Type I-E CRISPR-Cas Systems Discriminate Target from Non-Target DNA through Base Pairing-Independent PAM Recognition

PLoS Genetics

Volumn 9, Issue 9, 2013, Pages

  Westra, Edze R ^a   Semenova, Ekaterina ^b   Datsenko, Kirill A ^b,c   Jackson, Ryan N ^d   Wiedenheft, Blake ^d   Severinov, Konstantin ^b,e,f   Brouns, Stan J J ^a  

^a WAGENINGEN UNIVERSITY   (Netherlands)

^b RUTGERS UNIVERSITY   (United States)

^c PURDUE UNIVERSITY   (United States)

^d MONTANA STATE UNIVERSITY   (United States)

^e RUTGERS UNIVERSITY   (United States)

^f INSTITUTE OF MOLECULAR GENETICS   (Russian Federation)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEAT ASSOCIATED (CAS) PROTEIN; DNA; RNA; UNCLASSIFIED DRUG;

ARTICLE; AUTOIMMUNITY; BACTERIAL GENOME; BASE PAIRING; CONTROLLED STUDY; DNA FLANKING REGION; DNA STRUCTURE; ESCHERICHIA COLI; GENE LOCUS; GENE SEQUENCE; GENE TARGETING; GENETIC CONSERVATION; MOLECULAR RECOGNITION; NONHUMAN; PHENOTYPE; PROTEIN MOTIF; PROTOSPACER ADJACENT MOTIF; SEQUENCE ANALYSIS; TYPE I E CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEAT CAS SYSTEM;

ADAPTIVE IMMUNITY; BASE PAIRING; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEATS; CRISPR-ASSOCIATED PROTEINS; DNA; ESCHERICHIA COLI; NUCLEOTIDE MOTIFS; RNA;

EID: 84884687531     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1003742     Document Type: Article

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