Human lung fibroblasts increase CD4(+)CD25(+)Foxp3(+) T cells in co-cultured CD4(+) lymphocytes

Cellular Immunology

Volumn 285, Issue 1-2, 2013, Pages 55-61

  Conte, Enrico ^a   Gili, Elisa ^a   Fruciano, Mary ^a   Fagone, Evelina ^a   Vancheri, Carlo ^a  

^a UNIVERSITY OF CATANIA   (Italy)

Author keywords

Human lung fibroblasts; PGE2; T regulatory cells

Indexed keywords

CD28 ANTIBODY; CD3 ANTIGEN; CD4 ANTIGEN; CYTOKINE ANTIBODY; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR ALPHA; INTERLEUKIN 4; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG;

ADULT; ANTIGEN EXPRESSION; ARTICLE; ARTIFICIAL MEMBRANE; CD25+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; COCULTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; FIBROBLAST CULTURE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; HUMAN TISSUE; LUNG BIOPSY; LUNG FIBROBLAST; LYMPHOCYTE PROLIFERATION; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION;

HUMAN LUNG FIBROBLASTS; PGE(2); T REGULATORY CELLS;

ANTIGENS, CD28; ANTIGENS, CD3; CD4-POSITIVE T-LYMPHOCYTES; CELL PROLIFERATION; COCULTURE TECHNIQUES; CTLA-4 ANTIGEN; CYCLOOXYGENASE 2 INHIBITORS; DINOPROSTONE; FIBROBLASTS; FORKHEAD TRANSCRIPTION FACTORS; HUMANS; INTERFERON-GAMMA; INTERLEUKIN-10; INTERLEUKIN-2; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; INTERLEUKIN-4; IONOMYCIN; LUNG; LYMPHOCYTE ACTIVATION; TRANSFORMING GROWTH FACTOR BETA;

EID: 84884551777     PISSN: 00088749     EISSN: 10902163     Source Type: Journal    
DOI: 10.1016/j.cellimm.2013.09.002     Document Type: Article

References (48)

