Development of a perfusion flow bioreactor system for culturing human alveolar bone marrow stem cells

Tissue Engineering and Regenerative Medicine

Volumn 6, Issue 14, 2009, Pages 1410-1419

  Lim, Ki Taek ^a,b   Cho, Chong Su ^c   Choung, Yun Hoon ^d   Seonwoo, Hoon ^a   Son, Hyun Mok ^a   Baik, Soo Jung ^a   Kim, Jang Ho ^a   Hong, Sung Min ^e   Park, Joo Young ^b   Jeon, Soung Hoo ^b   Choung, Pill Hoon ^b   Chung, Jong Hoon ^a,b  

^a Seoul National University   (South Korea)

^b Seoul National University   (South Korea)

^c Seoul National University   (South Korea)

^d Ajou University School of Medicine   (South Korea)

^e Korea Electronic Technology Institute (KETI)   (South Korea)

Author keywords

Alveolar bone marrow stem cells; Bioreactor system; Perfusion; Tissue engineering

Indexed keywords

ALVEOLAR BONES; BIOREACTOR SYSTEM; CELLULAR ACTIVITIES; MECHANICAL STIMULATION; MECHANICAL STIMULUS; PERFUSION; PERFUSION BIOREACTOR; PERFUSION BIOREACTOR SYSTEMS;

BIOCONVERSION; BONE; CELL CULTURE; CELL GROWTH; GROWTH KINETICS; GROWTH RATE; MORPHOLOGY; STEM CELLS; TISSUE ENGINEERING;

BIOREACTORS;

EID: 84884545554     PISSN: 17382696     EISSN: 22125469     Source Type: Journal    
DOI: None     Document Type: Article

References (63)

