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Volumn 33, Issue 36, 2014, Pages 4474-4484

Cell type-dependent pathogenic functions of overexpressed human cathepsin B in murine breast cancer progression

Author keywords

breast cancer; CTSB; invasion; macrophages

Indexed keywords

CATHEPSIN B; CTSB PROTEIN, HUMAN; DOXYCYCLINE; SCLEROPROTEIN; VIRUS T ANTIGEN;

EID: 84884654881     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2013.395     Document Type: Article
Times cited : (84)

References (55)
  • 1
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell 2011; 144: 646-674.
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 2
    • 3042822267 scopus 로고    scopus 로고
    • Cancer and the chemokine network
    • Balkwill F. Cancer and the chemokine network. Nat Rev Cancer 2004; 4: 540-550.
    • (2004) Nat Rev Cancer , vol.4 , pp. 540-550
    • Balkwill, F.1
  • 4
    • 79953163995 scopus 로고    scopus 로고
    • Proteolytic networks in cancer
    • Mason SD, Joyce JA. Proteolytic networks in cancer. Trends Cell Biol 2011; 21: 228-237.
    • (2011) Trends Cell Biol , vol.21 , pp. 228-237
    • Mason, S.D.1    Joyce, J.A.2
  • 6
    • 56449113201 scopus 로고    scopus 로고
    • Lysosomal cathepsin B participates in the podosome-mediated extracellular matrix degradation and invasion via secreted lysosomes in v-Src fibroblasts
    • Tu C, Ortega-Cava CF, Chen G, Fernandes ND, Cavallo-Medved D, Sloane BF et al. Lysosomal cathepsin B participates in the podosome-mediated extracellular matrix degradation and invasion via secreted lysosomes in v-Src fibroblasts. Cancer Res 2008; 68: 9147-9156.
    • (2008) Cancer Res , vol.68 , pp. 9147-9156
    • Tu, C.1    Ortega-Cava, C.F.2    Chen, G.3    Fernandes, N.D.4    Cavallo-Medved, D.5    Sloane, B.F.6
  • 7
    • 32344440534 scopus 로고    scopus 로고
    • Cathepsin B localizes to plasma membrane caveolae of differentiating myoblasts and is secreted in an active form at physiological pH
    • Jane DT, Morvay L, Dasilva L, Cavallo-Medved D, Sloane BF, Dufresne MJ. Cathepsin B localizes to plasma membrane caveolae of differentiating myoblasts and is secreted in an active form at physiological pH. Biol Chem 2006; 387: 223-234.
    • (2006) Biol Chem , vol.387 , pp. 223-234
    • Jane, D.T.1    Morvay, L.2    Dasilva, L.3    Cavallo-Medved, D.4    Sloane, B.F.5    Dufresne, M.J.6
  • 8
    • 0034802806 scopus 로고    scopus 로고
    • Prognostic impact of proteolytic factors (urokinase-type plasminogen activator, plasminogen activator inhibitor 1, and cathepsins B, D, and L) in primary breast cancer reflects effects of adjuvant systemic therapy
    • Harbeck N, Alt U, Berger U, Kruger A, Thomssen C, Janicke F et al. Prognostic impact of proteolytic factors (urokinase-type plasminogen activator, plasminogen activator inhibitor 1, and cathepsins B, D, and L) in primary breast cancer reflects effects of adjuvant systemic therapy. Clin Cancer Res 2001; 7: 2757-2764.
    • (2001) Clin Cancer Res , vol.7 , pp. 2757-2764
    • Harbeck, N.1    Alt, U.2    Berger, U.3    Kruger, A.4    Thomssen, C.5    Janicke, F.6
  • 10
    • 10044296973 scopus 로고    scopus 로고
    • Cysteine cathepsins in human cancer
    • Jedeszko C, Sloane BF. Cysteine cathepsins in human cancer. Biol Chem 2004; 385: 1017-1027.
    • (2004) Biol Chem , vol.385 , pp. 1017-1027
    • Jedeszko, C.1    Sloane, B.F.2
  • 11
    • 33744917827 scopus 로고    scopus 로고
    • Tumor cell-derived and macrophage-derived cathepsin B promotes progression and lung metastasis of mammary cancer
    • Vasiljeva O, Papazoglou A, Kruger A, Brodoefel H, Korovin M, Deussing J et al. Tumor cell-derived and macrophage-derived cathepsin B promotes progression and lung metastasis of mammary cancer. Cancer Res 2006; 66: 5242-5250.
