Genetic evidence for the vital function of osterix in cementogenesis

Journal of Bone and Mineral Research

Volumn 27, Issue 5, 2012, Pages 1080-1092

  Cao, Zhengguo ^a,b   Zhang, Hua ^b   Zhou, Xin ^c   Han, Xianglong ^b   Ren, Yinshi ^b   Gao, Tian ^b   Xiao, Yin ^d   De Crombrugghe, Benoit ^c   Somerman, Martha J ^e   Feng, Jian Q ^b  

^a WUHAN UNIVERSITY   (China)

^b BAYLOR COLLEGE OF DENTISTRY   (United States)

^c UNIVERSITY OF TEXAS   (United States)

^d QUEENSLAND UNIVERSITY OF TECHNOLOGY   (Australia)

^e NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH   (United States)

Author keywords

CEMENTOGENESIS; CEMENTUM; DMP1; OSX; TOOTH ROOT

Indexed keywords

BONE SIALOPROTEIN; DENTIN MATRIX PROTEIN 1; TRANSCRIPTION FACTOR OSTERIX;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL COUNT; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL STRUCTURE; CEMENTOBLAST; CEMENTOCYTE; CEMENTUM; CONTROLLED STUDY; EXTRACELLULAR MATRIX; MESENCHYME CELL; MOUSE; NONHUMAN; ODONTOBLAST; PROTEIN EXPRESSION; TOOTH DEVELOPMENT; TRANSGENIC MOUSE; WILD TYPE;

ANIMALS; CELL LINE; CEMENTOGENESIS; DENTAL CEMENTUM; EXTRACELLULAR MATRIX PROTEINS; GENE DELETION; GENE EXPRESSION REGULATION, DEVELOPMENTAL; MICE; MICE, TRANSGENIC; MICROSCOPY, ELECTRON, SCANNING; POLYMERASE CHAIN REACTION; TRANSCRIPTION FACTORS; UP-REGULATION;

EID: 84859883594     PISSN: 08840431     EISSN: 15234681     Source Type: Journal    
DOI: 10.1002/jbmr.1552     Document Type: Article

References (46)

