Abnormal fibrillin-1 expression and chronic oxidative stress mediate endothelial mesenchymal transition in a murine model of systemic sclerosis

American Journal of Physiology - Cell Physiology

Volumn 300, Issue 3, 2011, Pages

  Xu, Hao ^a   Zaidi, Maria ^a   Struve, Janine ^a   Jones, Deron W ^a   Krolikowski, John G ^a   Nandedkar, Sandhya ^a   Lohr, Nicole L ^a   Gadicherla, Ashish ^a   Pagel, Paul S ^a   Csuka, Mary Ellen ^a   Pritchard, Kirkwood A ^a   Weihrauch, Dorothée ^a  

^a MEDICAL COLLEGE OF WISCONSIN   (United States)

Author keywords

Apo A I mimetic; Apoptosis; Collagen related proteins; Proliferation; Tight skin mouse

Indexed keywords

APOLIPOPROTEIN A1; D 4F; FIBRILLIN 1; NITRIC OXIDE; PHOSPHOLIPID; SUPEROXIDE; UNCLASSIFIED DRUG;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; AUTOIMMUNE DISEASE; CELL CULTURE; CELL ISOLATION; CELL PROLIFERATION; CELL TRANSFORMATION; CONNECTIVE TISSUE DISEASE; CONTROLLED STUDY; ENDOTHELIAL MESENCHYMAL TRANSITION; ENDOTHELIUM CELL; EXTRACELLULAR MATRIX; FEMALE; FIBER; HUMAN; HUMAN TISSUE; MALE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SYSTEMIC SCLEROSIS; UMBILICAL VEIN; WESTERN BLOTTING;

ANIMALS; CELL PROLIFERATION; CELLS, CULTURED; CHRONIC DISEASE; DISEASE MODELS, ANIMAL; ENDOTHELIAL CELLS; FEMALE; HUMANS; MALE; MESODERM; MICE; MICE, INBRED C57BL; MICROFILAMENT PROTEINS; MOLECULAR WEIGHT; NEOVASCULARIZATION, PHYSIOLOGIC; OXIDATIVE STRESS; SCLERODERMA, SYSTEMIC;

MURINAE; MUS;

EID: 79952158516     PISSN: 03636143     EISSN: 15221563     Source Type: Journal    
DOI: 10.1152/ajpcell.00123.2010     Document Type: Article

References (16)

1. Comporti M. Lipid peroxidation and biogenic aldehydes: from the identification of 4-hydroxynonenal to further achievements in biopathology. Free Radic Res 28: 623-635, 1998. (Pubitemid 28454255)
2. Datta G, Chaddha M, Hama S, Navab M, Fogelman AM, Garber DW, Mishra VK, Epand RM, Epand RF, Lund-Katz S, Phillips MC, Segrest JP, Anantharamaiah GM. Effects of increasing hydrophobicity on the physical-chemical and biological properties of a class A amphipathic helical peptide. J Lipid Res 42: 1096-1104, 2001. (Pubitemid 32645791)
3. Flavahan NA, Flavahan S, Mitra S, Chotani MA. The vasculopathy of Raynaud's phenomenon and scleroderma. Rheum Dis Clin North Am 29: 275-291, 2003. (Pubitemid 36765121)
4. Hu L, Roth JM, Brooks P, Ibrahim S, Karpatkin S. Twist is required for thrombin-induced tumorangiogenesis and growth. Cancer Res 68: 4296-4302, 2008.
5. Kielty CM, Cummings C, Whittaker SP, Shuttleworth CA, Grant ME. Isolation and ultrastructural analysis of microfibrillar structures from foetal bovine elastic tissues. Relative abundance and supramolecular architecture of type VI collagen assemblies and fibrillin. J Cell Sci 99: 797-807, 1991.
6. Kielty CM, Hanssen E, Shuttleworth CA. Purification of fibrillin-containing microfibrils and collagen VI microfibrils by density gradient centrifugation. Anal Biochem 255: 108-112, 1998. (Pubitemid 28047625)
7. Kojima H, Urano Y, Kikuchi K, Higuchi T, Hirata Y, Nagano T. Fluorescent indicators for imaging nitric oxide production. Angew Chem Int Ed Engl 38: 3209-3212, 1999. (Pubitemid 29533899)
8. Okada H, Ban S, Nagao S, Takahashi H, Suzuki H, Neilson EG. Progressive renal fibrosis in murine polycystic kidney disease: an immunohistochemical observation. Kidney Int 58: 587-597, 2000. (Pubitemid 30620008)
9. O'Riordan E, Mendelev N, Patschan S, Patschan D, Eskander J, Cohen-Gould L, Chander P, Goligorsky MS. Chronic NOS inhibition actuates endothelial-mesenchymal transformation. Am J Physiol Heart Circ Physiol 292: H285-H294, 2007. (Pubitemid 46105189)
10. Strutz F, Okada H, Lo CW, Danoff T, Carone RL, Tomaszewski JE, Neilson EG. Identification and characterization of a fibroblast marker: FSP1. J Cell Biol 130: 393-405, 1995.
11. Touyz RM, Chen X, Tabet F, Yao G, He G, Quinn MT, Pagano PJ, Schiffrin EL. Expression of a functionally active gp91phox-containing neutrophil-type NAD(P)H oxidase in smooth muscle cells from human resistance arteries: regulation by angiotensin II. Circ Res 90: 1205-1213, 2002. (Pubitemid 34786906)
12. Weihrauch D, Xu H, Shi Y, Wang J, Brien J, Jones DW, Kaul S, Komorowski RA, Csuka ME, Oldham KT, Pritchard KA. Effects of D-4F on vasodilation, oxidative stress, angiostatin, myocardial inflammation, and angiogenic potential in tight-skin mice. Am J Physiol Heart Circ Physiol 293: H1432-H1441, 2007. (Pubitemid 47367186)
13. Yang Y, Sharma R, Sharma A, Awasthi S, Awasthi YC. Lipid peroxidation and cell cycle signaling: 4-hydroxynonenal, a key molecule in stress mediated signaling. Acta Biochim Pol 50: 319-336, 2003. (Pubitemid 37034689)
14. Zeisberg EM, Tarnavski O, Zeisberg M, Dorfman AL, McMullen JR, Gustafsson E, Chandraker A, Yuan X, Pu WT, Roberts AB, Neilson EG, Sayegh MH, Izumo S, Kalluri R. Endothelial-to-mesenchymal transition contributes to cardiac fibrosis. Nat Med 13: 952-961, 2007. (Pubitemid 47222040)
15. Zeisberg M, Neilson EG. Biomarkers for epithelial-mesenchymal transitions. J Clin Invest 119: 1429-1437, 2009.
16. Zhao H, Kalivendi S, Zhang H, Joseph J, Nithipatikom K, Vásquez-Vivar J, Kalyanaraman B. Superoxide reacts with hydroethidine but forms a fluorescent product that is distinctly different from ethidium: potential implications in intracellular fluorescence detection of superoxide. Free Radic Biol Med 34: 1359-1368, 2003. (Pubitemid 36570409)