CD56+ monocytes have a dysregulated cytokine response to lipopolysaccharide and accumulate in rheumatoid arthritis and immunosenescence

Arthritis Research and Therapy

Volumn 15, Issue 5, 2013, Pages

  Krasselt, Marco ^a   Baerwald, Christoph ^a   Wagner, Ulf ^a   Rossol, Manuela ^a  

^a UNIVERSITY OF LEIPZIG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ABATACEPT; CD56 ANTIGEN; CYCLOSPORIN A; ETANERCEPT; HYDROXYCHLOROQUINE; INTERLEUKIN 10; INTERLEUKIN 23; LEFLUNOMIDE; LIPOPOLYSACCHARIDE; METHOTREXATE; REACTIVE OXYGEN METABOLITE; RITUXIMAB; TOCILIZUMAB; TUMOR NECROSIS FACTOR; TUMOR NECROSIS FACTOR INHIBITOR; ANTIRHEUMATIC AGENT; CD14 ANTIGEN; CYTOKINE; IMMUNOGLOBULIN G; TNFR FC FUSION PROTEIN; TNFR-FC FUSION PROTEIN; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR;

ADULT; AGE; AGED; ARTICLE; CELL FUNCTION; CELL STIMULATION; CELL SUBPOPULATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; MAJOR CLINICAL STUDY; MALE; MONOCYTE; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; RHEUMATOID ARTHRITIS; SINGLE CELL ANALYSIS; STAINING; BLOOD; CELL AGING; CELL CULTURE; CELL PROLIFERATION; DRUG EFFECT; IMMUNOLOGY; METABOLISM; MIDDLE AGED; VERY ELDERLY; YOUNG ADULT;

ADULT; AGE FACTORS; AGED; AGED, 80 AND OVER; ANTIGENS, CD14; ANTIGENS, CD56; ANTIRHEUMATIC AGENTS; ARTHRITIS, RHEUMATOID; CELL AGING; CELL PROLIFERATION; CELLS, CULTURED; CYTOKINES; FEMALE; FLOW CYTOMETRY; HUMANS; IMMUNOGLOBULIN G; INTERLEUKIN-10; INTERLEUKIN-23; LIPOPOLYSACCHARIDES; MALE; MIDDLE AGED; MONOCYTES; REACTIVE OXYGEN SPECIES; RECEPTORS, TUMOR NECROSIS FACTOR; TUMOR NECROSIS FACTOR-ALPHA; YOUNG ADULT;

EID: 84884732385     PISSN: 14786354     EISSN: 14786362     Source Type: Journal    
DOI: 10.1186/ar4321     Document Type: Article

References (30)