    • (2006) Cancer Res , vol.66 , pp. 5242-5250
    • Vasiljeva, O.1    Papazoglou, A.2    Kruger, A.3    Brodoefel, H.4    Korovin, M.5    Deussing, J.6
  • 12
    • 76149146398 scopus 로고    scopus 로고
    • IL-4 induces cathepsin protease activity in tumor-associated macrophages to promote cancer growth and invasion
    • Gocheva V, Wang HW, Gadea BB, Shree T, Hunter KE, Garfall AL et al. IL-4 induces cathepsin protease activity in tumor-associated macrophages to promote cancer growth and invasion. Genes Dev 2010; 24: 241-255.
    • (2010) Genes Dev , vol.24 , pp. 241-255
    • Gocheva, V.1    Wang, H.W.2    Gadea, B.B.3    Shree, T.4    Hunter, K.E.5    Garfall, A.L.6
  • 13
    • 84857692141 scopus 로고    scopus 로고
    • Differential macrophage programming in the tumor microenvironment
    • Ruffell B, Affara NI, Coussens LM. Differential macrophage programming in the tumor microenvironment. Trends Immunol 2012; 33: 119-126.
    • (2012) Trends Immunol , vol.33 , pp. 119-126
    • Ruffell, B.1    Affara, N.I.2    Coussens, L.M.3
  • 14
    • 67651160649 scopus 로고    scopus 로고
    • CD4(+) T cells regulate pulmonary metastasis of mammary carcinomas by enhancing protumor properties of macrophages
    • DeNardo DG, Barreto JB, Andreu P, Vasquez L, Tawfik D, Kolhatkar N et al. CD4(+) T cells regulate pulmonary metastasis of mammary carcinomas by enhancing protumor properties of macrophages. Cancer Cell 2009; 16: 91-102.
    • (2009) Cancer Cell , vol.16 , pp. 91-102
    • Denardo, D.G.1    Barreto, J.B.2    Andreu, P.3    Vasquez, L.4    Tawfik, D.5    Kolhatkar, N.6
  • 15
    • 31044433663 scopus 로고    scopus 로고
    • Macrophages: Obligate partners for tumor cell migration, invasion, and metastasis
    • Condeelis J, Pollard JW. Macrophages: obligate partners for tumor cell migration, invasion, and metastasis. Cell 2006; 124: 263-266.
    • (2006) Cell , vol.124 , pp. 263-266
    • Condeelis, J.1    Pollard, J.W.2
  • 16
    • 84858590826 scopus 로고    scopus 로고
    • Accessories to the crime: Functions of cells recruited to the tumor microenvironment
    • Hanahan D, Coussens LM. Accessories to the crime: functions of cells recruited to the tumor microenvironment. Cancer Cell 2012; 21: 309-322.
    • (2012) Cancer Cell , vol.21 , pp. 309-322
    • Hanahan, D.1    Coussens, L.M.2
  • 17
    • 50849090319 scopus 로고    scopus 로고
    • Macrophages define the invasive microenvironment in breast cancer
    • Pollard JW. Macrophages define the invasive microenvironment in breast cancer. J Leukoc Biol 2008; 84: 623-630.
    • (2008) J Leukoc Biol , vol.84 , pp. 623-630
    • Pollard, J.W.1
  • 18
    • 34047246527 scopus 로고    scopus 로고
    • Direct visualization of macrophage-assisted tumor cell intravasation in mammary tumors
    • Wyckoff JB, Wang Y, Lin EY, Li JF, Goswami S, Stanley ER et al. Direct visualization of macrophage-assisted tumor cell intravasation in mammary tumors. Cancer Res 2007; 67: 2649-2656.
    • (2007) Cancer Res , vol.67 , pp. 2649-2656
    • Wyckoff, J.B.1    Wang, Y.2    Lin, E.Y.3    Li, J.F.4    Goswami, S.5    Stanley, E.R.6
  • 19
    • 33644784910 scopus 로고    scopus 로고
    • Distinct roles for cysteine cathepsin genes in multistage tumorigenesis
    • Gocheva V, Zeng W, Ke D, Klimstra D, Reinheckel T, Peters C et al. Distinct roles for cysteine cathepsin genes in multistage tumorigenesis. Genes Dev 2006; 20: 543-556.
