Efflux of monoclonal antibodies from rat brain by neonatal Fc receptor, FcRn

Brain Research

Volumn 1534, Issue , 2013, Pages 13-21

  Cooper, Philip R ^a   Ciambrone, Gary J ^b   Kliwinski, Connie M ^c   Maze, Eva ^b   Johnson, Lowell ^b   Li, Qianqiu ^c   Feng, Yiqing ^a   Hornby, Pamela J ^a  

^a Biologics Research   (United States)

^b Drug Product Development   (United States)

^c Biologics Pharmacology and Toxicology ^*  (United States)

Author keywords

Blood brain barrier; Efflux; FcRn; IgG; Intracranial; Intranasal

Indexed keywords

FC RECEPTOR; IMMUNOGLOBULIN G; IMMUNOGLOBULIN G1; MONOCLONAL ANTIBODY;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN PERFUSION; BRAIN TISSUE; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; EFFUSION; ENZYME LINKED IMMUNOSORBENT ASSAY; HEMISPHERE; IMMUNOGLOBULIN BLOOD LEVEL; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; MALE; NEWBORN; NONHUMAN; PLASMA CLEARANCE; PRIORITY JOURNAL; PROTEIN STRUCTURE; RAT; TRANSCYTOSIS;

ANIMALIA; RATTUS;

BLOOD-BRAIN-BARRIER; EFFLUX; FCRN; IGG; IMMUNOGLOBULIN G; INTRACRANIAL; INTRANASAL; NEONATAL FC RECEPTOR; WILD TYPE; WT;

ANIMALS; ANTIBODIES, MONOCLONAL; BRAIN; DRUG DELIVERY SYSTEMS; HISTOCOMPATIBILITY ANTIGENS CLASS I; IMMUNOGLOBULIN G; MALE; OLFACTORY MUCOSA; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, FC;

EID: 84884672721     PISSN: 00068993     EISSN: 18726240     Source Type: Journal    
DOI: 10.1016/j.brainres.2013.08.035     Document Type: Article

References (38)

