The anticancer agent doxorubicin disrupts mitochondrial energy metabolism and redox balance in skeletal muscle

Free Radical Biology and Medicine

Volumn 65, Issue , 2013, Pages 988-996

  Gilliam, Laura A A ^a   Fisher Wellman, Kelsey H ^a,b   Lin, Chien Te ^a   Maples, Jill M ^a,b   Cathey, Brook L ^a   Neufer, P Darrell ^a,b  

^a EAST CAROLINA UNIVERSITY   (United States)

^b EAST CAROLINA UNIVERSITY   (United States)

Author keywords

Chemotherapy; Metabolism; Mitochondria; Reactive oxygen species; ROS; Skeletal muscle

Indexed keywords

DOXORUBICIN; HYDROGEN PEROXIDE; MITOCHONDRIAL PERMEABILITY TRANSITION PORE; OXYGEN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); SUCCINATE DEHYDROGENASE (UBIQUINONE); ANTINEOPLASTIC ANTIBIOTIC;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG INHIBITION; DRUG MECHANISM; DRUG SENSITIVITY; ELECTRON TRANSPORT; ENERGY EXPENDITURE; ENERGY METABOLISM; MALE; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRIAL RESPIRATION; MITOCHONDRION; MUSCLE CELL; NONHUMAN; OXIDATION REDUCTION STATE; OXYGEN CONSUMPTION; PRIORITY JOURNAL; PROTEIN FUNCTION; RAT; RESPIRATORY FUNCTION; SINGLE DRUG DOSE; SKELETAL MUSCLE; ANIMAL; DRUG EFFECTS; METABOLISM; MUSCLE MITOCHONDRION; OXIDATION REDUCTION REACTION; SPRAGUE DAWLEY RAT;

ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; DOXORUBICIN; ENERGY METABOLISM; HYDROGEN PEROXIDE; MALE; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA, MUSCLE; MUSCLE, SKELETAL; OXIDATION-REDUCTION; OXYGEN CONSUMPTION; RATS, SPRAGUE-DAWLEY;

EID: 84884484200     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2013.08.191     Document Type: Article

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