A study of cytotoxicity of novel chlorokojic acid derivatives with their antimicrobial and antiviral activities

European Journal of Medicinal Chemistry

Volumn 45, Issue 9, 2010, Pages 4089-4095

  Aytemir, Mutlu Dilsiz ^a   Özelik, Berrin ^b  

^a HACETTEPE UNIVERSITY   (Turkey)

^b GAZI UNIVERSITY   (Turkey)

Author keywords

Antimicrobial; Antiviral; Chlorokojic acid; Kojic acid; Mannich bases; Synthesis

Indexed keywords

2 [(4 ACETYL 4 PHENYLPIPERIDIN 1 YL)METHYL] 6 CHLOROMETHYL 3 HYDROXY 4H PYRAN 4 ONE; 2 [[4 (4 BROMOPHENYL) 4 HYDROXYPIPERIDIN 1 YL]METHYL] 6 CHLOROMETHYL 3 HYDROXY 4H PYRAN 4 ONE; 2 [[4 [4 CHLORO 3 (TRIFLUOROMETHYL)PHENYL] 4 HYDROXYPIPERIDIN 1 YL]METHYL] 6 CHLOROMETHYL 3-HYDROXY 4H PYRAN 4 ONE; 6 CHLOROMETHYL 2 [[4 (3,4 DICHLOROBENZYL)PIPERAZIN 1 YL]METHYL] 3 HYDROXY 4H PYRAN 4 ONE; 6 CHLOROMETHYL 2 [[4 [(4 CHLOROPHENYL)(PHENYL)METHYL]PIPERAZIN 1 YL]METHYL] 3 HYDROXY 4H PYRAN 4 ONE; PYRAN DERIVATIVE; TERT BUTYL 4 [[6 (CHLOROMETHYL) 3 HYDROXY 4 OXO 4H PYRAN 2 YL]METHYL]PIPERAZINE 1 CARBOXYLATE; UNCLASSIFIED DRUG;

ACINETOBACTER BAUMANNII; ANTIFUNGAL ACTIVITY; ANTIMICROBIAL ACTIVITY; ANTIVIRAL ACTIVITY; ARTICLE; BACILLUS SUBTILIS; CANDIDA ALBICANS; CANDIDA PARAPSILOSIS; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; CYTOTOXICITY; DRUG SYNTHESIS; ELECTROSPRAY MASS SPECTROMETRY; ESCHERICHIA COLI; HERPES SIMPLEX VIRUS 1; INFRARED SPECTROSCOPY; KLEBSIELLA PNEUMONIAE; MASS SPECTROMETRY; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PSEUDOMONAS AERUGINOSA; RNA VIRUS; SPECTROPHOTOMETRY; STAPHYLOCOCCUS AUREUS; STRUCTURE ACTIVITY RELATION; THIN LAYER CHROMATOGRAPHY;

ANIMALS; ANTI-INFECTIVE AGENTS; ANTIVIRAL AGENTS; BACTERIA; CELL LINE; CERCOPITHECUS AETHIOPS; DRUG EVALUATION, PRECLINICAL; FUNGI; HERPESVIRUS 1, HUMAN; MANNICH BASES; MICROBIAL SENSITIVITY TESTS; PARAINFLUENZA VIRUS 3, HUMAN; PYRONES; SPECTRUM ANALYSIS; VERO CELLS;

EID: 77955549675     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2010.05.069     Document Type: Article

References (36)

