-
1
-
-
78649489009
-
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci
-
Franke A, McGovern DPB, Barrett JC, et al. Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. Nat Genet. 2010;42:1118-1125.
-
(2010)
Nat Genet
, vol.42
, pp. 1118-1125
-
-
Franke, A.1
McGovern, D.P.B.2
Barrett, J.C.3
-
2
-
-
78049237784
-
Building genetic scores to predict risk of complex diseases in humans: Is it possible?
-
Liu S, Song Y. Building genetic scores to predict risk of complex diseases in humans: is it possible? Diabetes. 2010;59:2729-2731.
-
(2010)
Diabetes
, vol.59
, pp. 2729-2731
-
-
Liu, S.1
Song, Y.2
-
3
-
-
0037370188
-
Improving the prediction of complex diseases by testing for multiple disease-susceptibility genes
-
Yang Q, Khoury MJ, Botto L, et al. Improving the prediction of complex diseases by testing for multiple disease-susceptibility genes. Am J Hum Genet. 2003;72:636-649.
-
(2003)
Am J Hum Genet
, vol.72
, pp. 636-649
-
-
Yang, Q.1
Khoury, M.J.2
Botto, L.3
-
4
-
-
34948877698
-
Prediction of individual genetic risk to disease from genome-wide association studies
-
Wray NR, Goddard ME, Visscher PM. Prediction of individual genetic risk to disease from genome-wide association studies. Genome Res. 2007; 17:1520-1528.
-
(2007)
Genome Res
, vol.17
, pp. 1520-1528
-
-
Wray, N.R.1
Goddard, M.E.2
Visscher, P.M.3
-
5
-
-
62049085384
-
Confirmation of multiple Crohn's disease susceptibility loci in a large Dutch-Belgian cohort
-
Weersma RK, Stokkers PCF, Cleynen I, et al. Confirmation of multiple Crohn's disease susceptibility loci in a large Dutch-Belgian cohort. Am J Gastroenterol. 2009;104:630-638.
-
(2009)
Am J Gastroenterol
, vol.104
, pp. 630-638
-
-
Weersma, R.K.1
Stokkers, P.C.F.2
Cleynen, I.3
-
6
-
-
79955651296
-
Evaluation of 22 genetic variants with Crohn's disease risk in the Ashkenazi Jewish population: A case-control study
-
Peter I, Mitchell A, Ozelius L, et al. Evaluation of 22 genetic variants with Crohn's disease risk in the Ashkenazi Jewish population: a case-control study. BMC Med Genet. 2011;12:63.
-
(2011)
BMC Med Genet
, vol.12
, pp. 63
-
-
Peter, I.1
Mitchell, A.2
Ozelius, L.3
-
7
-
-
81055145433
-
Distribution of allele frequencies and effect sizes and their interrelationships for common genetic susceptibility variants
-
Park JH, Gail MH, Weinberg CR, et al. Distribution of allele frequencies and effect sizes and their interrelationships for common genetic susceptibility variants. Proc Natl Acad Sci USA. 2011;108:18026-18031.
-
(2011)
Proc Natl Acad Sci USA
, vol.108
, pp. 18026-18031
-
-
Park, J.H.1
Gail, M.H.2
Weinberg, C.R.3
-
8
-
-
84856405512
-
The mystery of missing heritability: Genetic interactions create phantom heritability
-
Zuk O, Hechter E, Sunyaev SR, et al. The mystery of missing heritability: genetic interactions create phantom heritability. Proc Natl Acad Sci USA. 2012;109:1193-1198.
-
(2012)
Proc Natl Acad Sci USA
, vol.109
, pp. 1193-1198
-
-
Zuk, O.1
Hechter, E.2
Sunyaev, S.R.3
-
10
-
-
12744255343
-
Exploring interactions in highdimensional genomic data: An overview of logic regression, with applications
-
Ruczinski I, Kooperberg C, LeBlanc L. Exploring interactions in highdimensional genomic data: an overview of logic regression, with applications. J Mult Anal. 2004;90:178-195.