1. Ziegler-Heitbrock L, Ancuta P, Crowe S, Dalod M, Grau V, Hart DN, Leenen PJ, Liu YJ, MacPherson G, Randolph GJ, Scherberich J, Schmitz J, Shortman K, Sozzani S, Strobl H, Zembala M, Austyn JM, Lutz MB. Nomenclature of monocytes and dendritic cells in blood. Blood 2010, 116:e74-e80. 10.1182/blood-2010-02-258558, 20628149.
2. Sconocchia G, Keyvanfar K, El Ouriaghli F, Grube M, Rezvani K, Fujiwara H, McCoy JP, Hensel N, Barrett AJ. Phenotype and function of a CD56+ peripheral blood monocyte. Leukemia 2005, 19:69-76.
3. Grip O, Bredberg A, Lindgren S, Henriksson G. Increased subpopulations of CD16+ and CD56+ blood monocytes in patients with active Crohn's disease. Inflamm Bowel Dis 2007, 13:566-572. 10.1002/ibd.20025, 17260384.
4. Karandikar NJ, Aquino DB, McKenna RW, Kroft SH. Transient myeloproliferative disorder and acute myeloid leukemia in Down syndrome: an immunophenotypic analysis. Am J Clin Pathol 2001, 116:204-210. 10.1309/XREF-C9T2-6U0A-4EDT, 11488066.
5. Xu Y, McKenna RW, Karandikar NJ, Pildain AJ, Kroft SH. Flow cytometric analysis of monocytes as a tool for distinguishing chronic myelomonocytic leukemia from reactive monocytosis. Am J Clin Pathol 2005, 124:799-806. 10.1309/HRJ1XKTD77J1UTFM, 16203279.
6. Rossol M, Kraus S, Pierer M, Baerwald C, Wagner U. The CD14brightCD16+ monocyte subset is expanded in rheumatoid arthritis and promotes expansion of the Th17 cell population. Arthritis Rheum 2012, 64:671-677. 10.1002/art.33418, 22006178.
7. Coulthard LR, Geiler J, Mathews RJ, Church LD, Dickie LJ, Cooper DL, Wong C, Savic S, Bryer D, Buch MH, Emery P, Morgan AW, McDermott MF. Differential effects of infliximab on absolute circulating blood leucocyte counts of innate immune cells in early and late rheumatoid arthritis patients. Clin Exp Immunol 2012, 170:36-46. 10.1111/j.1365-2249.2012.04626.x, 3444715, 22943199.
8. Kawanaka N, Yamamura M, Aita T, Morita Y, Okamoto A, Kawashima M, Iwahashi M, Ueno A, Ohmoto Y, Makino H. CD14+, CD16+ blood monocytes and joint inflammation in rheumatoid arthritis. Arthritis Rheum 2002, 46:2578-2586. 10.1002/art.10545, 12384915.
9. Aletaha D, Neogi T, Silman AJ, Funovits J, Felson DT, Bingham CO, Birnbaum NS, Burmester GR, Bykerk VP, Cohen MD, Combe B, Costenbader KH, Dougados M, Emery P, Ferraccioli G, Hazes JM, Hobbs K, Huizinga TW, Kavanaugh A, Kay J, Kvien TK, Laing T, Mease P, Ménard HA, Moreland LW, Naden RL, Pincus T, Smolen JS, Stanislawska-Biernat E, Symmons D, Tak PP, Upchurch KS, Vencovsky J, Wolfe F, Hawker G. 2010 rheumatoid arthritis classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative. Ann Rheum Dis 2010, 69:1580-1588. 10.1136/ard.2010.138461, 20699241.
10. Rossol M, Kaltenhäuser S, Scholz R, Häntzschel H, Hauschildt S, Wagner U. The contact-mediated response of peripheral-blood monocytes to preactivated T cells is suppressed by serum factors in rheumatoid arthritis. Arthritis Res Ther 2005, 7:R1189-R1199. 10.1186/ar1804, 1297564, 16277671.
11. Sconocchia G, Fujiwara H, Rezvani K, Keyvanfar K, El Ouriaghli F, Grube M, Melenhorst J, Hensel N, Barrett AJ. G-CSF-mobilized CD34+ cells cultured in interleukin-2 and stem cell factor generate a phenotypically novel monocyte. J Leukoc Biol 2004, 76:1214-1219. 10.1189/jlb.0504278, 15345723.
12. Gruenbacher G, Gander H, Rahm A, Nussbaumer W, Romani N, Thurnher M. CD56+ human blood dendritic cells effectively promote TH1-type γδ T-cell responses. Blood 2009, 114:4422-4431. 10.1182/blood-2009-06-227256, 19762486.
13. Sconocchia G, Del Principe D, Barrett AJ. CD16low/negative tumor-infiltrating lymphocyte: lymphoid or myeloid in origin?. Clin Cancer Res 2007, 13:1620-1621. 10.1158/1078-0432.CCR-06-2247, 17332309.