1. Fong HK, Foster BL, Popowics TE, Somerman MJ., The crowning achievement: getting to the root of the problem. J Dent Educ. 2005; 69 (5): 555-70.
2. Ten Cate AR., A fine structural study of coronal and root dentinogensis in the mouse: observations on the so-called 'von Korff fibres' and their contribution to mantle dentine. J Anat. 1978; 125 (Pt 1): 183-97.
3. Beertsen W, Niehof A., Root-analogue versus crown-analogue dentin: a radioautographic and ultrastructural investigation of the mouse incisor. Anat Rec. 1986; 215 (2): 106-18.
4. Thomas HF., Root formation. Int J Dev Biol. 1995; 39 (1): 231-7.
5. Andujar MB, Couble P, Couble ML, Magloire H., Differential expression of type I and type III collagen genes during tooth development. Development. 1991; 111 (3): 691-8.
6. Beertsen W, VandenBos T, Everts V., Root development in mice lacking functional tissue non-specific alkaline phosphatase gene: inhibition of acellular cementum formation. J Dent Res. 1999; 78 (6): 1221-9.
7. Somerman MJ, Shroff B, Agraves WS, Morrison G, Craig AM, Denhardt DT, Foster RA, Sauk JJ., Expression of attachment proteins during cementogenesis. J Biol Buccale. 1990; 18 (3): 207-14.
8. Bosshardt DD., Are cementoblasts a subpopulation of osteoblasts or a unique phenotype ? J Dent Res. 2005; 84 (5): 390-406.
9. D'Errico JA, Berry JE, Ouyang H, Strayhorn CL, Windle JJ, Somerman MJ., Employing a transgenic animal model to obtain cementoblasts in vitro. J Periodontol. 2000; 71 (1): 63-72.
10. Ducy P, Starbuck M, Priemel M, Shen J, Pinero G, Geoffroy V, Amling M, Karsenty G., A Cbfa1-dependent genetic pathway controls bone formation beyond embryonic development. Genes Dev. 1999; 13 (8): 1025-36.
11. Ducy P, Zhang R, Geoffroy V, Ridall AL, Karsenty G., Osf2/Cbfa1: a transcriptional activator of osteoblast differentiation. Cell. 1997; 89 (5): 747-54.
12. Nakashima K, Zhou X, Kunkel G, Zhang Z, Deng JM, Behringer RR, de Crombrugghe B., The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation. Cell. 2002; 108 (1): 17-29.
13. Zhou X, Zhang Z, Feng JQ, Dusevich VM, Sinha K, Zhang H, Darnay BG, de Crombrugghe B., Multiple functions of Osterix are required for bone growth and homeostasis in postnatal mice. Proc Natl Acad Sci U S A. 2010; 107 (29): 12919-24.
14. Hirata A, Sugahara T, Nakamura H., Localization of runx2, osterix, and osteopontin in tooth root formation in rat molars. J Histochem Cytochem. 2009; 57 (4): 397-403.
15. Foster BL, Popowics TE, Fong HK, Somerman MJ., Advances in defining regulators of cementum development and periodontal regeneration. Curr Top Dev Biol. 2007; 78: 47-126.
16. Orban B., The epithelial network in the periodontal membrane. J Am Dent Assoc. 1952; 44 (6): 632-5.
17. Huang X, Bringas P Jr, Slavkin HC, Chai Y., Fate of HERS during tooth root development. Dev Biol. 2009; 334 (1): 22-30.
18. Liu F, Woitge HW, Braut A, Kronenberg MS, Lichtler AC, Mina M, Kream BE., Expression and activity of osteoblast-targeted Cre recombinase transgenes in murine skeletal tissues. Int J Dev Biol. 2004; 48 (7): 645-53.
19. Hayashi S, McMahon AP., Efficient recombination in diverse tissues by a tamoxifen-inducible form of Cre: a tool for temporally regulated gene activation/inactivation in the mouse. Dev Biol. 2002; 244 (2): 305-18.
20. Akiyama H, Kim JE, Nakashima K, Balmes G, Iwai N, Deng JM, Zhang Z, Martin JF, Behringer RR, Nakamura T, de Crombrugghe B., Osteo-chondroprogenitor cells are derived from Sox9 expressing precursors. Proc Natl Acad Sci U S A. 2005; 102 (41): 14665-70.
21. Feng JQ, Huang H, Lu Y, Ye L, Xie Y, Tsutsui TW, Kunieda T, Castranio T, Scott G, Bonewald LB, Mishina Y., The Dentin matrix protein 1 (Dmp1) is specifically expressed in mineralized, but not soft, tissues during development. J Dent Res. 2003; 82 (10): 776-80.
22. Rios H, Koushik SV, Wang HY, Wang J, Zhou HM, Lindsley A, Rogers R, Chen Z, Maeda M, Kruzynska-Frejtag A, Feng JQ, Conway SJ., Periostin null mice exhibit dwarfism, incisor enamel defects, and an early-onset periodontal disease-like phenotype. Mol Cell Biol. 2005; 25 (24): 11131-44.
23. Braut A, Kalajzic I, Kalajzic Z, Rowe DW, Kollar EJ, Mina M., Col1a1-GFP transgene expression in developing incisors. Connect Tissue Res. 2002; 43 (2-3): 216-9.
24. Miller SC, Omura TH, Smith LJ., Changes in dentin appositional rates during pregnancy and lactation in rats. J Dent Res. 1985; 64 (8): 1062-4.
