Lack of variant specific CD8+ T-cell response against mutant and pre-existing variants leads to outgrowth of particular clones in acute hepatitis C

Virology Journal

Volumn 10, Issue , 2013, Pages

  Ulsenheimer, Axel ^a,b   Paranhos Baccalà, Gláucia ^c   Komurian Pradel, Florence ^c   Raziorrouh, Bijan ^a,b   Kurktschiev, Peter ^b   Diepolder, Helmut M ^a,b   Zachoval, Reinhart ^a   Spannagl, Michael ^d   Jung, Maria Christina ^a,b   Gruener, Norbert H ^a,b  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^b UNIVERSITY OF MUNICH   (Germany)

^c Emerging Pathogens Laboratory   (France)

^d Laboratory of Immunogenetics and Molecular Diagnostics   (Germany)

Author keywords

Acute hepatitis C; Epitope; Escape mutation; Quasispecies; T cell

Indexed keywords

ANTIVIRUS AGENT; DYE; EPITOPE; HLA A ANTIGEN; NONSTRUCTURAL PROTEIN 3; PENTAMER; UNCLASSIFIED DRUG;

ADULT; ANTIVIRAL THERAPY; ARTICLE; BLOOD SAMPLING; CASE REPORT; CD8+ T LYMPHOCYTE; EX VIVO STUDY; FEMALE; GENE FREQUENCY; GENE MUTATION; GENETIC VARIABILITY; GENOTYPE; HEPATITIS C; HEPATITIS C VIRUS; HISTOPATHOLOGY; HUMAN; HUMAN CELL; LYMPHOCYTE CLONE; MALE; PERIPHERAL BLOOD MONONUCLEAR CELL; STAINING; VIROGENESIS; VIRUS MUTANT; VIRUS STRAIN;

HEPATITIS C VIRUS;

ADAPTATION, BIOLOGICAL; ADULT; ANTIGENS, VIRAL; CD8-POSITIVE T-LYMPHOCYTES; DNA MUTATIONAL ANALYSIS; FEMALE; HEPACIVIRUS; HEPATITIS C; HUMANS; IMMUNE EVASION; MALE; MIDDLE AGED; MUTATION; SEQUENCE ANALYSIS, DNA;

EID: 84884647313     PISSN: None     EISSN: 1743422X     Source Type: Journal    
DOI: 10.1186/1743-422X-10-295     Document Type: Article

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