Correction of diabetes mellitus by transplanting minimal mass of syngeneic islets into vascularized small intestinal segment

American Journal of Transplantation

Volumn 13, Issue 10, 2013, Pages 2550-2557

  Kakabadze, Z ^a   Gupta, S ^b   Pileggi, A ^c   Molano, R D ^c   Ricordi, C ^c   Shatirishvili, G ^d   Loladze, G ^d   Mardaleishvili, K ^d   Kakabadze, M ^a   Berishvili, E ^a,e  

^a TBILISI STATE MEDICAL UNIVERSITY   (Georgia)

^b MARION BESSIN LIVER RESEARCH CENTER   (United States)

^c UNIVERSITY OF MIAMI   (United States)

^d Mardaleishvili Medical Center   (Georgia)

^e ILIA STATE UNIVERSITY   (Georgia)

Author keywords

Islets; pancreas; portal vein; small intestine; transplantation

Indexed keywords

BASIC FIBROBLAST GROWTH FACTOR RECEPTOR; GLUCAGON; GLUCOSE; GLUCOSE TRANSPORTER 2; INSULIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR PAX6; TRANSCRIPTION FACTOR PDX 1; TRANSFORMING GROWTH FACTOR ALPHA; VASCULOTROPIN;

ABDOMINAL AORTA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; ENGRAFTMENT; FOLLOW UP; GENE EXPRESSION; GLUCOSE BLOOD LEVEL; GLYCEMIC CONTROL; HISTOLOGY; NONHUMAN; PANCREAS ISLET CELL FUNCTION; PANCREAS ISLET TRANSPLANTATION; PORTAL VEIN; PRIORITY JOURNAL; RAT; REVASCULARIZATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SMALL INTESTINE; VASCULARIZATION;

ISLETS; PANCREAS; PORTAL VEIN; SMALL INTESTINE; TRANSPLANTATION;

ANIMALS; DIABETES MELLITUS, EXPERIMENTAL; GRAFT SURVIVAL; INTESTINE, SMALL; ISLETS OF LANGERHANS; ISLETS OF LANGERHANS TRANSPLANTATION; PORTAL VEIN; RATS; RATS, INBRED LEW; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TRANSPLANTATION, ISOGENEIC;

EID: 84884909292     PISSN: 16006135     EISSN: 16006143     Source Type: Journal    
DOI: 10.1111/ajt.12412     Document Type: Article

References (48)

1. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. The Diabetes Control and Complications Trial Research Group. N Engl J Med 1993; 329: 977-986. http://www.nejm.org/doi/pdf/10.1056/NEJM199309303291401, http://www.ncbi.nlm.nih.gov/pubmed/8366922
2. International Diabetes Federation. Diabetes atlas, 2nd ed. Brussels: International Diabetes Federation, 2003.
3. International Diabetes Federation. Diabetes atlas, 3rd ed. Brussels: International Diabetes Federation, 2006.
4. Ricordi C., Islet transplantation: A brave new world. Diabetes 2003; 52: 1595-1603.
5. Ricordi C, Strom TB., Clinical islet transplantation: Advances and immunological challenges. Nat Rev Immunol 2004; 4: 259-268.
6. Mineo D, Pileggi A, Alejandro R, Ricordi C., Point: Steady progress and current challenges in clinical islet transplantation. Diabetes Care 2009; 32: 1563-1569.
7. Shapiro AM, Lakey JR, Ryan EA, et al. Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen. N Engl J Med 2000; 343: 230-238.
8. Ryan EA, Paty BW, Senior PA, et al. Five-year follow-up after clinical islet transplantation. Diabetes 2005; 54: 2060-2069.
9. Cardani R, Pileggi A, Ricordi C, et al. Allosensitization of islet allograft recipients. Transplantation 2007; 84: 1413-1427.
10. Thomas F, Wu J, Contreras JL, et al. A tripartite anoikis-like mechanism causes early isolated islet apoptosis. Surgery 2001; 130: 333-338.
11. Pileggi A, Ribeiro MM, Hogan AR, et al. Impact of pancreatic cold preservation on rat islet recovery and function. Transplantation 2009; 87: 1442-1450.
12. Yasunami Y, Kojo S, Kitamura H, et al. Vα14 NK T cell-triggered IFN-γ production by Gr-1+CD11b+ cells mediates early graft loss of syngeneic transplanted islets. J Exp Med 2005; 202: 913-918.
13. Toyofuku A, Yasunami Y, Nabeyama K, et al. Natural killer T-cells participate in rejection of islet allografts in the liver of mice. Diabetes 2006; 55: 34-39.
14. Korsgren O, Lundgren T, Felldin M, et al. Optimizing islet engraftment is critical for successful clinical islet transplantation. Diabetologia 2008; 51: 227-232.
15. Carlsson PO, Palm F, Andersson A, Liss P., Markedly decreased oxygen tension in transplanted rat pancreatic islets irrespective of the implantation site. Diabetes 2001; 50: 489-495.
16. Al-Jazaeri A, Xu BY, Yang H, Macneil D, Leventhal JR, Wright JR Jr., Effect of glucose toxicity on intraportal tilapia islet xenotransplantation in nude mice. Xenotransplantation 2005; 12: 189-196.
17. Shapiro AM, Gallant HL, Hao EG, et al. The portal immunosuppressive storm: Relevance to islet transplantation ? Ther Drug Monit 2005; 27: 35-37.
18. Desai NM, Goss JA, Deng S, et al. Elevated portal vein drug levels of sirolimus and tacrolimus in islet transplant recipients: Local immunosuppression or islet toxicity ? Transplantation 2003; 76: 1623-1625.
19. Hara M, Yin D, Dizon RF, Shen J, Chong AS, Bindokas VP., A mouse model for studying intrahepatic islet transplantation. Transplantation 2004; 78: 615-618.
20. Cantarelli E, Piemonti L., Alternative transplantation sites for pancreatic islet grafts. Curr Diab Rep 2011; 11: 364-374.
21. Kakabadze Z, Gupta S, Brandhorst D, Korsgren O, Berishvili E., Long-term engraftment and function of transplanted pancreatic islets in vascularized segments of small intestine. Transpl Int 2011; 24: 175-183.
22. Harlan DM, Kenyon NS, Korsgren O, Roep BO, Immunology of Diabetes Society. Current advances and travails in islet transplantation. Diabetes 2009; 58: 2175-2184.
23. Eich T, Eriksson O, Sundin A, et al. Positron emission tomography: A real-time tool to quantify early islet engraftment in a preclinical large animal model. Transplantation 2007; 84: 893-898.
24. Ozmen L, Ekdahl KN, Elgue G, Larsson R, Korsgren O, Nilsson B., Inhibition of thrombin abrogates the instant blood-mediated inflammatory reaction triggered by isolated human islets: Possible application of the thrombin inhibitor melagatran in clinical islet transplantation. Diabetes 2002; 51: 1779-1784.
25. Stevens RB, Lokeh A, Ansite JD, Field MJ, Gores PF, Sutherland DER., Role of nitric oxide in the pathogenesis of early pancreatic islet dysfunction during rat and human intraportal islet transplantation. Transplant Proc 1994; 26: 692-694.
