Doxorubicin-induced cardiac dysfunction is attenuated by ciclosporin treatment in mice through improvements in mitochondrial bioenergetics

Clinical Science

Volumn 121, Issue 9, 2011, Pages 405-413

  Marechal, Xavier ^a   Montaigne, David ^a   Marciniak, Camille ^a   Marchetti, Philippe ^b,c   Hassoun, Sidi Mohamed ^a   Beauvillain, Jean Claude ^b,c   Lancel, Steve ^a   Neviere, Remi ^a  

^a University of the North of France   (France)

^b JEAN PIERRE AUBERT RESEARCH CENTER   (France)

^c UNIV LILLE   (France)

Author keywords

Biogenesis; Ciclosporin; Doxorubicin; Energetics; Heart; Mitochondrial transition permeability

Indexed keywords

CALCIUM; CYCLOSPORIN A; DOXORUBICIN; GUANOSINE TRIPHOSPHATASE; MITOCHONDRIAL DNA; MITOFUSIN 2; TACROLIMUS;

ACUTE DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOENERGY; BIOGENESIS; CARDIOTOXICITY; CELL FUSION; CHRONIC DISEASE; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DRP1 GENE; ECHOCARDIOGRAPHY; FIS1 GENE; FOLLOW UP; FRAGMENTATION REACTION; GENE; HEART FUNCTION; HEART LEFT VENTRICLE FUNCTION; LEFT VENTRICULAR FRACTIONAL SHORTENING; MALE; MITOCHONDRIAL FRAGMENTATION; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRIAL PERMEABILITY; MOUSE; MYOCARDIAL DISEASE; NONHUMAN; NUCLEOTIDE SEQUENCE; OPA1 GENE; OXYGEN CONSUMPTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; SURVIVAL RATE; TRANSMISSION ELECTRON MICROSCOPY;

ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; CYCLOSPORINE; DNA PRIMERS; DNA, MITOCHONDRIAL; DOXORUBICIN; HEART DISEASES; IMMUNOSUPPRESSIVE AGENTS; MALE; MICE; MICE, INBRED C57BL; MITOCHONDRIA, HEART; MITOCHONDRIAL MEMBRANE TRANSPORT PROTEINS; MYOCARDIUM; PERMEABILITY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 80052314927     PISSN: 01435221     EISSN: None     Source Type: Journal    
DOI: 10.1042/CS20110069     Document Type: Article

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