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Volumn 54, Issue 10, 2013, Pages 2263-2268

Natural Bcl-2 inhibitor (-)- Gossypol induces protective autophagy via reactive oxygen species-high mobility group box 1 pathway in Burkitt lymphoma

Author keywords

( ) Gossypol; Autophagy; HMGB1; ROS

Indexed keywords

ACETYLCYSTEINE; GOSSYPOL; HIGH MOBILITY GROUP B1 PROTEIN; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE;

EID: 84884482589     PISSN: 10428194     EISSN: 10292403     Source Type: Journal    
DOI: 10.3109/10428194.2013.775437     Document Type: Article
Times cited : (27)

References (45)
  • 1
    • 8644284227 scopus 로고    scopus 로고
    • A dult Burkitt leukemia and lymphoma
    • Blum KA, Lozanski G, Byrd JC. A dult Burkitt leukemia and lymphoma. Blood 2004; 104: 3009-3020.
    • (2004) Blood , vol.104 , pp. 3009-3020
    • Blum, K.A.1    Lozanski, G.2    Byrd, J.C.3
  • 2
    • 59449095496 scopus 로고    scopus 로고
    • AT-101 induces apoptosis in CLL B cells and overcomes stromal cell-mediated Mcl-1 induction and drug resistance
    • Balakrishnan K, Burger JA, Wierda WG, et al. AT-101 induces apoptosis in CLL B cells and overcomes stromal cell-mediated Mcl-1 induction and drug resistance. Blood 2009; 113: 149-153.
    • (2009) Blood , vol.113 , pp. 149-153
    • Balakrishnan, K.1    Burger, J.A.2    Wierda, W.G.3
  • 3
    • 78651379962 scopus 로고    scopus 로고
    • Radiosensitization of hormone-refractory prostate cancer cells by gossypol treatment
    • Akagunduz O, Karaca B, Atmaca H, et al. Radiosensitization of hormone-refractory prostate cancer cells by gossypol treatment. J BUON 2010; 15: 763-767.
    • (2010) J BUON , vol.15 , pp. 763-767
    • Akagunduz, O.1    Karaca, B.2    Atmaca, H.3
  • 4
    • 13944252626 scopus 로고    scopus 로고
    • Preclinical studies of a nonpeptidic small-molecule inhibitor of Bcl-2 and Bcl-X(L) [(+)-gossypol] against diffuse large cell lymphoma
    • Mohammad RM, Wang S, Aboukameel A, et al. Preclinical studies of a nonpeptidic small-molecule inhibitor of Bcl-2 and Bcl-X(L) [(+)-gossypol] against diffuse large cell lymphoma. Mol Cancer Ther 2005; 4: 13-21.
    • (2005) Mol Cancer Ther , vol.4 , pp. 13-21
    • Mohammad, R.M.1    Wang, S.2    Aboukameel, A.3
  • 5
    • 56149092147 scopus 로고    scopus 로고
    • Regulation of antiapoptotic MCL-1 function by gossypol: Mechanistic insights from in vitro reconstituted systems
    • Etxebarria A, Landeta O, Antonsson B, et al. Regulation of antiapoptotic MCL-1 function by gossypol: Mechanistic insights from in vitro reconstituted systems. Biochem Pharmacol 2008; 76: 1563-1576.
    • (2008) Biochem Pharmacol , vol.76 , pp. 1563-1576
    • Etxebarria, A.1    Landeta, O.2    Antonsson, B.3
  • 6
    • 36048943429 scopus 로고    scopus 로고
    • Gossypol and its combination with imatinib induce apoptosis in human chronic myeloid leukemic cells
    • Meng Y, Li Y, Li J, et al. ( +) Gossypol and its combination with imatinib induce apoptosis in human chronic myeloid leukemic cells. Leuk Lymphoma 2007; 48: 2204-2212.
    • (2007) Leuk Lymphoma , vol.48 , pp. 2204-2212
    • Meng, Y.1    Li, Y.2    Li, J.3
  • 7
    • 42249110185 scopus 로고    scopus 로고
    • R -( + )-gossypol (AT- 101) activates programmed cell death in multiple myeloma cells
    • Kline MP, Rajkumar SV, Timm MM, et al. R -( + )-gossypol (AT- 101) activates programmed cell death in multiple myeloma cells. Exp Hematol 2008; 36: 568-576.
