Role of tetrahydrobiopterin in pulmonary vascular remodelling associated with pulmonary fibrosis

Thorax

Volumn 68, Issue 10, 2013, Pages 938-948

  Almudéver, Patricia ^a   Milara, Javier ^b,c,d   De Diego, Alfredo ^e   Serrano Mollar, Ana ^d,f   Xaubet, Antoni ^d,g   Perez Vizcaino, Francisco ^d,h   Cogolludo, Angel ^d,h   Cortijo, Julio ^a,b,d  

^a UNIVERSITY OF VALENCIA   (Spain)

^b HOSPITAL GENERAL UNIVERSITARIO DE VALENCIA   (Spain)

^c UNIVERSITAT POLITÈCNICA DE VALÈNCIA   (Spain)

^d INSTITUTO DE SALUD CARLOS III   (Spain)

^e HOSPITAL UNIVERSITARIO LA FE   (Spain)

^f INST D INVESTIGACIONS B   (Spain)

^g HOSPITAL CLÍNIC   (Spain)

^h SCHOOL OF MEDICINE   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

3 NITROTYROSINE; BLEOMYCIN; ENDOTHELIAL NITRIC OXIDE SYNTHASE; ENDOTHELIN 1; GUANOSINE TRIPHOSPHATE CYCLOHYDROLASE I; INDUCIBLE NITRIC OXIDE SYNTHASE; MESSENGER RNA; NITRATE; NITRIC OXIDE; NITRITE; REACTIVE OXYGEN METABOLITE; SEPIAPTERIN; SEPIAPTERIN REDUCTASE; TETRAHYDROBIOPTERIN; TRANSFORMING GROWTH FACTOR BETA1;

ADULT; AGED; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY ENDOTHELIUM; ARTICLE; BLOOD LEVEL; CELL TRANSFORMATION; CONTROLLED STUDY; DISEASE ASSOCIATION; DOWN REGULATION; DRUG MECHANISM; DRUG TARGETING; ENDOTHELIAL TO MESENCHYMAL TRANSITION; ENDOTHELIUM CELL; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FIBROSING ALVEOLITIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; LUNG FIBROSIS; MAJOR CLINICAL STUDY; MALE; MORTALITY; NONHUMAN; PATHOPHYSIOLOGY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PULMONARY ARTERY; PULMONARY HYPERTENSION; PULMONARY VASCULAR DISEASE; PULMONARY VASCULAR REMODELING; RAT; SIGNAL TRANSDUCTION; UPREGULATION;

IDIOPATHIC PULMONARY FIBROSIS; INTERSTITIAL FIBROSIS; OXIDATIVE STRESS;

AGED; ALCOHOL OXIDOREDUCTASES; ANIMALS; BIOPTERIN; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DISEASE MODELS, ANIMAL; ENDOTHELIUM, VASCULAR; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; GTP CYCLOHYDROLASE; HUMANS; HYPERTENSION, PULMONARY; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; NITRIC OXIDE SYNTHASE TYPE II; NITRIC OXIDE SYNTHASE TYPE III; PULMONARY ARTERY; PULMONARY FIBROSIS; RATS; RATS, WISTAR; REAL-TIME POLYMERASE CHAIN REACTION; TYROSINE;

EID: 84884586939     PISSN: 00406376     EISSN: 14683296     Source Type: Journal    
DOI: 10.1136/thoraxjnl-2013-203408     Document Type: Article

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