-
(2004)
J Mult Anal
, vol.90
, pp. 178-195
-
-
Ruczinski, I.1
Kooperberg, C.2
Leblanc, L.3
-
11
-
-
77958450848
-
Logic regression and its extensions
-
Schwender H, Ruczinski I. Logic regression and its extensions. Adv Genet. 2010;72:25-45.
-
(2010)
Adv Genet
, vol.72
, pp. 25-45
-
-
Schwender, H.1
Ruczinski, I.2
-
12
-
-
84859913926
-
Amino acid position 11 of HLA-DR [beta]1 is a major determinant of chromosome 6p association with ulcerative colitis
-
Achkar JP, Klei L, Bakker PIW, et al. Amino acid position 11 of HLA-DR [beta]1 is a major determinant of chromosome 6p association with ulcerative colitis. Genes Immun. 2012;13:245-252.
-
(2012)
Genes Immun
, vol.13
, pp. 245-252
-
-
Achkar, J.P.1
Klei, L.2
Bakker, P.I.W.3
-
14
-
-
34347344976
-
A new multipoint method for genome-wide association studies by imputation of genotypes
-
Marchini J, Howie B, Myers S, et al. A new multipoint method for genome-wide association studies by imputation of genotypes. Nat Genet. 2007;39:906-913.
-
(2007)
Nat Genet
, vol.39
, pp. 906-913
-
-
Marchini, J.1
Howie, B.2
Myers, S.3
-
15
-
-
84969213492
-
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls
-
The Wellcome Trust Case Control Consortium
-
The Wellcome Trust Case Control Consortium. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature. 2007;447:661-678.
-
(2007)
Nature
, vol.447
, pp. 661-678
-
-
-
17
-
-
78649508578
-
MaCH: Using sequence and genotype data to estimate haplotypes and unobserved genotypes
-
Li Y, Willer CJ, Ding J, et al. MaCH: using sequence and genotype data to estimate haplotypes and unobserved genotypes. Genet Epidemiol. 2010; 34:816-834.
-
(2010)
Genet Epidemiol
, vol.34
, pp. 816-834
-
-
Li, Y.1
Willer, C.J.2
Ding, J.3
-
18
-
-
79955643147
-
Beyond missing heritability: Prediction of complex traits
-
Makowsky R, Pajewski NM, Klimentidis YC, et al. Beyond missing heritability: prediction of complex traits. PLoS Genet. 2011;7:e1002051.
-
(2011)
PLoS Genet
, vol.7
-
-
Makowsky, R.1
Pajewski, N.M.2
Klimentidis, Y.C.3
-
21
-
-
0029363582
-
An introduction to multivariate adaptive regression splines
-
Friedman JH, Roosen CB. An introduction to multivariate adaptive regression splines. Stat Methods Med Res. 1995;4:197-217.
-
(1995)
Stat Methods Med Res
, vol.4
, pp. 197-217
-
-
Friedman, J.H.1
Roosen, C.B.2
-
22
-
-
84957054016
-
Analysis of interaction for identifying causal mechanisms
-
In: Berzuini C, Dawid P, Bernardinelli L, eds. Wiley
-
Berzuini C, Dawid P, Zhang H, et al. Analysis of interaction for identifying causal mechanisms. In: Berzuini C, Dawid P, Bernardinelli L, eds. Causality: Statistical Perspectives and Applications. Wiley; 2012: 192-207.
-
(2012)
Causality: Statistical Perspectives and Applications
, pp. 192-207
-
-
Berzuini, C.1
Dawid, P.2
Zhang, H.3
-
23
-
-
0035978651
-
Association of NOD2 leucinerich repeat variants with susceptibility to Crohn's disease
-
Hugot JP, Chamaillard M, Zouali H, et al. Association of NOD2 leucinerich repeat variants with susceptibility to Crohn's disease. Nature. 2001; 411:599-603.
-
(2001)
Nature
, vol.411
, pp. 599-603
-
-
Hugot, J.P.1
Chamaillard, M.2
Zouali, H.3
-
24
-
-
0035978533
-
A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease
-
Ogura Y, Bonen DK, Inohara N, et al. A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease. Nature. 2001;411: 603-606.