    • (2006) Genes Dev , vol.20 , pp. 543-556
    • Gocheva, V.1    Zeng, W.2    Ke, D.3    Klimstra, D.4    Reinheckel, T.5    Peters, C.6
  • 20
    • 84860557204 scopus 로고    scopus 로고
    • Cathepsin B promotes the progression of pancreatic ductal adenocarcinoma in mice
    • Gopinathan A, Denicola GM, Frese KK, Cook N, Karreth FA, Mayerle J et al. Cathepsin B promotes the progression of pancreatic ductal adenocarcinoma in mice. Gut 2012; 61: 877-884.
    • (2012) Gut , vol.61 , pp. 877-884
    • Gopinathan, A.1    Denicola, G.M.2    Frese, K.K.3    Cook, N.4    Karreth, F.A.5    Mayerle, J.6
  • 21
    • 77249161680 scopus 로고    scopus 로고
    • Synergistic anti-tumor effects of cathepsin B and cathepsin Z deficiencies on breast cancer progression and metastasis in mice
    • Sevenich L, Schurigt U, Sachse K, Gajda M, Werner F, Müller S et al. Synergistic anti-tumor effects of cathepsin B and cathepsin Z deficiencies on breast cancer progression and metastasis in mice. Proc Natl Acad Sci USA 2010; 107: 2497-2502.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 2497-2502
    • Sevenich, L.1    Schurigt, U.2    Sachse, K.3    Gajda, M.4    Werner, F.5    Müller, S.6
  • 22
    • 9144231998 scopus 로고    scopus 로고
    • RNAi-mediated inhibition of cathepsin B and uPAR leads to decreased cell invasion, angiogenesis and tumor growth in gliomas
    • Gondi CS, Lakka SS, Dinh DH, Olivero WC, Gujrati M, Rao JS. RNAi-mediated inhibition of cathepsin B and uPAR leads to decreased cell invasion, angiogenesis and tumor growth in gliomas. Oncogene 2004; 23: 8486-8496.
    • (2004) Oncogene , vol.23 , pp. 8486-8496
    • Gondi, C.S.1    Lakka, S.S.2    Dinh, D.H.3    Olivero, W.C.4    Gujrati, M.5    Rao, J.S.6
  • 23
    • 2942718949 scopus 로고    scopus 로고
    • Inhibition of cathepsin B and MMP-9 gene expression in glioblastoma cell line via RNA interference reduces tumor cell invasion, tumor growth and angiogenesis
    • Lakka SS, Gondi CS, Yanamandra N, Olivero WC, Dinh DH, Gujrati M et al. Inhibition of cathepsin B and MMP-9 gene expression in glioblastoma cell line via RNA interference reduces tumor cell invasion, tumor growth and angiogenesis. Oncogene 2004; 23: 4681-4689.
    • (2004) Oncogene , vol.23 , pp. 4681-4689
    • Lakka, S.S.1    Gondi, C.S.2    Yanamandra, N.3    Olivero, W.C.4    Dinh, D.H.5    Gujrati, M.6
  • 24
    • 79956136629 scopus 로고    scopus 로고
    • Cathepsin B and uPAR knockdown inhibits tumor-induced angiogenesis by modulating VEGF expression in glioma
    • Malla RR, Gopinath S, Gondi CS, Alapati K, Dinh DH, Gujrati M et al. Cathepsin B and uPAR knockdown inhibits tumor-induced angiogenesis by modulating VEGF expression in glioma. Cancer Gene Ther 2011; 18: 419-434.
    • (2011) Cancer Gene Ther , vol.18 , pp. 419-434
    • Malla, R.R.1    Gopinath, S.2    Gondi, C.S.3    Alapati, K.4    Dinh, D.H.5    Gujrati, M.6
  • 25
    • 2342603891 scopus 로고    scopus 로고
    • Cathepsin cysteine proteases are effectors of invasive growth and angiogenesis during multistage tumorigenesis
    • Joyce JA, Baruch A, Chehade K, Meyer-Morse N, Giraudo E, Tsai FY et al. Cathepsin cysteine proteases are effectors of invasive growth and angiogenesis during multistage tumorigenesis. Cancer Cell 2004; 5: 443-453.
