메뉴 건너뛰기




Volumn 8, Issue , 2013, Pages 1259-1271

Upregulation of genes related to bone formation by γ-amino butyric acid and γ-oryzanol in germinated brown rice is via the activation of GABAB-receptors and reduction of serum IL-6 in rats

Author keywords

GBR bioactive compounds; Gene expression; Osteocalcin; Ovariectomized rats

Indexed keywords

4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID B RECEPTOR; ACYLATED STERYL GLUCOSIDE; BONE MORPHOGENETIC PROTEIN 2; CALCITONIN RECEPTOR; CIMICIFUGA RACEMOSA EXTRACT; COLLAGEN TYPE 1; COLLAGEN TYPE 2; ESTROGEN; GAMMA ORYZANOL; INTERLEUKIN 6; OSTEOCALCIN; OSTEONECTIN; PLANT MEDICINAL PRODUCT; TRANSCRIPTION FACTOR OSTERIX; TRANSCRIPTION FACTOR RUNX2; UNCLASSIFIED DRUG;

EID: 84884556246     PISSN: 11769092     EISSN: 11781998     Source Type: Journal    
DOI: 10.2147/CIA.S45943     Document Type: Article
Times cited : (26)

References (56)
  • 1
    • 0025085822 scopus 로고
    • Relationship of cell growth to the regulation of tissue-specific gene expression during osteoblast differentiation
    • Stein GS, Lian JB, Owen TA. Relationship of cell growth to the regulation of tissue-specific gene expression during osteoblast differentiation. FASEB J. 1990;4(13):3111-3123.
    • (1990) FASEB J , vol.4 , Issue.13 , pp. 3111-3123
    • Stein, G.S.1    Lian, J.B.2    Owen, T.A.3
  • 2
    • 0025316785 scopus 로고
    • Progressive development of the rat osteoblast phenotype in vitro: Reciprocal relationships in expression of genes associated with osteoblast proliferation and differentiation during formation of the bone extracellular matrix
    • Owen TA, Aronow M, Shalhoub V, et al. Progressive development of the rat osteoblast phenotype in vitro: reciprocal relationships in expression of genes associated with osteoblast proliferation and differentiation during formation of the bone extracellular matrix. J Cell Physiol. 1990;143(3): 420-430.
    • (1990) J Cell Physiol , vol.143 , Issue.3 , pp. 420-430
    • Owen, T.A.1    Aronow, M.2    Shalhoub, V.3
  • 3
    • 34548404223 scopus 로고    scopus 로고
    • Differential gene expression in femoral bone from red junglefowl and domestic chicken, differing for bone phenotypic traits
    • Rubin C-J, Lindberg J, Fitzsimmons C, et al. Differential gene expression in femoral bone from red junglefowl and domestic chicken, differing for bone phenotypic traits. BMC genomics. 2007;8(1):208.
    • (2007) BMC Genomics , vol.8 , Issue.1 , pp. 208
    • Rubin, C.-J.1    Lindberg, J.2    Fitzsimmons, C.3
  • 4
    • 0029922240 scopus 로고    scopus 로고
    • The heritability of bone mineral density, ultrasound of the calcaneus and hip axis length: A study of postmenopausal twins
    • Arden N, Baker J, Hogg C, Baan K, Spector T. The heritability of bone mineral density, ultrasound of the calcaneus and hip axis length: a study of postmenopausal twins. J Bone Miner Res. 1996;11(4):530-534.
    • (1996) J Bone Miner Res , vol.11 , Issue.4 , pp. 530-534
    • Arden, N.1    Baker, J.2    Hogg, C.3    Baan, K.4    Spector, T.5
  • 5
    • 0031984222 scopus 로고    scopus 로고
    • Genetic and environmental correlations between bone formation and bone mineral density: A twin study
    • Harris M, Nguyen T, Howard G, Kelly P, Eisman J. Genetic and environmental correlations between bone formation and bone mineral density: a twin study. Bone. 1998;22(2):141-145.
    • (1998) Bone , vol.22 , Issue.2 , pp. 141-145
    • Harris, M.1    Nguyen, T.2    Howard, G.3    Kelly, P.4    Eisman, J.5
  • 6
    • 0034047682 scopus 로고    scopus 로고
    • Genetic determination of Colles' fracture and differential bone mass in women with and without Colles' fracture
    • Deng HW, Chen WM, Recker S, et al. Genetic determination of Colles' fracture and differential bone mass in women with and without Colles' fracture. J Bone Miner Res. 2000;15(7):1243-1252.