1. L. Abuqayyas, and J.P. Balthasar Investigation of the role of FcγR and FcRn in mAb distribution to the brain Mol. Pharm. 10 2013 1505 1513
2. N.S. Barakat, S.A. Omar, and A.A. Ahmed Carbamazepine uptake into rat brain following intra-olfactory transport J. Pharm. Pharmacol. 58 2006 63 72
3. I. Bergman, G.J. Burckart, C.R. Pohl, R. Venkataramanan, M.A. Barmada, J.A. Griffin, and N.K. Cheung Pharmacokinetics of IgG and IgM anti-ganglioside antibodies in rats and monkeys after intrathecal administration J. Pharmacol. Exp. Ther. 284 1998 111 115
4. U. Bickel, Y.S. Kang, T. Yoshikawa, and W.M. Pardridge In vivo demonstration of subcellular localization of anti-transferrin receptor monoclonal antibody-colloidal gold conjugate in brain capillary endothelium J. Histochem. Cytochem. 42 1994 1493 1497
5. R.J. Boado, Y. Zhang, Y. Zhang, and W.M. Pardridge Humanization of anti-human insulin receptor antibody for drug targeting across the human blood-brain barrier Biotechnol. Bioeng. 96 2007 381 391
6. M.W. Bradbury, H.F. Cserr, and R.J. Westrop Drainage of cerebral interstitial fluid into deep cervical lymph of the rabbit Am. J. Physiol. 240 1981 F329 F336
7. M.W. Bradbury, and R.J. Westrop Factors influencing exit of substances from cerebrospinal fluid into deep cervical lymph of the rabbit J. Physiol. 339 1983 519 534
8. A. Cetin, S. Komai, M. Eliava, P.H. Seeburg, and P. Osten Stereotaxic gene delivery in the rodent brain Nat. Protoc. 1 2006 3166 3173
9. H.F. Cserr, C.J. Harling-Berg, and P.M. Knopf Drainage of brain extracellular fluid into blood and deep cervical lymph and its immunological significance Brain Pathol. 2 1992 269 276
10. R. Deane, A. Sagare, K. Hamm, M. Parisi, B. LaRue, H. Guo, Z. Wu, D.M. Holtzman, and B.V. Zlokovic IgG-assisted age-dependent clearance of Alzheimer's amyloid beta peptide by the blood-brain barrier neonatal Fc receptor J. Neurosci. 25 2005 11495 11503
11. R. Deane, R.D. Bell, A. Sagare, and B.V. Zlokovic Clearance of amyloid-beta peptide across the blood-brain barrier: implication for therapies in Alzheimer's disease CNS Neurol. Disord. Drug Targets 8 2009 16 30
12. S.V. Dhuria, L.R. Hanson, and W.H. Frey 2nd Intranasal delivery to the central nervous system: mechanisms and experimental considerations J. Pharm. Sci. 99 2010 1654 1673
13. V.A. Evseev, L.A. Vetrile, and I.A. Zaharova Effect of intranasal administration of anti-glutamate antibodies after stress exposure on the stress response Bull. Exp. Biol. Med. 149 2010 551 553
14. P. Field, Y. Li, and G. Raisman Ensheathment of the olfactory nerves in the adult rat J. Neurocytol. 32 2003 317 324
15. M. Firan, R. Bawdon, C. Radu, R.J. Ober, D. Eaken, F. Antohe, V. Ghetie, and E.S. Ward The MHC class I-related receptor, FcRn, plays an essential role in the maternofetal transfer of gamma-globulin in humans Int. Immunol. 13 2001 993 1002
16. E. Furrer, V. Hulmann, and D.M. Urech Intranasal delivery of ESBA105, a TNF-alpha-inhibitory scFv antibody fragment to the brain J. Neuroimmunol. 215 2009 65 72
17. A. Garg, and J.P. Balthasar Investigation of the influence of FcRn on the distribution of IgG to the brain AAPS J. 11 2009 553 557
18. V.Y. Gorbatov, N.A. Trekova, V.G. Fomina, and T.V. Davydova Antiamnestic effects of antibodies to glutamate in experimental Alzheimer's disease Bull. Exp. Biol. Med. 150 2010 23 25
19. J.D. Hoekman, and R.J. Ho Enhanced analgesic responses after preferential delivery of morphine and fentanyl to the olfactory epithelium in rats Anesth. Analg. 113 2011 641 651
20. C. Kliwinski, P. Cooper, R. Perkinson, J. Mabus, S. Tam, T. Wilkinson, J. Giles-Komar, B. Scallon, G. Powers, and P. Hornby The contribution of FcRn binding to intestinal uptake of IgG in suckling rat pups and human FcRn-transgenic mice Am. J. Physiol. Gastrointest. Liver Physiol. 304 2013 G262 G270
21. Y. Li, P.M. Field, and G. Raisman Olfactory ensheathing cells and olfactory nerve fibroblasts maintain continuous open channels for regrowth of olfactory nerve fibres Glia 52 2005 245 251
22. J.J. Lochhead, and R.G. Thorne Intranasal delivery of biologics to the central nervous system Adv. Drug Delivery Rev. 64 2012 614 628
23. W.M. Pardridge, J.L. Buciak, and P.M. Friden Selective transport of an anti-transferrin receptor antibody through the blood-brain barrier in vivo J. Pharmacol. Exp. Ther. 259 1991 66 70
24. W.M. Pardridge, Y.S. Kang, J.L. Buciak, and J. Yang Human insulin receptor monoclonal antibody undergoes high affinity binding to human brain capillaries in vitro and rapid transcytosis through the blood-brain barrier in vivo in the primate Pharm. Res. 12 1995 807 816
25. J.F. Poduslo, G.L. Curran, and C.T. Berg Macromolecular permeability across the blood-nerve and blood-brain barriers Proc. Natl. Acad. Sci. USA 91 1994 5705 5709
26. C. Pujara, Z. Shao, M. Duncan, and A. Mitra Effects of formulation variables on nasal epithelial cell integrity: biochemical evaluations Int. J. Pharm. 114 1995 197 203
27. G.A. Romanova, F.M. Shakova, V.Y. Gorbatov, Y.N. Kvashennikova, and T.V. Davydova Effect of antibodies to glutamate on retention of conditioned passive avoidance response in rats with ischemic injury of the prefrontal cortex Bull. Exp. Biol. Med. 149 2010 289 292
28. D.C. Roopenian, and S. Akilesh FcRn: the neonatal Fc receptor comes of age Nat. Rev. Immunol. 7 2007 715 725
29. F. Schlachetzki, C. Zhu, and W.M. Pardridge Expression of the neonatal Fc receptor (FcRn) at the blood-brain barrier J. Neurochem. 81 2002 203 206
30. E. Sipos, A. Kurunczi, A. Feher, Z. Penke, L. Fulop, A. Kasza, J. Horvath, S. Horvat, S. Veszelka, G. Balogh, L. Kurti, I. Eros, P. Szabo-Revesz, A. Parducz, B. Penke, and M.A. Deli Intranasal delivery of human beta-amyloid peptide in rats: effective brain targeting Cell. Mol. Neurobiol. 30 2010 405 413
31. R.G. Thorne, G.J. Pronk, V. Padmanabhan, and W.H. Frey 2nd Delivery of insulin-like growth factor-I to the rat brain and spinal cord along olfactory and trigeminal pathways following intranasal administration Neuroscience 127 2004 481 496
32. T.K. Vyas, S.B. Tiwari, and M.M. Amiji Formulation and physiological factors influencing CNS delivery upon intranasal administration Crit. Rev. Ther. Drug Carrier Syst. 23 2006 319 347
33. N. Washington, R.J. Steele, S.J. Jackson, D. Bush, J. Mason, D.A. Gill, K. Pitt, and D.A. Rawlins Determination of baseline human nasal pH and the effect of intranasally administered buffers Int. J. Pharm. 198 2000 139 146
34. M.J. Wolfsegger, and T. Jaki Estimation of AUC from 0 to infinity in serial sacrifice designs J. Pharmacokinet. Pharmacodyn. 32 2005 757 766
35. M.J. Wolfsegger Establishing bioequivalence in serial sacrifice designs J. Pharmacokinet. Pharmacodyn. 34 2007 103 113
36. Y.A. Yeung, M.K. Leabman, J.S. Marvin, J. Qiu, C.W. Adams, S. Lien, M.A. Starovasnik, and H.B. Lowman Engineering human IgG1 affinity to human neonatal Fc receptor: impact of affinity improvement on pharmacokinetics in primates J. Immunol. 182 2009 7663 7671
37. Y.J. Yu, Y. Zhang, M. Kenrick, K. Hoyte, W. Luk, Y. Lu, J. Atwal, J.M. Elliott, S. Prabhu, R.J. Watts, and M.S. Dennis Boosting brain uptake of a therapeutic antibody by reducing its affinity for a transcytosis target Sci. Transl. Med. 3 2011 (84ra44)
38. Y. Zhang, and W.M. Pardridge Mediated efflux of IgG molecules from brain to blood across the blood-brain barrier J. Neuroimmunol. 114 2001 168 172