    • (2004) Cancer Cell , vol.5 , pp. 443-453
    • Joyce, J.A.1    Baruch, A.2    Chehade, K.3    Meyer-Morse, N.4    Giraudo, E.5    Tsai, F.Y.6
  • 26
    • 82955189189 scopus 로고    scopus 로고
    • Macrophages and cathepsin proteases blunt chemotherapeutic response in breast cancer
    • Shree T, Olson OC, Elie BT, Kester JC, Garfall AL, Simpson K et al. Macrophages and cathepsin proteases blunt chemotherapeutic response in breast cancer. Genes Dev 2011; 25: 2465-2479.
    • (2011) Genes Dev , vol.25 , pp. 2465-2479
    • Shree, T.1    Olson, O.C.2    Elie, B.T.3    Kester, J.C.4    Garfall, A.L.5    Simpson, K.6
  • 28
    • 34547640302 scopus 로고    scopus 로고
    • Inhibition of cysteine cathepsin protease activity enhances chemotherapy regimens by decreasing tumor growth and invasiveness in a mouse model of multistage cancer
    • Bell-McGuinn KM, Garfall AL, Bogyo M, Hanahan D, Joyce JA. Inhibition of cysteine cathepsin protease activity enhances chemotherapy regimens by decreasing tumor growth and invasiveness in a mouse model of multistage cancer. Cancer Res 2007; 67: 7378-7385.
    • (2007) Cancer Res , vol.67 , pp. 7378-7385
    • Bell-Mcguinn, K.M.1    Garfall, A.L.2    Bogyo, M.3    Hanahan, D.4    Joyce, J.A.5
  • 30
    • 33749017931 scopus 로고    scopus 로고
    • Cysteine cathepsins: Multifunctional enzymes in cancer
    • Mohamed MM, Sloane BF. Cysteine cathepsins: multifunctional enzymes in cancer. Nat Rev Cancer 2006; 6: 764-775.
    • (2006) Nat Rev Cancer , vol.6 , pp. 764-775
    • Mohamed, M.M.1    Sloane, B.F.2
  • 31
    • 84859085199 scopus 로고    scopus 로고
    • ErbB2-driven breast cancer cell invasion depends on a complex signaling network activating myeloid zinc finger-1-dependent cathepsin B expression
    • Rafn B, Nielsen CF, Andersen SH, Szyniarowski P, Corcelle-Termeau E, Valo E et al. ErbB2-driven breast cancer cell invasion depends on a complex signaling network activating myeloid zinc finger-1-dependent cathepsin B expression. Mol Cell 2012; 45: 764-776.
    • (2012) Mol Cell , vol.45 , pp. 764-776
    • Rafn, B.1    Nielsen, C.F.2    Andersen, S.H.3    Szyniarowski, P.4    Corcelle-Termeau, E.5    Valo, E.6
  • 32
    • 78650988139 scopus 로고    scopus 로고
    • Transgenic expression of human cathepsin B promotes progression and metastasis of polyoma- middle-T-induced breast cancer in mice
    • Sevenich L, Werner F, Gajda M, Schurigt U, Sieber C, Muller S et al. Transgenic expression of human cathepsin B promotes progression and metastasis of polyoma- middle-T-induced breast cancer in mice. Oncogene 2011; 30: 54-64.
    • (2011) Oncogene , vol.30 , pp. 54-64
    • Sevenich, L.1    Werner, F.2    Gajda, M.3    Schurigt, U.4    Sieber, C.5    Muller, S.6
  • 35
    • 0029953670 scopus 로고    scopus 로고
    • Cathepsin B: Multiple enzyme forms from a single gene and their relation to cancer
    • Keppler DSloane BF. Cathepsin B: multiple enzyme forms from a single gene and their relation to cancer. Enzyme Protein 1996; 49: 94-105.
    • (1996) Enzyme Protein , vol.49 , pp. 94-105
    • Keppler Dsloane, B.F.1
  • 36
    • 80052587306 scopus 로고    scopus 로고
    • Ferri-liposomes as an MRI-visible drug-delivery system for targeting tumours and their microenvironment
    • Mikhaylov G, Mikac U, Magaeva AA, Itin VI, Naiden EP, Psakhye I et al. Ferri-liposomes as an MRI-visible drug-delivery system for targeting tumours and their microenvironment. Nat Nanotechnol 2011; 6: 594-602.
