Highly Pathogenic Avian Influenza Virus Nucleoprotein Interacts with TREX Complex Adaptor Protein Aly/REF

PLoS ONE

Volumn 8, Issue 9, 2013, Pages

  Balasubramaniam, Vinod R M T ^a   Hong Wai, Tham ^a   Ario Tejo, Bimo ^b   Omar, Abdul Rahman ^b   Syed Hassan, Sharifah ^a  

^a MONASH UNIVERSITY MALAYSIA   (Malaysia)

^b UNIVERSITY PUTRA MALAYSIA   (Malaysia)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEIN; ALKALINE PHOSPHATASE; COMPLEMENTARY DNA; NUCLEAR PROTEIN; PROTEIN ALY; PROTEIN UAP56; SMALL INTERFERING RNA; THO COMPLEX 4 PROTEIN; TREX COMPLEX; UNCLASSIFIED DRUG; VIRUS NUCLEOPROTEIN; VIRUS RNA;

ANIMAL TISSUE; ARTICLE; AVIAN INFLUENZA VIRUS; CELL STRAIN HEK293; CELLULAR DISTRIBUTION; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CRYSTAL STRUCTURE; DNA LIBRARY; GALLUS GALLUS; GENE SILENCING; HUMAN; IMMUNOPRECIPITATION; INFLUENZA VIRUS A H1N1; INFLUENZA VIRUS A H5N1; MOLECULAR DOCKING; NONHUMAN; PROTEIN BINDING; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; RNA TRANSPORT; TWO HYBRID SYSTEM; VALIDATION PROCESS; VERO CELL;

ACTIVE TRANSPORT, CELL NUCLEUS; ADENOCARCINOMA; ANIMALS; CELL NUCLEUS; CHICKENS; CRYSTALLOGRAPHY, X-RAY; DNA-(APURINIC OR APYRIMIDINIC SITE) LYASE; GENE LIBRARY; HUMANS; IMMUNOBLOTTING; INFLUENZA A VIRUS, H1N1 SUBTYPE; INFLUENZA A VIRUS, H5N1 SUBTYPE; INFLUENZA, HUMAN; LUNG NEOPLASMS; NUCLEAR PROTEINS; NUCLEOPROTEINS; ORTHOMYXOVIRIDAE INFECTIONS; PROTEIN CONFORMATION; RNA, SMALL INTERFERING; RNA-BINDING PROTEINS; SWINE; TRANSCRIPTION FACTORS; TUMOR CELLS, CULTURED; TWO-HYBRID SYSTEM TECHNIQUES;

EID: 84884490302     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0072429     Document Type: Article

References (33)