1. V.A. Rahangdale, G. Agrawal, and S.V. Jalgaonkar Indian J. Med. Microbiol. 26 2008 285 287
2. D. Pillay, and M.G. Alisdair BMJ 313 1996 503 504
3. B. Özelik, I. Gürbüz, T. Karaoglu, and E. Yesilada Microbiol. Res. 164 5 2009 545 552
4. B. Özelik, I. Orhan, and G. Toker Z. Naturforsch. C 61 2006 632 638
5. M.U. Göke, B. Özelik, G. Bakr, T. Karaoglu, E. Bercin, and N. Noyanalpan Arzneim.-Forsch./Drug Res. 54 12 2004 891 897
6. D. Esquenazi, M.D. Wigg, and M.F.S. Miranda Res. Microbiol. 153 2002 647 652
7. P. Vijayan, C. Raghu, G. Ashok, S.A. Dhanaraj, and B. Suresh Indian J. Med. Res. 120 2004 24 29
8. P.A. Wolf, and W.M. Westveer Arch. Biochem. 28 1950 201 206
9. T. Kotani, I. Ichimoto, C. Tatsumi, and T. Fujita Agric. Biol. Chem. 39 6 1975 1311 1317
10. K. Pirselova, S. Balaz, R. Ujhelyova, and E. Sturdik Quant. Struct-Act. Relat. 15 1996 87 93
11. R. Bentley Nat. Prod. Rep. 23 2006 1046 1062
12. M. Veverka Chem. Pap. 46 3 1992 206 210
13. M.D. Aytemir, D.D. Erol, R.C. Hider, and M. Özalp Turk. J. Chem. 27 6 2003 757 764
14. M.D. Aytemir, R.C. Hider, D.D. Erol, M. Özalp, and M. Ekizolu Turk. J. Chem. 27 4 2003 445 452
15. A. Fassihi, D. Abedi, L. Saghaie, R. Sabet, H. Fazeli, G. Bostaki, O. Deilami, and H. Sadinpour Eur. J. Med. Chem. 44 5 2009 2145 2157
16. J. Brtko, L. Rondahl, M. Fickova, D. Hudecova, V. Eybl, and M. Uher Cent. Eur. J. Publ. Health 12 2004 16 18
17. G.A. Burdock, M. Soni, and I.G. Carabin Regul. Toxicol. and Pharm. 33 2001 80 101
18. M. Veverka, and E. Kralovicova Collect. Czech. Chem. Commun. 55 1990 833 840
19. K. Uchino, M. Nagawa, Y. Tanasaki, M. Oda, and A. Fukuchi Agric. Biol. Chem. 52 1988 2609 2610
20. M. Uher, V. Konecny, and O. Rajniakova Chem. Pap-Chem. Zvesti. 48 4 1994 282 284
21. V. Kahn, N. Ben-Shalom, and V. Zakin J. Agric. Food Chem. 45 1997 4460 4465
22. J. Alverson J. Invertebr. Pathol. 83 2003 60 62
23. M.D. Aytemir, Ü. al, and M. Özalp Arch. Pharm. Pharm. Med. Chem. 337 2004 281 288
24. I. Ichimoto, and C. Tatsumi Agric. Biol. Chem. 1 2 1965 94 98
25. M. Uher Monatsh. Chem. 131 2000 301 307
26. A. Beelik, and C.B. Purves Can. J. Chem. Soc. 33 1955 1361 1374
27. G.J. O'Brien, M. Patterson, and J.R. Meadow J. Org. Chem. 25 1960 86 89
28. B.L. Ellis, A.K. Duhme, R.C. Hider, M.B. Hossain, S. Rizvi, and D. Van der Helm J. Med. Chem. 39 1996 3659 3670
29. L.S. Dehkordi, Z.D. Liu, and R.C. Hider Eur. J. Med. Chem. 43 2008 1035 1047
30. L.L. Woods, and J. Am Chem. Soc. 68 1946 2744 2745
31. M.D. Aytemir, E. Septiolu, and Ü. al Arzneim.-Forsch./Drug Res. 60 1 2010 22 29
32. R.H. Drew Pharmacotherapy 27 2 2007 227 249
33. C.A. Arias, and B.E. Murray Expert Rev. Anti Infect. Ther. 6 5 2008 637 655
34. R. Ray, Y. Matsuoka, T.L. Burnett, B.J. Glaze, and R.W. Compans J. Infect. Dis. 162 3 1990 746 749
35. Clinical and Laboratory Standards Institute (CLSI; formerly NCCLS), National Committee for Clinical Laboratory Standards, Performance standards for Antimicrobial Susceptibility Testing; 16th Informational supplement. CLSI document M7-A7, 940 West Valley Road, Wayne, Pennsylvania 19087, 2006.
36. Clinical and Laboratory Standards Institute (CLSI) Reference Method for Broth Dilution Antifungal Susceptibility Testing of Yeast; Approved Standard - Third Edition. CLSI document M27-A3 2008 Clinical and Laboratory Standards Institute 940 West Valley Road, Suite 1400, Wayne, Pennsylvania USA