Synthesis, transformation and biological evaluation of 2,3-secotriterpene acetylhydrazones and their derivatives

European Journal of Medicinal Chemistry

Volumn 68, Issue , 2013, Pages 203-211

  Grishko, Victoria V ^a   Tolmacheva, Irina A ^a   Galaiko, Natalia V ^a   Pereslavceva, Anastasia V ^a   Anikina, Lada V ^a   Volkova, Larisa V ^b   Bachmetyev, Boris A ^c   Slepukhin, Pavel A ^d  

^a INSTITUTE OF TECHNICAL CHEMISTRY   (Russian Federation)

^b Federal State Unitary Enterprise   (Russian Federation)

^c INSTITUTE OF ECOLOGY AND GENETICS OF MICROORGANISMS   (Russian Federation)

^d INSTITUTE OF ORGANIC SYNTHESIS   (Russian Federation)

Author keywords

18 Glycyrrhetinic acid; A secotriterpenoids; Antiviral activity; Apoptosis; Betulin; Cytotoxicity

Indexed keywords

11,30 DIOXO 30 METHOXY 1 CYANO 2,3 SECO 2 NOR 18BETAH OLEAN 12(13) ENE 3 AL; 2,3 SECOTRITERPENE ACETYLHYDRAZONE; 3 (3' ACETYL 5' METHYL 2',3' DIHYDRO 1',3',4' OXADIAZOLYL 2') 1 CYANO 2,3 SECO 2 NOR 19BETA,28 EPOXY 18ALPHAH OLEANANE; 3' ACETYL 5' METHYL 1,3,4 OXADIAZOLINE; ANTINEOPLASTIC AGENT; ANTIVIRUS AGENT; BETULIC ACID; ETHYL N''[3 (N' ACETYLHYDRAZONO) 1 CYANO 2,3 SECO 2 NORLUP 20(29) ENE 28 OIL]BETA ALANINATE; HYDRAZONE DERIVATIVE; LIPOCORTIN 5; METHYL 3 (3' ACETYL 5' METHYL 2',3' DIHYDRO 1',3',4' OXADIAZOLYL 2') 1 CYANO 2,3 SECO 2 NORLUP 20(29) ENE 28 OATE; METHYL 3 (3' ACETYL 5' METHYL 2',3' DIHYDRO 1',3',4' OXADIAZOLYL 2') 11 OXO 1 CYANO 2,3 SECO 2 NOR 18BETAH OLEAN 12(13) ENE 30 OATE; N''[3 (N' ACETYLHYDRAZONO) 1 CYANO 2,3 SECO 2 NORLUP 20(29) ENE 28 OIL] 2 AMINOPROPANE; TRITERPENE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; ANTIVIRAL ACTIVITY; APOPTOSIS; ARTICLE; CELL GROWTH; CONTROLLED STUDY; CRYSTAL STRUCTURE; CULTURE MEDIUM; CYTOTOXICITY; DRUG SYNTHESIS; DRUG TRANSFORMATION; EMBRYO; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; LUNG CARCINOMA; MELANOMA; NONHUMAN; RHABDOMYOSARCOMA; TUMOR CELL LINE; VESICULAR STOMATITIS VIRUS; VIRUS INHIBITION; VIRUS REPLICATION; X RAY DIFFRACTION;

18Β-GLYCYRRHETINIC ACID; A-SECOTRITERPENOIDS; ANTIVIRAL ACTIVITY; APOPTOSIS; BETULIN; CYTOTOXICITY;

ANIMALS; ANTIVIRAL AGENTS; CELL LINE, TUMOR; CELLS, CULTURED; CRYSTALLOGRAPHY, X-RAY; FLOW CYTOMETRY; HUMANS; HYDRAZONES; INHIBITORY CONCENTRATION 50; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR STRUCTURE; SWINE; TRITERPENES; VESICULOVIRUS; VIRUS REPLICATION;

EID: 84884490121     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2013.07.016     Document Type: Article

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