    • (2000) J Bone Miner Res , vol.15 , Issue.7 , pp. 1243-1252
    • Deng, H.W.1    Chen, W.M.2    Recker, S.3
  • 7
    • 0035137810 scopus 로고    scopus 로고
    • Sex steroids and bone
    • Compston JE. Sex steroids and bone. Physiol Rev. 2001;81(1):419-447.
    • (2001) Physiol Rev , vol.81 , Issue.1 , pp. 419-447
    • Compston, J.E.1
  • 8
    • 33645241407 scopus 로고    scopus 로고
    • The RIN: An RNA integrity number for assigning integrity values to RNA measurements
    • Schroeder A, Mueller O, Stocker S, et al. The RIN: an RNA integrity number for assigning integrity values to RNA measurements. BMC Mol Biol. 2006;7(1):3.
    • (2006) BMC Mol Biol , vol.7 , Issue.1 , pp. 3
    • Schroeder, A.1    Mueller, O.2    Stocker, S.3
  • 11
    • 0024252149 scopus 로고
    • Stromal stem cells: Marrow-derived osteogenic precursors
    • Owen M, Friedenstein A. Stromal stem cells: marrow-derived osteogenic precursors. Ciba Found Symp. 1988;136:42-60.
    • (1988) Ciba Found Symp , vol.136 , pp. 42-60
    • Owen, M.1    Friedenstein, A.2
  • 12
    • 0025216220 scopus 로고
    • Recombinant human bone morphogenetic protein induces bone formation
    • Wang EA, Rosen V, D'Alessandro JS, et al. Recombinant human bone morphogenetic protein induces bone formation. Proc Natl Acad Sci. 1990;87(6):2220-2224.
    • (1990) Proc Natl Acad Sci , vol.87 , Issue.6 , pp. 2220-2224
    • Wang, E.A.1    Rosen, V.2    D'Alessandro, J.S.3
  • 14
    • 33646054249 scopus 로고    scopus 로고
    • Dynamic expression of sparc precedes formation of skeletal elements in the Medaka (Oryzias latipes)
    • Renn J, Schaedel M, Volff J-N, Goerlich R, Schartl M, Winkler C. Dynamic expression of sparc precedes formation of skeletal elements in the Medaka (Oryzias latipes). Gene. 2006;372:208-218.
    • (2006) Gene , vol.372 , pp. 208-218
    • Renn, J.1    Schaedel, M.2    Volff, J.-N.3    Goerlich, R.4    Schartl, M.5    Winkler, C.6
  • 15
    • 0026787956 scopus 로고
    • Temporal studies on the tissue compartmentalization of bone sialoprotein (BSP), osteopontin (OPN), and SPARC protein during bone formation in vitro
    • Kasugai S, Nagata T, Sodek J. Temporal studies on the tissue compartmentalization of bone sialoprotein (BSP), osteopontin (OPN), and SPARC protein during bone formation in vitro. J Cell Physiol. 1992; 152(3):467-477.
    • (1992) J Cell Physiol , vol.152 , Issue.3 , pp. 467-477
    • Kasugai, S.1    Nagata, T.2    Sodek, J.3
  • 16
    • 0030684749 scopus 로고    scopus 로고
    • Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts
    • Komori T, Yagi H, Nomura S, et al. Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts. Cell. 1997;89(5):755-764.
    • (1997) Cell , vol.89 , Issue.5 , pp. 755-764
    • Komori, T.1    Yagi, H.2    Nomura, S.3
  • 17
    • 0030666372 scopus 로고    scopus 로고
    • Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development
    • Otto F, Thornell AP, Crompton T, et al. Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development. Cell. 1997;89(5):765-771.
    • (1997) Cell , vol.89 , Issue.5 , pp. 765-771
    • Otto, F.1    Thornell, A.P.2    Crompton, T.3
  • 18
    • 13944264312 scopus 로고    scopus 로고
    • Osterix, a transcription factor for osteoblast differentiation, mediates antitumor activity in murine osteosarcoma
    • Cao Y, Zhou Z, de Crombrugghe B, et al. Osterix, a transcription factor for osteoblast differentiation, mediates antitumor activity in murine osteosarcoma. Cancer Res. 2005;65(4):1124-1128.