    • (2011) Nat Nanotechnol , vol.6 , pp. 594-602
    • Mikhaylov, G.1    Mikac, U.2    Magaeva, A.A.3    Itin, V.I.4    Naiden, E.P.5    Psakhye, I.6
  • 37
    • 0027531160 scopus 로고
    • Localization of a biotinylated cathepsin B oligonucleotide probe in human prostate including invasive cells and invasive edges by in situ hybridization
    • Sinha AA, Gleason DF, Deleon OF, Wilson MJ, Sloane BF. Localization of a biotinylated cathepsin B oligonucleotide probe in human prostate including invasive cells and invasive edges by in situ hybridization. Anat Rec 1993; 235: 233-240.
    • (1993) Anat Rec , vol.235 , pp. 233-240
    • Sinha, A.A.1    Gleason, D.F.2    Deleon, O.F.3    Wilson, M.J.4    Sloane, B.F.5
  • 38
    • 0024263314 scopus 로고
    • A comparison of four cathepsins (B, L, N and S) with collagenolytic activity from rabbit spleen
    • Maciewicz RA, Etherington DJ. A comparison of four cathepsins (B, L, N and S) with collagenolytic activity from rabbit spleen. Biochem J 1988; 256: 433-440.
    • (1988) Biochem J , vol.256 , pp. 433-440
    • Maciewicz, R.A.1    Etherington, D.J.2
  • 39
    • 0026575258 scopus 로고
    • Degradation of extracellularmatrix proteins by human cathepsin B from normal and tumour tissues
    • Buck MR, Karustis DG, Day NA, Honn KVSloane BF. Degradation of extracellularmatrix proteins by human cathepsin B from normal and tumour tissues. Biochem J 1992; 282(Pt 1): 273-278.
    • (1992) Biochem J , vol.282 , pp. 273-278
    • Buck, M.R.1    Karustis, D.G.2    Day, N.A.3    Honn Kvsloane, B.F.4
  • 42
    • 17844362479 scopus 로고    scopus 로고
    • Caveolin-1 mediates the expression and localization of cathepsin B, pro-urokinase plasminogen activator and their cell-surface receptors in human colorectal carcinoma cells
    • Cavallo-Medved D, Mai J, Dosescu J, Sameni M, Sloane BF. Caveolin-1 mediates the expression and localization of cathepsin B, pro-urokinase plasminogen activator and their cell-surface receptors in human colorectal carcinoma cells. J Cell Sci 2005; 118: 1493-1503.
    • (2005) J Cell Sci , vol.118 , pp. 1493-1503
    • Cavallo-Medved, D.1    Mai, J.2    Dosescu, J.3    Sameni, M.4    Sloane, B.F.5
  • 43
    • 35848947186 scopus 로고    scopus 로고
    • Cysteine cathepsin non-inhibitory binding partners: Modulating intracellular trafficking and function
    • Victor BC, Sloane BF. Cysteine cathepsin non-inhibitory binding partners: modulating intracellular trafficking and function. Biol Chem 2007; 388: 1131-1140.
    • (2007) Biol Chem , vol.388 , pp. 1131-1140
    • Victor, B.C.1    Sloane, B.F.2
  • 44
    • 84867405330 scopus 로고    scopus 로고
    • PH regulators in invadosomal functioning: Proton delivery for matrix tasting
    • Brisson L, Reshkin SJ, Gore J, Roger S. pH regulators in invadosomal functioning: Proton delivery for matrix tasting. Eur J Cell Biol 2012; 91: 847-860.
    • (2012) Eur J Cell Biol , vol.91 , pp. 847-860
    • Brisson, L.1    Reshkin, S.J.2    Gore, J.3    Roger, S.4
  • 45
    • 84861671713 scopus 로고    scopus 로고
    • Lysosomal pathways to cell death and their therapeutic applications
    • Cesen MH, Pegan K, Spes A, Turk B. Lysosomal pathways to cell death and their therapeutic applications. Exp Cell Res 2012; 318: 1245-1251.
    • (2012) Exp Cell Res , vol.318 , pp. 1245-1251
    • Cesen, M.H.1    Pegan, K.2    Spes, A.3    Turk, B.4
  • 46
    • 84876664386 scopus 로고    scopus 로고
    • Cancer-associated lysosomal changes: Friends or foes?
