Mitochondrial mutations and ageing: Can mitochondrial deletion mutants accumulate via a size based replication advantage?

Journal of Theoretical Biology

Volumn 340, Issue , 2014, Pages 111-118

  Kowald, Axel ^a   Dawson, Marcus ^a,b   Kirkwood, Thomas B L ^a  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

^b UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

Ageing; Mathematical model; Mitochondrial mutation

Indexed keywords

CYTOCHROME C OXIDASE; MITOCHONDRIAL DNA;

AGING; BIOCHEMISTRY; MATHEMATICAL ANALYSIS; MITOCHONDRIAL DNA; MITOCHONDRION; MUTATION; NUMERICAL MODEL;

AGING; ARTICLE; COMPUTER SIMULATION; DELETION MUTANT; GENE DELETION; GENE MUTATION; HALF LIFE TIME; MATHEMATICAL MODEL; MITOCHONDRIAL DNA REPLICATION; MITOCHONDRION; PRIORITY JOURNAL;

AGEING; MATHEMATICAL MODEL; MITOCHONDRIAL MUTATION;

AGING; ANIMALS; COMPUTER SIMULATION; DNA, MITOCHONDRIAL; ELECTRON TRANSPORT COMPLEX IV; GENETIC DRIFT; HUMANS; LONGEVITY; MICE; MITOCHONDRIA; MODELS, BIOLOGICAL; MUTATION RATE; RATS; SEQUENCE DELETION; STOCHASTIC PROCESSES; TIME FACTORS;

EID: 84884929216     PISSN: 00225193     EISSN: 10958541     Source Type: Journal    
DOI: 10.1016/j.jtbi.2013.09.009     Document Type: Article

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