14. Cros J, Cagnard N, Woollard K, Patey N, Zhang SY, Senechal B, Puel A, Biswas SK, Moshous D, Picard C, Jais JP, D'Cruz D, Casanova JL, Trouillet C, Geissmann F. Human CD14dim monocytes patrol and sense nucleic acids and viruses via TLR7 and TLR8 receptors. Immunity 2010, 33:375-386. 10.1016/j.immuni.2010.08.012, 3063338, 20832340.
15. Miller RA. The aging immune system: primer and prospectus. Science 1996, 273:70-74. 10.1126/science.273.5271.70, 8658199.
16. Panda A, Arjona A, Sapey E, Bai F, Fikrig E, Montgomery RR, Lord JM, Shaw AC. Human innate immunosenescence: causes and consequences for immunity in old age. Trends Immunol 2009, 30:325-333. 10.1016/j.it.2009.05.004, 19541535.
17. Weyand CM, Fujii H, Shao L, Goronzy JJ. Rejuvenating the immune system in rheumatoid arthritis. Nat Rev Rheumatol 2009, 5:583-588. 10.1038/nrrheum.2009.180, 19798035.
18. Shaw AC, Joshi S, Greenwood H, Panda A, Lord JM. Aging of the innate immune system. Curr Opin Immunol 2010, 22:507-513. 10.1016/j.coi.2010.05.003, 20667703.
19. Boehmer ED, Goral J, Faunce DE, Kovacs EJ. Age-dependent decrease in Toll-like receptor 4-mediated proinflammatory cytokine production and mitogen-activated protein kinase expression. J Leukoc Biol 2004, 75:342-349.
20. Chelvarajan RL, Collins SM, Van Willigen JM, Bondada S. The unresponsiveness of aged mice to polysaccharide antigens is a result of a defect in macrophage function. J Leukoc Biol 2005, 77:503-512.
21. Gomez CR, Hirano S, Cutro BT, Birjandi S, Baila H, Nomellini V, Kovacs EJ. Advanced age exacerbates the pulmonary inflammatory response after lipopolysaccharide exposure. Crit Care Med 2007, 35:246-251. 10.1097/01.CCM.0000251639.05135.E0, 17133178.
22. Turnbull IR, Clark AT, Stromberg PE, Dixon DJ, Woolsey CA, Davis CG, Hotchkiss RS, Buchman TG, Coopersmith CM. Effects of aging on the immunopathologic response to sepsis. Crit Care Med 2009, 37:1018-1023. 10.1097/CCM.0b013e3181968f3a, 2760736, 19237912.
23. Hearps AC, Martin GE, Angelovich TA, Cheng WJ, Maisa A, Landay AL, Jaworowski A, Crowe SM. Aging is associated with chronic innate immune activation and dysregulation of monocyte phenotype and function. Aging Cell 2012, 11:867-875. 10.1111/j.1474-9726.2012.00851.x, 22708967.
24. Clark JA, Peterson TC. Cytokine production and aging: overproduction of IL-8 in elderly males in response to lipopolysaccharide. Mech Ageing Dev 1994, 77:127-139. 10.1016/0047-6374(94)90020-5, 7745991.
25. Delpedro AD, Barjavel MJ, Mamdouh Z, Faure S, Bakouche O. Signal transduction in LPS-activated aged and young monocytes. J Interferon Cytokine Res 1998, 18:429-437. 10.1089/jir.1998.18.429, 9660251.
26. Qian F, Wang X, Zhang L, Chen S, Piecychna M, Allore H, Bockenstedt L, Malawista S, Bucala R, Shaw AC, Fikrig E, Montgomery RR. Age-associated elevation in TLR5 leads to increased inflammatory responses in the elderly. Aging Cell 2012, 11:104-110. 10.1111/j.1474-9726.2011.00759.x, 3257374,3257374, 22023165.
27. Della Bella S, Bierti L, Presicce P, Arienti R, Valenti M, Saresella M, Vergani C, Villa ML. Peripheral blood dendritic cells and monocytes are differently regulated in the elderly. Clin Immunol 2007, 122:220-228. 10.1016/j.clim.2006.09.012, 17101294.
28. Seidler S, Zimmermann HW, Bartneck M, Trautwein C, Tacke F. Age-dependent alterations of monocyte subsets and monocyte-related chemokine pathways in healthy adults. BMC Immunol 2010, 11:30. 10.1186/1471-2172-11-30, 2910032, 20565954.
29. Nyugen J, Agrawal S, Gollapudi S, Gupta S. Impaired functions of peripheral blood monocyte subpopulations in aged humans. J Clin Immunol 2010, 30:806-813. 10.1007/s10875-010-9448-8, 2970801, 20703784.
30. Chara L, Sánchez-Atrio A, Pérez A, Cuende E, Albarrán F, Turrión A, Chevarria J, Sánchez MA, Monserrat J, de la Hera A, Prieto A, Sanz I, Diaz D, Alvarez-Mon M. Monocyte populations as markers of response to adalimumab plus MTX in rheumatoid arthritis. Arthritis Res Ther 2012, 14:R175. 10.1186/ar3928, 3580569, 22838733.