Mannich bases of 7-piperazinylquinolones and kojic acid derivatives: Synthesis, in vitro antibacterial activity and in silico study

European Journal of Medicinal Chemistry

Volumn 68, Issue , 2013, Pages 185-191

  Emami, Saeed ^a   Ghafouri, Ebrahim ^b   Faramarzi, Mohammad Ali ^c   Samadi, Nasrin ^d   Irannejad, Hamid ^a   Foroumadi, Alireza ^e  

^a MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^d TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^e TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Antibacterial activity; Docking study; Kojic acid; Mannich bases; Quinolones

Indexed keywords

1 CYCLOPROPYL 6 FLUORO 1,4 DIHYDRO 7 [4 [(3 HYDROXY 6 HYDROXYMETHYL 4 OXO 4H PYRAN 2 YL)METHYL]PIPERAZIN 1 YL] 4 OXOQUINOLINE 3 CARBOXYLIC ACID; 1 CYCLOPROPYL 6 FLUORO 1,4 DIHYDRO 8 METHOXY 7 [3 METHYL 4 [(3 HYDROXY 6 CHLOROMETHYL 4 OXO 4H PYRAN 2 YL)METHYL]PIPERAZIN 1 YL] 4 OXOQUINOLINE 3 CARBOXYLIC ACID; 1 CYCLOPROPYL 6 FLUORO 1,4 DIHYDRO 8 METHOXY 7 [3 METHYL 4 [(3 HYDROXY 6 HYDROXYMETHYL 4 OXO 4H PYRAN 2 YL)METHYL]PIPERAZIN 1 YL] 4 OXOQUINOLINE 3 CARBOXYLIC ACID; 1 ETHYL 6 FLUORO 1,4 DIHYDRO 7 [4 [(3 HYDROXY 6 CHLOROMETHYL 4 OXO 4H PYRAN 2 YL)METHYL]PIPERAZIN 1 YL] 4 OXOQUINOLINE 3 CARBOXYLIC ACID; 1 ETHYL 6 FLUORO 1,4 DIHYDRO 7 [4 [(3 HYDROXY 6 HYDROXYMETHYL 4 OXO 4H PYRAN 2 YL)METHYL]PIPERAZIN 1 YL] 4 OXO 1,8 NAPHTHYRIDINE 3 CARBOXYLIC ACID; 1 ETHYL 6 FLUORO 1,4 DIHYDRO 7 [4 [(3 HYDROXY 6 HYDROXYMETHYL 4 OXO 4H PYRAN 2 YL)METHYL]PIPERAZIN 1 YL] 4 OXOQUINOLINE 3 CARBOXYLIC ACID; 1 ETHYL 6,8 DIFLUORO 1,4 DIHYDRO 7 [3 METHYL 4 [(3 HYDROXY 6 HYDROXYMETHYL 4 OXO 4H PYRAN 2 YL)METHYL]PIPERAZIN 1 YL] 4 OXOQUINOLINE 3 CARBOXYLIC ACID; KOJIC ACID; MANNICH BASE; QUINOLONE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; BACILLUS SUBTILIS; COMPUTER MODEL; DRUG SYNTHESIS; ESCHERICHIA COLI; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; IN VITRO STUDY; KLEBSIELLA PNEUMONIAE; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PSEUDOMONAS AERUGINOSA; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS EPIDERMIDIS;

ANTIBACTERIAL ACTIVITY; DOCKING STUDY; KOJIC ACID; MANNICH BASES; QUINOLONES;

ANTI-BACTERIAL AGENTS; MANNICH BASES; MICROBIAL SENSITIVITY TESTS; MOLECULAR DOCKING SIMULATION; MOLECULAR STRUCTURE; NORFLOXACIN; PIPERAZINES; PYRONES; QUINOLONES;

EID: 84884483700     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2013.07.032     Document Type: Article

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