    • (2008) Exp Hematol , vol.36 , pp. 568-576
    • Kline, M.P.1    Rajkumar, S.V.2    Timm, M.M.3
  • 8
    • 68749112763 scopus 로고    scopus 로고
    • Small-molecule Bcl-2 antagonists as targeted therapy in oncology
    • Warr MR, Shore GC. Small-molecule Bcl-2 antagonists as targeted therapy in oncology. Curr Oncol 2008; 15: 256-261.
    • (2008) Curr Oncol , vol.15 , pp. 256-261
    • Warr, M.R.1    Shore, G.C.2
  • 9
    • 13944262237 scopus 로고    scopus 로고
    • Gossypol acts directly on the mitochondria to overcome Bcl-2- and Bcl-X(L)-mediated apoptosis resistance
    • Oliver CL, Miranda MB, Shangary S, et al. (+ ) -Gossypol acts directly on the mitochondria to overcome Bcl-2- and Bcl-X(L)-mediated apoptosis resistance. Mol Cancer Ther 2005; 4: 23-31.
    • (2005) Mol Cancer Ther , vol.4 , pp. 23-31
    • Oliver, C.L.1    Miranda, M.B.2    Shangary, S.3
  • 10
    • 40549146581 scopus 로고    scopus 로고
    • Preclinical studies of apogossypolone: A new nonpeptidic pan small-molecule inhibitor of Bcl-2, Bcl-XL and Mcl-1 proteins in follicular small cleaved cell lymphoma model
    • Arnold AA, Aboukameel A, Chen J, et al. Preclinical studies of apogossypolone: A new nonpeptidic pan small-molecule inhibitor of Bcl-2, Bcl-XL and Mcl-1 proteins in follicular small cleaved cell lymphoma model. Mol Cancer 2008; 7: 20.
    • (2008) Mol Cancer , vol.7 , pp. 20
    • Arnold, A.A.1    Aboukameel, A.2    Chen, J.3
  • 11
    • 65249106965 scopus 로고    scopus 로고
    • Expression of autophagy-related genes Beclin1 and MAPLC3 in non-small cell lung cancer]
    • Liu Q, Wang JJ, Pan YC, et al. [Expression of autophagy-related genes Beclin1 and MAPLC3 in non-small cell lung cancer]. Ai Zheng 2008; 27: 25-29.
    • (2008) Ai Zheng , vol.27 , pp. 25-29
    • Liu, Q.1    Wang, J.J.2    Pan, Y.C.3
  • 12
    • 56649095807 scopus 로고    scopus 로고
    • Gossypol promotes the apoptosis of bladder cancer cells in vitro
    • Macoska JA, Adsule S, Tantivejkul K, et al. - (+ )Gossypol promotes the apoptosis of bladder cancer cells in vitro. Pharmacol Res 2008; 58: 323-331.
    • (2008) Pharmacol Res , vol.58 , pp. 323-331
    • Macoska, J.A.1    Adsule, S.2    Tantivejkul, K.3
  • 13
    • 51049106854 scopus 로고    scopus 로고
    • Natural BH3 mimetic (+ )-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa
    • Meng Y, Tang W, Dai Y, et al. Natural BH3 mimetic (+ )-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa. Mol Cancer Ther 2008; 7: 2192-2202.
    • (2008) Mol Cancer Ther , vol.7 , pp. 2192-2202
    • Meng, Y.1    Tang, W.2    Dai, Y.3
  • 14
    • 56149114534 scopus 로고    scopus 로고
    • Anti-oxidant treatment enhances anti-tumor cytotoxicity of ( + )-gossypol
    • Sikora MJ, Bauer JA, Verhaegen M, et al. Anti-oxidant treatment enhances anti-tumor cytotoxicity of ( + )-gossypol. Cancer Biol Ther 2008; 7: 767-776.
    • (2008) Cancer Biol Ther , vol.7 , pp. 767-776
    • Sikora, M.J.1    Bauer, J.A.2    Verhaegen, M.3
  • 15
    • 77955485416 scopus 로고    scopus 로고
    • The Bcl-2 homology domain 3 mimetic gossypol induces both Beclin 1-dependent and Beclin 1-independent cytoprotective autophagy in cancer cells
    • Gao P, Bauvy C, Souquere S, et al. The Bcl-2 homology domain 3 mimetic gossypol induces both Beclin 1-dependent and Beclin 1-independent cytoprotective autophagy in cancer cells. J Biol Chem 2010; 285: 25570-25581.
