 2001.
26. Paton JF, Sobotka PA, Fudim M, Engleman ZJ, Hart EC, McBryde FD, Abdala AP, Marina N, Gourine AV, Lobo M, Patel N, Burchell A, Ratcliffe L, Nightingale A. The carotid body as a therapeutic target for the treatment of sympathetically mediated diseases. Hypertension 61: 5-13, 2013.
27. Schlaich MP, Kaye DM, Lambert E, Sommerville M, Socratous F, Esler MD. Relation between cardiac sympathetic activity and hypertensive left ventricular hypertrophy. Circulation 108: 560-565, 2003.
28. Schlaich MP, Lambert E, Kaye DM, Krozowski Z, Campbell DJ, Lambert G, Hastings JA, Aggarwal A, Esler MD. Sympathetic augmentation in hypertension: role of nerve firing, norepinephrine reuptake, and angiotensin neuromodulation. Hypertension 43: 169-175, 2004.
29. Schlaich MP, Sobotka PA, Krum H, Lambert E, Esler MD. Renal sympathetic-nerve ablation for uncontrolled hypertension. N Engl J Med 361: 932-934, 2009.
30. Sendeski MM, Consolim-Colombo FM, Leite CC, Rubira MC, Lessa P, Krieger EM. Increased sympathetic nerve activity correlates with neurovascular compression at the rostral ventrolateral medulla. Hypertension 47: 988-995, 2006.
31. Shanks J, Mane S, Ryan R, Paterson DJ. Ganglion-specific impairment of the norepinephrine transporter in the hypertensive rat. Hypertension 61: 187-193, 2013.
32. Simms AE, Paton JF, Pickering AE, Allen AM. Amplified respiratorysympathetic coupling in the spontaneously hypertensive rat: does it contribute to hypertension? J Physiol 587: 597-610, 2009.
33. Takeda K, Nakata T, Takesako T, Itoh H, Hirata M, Kawasaki S, Hayashi J, Oguro M, Sasaki S, Nakagawa M. Sympathetic inhibition and attenuation of spontaneous hypertension by PVN lesions in rats. Brain Res 543: 296-300, 1991.
34. Tan ZY, Lu Y, Whiteis CA, Simms AE, Paton JF, Chapleau MW, Abboud FM. Chemoreceptor hypersensitivity, sympathetic excitation, and overexpression of ASIC and TASK channels before the onset of hypertension in SHR. Circ Res 106: 536-545, 2010.
35. Zucker IH, Schultz HD, Li YF, Wang Y, Wang W, Patel KP. The origin of sympathetic outflow in heart failure: the roles of angiotensin II and nitric oxide. Prog Biophys Mol Biol 84: 217-232, 2004.
36. A adrenoceptors. Hypertension 21: 1363-1369, 2003.