Kaurane diterpenes from Sideritis spp. exert a cytoprotective effect against oxidative injury that is associated with modulation of the Nrf2 system

Phytochemistry

Volumn 93, Issue , 2013, Pages 116-123

  Gonzalez Burgos E ^a   Carretero, M E ^a   Gomez Serranillos M P ^a  

^a UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

Author keywords

Hydrogen peroxide; Kaurane diterpenes; Oxidative stress; PC12 cells; Sideritis

Indexed keywords

SIDERITIS; SIDERITIS LEUCANTHA;

ANTIOXIDANT; CATALASE; DIMETHYL SULFOXIDE; GLUTATHIONE; GLUTATHIONE DISULFIDE; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; HYDROGEN PEROXIDE; KAURANE DERIVATIVE; NFE2L2 PROTEIN, RAT; PLANT EXTRACT; REACTIVE OXYGEN METABOLITE; SUPEROXIDE DISMUTASE; TRANSCRIPTION FACTOR NRF2;

2′,7′-DICHLOROFLUORESCIN DIACETATE; 3-(4,5-DIMETHYLTHIAZOL-2-YL)-2,5-DIPHENYL-TETRAZOLIUM BROMIDE; ANIMAL; ARTICLE; CAT; CELL CULTURE; CELL PROTECTION; CELL SURVIVAL; CHEMISTRY; CONFORMATION; DCFH-DA; DOSE RESPONSE; DRUG EFFECT; GPX; GR; HEMEOXYGENASE-1; HO-1; ISOLATION AND PURIFICATION; KAURANE DITERPENES; METABOLISM; MTT; NRF2; NUCLEAR FACTOR-ERYTHROID 2; OXIDATIVE STRESS; PC12 CELL; RAT; ROS; SIDERITIS; SOD; STRUCTURE ACTIVITY RELATION;

2′,7′-DICHLOROFLUORESCIN DIACETATE; 3-(4,5-DIMETHYLTHIAZOL-2-YL)-2,5-DIPHENYL-TETRAZOLIUM BROMIDE; CAT; CATALASE; DCFH-DA; DIMETHYLSULFOXIDE; DMSO; GLUTATHIONE; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; GPX; GR; GSH; GSSG; HEMEOXYGENASE-1; HO-1; HYDROGEN PEROXIDE; KAURANE DITERPENES; MTT; NRF2; NUCLEAR FACTOR-ERYTHROID 2; OXIDATIVE STRESS; OXIDIZED GLUTATHIONE; PC12 CELLS; REACTIVE OXYGEN SPECIES; ROS; SIDERITIS; SOD; SUPEROXIDE DISMUTASE;

ANIMALS; ANTIOXIDANTS; CELL SURVIVAL; CELLS, CULTURED; CYTOPROTECTION; DITERPENES, KAURANE; DOSE-RESPONSE RELATIONSHIP, DRUG; HYDROGEN PEROXIDE; MOLECULAR CONFORMATION; NF-E2-RELATED FACTOR 2; OXIDATIVE STRESS; PC12 CELLS; PLANT EXTRACTS; RATS; SIDERITIS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84884900948     PISSN: 00319422     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.phytochem.2013.03.017     Document Type: Article

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