1. GN Bancroft, VI Sikavitsas, JVd Dolder, et al., Fluid flow increases mineralized matrix deposition in 3D perfusion culture of marrow stromal osteoblasts in adose-dependant manner, PNAS, 99, 12600 (2002).
2. Y Martin, P Vermette, Bioreactors for tissue mass culture: Design, characterization, and recent advances, Biomaterials 26(35), 7481 (2005).
3. P Pathi, T Ma, BR Locke, Role of nutrient supply on cell growth in bioreactor design for tissue engineering of hematopoietic cells, Biotechnol Bioeng, 89(7), 743 (2005).
4. XJ Yu, EA Botchwey, EM Levine, et al, Bioreactor based bone tissue engineering: The influence of dynamic flow on osteoblast phenotypic expression and matrix mineralization, PNAS, 101, 11203 (2004).
5. L Schropp, A Wenzel, L Kostopoulos, et al, Bone healing and soft tissue contour changes following single-tooth extraction: a clinical and radiographic 12-month prospective study, Int J Periodont Restor Dent, 23, 313 (2003).
6. VI Sikavitsas, JS Temenoff, AG Mikos, Biomaterials and bone mechanotransduction, Biomaterials, 22, 2581 (2001).
7. J Vance, S Galley, DF Liu, et al, Mechanical stimulation of MC3T3 osteoblastic cells in a bone tissue-engineering bioreactor enhances prostaglandin E-2 release, Tissue Eng, 11, 1832 (2005).
8. S Weinbaum, SC Cowin, Y Zeng, A model for the excitation of osteocytes by mechanical loading induced bone fluid shear stresses. J Biomech, 27, 339 (1994).
9. M Shachar, S Cohen, Cardiac tissue engineering, ex vivo: design principles in biomaterials and bioreactors, Heart Fail Rev, 8(3), 271 (2003)
10. I Martin, D Wendt, M Heberer, The role of bioreactors in tissue engineering, Trends Biotechnol, 22(2), 80 (2004)
11. HW Blanch, DS Clark, Biochemical Engineering: Basic Concepts, 2nd edn, Marcel Dekker Inc (1996).
12. K Ret J Tramper, Basic Bioreactor Design, Marce lDekker Inc (1991).
13. ML Shuler, F Kargi, Bioprocessing Engineering: Basic Concepts NJ: Upper Saddle Rver, Prentice-Hall Inc (2002).
14. GH Altman, RL Horan, I Martin, et al, Cell differentiation by mechanical stress. J FASEB, 16, 270 (2002).
15. FW Janssen, J Oostra, A van Oorschot, et al, A perfusion bioreactor system capable of producing clinically relevant volumes of tissue-engineered bone: in vivo bone formation showing proof of concept, Biomaterials, 27, 315 (2006).
16. Y Wang, T Uemura, J Dong, et al, Perfusion culture system improves osteogenesis of rat bone marrow derived osteoblastic cells in porous ceramic materials, J Bone Miner Res, 17, 338 (2002).
17. M Radisic, L Yang, J Boublik, et al., Medium perfusion enables engineering of compact and contractile cardiac tissue, Am J Physiol Heart Circ Physiol, 286(2), 507 (2004).
18. J Glowacki, S Mizuno, JS Greenberger, Perfusion enhances functions of bone marrow stromal cells in three-dimensional culture, Cell Transplant, 7(3), 319 (1998).
19. SH Cartmell, BD Porter, AJ Garcia, et al., Effects of Medium Perfusion Rate on Cell-Seeded Three-Dimensional Bone Constructs in vitro. Tissue Eng, 9(6), 1197 (2003).
20. ME Gomes, VI Sikavitsas, E Behravesh, et al., Effect of flow perfusion on the osteogenic differentiation of bone marrow stromal cells cultured on starch-based three-dimensional scaffolds, Biotechnol Bioeng, 67(1), 87 (2003).
21. B Rath, J Nam, TJ Knobloch, et al., Compressive forces induce osteogenic gene expression in calvarial osteoblasts, J Biomech, 41, 1095 (2008).
22. GN Bancroft, VI Sikavitsas, AG Mikos, Design of a flow perfusion bioreactor system for bone tissue-engineering applications, Tissue Eng, 9, 549 (2003).
23. AS Goldstein, TM Juarez, CD Helmke, et al., Effect of convection on osteoblastic cell growth and function in biodegradable polymer foam scaffolds, Biomaterials, 22(11), 1279 (2001).
24. Beckman M, Play by play imaging rewrites cells rules, Science 300, 76 (2003).
25. DJ Stephens, VJ Allan, Light microscopy techniques for live cell imaging, Science, 300, 82 (2003).
26. C Thomas, P De Vries, J Hardin, et al., Four dimensional imaging: Computer visualization of 3D movements in living specimens, Science, 273, 603 (1996).
27. SP Hoerstrup, R Sodian, JS Sperling, et al., New pulsatile bioreactor for in vitro formation of tissue engineered heart valves, Tissue Eng, 6, 75 (2000).
28. MJ Powers, K Domansky, MR Kaazempur-Mofrad, et al., A microfabricated array bioreactor for perfused 3D liver culture, Biotechnol Bioeng, 78(3), 257 (2002).
29. F Zhao, T Ma, Perfusion bioreactor system for human mesenchymal stem cell tissue engineering: dynamic cell seeding and construct development, Biotechnology and bioengineering, 91(4), 482 (2005).
30. C Williams, TM Wick, Perfusion bioreactor for small diameter tissue engineered arteries, Tissue Eng, 10(5-6), 930 (2004).
31. DC Focht, Live-cell microscopy: Environmental control for mammalian specimens, Nat Biotechnol, 14, 361 (1996).
32. WA Hing, CA Poole, CG Jensen, et al., An integrated environmental perfusion chamber and heating system for longterm, high resolution imaging of living cells, J Microsc Oxf, 199, 90 (2000).