26. Bottino R, Fernandez LA, Ricordi C, et al. Transplantation of allogeneic islets of Langerhans in the rat liver: Effects of macrophage depletion on graft survival and microenvironment activation. Diabetes 1998; 47: 316-323.
27. Berman DM, O'Neil JJ, Coffey LC, et al. Long-term survival of nonhuman primate islets implanted in an omental pouch on a biodegradable scaffold. Am J Transplant 2009; 9: 91-104.
28. Weber CJ, Hardy MA, Pi-Sunyer F, Zimmerman E, Reemtsma K., Tissue culture preservation and intramuscular transplantation of pancreatic islets. Surgery 1978; 84: 166-174.
29. Svensson J, Lau J, Sandberg M, Carlsson PO., High vascular density and oxygenation of pancreatic islets transplanted in clusters into striated muscle. Cell Transplant 2011; 20: 783-788.
30. Cantarelli E, Melzi R, Mercalli A, et al. Bone marrow as an alternative site for islet transplantation. Blood 2009; 114: 4566-4574.
31. Rilo HL, Fontes PA, Nussler AK, et al. Intrapancreatic islet transplantation as a potential solution to chronic failure of intraportal islet grafts. Transplant Proc 1993; 25: 988.
32. Stagner JI, Rilo HL, White KK., The pancreas as an islet transplantation site confirmation in a syngeneic rodent and canine autotransplant model. JOP 2007; 8: 628-636.
33. Perez VL, Caicedo A, Berman DM, et al. The anterior chamber of the eye as a clinical transplantation site for the treatment of diabetes: A study in a baboon model of diabetes. Diabetologia 2011; 54: 1121-1126.
34. Kakabadze Z, Shanava K, Ricordi C, Shapiro AM, Gupta S, Berishvili E., An isolated venous sac as a novel site for cell therapy in diabetes mellitus. Transplantation 2012; 94: 319-324.
35. De Vos P, Hillebrands JL, De Haan BJ, Strubbe JH, Van Schilfgaarde R., Efficacy of a prevascularized expanded polytetrafluoroethylene solid support system as a transplantation site for pancreatic islets. Transplantation 1997; 63: 824-830.
36. Pileggi A, Molano RD, Ricordi C, et al. Reversal of diabetes by pancreatic islet transplantation into a subcutaneous, neovascularized device. Transplantation 2006; 81: 1318-1324.
37. Buchwald P, Bocca N, Marzorati S, et al. Feasibility of localized immunosuppression: 1. Exploratory studies with glucocorticoids in a biohybrid device designed for cell transplantation. Pharmazie 2010; 65: 421-428.
38. Sageshima J, Kirchhof N, Shibata S, Hiraoka K, Sutherland DE, Hering BJ., Small bowel subserosal space as a site for islet transplantation and local drug delivery. Transplant Proc 2001; 33: 1710.
39. Caiazzo R, Gmyr V, Hubert T, et al. Evaluation of alternative sites for islet transplantation in the minipig: Interest and limits of the gastric submucosa. Transplant Proc 2007; 39: 2620-2623.
40. Wszola M, Berman A, Fabisiak M, et al. TransEndoscopic Gastric SubMucosa Islet Transplantation (eGSM-ITx) in pigs with streptozotocine induced diabetes-Technical aspects of the procedure-Preliminary report. Ann Transplant 2009; 14: 45-50.
41. Echeverri GJ, McGrath K, Bottino R, et al. Endoscopic gastric submucosal transplantation of islets (ENDO-STI): Technique and initial results in diabetic pigs. Am J Transplant 2009; 9: 2485-2496.
42. Berishvili E, Liponava E, Kochlavashvili N, et al. Heterotopic auxiliary liver in an isolated and vascularized segment of the small intestine in rats. Transplantation 2003; 75: 1827-1832.
43. Joseph B, Berishvili E, Benten D, et al. Isolated small intestinal segments support auxiliary livers with maintenance of hepatic functions. Nat Med 2004; 10: 749-753.
44. Nussler AK, Ricordi C, Carroll PB, et al. Hepatic nitric oxide generation as a putative mechanism for failure of intrahepatic cell grafts. Transplant Proc 1992; 24: 2997.
45. Kawakami Y, Iwata H, Gu Y, et al. Modified subcutaneous tissue with neovascularization is useful as the site for pancreatic islet transplantation. Cell Transplant 2000; 9: 729-732.
46. Inoue M, Hager JH, Ferrara N, Gerber HP, Hanahan D., VEGF-A has a critical, nonredundant role in angiogenic switching and pancreatic beta cell carcinogenesis. Cancer Cell 2002; 1: 193-202.
47. Lammert E, Gu G, McLaughlin M, et al. Role of VEGF-A in vascularization of pancreatic islets. Curr Biol 2003; 13: 1070-1074.
48. Tian XH, Xue WJ, Ding XM, et al. Small intestinal submucosa improves islet survival and function during in vitro culture. World J Gastroenterol 2005; 11: 7378-7383.