A constitutively activating mutation alters the dynamics and energetics of a key conformational change in a ligand-free G protein-coupled receptor

Journal of Biological Chemistry

Volumn 288, Issue 39, 2013, Pages 28207-28216

  Tsukamoto, Hisao ^a,b   Farrens, David L ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b INSTITUTE FOR MOLECULAR SCIENCE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CONFORMATIONAL CHANGE; CONSTITUTIVELY ACTIVES; FLUORESCENCE LABELING; G PROTEIN COUPLED RECEPTORS; GAIN INSIGHT; LIGAND-FREE;

CAMS; PROTEINS;

DYNAMICS;

G PROTEIN COUPLED RECEPTOR; OPSIN; RHODOPSIN;

ARTICLE; CONFORMATIONAL TRANSITION; CONSTITUTIVELY ACTIVE MUTATION; CONTROLLED STUDY; FLUORESCENCE SPECTROSCOPY; LIPID MEMBRANE; MICELLE; MOLECULAR DYNAMICS; MUTATION; PRIORITY JOURNAL; PROTEIN STRUCTURE; SITE DIRECTED FLUORESCENCE LABELING SPECTROSCOPY;

CONFORMATIONAL TRANSITIONS; ENERGY LANDSCAPES; FLUORESCENCE; G PROTEIN-COUPLED RECEPTORS (GPCR); PROTEIN DYNAMICS; PROTEIN ENERGETICS; RECEPTOR STRUCTURE-FUNCTION; RHODOPSIN; SITE-DIRECTED FLUORESCENCE LABELING (SDFL); TRYPTOPHAN-INDUCED QUENCHING (TRIQ);

ANIMALS; CATTLE; CERCOPITHECUS AETHIOPS; COS CELLS; CRYSTALLOGRAPHY, X-RAY; DETERGENTS; LIGANDS; LIPIDS; MICELLES; MUTATION; OPSINS; PROTEIN STRUCTURE, SECONDARY; RECEPTORS, G-PROTEIN-COUPLED; RHODOPSIN; SPECTROMETRY, FLUORESCENCE; TRYPTOPHAN;

EID: 84884776927     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.472464     Document Type: Article

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