    • Kallunki T, Olsen OD, Jaattela M. Cancer-associated lysosomal changes: friends or foes? Oncogene 2013; 32: 1995-2004.
    • (2013) Oncogene , vol.32 , pp. 1995-2004
    • Kallunki, T.1    Olsen, O.D.2    Jaattela, M.3
  • 47
    • 38649084746 scopus 로고    scopus 로고
    • Dual contrasting roles of cysteine cathepsins in cancer progression: Apoptosis versus tumour invasion
    • Vasiljeva O, Turk B. Dual contrasting roles of cysteine cathepsins in cancer progression: apoptosis versus tumour invasion. Biochimie 2008; 90: 380-386.
    • (2008) Biochimie , vol.90 , pp. 380-386
    • Vasiljeva, O.1    Turk, B.2
  • 48
    • 17144361820 scopus 로고    scopus 로고
    • Lysosomes as targets for cancer therapy
    • Fehrenbacher N, Jaattela M. Lysosomes as targets for cancer therapy. Cancer Res 2005; 65: 2993-2995.
    • (2005) Cancer Res , vol.65 , pp. 2993-2995
    • Fehrenbacher, N.1    Jaattela, M.2
  • 49
    • 0043011297 scopus 로고    scopus 로고
    • Cathepsin B but not cathepsins L or S contributes to the pathogenesis of Unverricht-Lundborg progressive myoclonus epilepsy (EPM1)
    • Houseweart MK, Pennacchio LA, Vilaythong A, Peters C, Noebels JL, Myers RM. Cathepsin B but not cathepsins L or S contributes to the pathogenesis of Unverricht-Lundborg progressive myoclonus epilepsy (EPM1). J Neurobiol 2003; 56: 315-327.
    • (2003) J Neurobiol , vol.56 , pp. 315-327
    • Houseweart, M.K.1    Pennacchio, L.A.2    Vilaythong, A.3    Peters, C.4    Noebels, J.L.5    Myers, R.M.6
  • 50
    • 0026587657 scopus 로고
    • Induction of mammary tumors by expression of polyomavirus middle T oncogene: A transgenic mouse model for metastatic disease
    • Guy CT, Cardiff RD, Muller WJ. Induction of mammary tumors by expression of polyomavirus middle T oncogene: a transgenic mouse model for metastatic disease. Mol Cell Biol 1992; 12: 954-961.
    • (1992) Mol Cell Biol , vol.12 , pp. 954-961
    • Guy, C.T.1    Cardiff, R.D.2    Muller, W.J.3
  • 52
    • 0034948896 scopus 로고    scopus 로고
    • A Bayesian framework for the analysis of microarray expression data: Regularized t -test and statistical inferences of gene changes
    • Baldi P, Long AD. A Bayesian framework for the analysis of microarray expression data: regularized t -test and statistical inferences of gene changes. Bioinformatics 2001; 17: 509-519.
    • (2001) Bioinformatics , vol.17 , pp. 509-519
    • Baldi, P.1    Long, A.D.2
  • 53
    • 0035829361 scopus 로고    scopus 로고
    • Controlling the false discovery rate in behavior genetics research
    • Benjamini Y, Drai D, Elmer G, Kafkafi N, Golani I. Controlling the false discovery rate in behavior genetics research. Behav Brain Res 2001; 125: 279-284.
    • (2001) Behav Brain Res , vol.125 , pp. 279-284
    • Benjamini, Y.1    Drai, D.2    Elmer, G.3    Kafkafi, N.4    Golani, I.5
  • 55
    • 50849133244 scopus 로고    scopus 로고
    • Trial of the cysteine cathepsin inhibitor JPM-OEt on early and advanced mammary cancer stages in the MMTV-PyMT-transgenic mouse model
    • Schurigt U, Sevenich L, Vannier C, Gajda M, Schwinde A, Werner F et al. Trial of the cysteine cathepsin inhibitor JPM-OEt on early and advanced mammary cancer stages in the MMTV-PyMT-transgenic mouse model. Biol Chem 2008; 389: 1067-1074.
    • (2008) Biol Chem , vol.389 , pp. 1067-1074
    • Schurigt, U.1    Sevenich, L.2    Vannier, C.3    Gajda, M.4    Schwinde, A.5    Werner, F.6


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