    • (2010) J Biol Chem , vol.285 , pp. 25570-25581
    • Gao, P.1    Bauvy, C.2    Souquere, S.3
  • 16
    • 77955432889 scopus 로고    scopus 로고
    • The pan-Bcl-2 inhibitor ( + )-gossypol triggers autophagic cell death in malignant glioma
    • Voss V CS, Lang V, Ronellenfitsch MW, et al. The pan-Bcl-2 inhibitor ( + )-gossypol triggers autophagic cell death in malignant glioma. Mol Cancer Res 2010; 8: 15-23.
    • (2010) Mol Cancer Res , vol.8 , pp. 15-23
    • Voss V, C.S.1    Lang, V.2    Ronellenfitsch, M.W.3
  • 17
    • 78650170269 scopus 로고    scopus 로고
    • A natural BH3 mimetic induces autophagy in apoptosis-resistant prostate cancer via modulating Bcl-2-Beclin1 interaction at endoplasmic reticulum
    • Lian J, W u X, H e F, et al. A natural BH3 mimetic induces autophagy in apoptosis-resistant prostate cancer via modulating Bcl-2-Beclin1 interaction at endoplasmic reticulum. Cell Death Differ 2011; 18: 60-71.
    • (2011) Cell Death Differ , vol.18 , pp. 60-71
    • Lian, J.1    Wu, X.2    He, F.3
  • 18
    • 78149256773 scopus 로고    scopus 로고
    • Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL
    • Sung B, Ravindran J, Prasad S, et al. Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL. J Biol Chem 2010; 285: 35418-35427.
    • (2010) J Biol Chem , vol.285 , pp. 35418-35427
    • Sung, B.1    Ravindran, J.2    Prasad, S.3
  • 19
    • 52649179285 scopus 로고    scopus 로고
    • Gossypol, a BH3 mimetic, induces apoptosis in chronic lymphocytic leukemia cells
    • Balakrishnan K, Wierda WG, Keating MJ, et al. Gossypol, a BH3 mimetic, induces apoptosis in chronic lymphocytic leukemia cells. Blood 2008; 112: 1971-1980.
    • (2008) Blood , vol.112 , pp. 1971-1980
    • Balakrishnan, K.1    Wierda, W.G.2    Keating, M.J.3
  • 20
    • 84863116789 scopus 로고    scopus 로고
    • Sorafenib sensitizes (+ )-gossypolinduced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation
    • Lian J, N i Z, Dai X, et al. Sorafenib sensitizes (+ )-gossypolinduced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation. Mol Cancer Ther 2012; 11: 416-426.
    • (2012) Mol Cancer Ther , vol.11 , pp. 416-426
    • Lian, J.1    Ni, Z.2    Dai, X.3
  • 21
    • 77950886468 scopus 로고    scopus 로고
    • Methods for detecting autophagy and determining autophagy-induced cell death
    • Chen Y, Azad MB, Gibson SB. Methods for detecting autophagy and determining autophagy-induced cell death. Can J Physiol Pharmacol 2010; 88: 285-295.
    • (2010) Can J Physiol Pharmacol , vol.88 , pp. 285-295
    • Chen, Y.1    Azad, M.B.2    Gibson, S.B.3
  • 22
    • 78649251524 scopus 로고    scopus 로고
    • Roles of autophagy in cetuximab-mediated cancer therapy against EGFR
    • Li X, Lu Y, Pan T, et al. Roles of autophagy in cetuximab-mediated cancer therapy against EGFR. Autophagy 2010; 6: 1066-1077.
    • (2010) Autophagy , vol.6 , pp. 1066-1077
    • Li, X.1    Lu, Y.2    Pan, T.3
  • 23
    • 70349220767 scopus 로고    scopus 로고
    • Repression of the miR-17-92 cluster by p53 has an important function in hypoxia-induced apoptosis
    • Yan HL, Xue G, Mei Q, et al. Repression of the miR-17-92 cluster by p53 has an important function in hypoxia-induced apoptosis. EMBO J 2009; 28: 2719-2732.