    • (2005) Cancer Res , vol.65 , Issue.4 , pp. 1124-1128
    • Cao, Y.1    Zhou, Z.2    de Crombrugghe, B.3
  • 19
    • 80054729040 scopus 로고    scopus 로고
    • Osteoblastspecific transcription factor Osterix increases vitamin D receptor gene expression in osteoblasts
    • Zhang C, Tang W, Li Y, Yang F, Dowd DR, MacDonald PN. Osteoblastspecific transcription factor Osterix increases vitamin D receptor gene expression in osteoblasts. PloS one. 2011;6(10):e26504.
    • (2011) PloS One , vol.6 , Issue.10
    • Zhang, C.1    Tang, W.2    Li, Y.3    Yang, F.4    Dowd, D.R.5    Macdonald, P.N.6
  • 20
    • 0031408156 scopus 로고    scopus 로고
    • Influence of ovariectomy and estradiol treatment on calcium homeostasis during aging in rats
    • Gaumet N, Seibel M, Coxam V, Davicco M, Lebecque P, Barlet J. Influence of ovariectomy and estradiol treatment on calcium homeostasis during aging in rats. Arch Physiol Biochem. 1997;105(5):435-444.
    • (1997) Arch Physiol Biochem , vol.105 , Issue.5 , pp. 435-444
    • Gaumet, N.1    Seibel, M.2    Coxam, V.3    Davicco, M.4    Lebecque, P.5    Barlet, J.6
  • 21
    • 0036188807 scopus 로고    scopus 로고
    • Changes in proinflammatory cytokine activity after menopause
    • Pfeilschifter J, Köditz R, Pfohl M, Schatz H. Changes in proinflammatory cytokine activity after menopause. Endocr rev. 2002;23(1):90-119.
    • (2002) Endocr Rev , vol.23 , Issue.1 , pp. 90-119
    • Pfeilschifter, J.1    Köditz, R.2    Pfohl, M.3    Schatz, H.4
  • 24
    • 1842423821 scopus 로고    scopus 로고
    • Effects of germinated brown rice extracts with enhanced levels of GABA on cancer cell proliferation and apoptosis
    • Oh C-H, Oh S-H. Effects of germinated brown rice extracts with enhanced levels of GABA on cancer cell proliferation and apoptosis. J Med Food. 2004;7(1):19-23.
    • (2004) J Med Food , vol.7 , Issue.1 , pp. 19-23
    • Oh, C.-H.1    Oh, S.-H.2
  • 25
    • 84864303961 scopus 로고    scopus 로고
    • Changes in nutritional components throughout germination in paddy rice and brown rice
    • Lee JH. Changes in nutritional components throughout germination in paddy rice and brown rice. J Food Sci Nutr. 2010;15(2):113-119.
    • (2010) J Food Sci Nutr , vol.15 , Issue.2 , pp. 113-119
    • Lee, J.H.1
  • 26
    • 80054682184 scopus 로고    scopus 로고
    • Effect of pregermination time on amino acid profile and gamma amino butyric acid (GABA) contents in different varieties of Malaysian brown rice
    • Roohinejad S, Omidizadeh A, Mirhosseini H, et al. Effect of pregermination time on amino acid profile and gamma amino butyric acid (GABA) contents in different varieties of Malaysian brown rice. Int J Food Propert. 2011;14(6):1386-1399.
    • (2011) Int J Food Propert , vol.14 , Issue.6 , pp. 1386-1399
    • Roohinejad, S.1    Omidizadeh, A.2    Mirhosseini, H.3
  • 27
    • 84867838701 scopus 로고    scopus 로고
    • Effects of white rice, brown rice and germinated brown rice on antioxidant status of type 2 diabetic rats
    • Imam MU, Musa SN, Azmi NH, Ismail M. Effects of white rice, brown rice and germinated brown rice on antioxidant status of type 2 diabetic rats. Int J Mol Sci. 2012;13(10):12952-12969.
    • (2012) Int J Mol Sci , vol.13 , Issue.10 , pp. 12952-12969
    • Imam, M.U.1    Musa, S.N.2    Azmi, N.H.3    Ismail, M.4
  • 28
    • 84858703121 scopus 로고    scopus 로고
    • Physicochemical property changes in germinated brown rice flour from different storage periods of paddy rice
    • Songtip P, Jangchud K, Jangchud A, Tungtrakul P. Physicochemical property changes in germinated brown rice flour from different storage periods of paddy rice. Int J Food Sci Technol. 2012;47(4):682-688.