1. Watanabe T, Watanabe S, Kawaoka Y, (2010) Cellular networks involved in the influenza virus life cycle. Cell Host Microbe 7: 427-439.
2. O'Neill RE, Talon J, Palese P, (1998) The influenza virus NEP (NS2 protein) mediates the nuclear export of viral ribonucleoproteins. EMBO J 17: 288-296.
3. Kao RY, Yang D, Lau LS, Tsui WH, Hu L, et al. (2010) Identification of influenza A nucleoprotein as an antiviral target. Nat Biotechnol 28(6): 600-605.
4. Davey J, Dimmock NJ, Colman A, (1985) Identification of the sequence responsible for the nuclear accumulation of the influenza virus nucleoprotein in Xenopus oocytes. Cell 40: 667.
5. Ye Q, Krug RM, Tao YJ, (2006) The mechanism by which influenza A virus nucleoprotein forms oligomers and binds RNA. Nature 444(7122): 1078-82.
6. Portela A, Digard P, (2002) The influenza virus nucleoprotein: a multifunctional RNA-binding protein pivotal to virus replication. J Gen Virol 83(4): 723-734.
7. Chen IHB, Li L, Silva L, Sandri-Goldin RM, (2005) ICP27 recruits Aly/REF but not TAP/NXF1 to herpes simplex virus type 1 transcription sites although TAP/NXF1 is required for ICP27 export. J Virol 79(7): 3949-3961.
8. Gupta R, Srivastava OP, (2004) Deamidation affects structural and functional properties of human αA-crystallin and its oligomerization with αB-crystallin. J Biol Chem 279(43): 44258-44269.
9. Kang Y, Cullen BR, (1999) The human TAP protein is a nuclear mRNA export factor that contains novel RNA-binding and nucleocytoplasmic transport sequences. Genes & Dev 13: 1126-1139.
10. Reed R, Hurt E, (2002) A conserved mRNA export machinery coupled to pre-mRNA splicing. Cell108: 523-531.
11. Cullen BR, (2003) Nuclear RNA export. J Cell Sci 116: 587-597.
12. Strasser K, Masuda S, Mason P, Pfannstiel J, Oppizzi M, et al. (2002) TREX is a conserved complex coupling transcription with messenger RNA export. Nature 417: 304-308.
13. Katahira J, (2012) mRNA export and the TREX complex. Biochim Biophys Acta1819: 507-513.
14. Johnson LA, Li L, Sandri-Goldin RM, (2009) The cellular RNA export receptor TAP/NXF1 is required for ICP27-mediated export of herpes simplex virus 1 RNA, but the TREX complex adaptor protein Aly/REF appears to be dispensable. J Virol83: 6335-6346.
15. Gatfield D, Izaurralde E, (2002) REF1/Aly and the additional exon junction complex proteins are dispensable for nuclear mRNA export. J Cell Biol 159: 579-588.
16. Longman D, Johnstone IL, Caceres JF, (2003) The Ref/Aly proteins are dispensable for mRNA export and development in Caenorhabditis elegans. RNA 9: 881-891.
17. Hiriart E, Farjot G, Gruffat H, Nguyen MVC, Sergeant A, et al. (2003) A novel nuclear export signal and a REF interaction domain both promote mRNA export by the Epstein-Barr virus EB2 protein. J Biol Chem 278(1): 335-342.
18. Malik P, Blackbourn DJ, Clements JB, (2004) The evolutionarily conserved Kaposi's sarcoma-associated herpesvirus ORF57 protein interacts with REF protein and acts as an RNA export factor. J Biol Chem 279(31): 33001-33011.
19. Gatfield D, Le Hir H, Schmitt C, Braun IC, Kocher T, et al. (2001) The DExH/D box protein HEL/UAP56 is essential for mRNA nuclear export in Drosophila. Curr Biol 11 (21): 1716-1721.
20. Luo MJ, Zhou Z, Magni K, Christoforides C, Rappsilber J, et al. (2001) Pre-mRNA splicing and mRNA export linked by direct interactions between UAP56 and Aly. Nature 413(6856): 644-647.
21. MacMorris M, Brocker C, Blumenthal T, (2003) UAP56 levels affect viability and mRNA export in Caenorhabditis elegans. RNA 9(7): 847-857.
22. Lischka P, Toth Z, Thomas M, Mueller R, Stamminger T, (2006) The UL69 transactivator protein of human cytomegalovirus interacts with DEXD/H-Box RNA helicase UAP56 to promote cytoplasmic accumulation of unspliced RNA. Mol Cell Biol 26(5): 1631-1643.
23. Boyne JR, Colgan KJ, Whitehouse A, (2008) Recruitment of the complete hTREX complex is required for Kaposi's sarcoma-associated herpesvirus intronless mRNA nuclear export and virus replication. PLoS Pathog 4: e1000194.
24. Cheng H, Dufu K, Lee CS, Hsu JL, Dias A, et al. (2006) Human mRNA export machinery recruited to the 5′ end of mRNA. Cell 127(7): 1389-1400.
25. Katahira J, Inoue H, Hurt E, Yoneda Y, (2009) Adaptor Aly and coadaptor Thoc5 function in the Tap-p15-mediated nuclear export of HSP70 mRNA. EMBO J 28: 556-567.
26. Masuyama K, Taniguchi I, Kataoka N, Ohno M, (2004) RNA length defines RNA export pathway. Genes Dev 18: 2074-2085.
27. Nojima T, Hirose T, Kimura H, Hagiwara M, (2007) The interaction between cap-binding complex and RNA export factor is required for intronless mRNA export. J Biol Chem 282: 15645-15651.
28. Ohno M, Segref A, Kuersten S, Mattaj IW, (2002) Identity elements used in export of mRNAs. Mol Cell 9: 659-671.
29. Rodrigues JP, Rode M, Gatfield D, Blencowe BJ, Carmo-Fonseca M, et al. (2001) REF proteins mediate the export of spliced and unspliced mRNAs from the nucleus. Proc Natl Acad Sci USA 98(3): 1030-1035.
30. Zhou Z, Luo MJ, Straesser K, Katahira J, (2000) The protein Aly links pre-messenger-RNA splicing to nuclear export in metazoans. Nature 407(6802): 401-405.
31. Li DJ, Verma D, Swaminathan S, (2012) Binding of Cellular Export Factor REF/Aly by Kaposi's Sarcoma-Associated Herpesvirus (KSHV) ORF57 Protein Is Not Required for Efficient KSHV Lytic Replication. J Virol 86(18): 9866-9874.
32. Lei H, Dias AP, Reed R, (2011) Export and stability of naturally intronless mRNAs require specific coding region sequences and the TREX mRNA export complex. Proc Natl Acad Sci USA 108(44): 17985-17990.
33. Gietz RD, Schiestl RH, (2007) Quick and easy yeast transformation using the LiAc/SS carrier DNA/PEG method. Nat Protoc 2(1): 35-37.