    • (2009) EMBO J , vol.28 , pp. 2719-2732
    • Yan, H.L.1    Xue, G.2    Mei, Q.3
  • 24
    • 53249140333 scopus 로고    scopus 로고
    • Silencing alpha-fetoprotein expression induces growth arrest and apoptosis in human hepatocellular cancer cell
    • Yang X, Zhang Y, Zhang L, et al. Silencing alpha-fetoprotein expression induces growth arrest and apoptosis in human hepatocellular cancer cell. Cancer Lett 2008; 271: 281-293.
    • (2008) Cancer Lett , vol.271 , pp. 281-293
    • Yang, X.1    Zhang, Y.2    Zhang, L.3
  • 25
    • 0035863399 scopus 로고    scopus 로고
    • A novel response of cancer cells to radiation involves autophagy and formation of acidic vesicles
    • Paglin, H ollister T, Delohery T, et al. A novel response of cancer cells to radiation involves autophagy and formation of acidic vesicles. Cancer Res 2001; 61: 439-444.
    • (2001) Cancer Res , vol.61 , pp. 439-444
    • Paglin, H.1    Ollister, T.2    Delohery, T.3
  • 26
    • 79961120130 scopus 로고    scopus 로고
    • HMGB1 as an autophagy sensor in oxidative stress
    • Kang R, Livesey KM, Zeh HJ 3rd, et al. HMGB1 as an autophagy sensor in oxidative stress. Autophagy 2011; 7: 904-908.
    • (2011) Autophagy , vol.7 , pp. 904-908
    • Kang, R.1    Livesey, K.M.2    Zeh III, H.J.3
  • 27
    • 77953699668 scopus 로고    scopus 로고
    • Targeting the prodeath and prosurvival functions of autophagy as novel therapeutic strategies in cancer
    • Dalby KN, Tekedereli I, Lopez-Berestein G, et al. Targeting the prodeath and prosurvival functions of autophagy as novel therapeutic strategies in cancer. Autophagy 2010; 6: 322-329.
    • (2010) Autophagy , vol.6 , pp. 322-329
    • Dalby, K.N.1    Tekedereli, I.2    Lopez-Berestein, G.3
  • 28
    • 20344387475 scopus 로고    scopus 로고
    • Autophagy: Dual roles in life and death?
    • Baehrecke EH. Autophagy: Dual roles in life and death? Nat Rev Mol Cell Biol 2005; 6: 505-510.
    • (2005) Nat Rev Mol Cell Biol , vol.6 , pp. 505-510
    • Baehrecke, E.H.1
  • 29
    • 33645944960 scopus 로고    scopus 로고
    • Autophagy and cancer therapy
    • Kondo Y, Kondo S. Autophagy and cancer therapy. Autophagy 2006; 2: 85-90.
    • (2006) Autophagy , vol.2 , pp. 85-90
    • Kondo, Y.1    Kondo, S.2
  • 30
    • 78649308481 scopus 로고    scopus 로고
    • The Bcl-2-Beclin 1 interaction in (+ )-gossypol-induced autophagy versus apoptosis in prostate cancer cells
    • Lian J, Karnak D, Xu L. The Bcl-2-Beclin 1 interaction in (+ )-gossypol-induced autophagy versus apoptosis in prostate cancer cells. Autophagy 2010; 6: 1201-1203.
    • (2010) Autophagy , vol.6 , pp. 1201-1203
    • Lian, J.1    Karnak, D.2    Xu, L.3
  • 31
    • 34250894388 scopus 로고    scopus 로고
    • BH3-only proteins and BH3 mimetics induce autophagy by competitively disrupting the interaction between Beclin 1 and Bcl-2/Bcl-X(L)
    • Maiuri MC, Criollo A, Tasdemir E, et al. BH3-only proteins and BH3 mimetics induce autophagy by competitively disrupting the interaction between Beclin 1 and Bcl-2/Bcl-X(L). Autophagy 2007; 3: 374-376.
    • (2007) Autophagy , vol.3 , pp. 374-376
    • Maiuri, M.C.1    Criollo, A.2    Tasdemir, E.3
  • 32
    • 77957681100 scopus 로고    scopus 로고
    • ROS-mediated mechanisms of autophagy stimulation and their relevance in cancer therapy
    • Dewaele M, Maes H, Agostinis P. ROS-mediated mechanisms of autophagy stimulation and their relevance in cancer therapy. Autophagy 2010; 6: 838-854.