    • (2012) Int J Food Sci Technol , vol.47 , Issue.4 , pp. 682-688
    • Songtip, P.1    Jangchud, K.2    Jangchud, A.3    Tungtrakul, P.4
  • 29
    • 84862995018 scopus 로고    scopus 로고
    • Effect of acid and base catalyzed hydrolysis on the yield of phenolics and antioxidant activity of extracts from germinated brown rice (GBR)
    • Sani IM, Iqbal S, Chan KW, Ismail M. Effect of acid and base catalyzed hydrolysis on the yield of phenolics and antioxidant activity of extracts from germinated brown rice (GBR). Molecules. 2012;17(6):7584-7594.
    • (2012) Molecules , vol.17 , Issue.6 , pp. 7584-7594
    • Sani, I.M.1    Iqbal, S.2    Chan, K.W.3    Ismail, M.4
  • 30
    • 0034036013 scopus 로고    scopus 로고
    • Free amino acids present in commercially available seedlings sold for human consumption. A potential hazard for consumers
    • Rozan P, Kuo Y-H, Lambein F. Free amino acids present in commercially available seedlings sold for human consumption. A potential hazard for consumers. J Agric Food Chem. 2000;48(3):716-723.
    • (2000) J Agric Food Chem , vol.48 , Issue.3 , pp. 716-723
    • Rozan, P.1    Kuo, Y.-H.2    Lambein, F.3
  • 31
    • 57549089635 scopus 로고    scopus 로고
    • Extraction and determination of oryzanol in rice bran of mixed herbarium UKMB: AZ 6807: MR 185, AZ 6808: MR 211, AZ6809: MR 29
    • Azlan A, Ismail M, Abdul Hamid A. Extraction and determination of oryzanol in rice bran of mixed herbarium UKMB: AZ 6807: MR 185, AZ 6808: MR 211, AZ6809: MR 29. ASEAN Food J. 2008;15(1):89-96.
    • (2008) ASEAN Food J , vol.15 , Issue.1 , pp. 89-96
    • Azlan, A.1    Ismail, M.2    Abdul, H.A.3
  • 32
    • 39549122594 scopus 로고    scopus 로고
    • Effect of pre-germinated brown rice intake on diabetic neuropathy in streptozotocin-induced diabetic rats
    • Usuki S, Ito Y, Morikawa K, et al. Effect of pre-germinated brown rice intake on diabetic neuropathy in streptozotocin-induced diabetic rats. Nutr Metab (Lond). 2007;4(1):25.
    • (2007) Nutr Metab (Lond) , vol.4 , Issue.1 , pp. 25
    • Usuki, S.1    Ito, Y.2    Morikawa, K.3
  • 33
    • 0034997654 scopus 로고    scopus 로고
    • Increased weight gain after ovariectomy is not a consequence of leptin resistance
    • Chen Y, Heiman ML. Increased weight gain after ovariectomy is not a consequence of leptin resistance. Am J Physiol Endocrinol Metab. 2001;280(2):E315-E322.
    • (2001) Am J Physiol Endocrinol Metab , vol.280 , Issue.2
    • Chen, Y.1    Heiman, M.L.2
  • 35
    • 0017722316 scopus 로고
    • Role of food intake in estradiol-induced body weight changes in female rats
    • Roy EJ, Wade GN. Role of food intake in estradiol-induced body weight changes in female rats. Horm Behav. 1977;8(3):265-274.
    • (1977) Horm Behav , vol.8 , Issue.3 , pp. 265-274
    • Roy, E.J.1    Wade, G.N.2
  • 36
    • 78651101764 scopus 로고    scopus 로고
    • Inhibitory activities of soluble and bound millet seed phenolics on free radicals and reactive oxygen species
    • Chandrasekara A, Shahidi F. Inhibitory activities of soluble and bound millet seed phenolics on free radicals and reactive oxygen species. J Agric Food Chem. 2010;59(1):428-436.
    • (2010) J Agric Food Chem , vol.59 , Issue.1 , pp. 428-436
    • Chandrasekara, A.1    Shahidi, F.2
  • 38
    • 3242788818 scopus 로고    scopus 로고
    • Gamma-oryzanol from rice bran oil: A review
    • Patel M, Naik S. Gamma-oryzanol from rice bran oil: a review. J Sci Ind Res India. 2004;63:569-578.