-
(2001)
Nature
, vol.411
, pp. 603-606
-
-
Ogura, Y.1
Bonen, D.K.2
Inohara, N.3
-
25
-
-
77957682295
-
ATG16L1 and NOD2 interact in an autophagy-dependent antibacterial pathway implicated in Crohn's disease pathogenesis
-
Homer CR, Richmond AL, Rebert NA, et al. ATG16L1 and NOD2 interact in an autophagy-dependent antibacterial pathway implicated in Crohn's disease pathogenesis. Gastroenterology. 2010;139: 1630-1641.
-
(2010)
Gastroenterology
, vol.139
, pp. 1630-1641
-
-
Homer, C.R.1
Richmond, A.L.2
Rebert, N.A.3
-
26
-
-
73849121209
-
Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry
-
Travassos LH, Carneiro LAM, Ramjeet M, et al. Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry. Nat Immunol. 2010;11:55-62.
-
(2010)
Nat Immunol
, vol.11
, pp. 55-62
-
-
Travassos, L.H.1
Carneiro, L.A.M.2
Ramjeet, M.3
-
27
-
-
1542580481
-
IL-10 and its related cytokines for treatment of inflammatory bowel disease
-
Li MC, He SH. IL-10 and its related cytokines for treatment of inflammatory bowel disease. World J Gastroenterol. 2004;10:620-625.
-
(2004)
World J Gastroenterol
, vol.10
, pp. 620-625
-
-
Li, M.C.1
He, S.H.2
-
28
-
-
0027521572
-
Interleukin-10-deficient mice develop chronic enterocolitis
-
Kuhn R, Lohler J, Rennick D, et al. Interleukin-10-deficient mice develop chronic enterocolitis. Cell. 1993;75:263-274.
-
(1993)
Cell
, vol.75
, pp. 263-274
-
-
Kuhn, R.1
Lohler, J.2
Rennick, D.3
-
29
-
-
84864206050
-
Loss of interleukin-10 signaling and infantile inflammatory bowel disease: Implications for diagnosis and therapy
-
Kotlarz D, Beier R, Murugan D, et al. Loss of interleukin-10 signaling and infantile inflammatory bowel disease: implications for diagnosis and therapy. Gastroenterology. 2012;143:347-355.
-
(2012)
Gastroenterology
, vol.143
, pp. 347-355
-
-
Kotlarz, D.1
Beier, R.2
Murugan, D.3
-
30
-
-
70949087383
-
Inflammatory bowel disease and mutations affecting the interleukin-10 receptor
-
Glocker EO, Kotlarz D, Boztug K, et al. Inflammatory bowel disease and mutations affecting the interleukin-10 receptor. N Engl J Med. 2009;361: 2033-2045.
-
(2009)
N Engl J Med
, vol.361
, pp. 2033-2045
-
-
Glocker, E.O.1
Kotlarz, D.2
Boztug, K.3
-
31
-
-
3442899939
-
NOD2 mediates anti-inflammatory signals induced by TLR2 ligands: Implications for Crohn's disease
-
Netea MG, Kullberg BJ, de Jong DJ, et al. NOD2 mediates anti-inflammatory signals induced by TLR2 ligands: implications for Crohn's disease. Eur J Immunol. 2004;34:2052-2059.
-
(2004)
Eur J Immunol
, vol.34
, pp. 2052-2059
-
-
Netea, M.G.1
Kullberg, B.J.2
De Jong, D.J.3
-
32
-
-
65249115914
-
A Crohn's disease-associated NOD2 mutation suppresses transcription of human IL10 by inhibiting activity of the nuclear ribonucleoprotein hnRNP-A1
-
Noguchi E, Homma Y, Kang X, et al. A Crohn's disease-associated NOD2 mutation suppresses transcription of human IL10 by inhibiting activity of the nuclear ribonucleoprotein hnRNP-A1. Nat Immunol. 2009;10:471-479.