1. Shevach E.M. CD4+ CD25+ suppressor T cells: more questions than answers. Nat. Rev. Immunol. 2002, 2:389-400.
2. Walker M.R., Kasprowicz D.J., Gersuk V.H., Benard A., Van L.M., Buckner J.H., Ziegler S.F. Induction of FoxP3 and acquisition of T regulatory activity by stimulated human CD4+CD25- T cells. J. Clin. Invest. 2003, 112:1437-1443.
3. de Boer O.J., van der Loos C.M., Teeling P., van der Wal A.C., Teunissen M.B. Immunohistochemical analysis of regulatory T cell markers FOXP3 and GITR on CD4+CD25+ T cells in normal skin and inflammatory dermatoses. J. Histochem. Cytochem. 2007, 55:891-898.
4. Takahashi T., Tagami T., Yamazaki S., Uede T., Shimizu J., Sakaguchi N., Mak T.W., Sakaguchi S. Immunologic self-tolerance maintained by CD25(+)CD4(+) regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4. J. Exp. Med. 2000, 192:303-310.
5. Levings M.K., Bacchetta R., Schulz U., Roncarolo M.G. The role of IL-10 and TGF-beta in the differentiation and effector function of T regulatory cells. Int. Arch. Allergy Immunol. 2002, 129:263-276.
6. Yamagiwa S., Gray J.D., Hashimoto S., Horwitz D.A. A role for TGF-beta in the generation and expansion of CD4+CD25+ regulatory T cells from human peripheral blood. J. Immunol. 2001, 166:7282-7289.
7. Zheng S.G., Gray J.D., Ohtsuka K., Yamagiwa S., Horwitz D.A. Generation ex vivo of TGF-beta-producing regulatory T cells from CD4+CD25- precursors. J. Immunol. 2002, 169:4183-4189.
8. Zheng S.G., Wang J.H., Gray J.D., Soucier H., Horwitz D.A. Natural and induced CD4+CD25+ cells educate CD4+CD25- cells to develop suppressive activity:the role of IL-2, TGF-beta, and IL-10. J. Immunol. 2004, 172:5213-5221.
9. Boyer O., Saadoun D., Abriol J., Dodille M., Piette J.C., Cacoub P., Klatzmann D. CD4+CD25+ regulatory T-cell deficiency in patients with hepatitis C-mixed cryoglobulinemia vasculitis. Blood 2004, 103:3428-3430.
10. Miyara M., Amoura Z., Parizot C., Badoual C., Dorgham K., Trad S., Nochy D., Debre P., Piette J.C., Gorochov G. Global natural regulatory T cell depletion in active systemic lupus erythematosus. J. Immunol. 2005, 175:8392-8400.
11. Venken K., Hellings N., Broekmans T., Hensen K., Rummens J.L., Stinissen P. Natural naive CD4+CD25+CD127low regulatory T cell (Treg) development and function are disturbed in multiple sclerosis patients: recovery of memory Treg homeostasis during disease progression. J. Immunol. 2008, 180:6411-6420.
12. Kotsianidis I., Nakou E., Bouchliou I., Tzouvelekis A., Spanoudakis E., Steiropoulos P., Sotiriou I., Aidinis V., Margaritis D., Tsatalas C., Bouros D. Global impairment of CD4+CD25+FOXP3+ regulatory T cells in idiopathic pulmonary fibrosis. Am. J. Respir. Crit. Care Med. 2009, 179:1121-1130.
13. Luzina I.G., Todd N.W., Iacono A.T., Atamas S.P. Roles of T lymphocytes in pulmonary fibrosis. J. Leukoc. Biol. 2008, 83:237-244.
14. Homolka J., Ziegenhagen M.W., Gaede K.I., Entzian P., Zissel G., Muller-Quernheim J. Systemic immune cell activation in a subgroup of patients with idiopathic pulmonary fibrosis. Respiration 2003, 70:262-269.
15. Feghali-Bostwick C.A., Tsai C.G., Valentine V.G., Kantrow S., Stoner M.W., Pilewski J.M., Gadgil A., George M.P., Gibson K.F., Choi A.M., Kaminski N., Zhang Y., Duncan S.R. Cellular and humoral autoreactivity in idiopathic pulmonary fibrosis. J. Immunol. 2007, 179:2592-2599.
16. Murakami S., Hino E., Shimabukuro Y., Nozaki T., Kusumoto Y., Saho T., Hirano F., Hirano H., Okada H. Direct interaction between gingival fibroblasts and lymphoid cells induces inflammatory cytokine mRNA expression in gingival fibroblasts. J. Dent. Res. 1999, 78:69-76.
