Distinguishing on-target versus off-target activity in early antibacterial drug discovery using a macromolecular synthesis assay

Journal of Biomolecular Screening

Volumn 18, Issue 9, 2013, Pages 1018-1026

  Cunningham, Mark L ^a   Kwan, Bryan P ^a   Nelson, Kirk J ^a   Bensen, Daniel C ^a   Shaw, Karen J ^a  

^a Trius Therapeutics Inc   (United States)

Author keywords

DNA gyrase; GyrB; macromolecular synthesis; ParE; pyrrolopyrimidine

Indexed keywords

ADENOSINE TRIPHOSPHATASE; CARBONYL CYANIDE 4 (TRIFLUOROMETHOXY)PHENYLHYDRAZONE; CEFEPIME; CHLORAMPHENICOL; CIPROFLOXACIN; DAPTOMYCIN; DNA TOPOISOMERASE (ATP HYDROLYSING) B; FOSFOMYCIN; KANAMYCIN; LINEZOLID; NOVOBIOCIN; RIFAMPICIN; TEDIZOLID; TETRACYCLINE; VANCOMYCIN;

ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL CELL WALL; BACTERIAL GROWTH; BIOSYNTHESIS; CELL VIABILITY; COMPETITIVE INHIBITION; CONCENTRATION RESPONSE; DRUG DESIGN; DRUG SYNTHESIS; ENZYME ACTIVITY; ESCHERICHIA COLI; MACROMOLECULE; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; OXIDATIVE PHOSPHORYLATION; PRIORITY JOURNAL; PROTEIN TARGETING; STAPHYLOCOCCUS AUREUS;

DNA GYRASE; GYRB; MACROMOLECULAR SYNTHESIS; PARE; PYRROLOPYRIMIDINE;

ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; BIOLOGICAL ASSAY; CELL WALL; DNA GYRASE; DNA, BACTERIAL; DRUG DISCOVERY; ESCHERICHIA COLI; MICROBIAL SENSITIVITY TESTS; RNA, BACTERIAL; STAPHYLOCOCCUS AUREUS;

EID: 84884640563     PISSN: 10870571     EISSN: 1552454X     Source Type: Journal    
DOI: 10.1177/1087057113487208     Document Type: Article

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