25. Lu Y, Ye L, Yu S, Zhang S, Xie Y, McKee MD, Li YC, Kong J, Eick JD, Dallas SL, Feng JQ., Rescue of odontogenesis in Dmp1-deficient mice by targeted re-expression of DMP1 reveals roles for DMP1 in early odontogenesis and dentin apposition in vivo. Dev Biol. 2007; 303 (1): 191-201.
26. Fen JQ, Zhang J, Dallas SL, Lu Y, Chen S, Tan X, Owen M, Harris SE, MacDougall M., Dentin matrix protein 1, a target molecule for Cbfa1 in bone, is a unique bone marker gene. J Bone Miner Res. 2002; 17 (10): 1822-31.
27. Lu Y, Yuan B, Qin C, Cao Z, Xie Y, Dallas SL, McKee MD, Drezner MK, Bonewald LF, Feng JQ., The biological function of DMP1 in osteocyte maturation is mediated by its 57 kDa C-terminal fragment. J Bone Miner Res. 2011; 26 (2): 331-40.
28. Ye L, MacDougall M, Zhang S, Xie Y, Zhang J, Li Z, Lu Y, Mishina Y, Feng JQ., Deletion of dentin matrix protein-1 leads to a partial failure of maturation of predentin into dentin, hypomineralization, and expanded cavities of pulp and root canal during postnatal tooth development. J Biol Chem. 2004; 279 (18): 19141-8.
29. Martin DM, Hallsworth AS, Buckley T., A method for the study of internal spaces in hard tissue matrices by SEM, with special reference to dentine. J Microsc. 1978; 112 (3): 345-52.
30. Feng JQ, Ward LM, Liu S, Lu Y, Xie Y, Yuan B, Yu X, Rauch F, Davis SI, Zhang S, Rios H, Drezner MK, Quarles LD, Bonewald LF, White KE., Loss of DMP1 causes rickets and osteomalacia and identifies a role for osteocytes in mineral metabolism. Nat Genet. 2006; 38 (11): 1310-5.
31. Ciani C, Doty SB, Fritton SP., An effective histological staining process to visualize bone interstitial fluid space using confocal microscopy. Bone. 2009; 44 (5): 1015-7.
32. Zhang C, Cho K, Huang Y, Lyons JP, Zhou X, Sinha K, McCrea PD, de Crombrugghe B., Inhibition of Wnt signaling by the osteoblast-specific transcription factor Osterix. Proc Natl Acad Sci U S A. 2008; 105 (19): 6936-41.
33. Mada Y, Miyauchi M, Oka H, Kitagawa M, Sakamoto K, Iizuka S, Sato S, Noguchi K, Somerman MJ, Takata T., Effects of endogenous and exogenous prostaglandin E2 on the proliferation and differentiation of a mouse cementoblast cell line (OCCM-30). J Periodontol. 2006; 77 (12): 2051-8.
34. Paynter KJ, Pudy G., A study of the structure, chemical nature, and development of cementum in the rat. Anat Rec. 1958; 131 (2): 233-51.
35. Cho MI, Garant PR., Ultrastructural evidence of directed cell migration during initial cementoblast differentiation in root formation. J Periodontal Res. 1988; 23 (4): 268-76.
36. Diekwisch TG., The developmental biology of cementum. Int J Dev Biol. 2001; 45 (5-6): 695-706.
37. Ten Cate AR., The development of the periodontium-a largely ectomesenchymally derived unit. Periodontol 2000. 1997; 13: 9-19.
38. Chai Y, Jiang X, Ito Y, Bringas P Jr, Han J, Rowitch DH, Soriano P, McMahon AP, Sucov HM., Fate of the mammalian cranial neural crest during tooth and mandibular morphogenesis. Development. 2000; 127 (8): 1671-9.
39. Slavkin HC., Towards a cellular and molecular understanding of periodontics. Cementogenesis revisited. J Periodontol. 1976; 47 (5): 249-55.
40. Slavkin HC, Bringas P Jr, Bessem C, Santos V, Nakamura M, Hsu MY, Snead ML, Zeichner-David M, Fincham AG., Hertwig's epithelial root sheath differentiation and initial cementum and bone formation during long-term organ culture of mouse mandibular first molars using serumless, chemically-defined medium. J Periodontal Res. 1989; 24 (1): 28-40.
41. Bosshardt DD, Nanci A., Hertwig's epithelial root sheath, enamel matrix proteins, and initiation of cementogenesis in porcine teeth. J Clin Periodontol. 2004; 31 (3): 184-92.
42. Ouyang H, McCauley LK, Berry JE, Saygin NE, Tokiyasu Y, Somerman MJ., Parathyroid hormone-related protein regulates extracellular matrix gene expression in cementoblasts and inhibits cementoblast-mediated mineralization in vitro. J Bone Miner Res. 2000; 15 (11): 2140-53.
43. Steele-Perkins G, Butz KG, Lyons GE, Zeichner-David M, Kim HJ, Cho MI, Gronostajski RM., Essential role for NFI-C/CTF transcription-replication factor in tooth root development. Mol Cell Biol. 2003; 23 (3): 1075-84.
44. Huang X, Xu X, Bringas P Jr, Hung YP, Chai Y., Smad4-Shh-Nfic signaling cascade-mediated epithelial-mesenchymal interaction is crucial in regulating tooth root development. J Bone Miner Res. 2010; 25 (5): 1167-78.
45. Zander HA, Hurzeler B., Continuous cementum apposition. J Dent Res. 1958; 37 (6): 1035-44.
46. Boabaid F, Berry JE, Koh AJ, Somerman MJ, McCcauley LK., The role of parathyroid hormone-related protein in the regulation of osteoclastogenesis by cementoblasts. J Periodontol. 2004; 75 (9): 1247-54.