17. Vancheri C., Sortino M.A., Tomaselli V., Mastruzzo C., Condorelli F., Bellistri G., Pistorio M.P., Canonico P.L., Crimi N. Different expression of TNF-alpha receptors and prostaglandin E(2)Production in normal and fibrotic lung fibroblasts: potential implications for the evolution of the inflammatory process. Am. J. Respir. Cell Mol. Biol. 2000, 22:628-634.
18. Vancheri C., Mastruzzo C., Trovato-Salinaro E., Gili E., Lo F.D., Pistorio M.P., Caruso M., La R.C., Crimi C., Failla M., Crimi N. Interaction between human lung fibroblasts and T-lymphocytes prevents activation of CD4+ cells. Respir. Res. 2005, 6:103.
19. Yucel-Lindberg T., Brunius G., Wondimu B., Anduren I., Modeer T. Enhanced cyclooxygenase-2 mRNA expression in human gingival fibroblasts induced by cell contact with human lymphocytes. Eur. J. Oral Sci. 2001, 109:187-192.
20. Vancheri C., Crimi N., Conte E., Pistorio M.P., Mastruzzo C., Lamicela M., Messina A., Mistretta A. Human lung fibroblasts inhibit tumor necrosis factor-alpha production by LPS-activated monocytes. Am. J. Respir. Cell Mol. Biol. 1996, 15:460-466.
21. Vancheri C., Mastruzzo C., Tomaselli V., Sortino M.A., D'Amico L., Bellistri G., Pistorio M.P., Salinaro E.T., Palermo F., Mistretta A., Crimi N. Normal human lung fibroblasts differently modulate interleukin-10 and interleukin-12 production by monocytes: implications for an altered immune response in pulmonary chronic inflammation. Am. J. Respir. Cell Mol. Biol. 2001, 25:592-599.
22. Conte E., Bonaiuto C., Nesci C., Crimi N., Vancheri C., Messina A. Nuclear factor-kappaB activation in human monocytes stimulated with lipopolysaccharide is inhibited by fibroblast conditioned medium and exogenous PGE2. FEBS Lett. 1997, 400:315-318.
23. Jordana M., Newhouse M.T., Gauldie J. Alveolar macrophage/peripheral blood monocyte-derived factors modulate proliferation of primary lines of human lung fibroblasts. J. Leukoc. Biol. 1987, 42:51-60.
24. Pinchuk I.V., Beswick E.J., Saada J.I., Boya G., Schmitt D., Raju G.S., Brenmoehl J., Rogler G., Reyes V.E., Powell D.W. Human colonic myofibroblasts promote expansion of CD4+ CD25high Foxp3+ regulatory T cells2. Gastroenterology 2011, 140:2019-2030.
25. English K., Ryan J.M., Tobin L., Murphy M.J., Barry F.P., Mahon B.P. Cell contact, prostaglandin E(2) and transforming growth factor beta 1 play non-redundant roles in human mesenchymal stem cell induction of CD4+CD25(High) forkhead box P3+ regulatory T cells. Clin. Exp. Immunol. 2009, 156:149-160.
26. Li Q., Guo Z., Xu X., Xia S., Cao X. Pulmonary stromal cells induce the generation of regulatory DC attenuating T-cell-mediated lung inflammation. Eur. J. Immunol. 2008, 38:2751-2761.
27. Baratelli F., Lin Y., Zhu L., Yang S.C., Heuze-Vourc'h N., Zeng G., Reckamp K., Dohadwala M., Sharma S., Dubinett S.M. Prostaglandin E2 induces FOXP3 gene expression and T regulatory cell function in human CD4+ T cells. J. Immunol. 2005, 175:1483-1490.
28. Bryn T., Yaqub S., Mahic M., Henjum K., Aandahl E.M., Tasken K. LPS-activated monocytes suppress T-cell immune responses and induce FOXP3+ T cells through a COX-2-PGE2-dependent mechanism. Int. Immunol. 2008, 20:235-245.
29. Garg A., Barnes P.F., Roy S., Quiroga M.F., Wu S., Garcia V.E., Krutzik S.R., Weis S.E., Vankayalapati R. Mannose-capped lipoarabinomannan- and prostaglandin E2-dependent expansion of regulatory T cells in human Mycobacterium tuberculosis infection. Eur. J. Immunol. 2008, 38:459-469.