    • (2004) J Sci Ind Res India , vol.63 , pp. 569-578
    • Patel, M.1    Naik, S.2
  • 39
    • 84864979361 scopus 로고    scopus 로고
    • Neuroprotective effects of germinated brown rice against hydrogen peroxide induced cell death in human SH-SY5Y cells
    • Ismail N, Ismail M, Farhana Fathy S, et al. Neuroprotective effects of germinated brown rice against hydrogen peroxide induced cell death in human SH-SY5Y cells. Int J Mol Sci. 2012;13(8):9692-9708.
    • (2012) Int J Mol Sci , vol.13 , Issue.8 , pp. 9692-9708
    • Ismail, N.1    Ismail, M.2    Farhana, F.S.3
  • 40
    • 77949913988 scopus 로고    scopus 로고
    • Protective effects of pre-germinated brown rice diet on low levels of Pb-induced learning and memory deficits in developing rat
    • Zhang R, Lu H, Tian S, et al. Protective effects of pre-germinated brown rice diet on low levels of Pb-induced learning and memory deficits in developing rat. Chem Biol Interact. 2010;184(3):484-491.
    • (2010) Chem Biol Interact , vol.184 , Issue.3 , pp. 484-491
    • Zhang, R.1    Lu, H.2    Tian, S.3
  • 41
    • 16644378019 scopus 로고    scopus 로고
    • Effects of pre-germinated brown rice on beta-amyloid protein-induced learning and memory deficits in mice
    • Mamiya T, Asanuma T, Kise M, et al. Effects of pre-germinated brown rice on beta-amyloid protein-induced learning and memory deficits in mice. Biol Pharm Bull. 2004;27(7):1041-1045.
    • (2004) Biol Pharm Bull , vol.27 , Issue.7 , pp. 1041-1045
    • Mamiya, T.1    Asanuma, T.2    Kise, M.3
  • 42
    • 0018898214 scopus 로고
    • Effect of acute and repeated administration of gamma aminobutyric acid (GABA) on growth hormone and prolactin secretion in man
    • Cavagnini F, Invitti C, Pinto M, et al. Effect of acute and repeated administration of gamma aminobutyric acid (GABA) on growth hormone and prolactin secretion in man. Acta Endocrinol (Copenh). 1980;93(2):149-154.
    • (1980) Acta Endocrinol (Copenh) , vol.93 , Issue.2 , pp. 149-154
    • Cavagnini, F.1    Invitti, C.2    Pinto, M.3
  • 44
    • 38049023548 scopus 로고    scopus 로고
    • Growth hormone isoform responses to GABA ingestion at rest and after exercise
    • Powers ME, Yarrow JF, McCoy SC, Borst SE. Growth hormone isoform responses to GABA ingestion at rest and after exercise. Med Sci Sports Exerc. 2008;40(1):104.
    • (2008) Med Sci Sports Exerc , vol.40 , Issue.1 , pp. 104
    • Powers, M.E.1    Yarrow, J.F.2    McCoy, S.C.3    Borst, S.E.4
  • 45
    • 0024272180 scopus 로고
    • Picrotoxin, a gammaaminobutyric acid-receptor antagonist, retards craniofacial development in the weaning rat: I. Effect on mandibular bone growth
    • Ben-Shachar D, Laufer D, Livne E, Silbermann M. Picrotoxin, a gammaaminobutyric acid-receptor antagonist, retards craniofacial development in the weaning rat: I. Effect on mandibular bone growth. J Craniofac Genet Dev Biol. 1988;8(4):351.
    • (1988) J Craniofac Genet Dev Biol , vol.8 , Issue.4 , pp. 351
    • Ben-Shachar, D.1    Laufer, D.2    Livne, E.3    Silbermann, M.4
  • 46
    • 0036076754 scopus 로고    scopus 로고
    • Functional GABA(B) receptors expressed in cultured calvarial osteoblasts
    • Fujimori S, Hinoi E, Yoneda Y. Functional GABA(B) receptors expressed in cultured calvarial osteoblasts. Biochem Biophysl Res Commun. 2002;293(5):1445-1452.
    • (2002) Biochem Biophysl Res Commun , vol.293 , Issue.5 , pp. 1445-1452
    • Fujimori, S.1    Hinoi, E.2    Yoneda, Y.3
  • 47
    • 80053006714 scopus 로고    scopus 로고
    • Osteoblastic γ-aminobutyric acid, type B receptors negatively regulate osteoblastogenesis toward disturbance of osteoclastogenesis mediated by receptor activator of nuclear factor κB ligand in mouse bone
    • Takahata Y, Takarada T, Hinoi E, Nakamura Y, Fujita H, Yoneda Y. Osteoblastic γ-aminobutyric acid, type B receptors negatively regulate osteoblastogenesis toward disturbance of osteoclastogenesis mediated by receptor activator of nuclear factor κB ligand in mouse bone. J Biol Chem. 2011;286(38):32906-32917.
