BMP receptor 1A determines the cell fate of the postnatal growth plate

International Journal of Biological Sciences

Volumn 9, Issue 9, 2013, Pages 895-906

  Jing, Junjun ^a,b   Ren, Yinshi ^b   Zong, Zhaowen ^b   Liu, Chuanju ^c   Kamiya, Nobuhiro ^d   Mishina, Yuji ^e   Liu, Ying ^b   Zhou, Xuedong ^a   Feng, Jian Q ^b  

^a SICHUAN UNIVERSITY   (China)

^b BAYLOR COLLEGE OF DENTISTRY   (United States)

^c NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d TEXAS SCOTTISH RITE HOSPITAL FOR CHILDREN   (United States)

^e UNIVERSITY OF MICHIGAN   (United States)

Author keywords

BMPR1A; Cell fate; Chondrogenesis; Endochondral Bone; Growth plate

Indexed keywords

BMPR1A PROTEIN, MOUSE; BONE MORPHOGENETIC PROTEIN; BONE MORPHOGENETIC PROTEIN RECEPTOR 1; TAMOXIFEN;

ANIMAL; ARTICLE; BMPR1A; BONE DEVELOPMENT; CARTILAGE; CELL DIFFERENTIATION; CELL FATE; CHONDROGENESIS; CYTOLOGY; ENDOCHONDRAL BONE.; GENE EXPRESSION REGULATION; GENETICS; GROWTH PLATE; GROWTH, DEVELOPMENT AND AGING; KNOCKOUT MOUSE; METABOLISM; MOUSE; PHYSIOLOGY; SCANNING ELECTRON MICROSCOPY; ULTRASTRUCTURE;

BMPR1A; CELL FATE; CHONDROGENESIS; ENDOCHONDRAL BONE.; GROWTH PLATE;

ANIMALS; BONE DEVELOPMENT; BONE MORPHOGENETIC PROTEIN RECEPTORS, TYPE I; BONE MORPHOGENETIC PROTEINS; CARTILAGE; CELL DIFFERENTIATION; CHONDROGENESIS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GROWTH PLATE; MICE; MICE, KNOCKOUT; MICROSCOPY, ELECTRON, SCANNING; TAMOXIFEN;

EID: 84884493169     PISSN: 14492288     EISSN: None     Source Type: Journal    
DOI: 10.7150/ijbs.7508     Document Type: Article

References (27)

