Selectively N-methylated soluble IAPP mimics as potent IAPP receptor agonists and nanomolar inhibitors of cytotoxic self-assembly of both IAPP and Aβ40

Angewandte Chemie - International Edition

Volumn 52, Issue 39, 2013, Pages 10378-10383

  Yan, Li Mei ^a   Velkova, Aleksandra ^a   Tatarek Nossol, Marianna ^b   Rammes, Gerhard ^c   Sibaev, Andrei ^d   Andreetto, Erika ^a   Kracklauer, Michael ^a   Bakou, Maria ^a   Malideli, Eleni ^a   Göke, Burkhard ^d   Schirra, Jörg ^d   Storr, Martin ^d   Kapurniotu, Aphrodite ^a  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^b RWTH AACHEN UNIVERSITY   (Germany)

^c TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^d LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

Author keywords

amyloid peptide; IAPP receptor agonist; islet amyloid polypeptide; protein interactions; self assembly

Indexed keywords

AMYLOID FORMATION; AMYLOID PEPTIDES; IAPP RECEPTOR AGONIST; ISLET AMYLOID POLYPEPTIDES; NANOMOLAR INHIBITORS; PROTEIN INTERACTION; SELECTIVE INCORPORATIONS; TYPE-2 DIABETES;

FUNCTIONAL GROUPS; PEPTIDES; POLYPEPTIDES; SELF ASSEMBLY;

GLYCOPROTEINS;

AMYLIN; AMYLIN RECEPTOR; AMYLOID; AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN (40 42); AMYLOID BETA-PROTEIN (40-42); PEPTIDE FRAGMENT; PEPTIDOMIMETIC AGENT;

AMINO ACID SEQUENCE; ARTICLE; CHEMISTRY; DRUG ANTAGONISM; DRUG POTENTIATION; HUMAN; IAPP RECEPTOR AGONIST; METABOLISM; METHYLATION; MOLECULAR GENETICS; PROTEIN INTERACTIONS; SELF-ASSEMBLY; ULTRASTRUCTURE; Β-AMYLOID PEPTIDE;

IAPP RECEPTOR AGONIST; ISLET AMYLOID POLYPEPTIDE; PROTEIN INTERACTIONS; SELF-ASSEMBLY; Β-AMYLOID PEPTIDE;

AMINO ACID SEQUENCE; AMYLOID; AMYLOID BETA-PEPTIDES; HUMANS; ISLET AMYLOID POLYPEPTIDE; METHYLATION; MOLECULAR SEQUENCE DATA; PEPTIDE FRAGMENTS; PEPTIDOMIMETICS; RECEPTORS, ISLET AMYLOID POLYPEPTIDE;

EID: 84884844389     PISSN: 14337851     EISSN: 15213773     Source Type: Journal    
DOI: 10.1002/anie.201302840     Document Type: Article

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