    • (2011) J Biol Chem , vol.286 , Issue.38 , pp. 32906-32917
    • Takahata, Y.1    Takarada, T.2    Hinoi, E.3    Nakamura, Y.4    Fujita, H.5    Yoneda, Y.6
  • 48
    • 0034951917 scopus 로고    scopus 로고
    • Rice bran oil and γ-Oryzanol in the treatment of hyperlipoproteinaemias and other conditions
    • Cicero A, Gaddi A. Rice bran oil and γ-Oryzanol in the treatment of hyperlipoproteinaemias and other conditions. Phytother Res. 2001;15(4):277-289.
    • (2001) Phytother Res , vol.15 , Issue.4 , pp. 277-289
    • Cicero, A.1    Gaddi, A.2
  • 49
    • 85007781598 scopus 로고
    • Measurement of superoxide dismutase-like activity of natural antioxidants
    • Kim SJ, Han D, Moon KD, Rhee JS. Measurement of superoxide dismutase-like activity of natural antioxidants. Biosci Biotechnol Biochem. 1995;59(5):822.
    • (1995) Biosci Biotechnol Biochem , vol.59 , Issue.5 , pp. 822
    • Kim, S.J.1    Han, D.2    Moon, K.D.3    Rhee, J.S.4
  • 50
    • 0029967376 scopus 로고    scopus 로고
    • Preventive effect of natural and synthetic antioxidants on lipid peroxidation in the mammalian eye
    • Ueda T, Armstrong D. Preventive effect of natural and synthetic antioxidants on lipid peroxidation in the mammalian eye. Ophthalmic Res. 1996;28(3):184-192.
    • (1996) Ophthalmic Res , vol.28 , Issue.3 , pp. 184-192
    • Ueda, T.1    Armstrong, D.2
  • 51
    • 24044460427 scopus 로고    scopus 로고
    • Ovariectomy induces oxidative stress and impairs bone antioxidant system in adult rats
    • Muthusami S, Ramachandran I, Muthusamy B, et al. Ovariectomy induces oxidative stress and impairs bone antioxidant system in adult rats. Clin Chim Acta. 2005;360(1-2):81-86.
    • (2005) Clin Chim Acta , vol.360 , Issue.1-2 , pp. 81-86
    • Muthusami, S.1    Ramachandran, I.2    Muthusamy, B.3
  • 53
    • 0033304632 scopus 로고    scopus 로고
    • Estrogen stimulates gene expression and protein production of osteoprotegerin in human osteoblastic cells
    • Hofbauer LC, Khosla S, Dunstan CR, Lacey DL, Spelsberg TC, Riggs BL. Estrogen stimulates gene expression and protein production of osteoprotegerin in human osteoblastic cells. Endocrinology. 1999;140(9):4367-4370.
    • (1999) Endocrinology , vol.140 , Issue.9 , pp. 4367-4370
    • Hofbauer, L.C.1    Khosla, S.2    Dunstan, C.R.3    Lacey, D.L.4    Spelsberg, T.C.5    Riggs, B.L.6
  • 54
    • 84967614664 scopus 로고    scopus 로고
    • Sex steroids and the construction and conservation of the adult skeleton
    • Riggs BL, Khosla S, Melton LJ. Sex steroids and the construction and conservation of the adult skeleton. Endocr Rev. 2002;23(3):279-302.
    • (2002) Endocr Rev , vol.23 , Issue.3 , pp. 279-302
    • Riggs, B.L.1    Khosla, S.2    Melton, L.J.3
  • 55
    • 77951588619 scopus 로고    scopus 로고
    • Gamma-oryzanol rich fraction regulates the expression of antioxidant and oxidative stress related genes in stressed rat's liver
    • Ismail M, Al-Naqeeb G, Mamat W, Ahmad Z. Gamma-oryzanol rich fraction regulates the expression of antioxidant and oxidative stress related genes in stressed rat's liver. Nutr Metab. 2010;7(23):1-13.
    • (2010) Nutr Metab , vol.7 , Issue.23 , pp. 1-13
    • Ismail, M.1    Al-Naqeeb, G.2    Mamat, W.3    Ahmad, Z.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.