33. RA Salzstein, SR Pollack, AFT Mak, et al., Electromechanical potentials in cortical bone a continuum approach, J Biomech, 20, 261 (1987).
34. AD Bakker, K Soejima, J Klein-Nulend, et al., The production of nitric oxide and prostaglandin e2 by primary bone cells is shear stress dependant, J Biomech, 34, 671 (2001).
35. CH Hammerle, R Glauser, Clinical evaluation of dental implant treatment, Periodontol, 2000(34), 230 (2004).
36. WV Giannobile, Periodontal tissue engineering by growth factors, Bone, 19(1S), 23S (1996).
37. ME Bolander, Regulation of fracture repair by growth factors, Proc Soc Exp Biol Med, 200(2), 165 (1992).
38. A Ignatius, H Blessing, A Liedert, Tissue engineering of bone: effects of mechanical strain on osteoblastic cells in type I collagen matrices, Biomaterials, 26, 311 (2005).
39. JR Mauney, S Sjostorm, J Blumberg, Mechanical stimulation promotes osteogenic differentiation of human bone marrow stromal cells on 3-D partially demineralized bone scaffolds in vitro, Calcif Tissue Int 74, 458 (2004).
40. S Judex, X Lei, D Han, et al., Low-magnitude mechanical signals that stimulate bone formation in the ovariectomized rat are dependent on the applied frequency but not on the strain magnitude, J Biomech, 40, 1333 (2007).
41. SM Tanaka, J Li, RL Duncan, et al., Effects of broad frequency vibration on cultured osteoblasts, J Biomech, 36(1), 73 (2003).
42. KJ Gooch, JH Kwon, T Blunk, et al., Effects of mixing intensity on tissue-engineered cartilage, Biotechnol Bioeng, 72(4), 402 (2001).
43. MJ Yaszemski, RG Payne, WC Hayes, et al., Evolution of bone transplantation: Molecular, cellular and tissue strategies to engineer human bone, Biomaterials 17, 175 (1996).
44. LE Niklason, J Gao, WM Abbott, et al., Functional arteries grown in vitro, Science, 284, 489 (1999).
45. D Seliktar, RA Black, RP Vito, et al., Dynamic mechanical conditioning of collagen-gel blood vessel constructs including remodeling in vitro, Ann Biomed Engineering, 28, 351 (2000).
46. SP Hoerstrup, G Zund, R Sodian, et al., Tissue engineering of small caliber vascular grafts, Europe J Cardio-thoracic Surg, 20, 164 (2001).
47. PF Davies, Flow mediated endothelial mechanotransduction, Physiology Review, 75, 519 (1995).
48. G Kasper, JD Glaeser, S Geissler, Matrix metalloprotease activity is an essential link between mechanical stimulus and mesenchymal stem cell behavior, Stem Cells, 25, 1985 (2007).
49. CA Simmons, S Matils, AJ Thornton, Cyclic strain enhances matrix mineralization by adult human mesenchymal stem cell via the extracellular signal-regulated kinase (ERK1/2) signaling pathway. J Biomech, 36, 1087 (2003)
50. L Zhang, N Tran, HQ Chen, Cyclic stretching promotes collagen synthesis and affects F-actin distribution in rat mesenchymal stem cells, Biomed Mater Eng., 18(4-5), 205 (2008).
51. L Malaval, D Modrowski, AK Gupta, et al., Cellular expression of bone-related proteins during in vitro osteogenesis in rat bone marrow stromal cell cultures, J. Cell Physiol, 158, 555 (1994).
52. EL Smith, C Gilligan, Mechanical forces and bone, Bone Miner Res, 6, 139 (1989)
53. GP homas, AJ EI Haj, Bone marrow stromal cells are load responsive In vitro, Calcif Tissue Int, 58, 101 (1996)
54. YJ Li, NN Batra, L You, et al., Oscillatory fluid flow affects human marrow stromal cell proliferation and differentiation, J Orthop Res, 22(6), 1283 (2004).
55. HL Holtorf, JA Jansen, AG Mikos, Flow perfusion culture induces the osteoblastic differentiation of marrow stromal cell-scaffold constructs in the absence of dexamethasone, J Biomed Master Res A. 72(3), 326 (2005).
56. CC Huang, KL Hagar, LE Frost, et al., Effects of Chondrogenesis of rabbit bone-marrow derived mesenchymal stem cells, Stem Cells, 22(3), 313 (2004).
57. TL Donahue, TR Haut, CE Yellowley, et al., Mechanosensitivity of bone cells to oscillating fluid flow induced shear stress may be modulated by chemotransport, J Biomech. 36, 1363 (2003).
58. RL Duncan, CH Turner, Mechanotransduction and the functional response of bone to mechanical strain, Calcif Tissue Int, 57(5), 344 (1995).
59. EH Burger, J Klein-Nulend, Mechanotransduction in bone: Role of the lacuno-canalicular network, FASEB J, 13S, S101 (1999).
60. I Owan, DB Burr, CH Turner, et al., Mechanotransduction in bone: Osteoblasts are more responsive to fluid forces than mechanical strain, Am J Physiol, 273, 810 (1997).
61. MM Sandberg, HT Aro, EI Vuorio, Gene expression during bone repair. Clin Orthop, 289, 292 (1993).
62. AL Bronckers, S Gay, RD Finkelman, et al., Developmental appearance of Gla proteins (osteocalcin) and alkaline phosphatase in tooth germs and bones of the rat, Bone Miner, 2, 361 (1987).
63. MA Aronow, LC Gerstenfeld, TA Owen, et al., Factors that promote progressive development of the osteoblast phenotype in cultured fetal rat calvaria cells. J Cell Physiol, 143, 213 (1990).