1. Anderson EJ, Kaliyamoorthy S, Iwan J, Alexander D, Knothe Tate ML. Nano-microscale models of periosteocytic flow show differences in stresses imparted to cell body and processes. Ann Biomed Eng. 2005; 33: 52-62.
2. Ascenzi MG, Roe AK. The osteon: the micromechanical unit of compact bone. Front Biosci. 2012; 17: 1551-81.
3. Bandyopadhyay A, Tsuji K, Cox K, Harfe BD, Rosen V, Tabin CJ. Genetic analysis of the roles of BMP2, BMP4, and BMP7 in limb patterning and skeletogenesis. PLoS Genet. 2006; 2: e216.
4. Bi W, Huang W, Whitworth DJ, Deng JM, Zhang Z, Behringer RR, et al. Haploinsufficiency of Sox9 results in defective cartilage primordia and premature skeletal mineralization. Proc Natl Acad Sci U S A. 2001; 98: 6698-703.
5. Cao Z, Zhang H, Zhou X, Han X, Ren Y, Gao T, et al. Genetic evidence for the vital function of Osterix in cementogenesis. J Bone Miner Res. 2012; 27: 1080-92.
6. Fen JQ, Zhang J, Dallas SL, Lu Y, Chen S, Tan X, et al. Dentin matrix protein 1, a target molecule for Cbfa1 in bone, is a unique bone marker gene. J Bone Miner Res. 2002; 17: 1822-31.
7. Feng JQ, Ward LM, Liu S, Lu Y, Xie Y, Yuan B, et al. Loss of DMP1 causes rickets and osteomalacia and identifies a role for osteocytes in mineral metabolism. Nat Genet. 2006; 38: 1310-5.
8. Hazen VM, Andrews MG, Umans L, Crenshaw EB, 3rd, Zwijsen A, Butler SJ. BMP receptor-activated Smads confer diverse functions during the development of the dorsal spinal cord. Dev Biol. 2012; 367: 216-27.
9. Henry SP, Liang S, Akdemir KC, de Crombrugghe B. The postnatal role of Sox9 in cartilage. J Bone Miner Res. 2012; 27: 2511-25.
10. Hilton MJ, Tu X, Cook J, Hu H, Long F. Ihh controls cartilage development by antagonizing Gli3, but requires additional effectors to regulate osteoblast and vascular development. Development. 2005; 132: 4339-51.
11. Kamiya N, Jikko A, Kimata K, Damsky C, Shimizu K, Watanabe H. Establishment of a novel chondrocytic cell line N1511 derived from p53-null mice. J Bone Miner Res. 2002; 17:1832-42.
12. Kamiya N, Ye L, Kobayashi T, Lucas DJ, Mochida Y, Yamauchi M, et al. Disruption of BMP signaling in osteoblasts through type IA receptor (BMPRIA) increases bone mass. J Bone Miner Res. 2008; 23: 2007-17.
13. Kamiya N, Ye L, Kobayashi T, Mochida Y, Yamauchi M, Kronenberg HM, et al. BMP signaling negatively regulates bone mass through sclerostin by inhibiting the canonical Wnt pathway. Development. 2008; 135: 3801-11.
14. Kronenberg HM. Developmental regulation of the growth plate. NATURE. 2003; 423: 332-6.
15. Long F, Chung UI, Ohba S, McMahon J, Kronenberg HM, McMahon AP. Ihh signaling is directly required for the osteoblast lineage in the endochondral skeleton. Development. 2004; 131: 1309-18.
16. Long F, Ornitz DM. Development of the endochondral skeleton. Cold Spring Harbor perspectives in biology. 2013; 5: a008334.
17. Martin DM, Hallsworth AS, Buckley T. A method for the study of internal spaces in hard tissue matrices by SEM, with special reference to dentine. Journal of microscopy. 1978; 112: 345-52.
18. Miller SC, Omura TH, Smith LJ. Changes in dentin appositional rates during pregnancy and lactation in rats. Journal of dental research. 1985; 64: 1062-4.
19. Mishina Y, Hanks MC, Miura S, Tallquist MD, Behringer RR. Generation of Bmpr/Alk3 conditional knockout mice. Genesis. 2002; 32: 69-72.
20. Ominsky MS, Vlasseros F, Jolette J, Smith SY, Stouch B, Doellgast G, et al. Two doses of sclerostin antibody in cynomolgus monkeys increases bone formation, bone mineral density, and bone strength. J Bone Miner Res. 2010; 25: 948-59.
21. Retting KN, Song B, Yoon BS, Lyons KM. BMP canonical Smad signaling through Smad1 and Smad5 is required for endochondral bone formation. Development. 2009; 136: 1093-104.
22. Roach HI, Mehta G, Oreffo RO, Clarke NM, Cooper C. Temporal analysis of rat growth plates: cessation of growth with age despite presence of a physis. J Histochem Cytochem. 2003; 5: 373-83.
23. Shu B, Zhang M, Xie R, Wang M, Jin H, Hou W, et al. BMP2, but not BMP4, is crucial for chondrocyte proliferation and maturation during endochondral bone development. J Cell Sci. 2011; 124: 3428-40.
24. Wuelling M, Vortkamp A. Chondrocyte proliferation and differentiation. Endocr Dev. 2011; 21: 1-11.
25. Ye L, Mishina Y, Chen D, Huang H, Dallas SL, Dallas MR, et al. Dmp1-deficient mice display severe defects in cartilage formation responsible for a chondrodysplasia-like phenotype. J Biol Chem. 2005; 280: 6197-203.
26. Yoon BS, Ovchinnikov DA, Yoshii I, Mishina Y, Behringer RR, Lyons KM. Bmpr1a and Bmpr1b have overlapping functions and are essential for chondrogenesis in vivo. Proc Natl Acad Sci U S A. 2005; 102: 5062-7.
27. Yoon BS, Pogue R, Ovchinnikov DA, Yoshii I, Mishina Y, Behringer RR, et al. BMPs regulate multiple aspects of growth-plate chondrogenesis through opposing actions on FGF pathways. Development. 2006; 133: 4667-78.