-
(2009)
Nat Immunol
, vol.10
, pp. 471-479
-
-
Noguchi, E.1
Homma, Y.2
Kang, X.3
-
33
-
-
77952716486
-
Interleukin-19 protects mice from innate-mediated colonic inflammation
-
Azuma YT, Matsuo Y, Kuwamura M, et al. Interleukin-19 protects mice from innate-mediated colonic inflammation. Inflamm Bowel Dis. 2010;16: 1017-1028.
-
(2010)
Inflamm Bowel Dis
, vol.16
, pp. 1017-1028
-
-
Azuma, Y.T.1
Matsuo, Y.2
Kuwamura, M.3
-
34
-
-
0033572623
-
USP25, a novel gene encoding a deubiquitinating enzyme, is located in the gene-poor region 21q11.2
-
Valero R, Marfany G, Gonzalez-Angulo O, et al. USP25, a novel gene encoding a deubiquitinating enzyme, is located in the gene-poor region 21q11.2. Genomics. 1999;62:395-405.
-
(1999)
Genomics
, vol.62
, pp. 395-405
-
-
Valero, R.1
Marfany, G.2
Gonzalez-Angulo, O.3
-
35
-
-
0041967054
-
The tumour suppressor CYLD negatively regulates NF-kappaB signalling by deubiquitination
-
Kovalenko A, Chable-Bessia C, Cantarella G, et al. The tumour suppressor CYLD negatively regulates NF-kappaB signalling by deubiquitination. Nature. 2003;424:801-805.
-
(2003)
Nature
, vol.424
, pp. 801-805
-
-
Kovalenko, A.1
Chable-Bessia, C.2
Cantarella, G.3
-
36
-
-
0032190090
-
The ubiquitin pathway in Parkinson's disease
-
Leroy E, Boyer R, Auburger G, et al. The ubiquitin pathway in Parkinson's disease. Nature. 1998;395:451-452.
-
(1998)
Nature
, vol.395
, pp. 451-452
-
-
Leroy, E.1
Boyer, R.2
Auburger, G.3
-
37
-
-
12144286902
-
The isopeptidase USP2a regulates the stability of fatty acid synthase in prostate cancer
-
Graner E, Tang D, Rossi S, et al. The isopeptidase USP2a regulates the stability of fatty acid synthase in prostate cancer. Cancer Cell. 2004;5: 253-261.
-
(2004)
Cancer Cell
, vol.5
, pp. 253-261
-
-
Graner, E.1
Tang, D.2
Rossi, S.3
-
38
-
-
74049127960
-
Genomewide association study of leprosy
-
Zhang FR, Huang W, Chen SM, et al. Genomewide association study of leprosy. N Engl J Med. 2009;361:2609-2618.
-
(2009)
N Engl J Med
, vol.361
, pp. 2609-2618
-
-
Zhang, F.R.1
Huang, W.2
Chen, S.M.3
-
39
-
-
48349136889
-
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease
-
Barrett JC, Hansoul S, Nicolae DL, et al. Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. Nat Genet. 2008;40:955-962.
-
(2008)
Nat Genet
, vol.40
, pp. 955-962
-
-
Barrett, J.C.1
Hansoul, S.2
Nicolae, D.L.3
-
40
-
-
34548523962
-
An evaluation of evidence for the carcinogenic activity of bisphenol A
-
Keri RA, Ho SM, Hunt PA, et al. An evaluation of evidence for the carcinogenic activity of bisphenol A. Reprod Toxicol. 2007;24: 240-252.
-
(2007)
Reprod Toxicol
, vol.24
, pp. 240-252
-
-
Keri, R.A.1
Ho, S.M.2
Hunt, P.A.3
-
41
-
-
84867163468
-
Immunochip-based analysis of a large IBD case-control cohort identifies 50 novel loci, refining definitions of disease pathways
-
IIBDGC
-
Cho JH, IIBDGC. Immunochip-based analysis of a large IBD case-control cohort identifies 50 novel loci, refining definitions of disease pathways. Gastroenterology. 2012;142:S149-S150.
-
(2012)
Gastroenterology
, vol.142
-
-
Cho, J.H.1
|