30. Mahic M., Yaqub S., Johansson C.C., Tasken K., Aandahl E.M. FOXP3+CD4+CD25+ adaptive regulatory T cells express cyclooxygenase-2 and suppress effector T cells by a prostaglandin E2-dependent mechanism. J. Immunol. 2006, 177:246-254.
31. Sharma S., Yang S.C., Zhu L., Reckamp K., Gardner B., Baratelli F., Huang M., Batra R.K., Dubinett S.M. Tumor cyclooxygenase-2/prostaglandin E2-dependent promotion of FOXP3 expression and CD4+ CD25+ T regulatory cell activities in lung cancer. Cancer Res. 2005, 65:5211-5220.
32. Chen H., Qin J., Wei P., Zhang J., Li Q., Fu L., Li S., Ma C., Cong B. Effects of leukotriene B4 and prostaglandin E2 on the differentiation of murine Foxp3+ T regulatory cells and Th17 cells. Prostaglandins Leukot. Essent. Fatty Acids 2009, 80:195-200.
33. Wohler J., Bullard D., Schoeb T., Barnum S. LFA-1 is critical for regulatory T cell homeostasis and function. Mol. Immunol. 2009, 46:2424-2428.
34. Fu S., Zhang N., Yopp A.C., Chen D., Mao M., Chen D., Zhang H., Ding Y., Bromberg J.S. TGF-beta induces Foxp3 + T-regulatory cells from CD4 + C. Am. J. Transplant. 2004, 4:1614-1627.
35. Horwitz D.A., Zheng S.G., Gray J.D. Natural and TGF-beta-induced Foxp3(+)CD4(+) CD25(+) regulatory T cells are not mirror images of each other. Trends Immunol. 2008, 29:429-435.
36. Romagnani S. Regulation of the T cell response. Clin. Exp. Allergy 2006, 36:1357-1366.
37. Wahl S.M., Wen J., Moutsopoulos N. TGF-beta: a mobile purveyor of immune privilege. Immunol. Rev. 2006, 213:213-227.
38. Wei J., Duramad O., Perng O.A., Reiner S.L., Liu Y.J., Qin F.X. Antagonistic nature of T helper 1/2 developmental programs in opposing peripheral induction of Foxp3+ regulatory T cells. Proc. Natl. Acad. Sci. USA 2007, 104:18169-18174.
39. Pace L., Rizzo S., Palombi C., Brombacher F., Doria G. Cutting edge: IL-4-induced protection of CD4+. J. Immunol. 2006, 176:3900-3904.
40. Skapenko A., Kalden J.R., Lipsky P.E., Schulze-Koops H. The IL-4 receptor alpha-chain-binding cytokines, IL-4 and IL-13, induce forkhead box P3-expressing CD25+CD4+ regulatory T cells from CD25-CD4+ precursors. J. Immunol. 2005, 175:6107-6116.
41. Pillai A.B., George T.I., Dutt S., Strober S. Host natural killer T cells induce an interleukin-4-dependent expansion of donor CD4+CD25+Foxp3+ T regulatory cells that protects against graft-versus-host disease. Blood 2009, 113:4458-4467.
42. Hadjur S., Bruno L., Hertweck A., Cobb B.S., Taylor B., Fisher A.G., Merkenschlager M. IL4 blockade of inducible regulatory T cell differentiation: the role of Th2 cells, Gata3 and PU.1. Immunol. Lett. 2009, 122:37-43.
43. Prochazkova J., Fric J., Pokorna K., Neuwirth A., Krulova M., Zajicova A., Holan V. Distinct regulatory roles of transforming growth factor-beta and interleukin-4 in the development and maintenance of natural and induced CD4+ CD25+ Foxp3+ regulatory T cells. Immunology 2009, 128:e670-e678.
44. Guo F., Iclozan C., Suh W.K., Anasetti C., Yu X.Z. CD28 controls differentiation of regulatory T cells from naive CD4 T cells. J. Immunol. 2008, 181:2285-2291.
45. Hori S., Nomura T., Sakaguchi S. Control of regulatory T cell development by the transcription factor Foxp3. Science 2003, 299:1057-1061.
46. Yagi H., Nomura T., Nakamura K., Yamazaki S., Kitawaki T., Hori S., Maeda M., Onodera M., Uchiyama T., Fujii S., Sakaguchi S. Crucial role of FOXP3 in the development and function of human CD25+CD4+ regulatory T cells. Int. Immunol. 2004, 16:1643-1656.
47. Corthay A. How do regulatory T cells work?. Scand. J. Immunol. 2009, 70:326-336.
48. Trickett A., Kwan Y.L. T cell stimulation and expansion using anti-CD3/CD28 beads. J. Immunol. Methods 2003, 275:251-255.