    • (2010) Autophagy , vol.6 , pp. 838-854
    • Dewaele, M.1    Maes, H.2    Agostinis, P.3
  • 33
    • 34848920863 scopus 로고    scopus 로고
    • ROS, mitochondria and the regulation of autophagy
    • Scherz-Shouval R, Elazar Z. ROS, mitochondria and the regulation of autophagy. Trends Cell Biol 2007; 17: 422-427.
    • (2007) Trends Cell Biol , vol.17 , pp. 422-427
    • Scherz-Shouval, R.1    Elazar, Z.2
  • 34
    • 80155199811 scopus 로고    scopus 로고
    • Bcl-2: A prime regulator of mitochondrial redox metabolism in cancer cells
    • Low ICC, Kang J, Pervaiz S. Bcl-2: A prime regulator of mitochondrial redox metabolism in cancer cells. Antioxid Redox Signal 2011; 15: 2975-2987.
    • (2011) Antioxid Redox Signal , vol.15 , pp. 2975-2987
    • Low, I.C.C.1    Kang, J.2    Pervaiz, S.3
  • 35
    • 84859509849 scopus 로고    scopus 로고
    • Gossypol inhibits electron transport and stimulates ROS generation in Yarrowia lipolytica mitochondria
    • Arinbasarova AY, Medentsev AG, Krupyanko VI. Gossypol inhibits electron transport and stimulates ROS generation in Yarrowia lipolytica mitochondria. Open Biochem J 2012; 6: 11-15.
    • (2012) Open Biochem J , vol.6 , pp. 11-15
    • Arinbasarova, A.Y.1    Medentsev, A.G.2    Krupyanko, V.I.3
  • 36
    • 77955423341 scopus 로고    scopus 로고
    • Simultaneous induction of non-canonical autophagy and apoptosis in cancer cells by ROSdependent ERK and JNK activation
    • Wong CH, Iskandar KB, Yadav SK, et al. Simultaneous induction of non-canonical autophagy and apoptosis in cancer cells by ROSdependent ERK and JNK activation. PLoS One 2010; 5: E9996.
    • (2010) PLoS One , vol.5
    • Wong, C.H.1    Iskandar, K.B.2    Yadav, S.K.3
  • 37
    • 84863516150 scopus 로고    scopus 로고
    • Resveratrol enhances the antitumor effects of temozolomide in glioblastoma via ROSdependent AMPK-TSC-mTOR signaling pathway
    • Yuan Y, Xue X, Guo R-B, et al. Resveratrol enhances the antitumor effects of temozolomide in glioblastoma via ROSdependent AMPK-TSC-mTOR signaling pathway. CNS Neurosci Ther 2012; 18: 536-546.
    • (2012) CNS Neurosci Ther , vol.18 , pp. 536-546
    • Yuan, Y.1    Xue, X.2    Guo, R.-B.3
  • 38
    • 67650831206 scopus 로고    scopus 로고
    • Sorafenib and vorinostat kill colon cancer cells by CD95-dependent and -independent mechanisms
    • Walker T, Mitchell C, Park MA, et al. Sorafenib and vorinostat kill colon cancer cells by CD95-dependent and -independent mechanisms. Mol Pharmacol 2009; 76: 342-355.
    • (2009) Mol Pharmacol , vol.76 , pp. 342-355
    • Walker, T.1    Mitchell, C.2    Park, M.A.3
  • 39
    • 48249123422 scopus 로고    scopus 로고
    • M 867, a novel selective inhibitor of caspase-3 enhances cell death and extends tumor growth delay in irradiated lung cancer models
    • Kim KW, Moretti L, L u B. M 867, a novel selective inhibitor of caspase-3 enhances cell death and extends tumor growth delay in irradiated lung cancer models. PLoS One 2008; 3: E2275.
    • (2008) PLoS One , vol.3
    • Kim, K.W.1    Moretti, L.2    Lu, B.3
  • 40
    • 34848909873 scopus 로고    scopus 로고
    • Comparison of pharmacokinetic and metabolic profiling among gossypol, apogossypol and apogossypol hexaacetate
    • Jia L, Coward LC, Kerstner-Wood CD, et al. Comparison of pharmacokinetic and metabolic profiling among gossypol, apogossypol and apogossypol hexaacetate. Cancer Chemother Pharmacol 2008; 61: 63-73.
    • (2008) Cancer Chemother Pharmacol , vol.61 , pp. 63-73
    • Jia, L.1    Coward, L.C.2    Kerstner-Wood, C.D.3
  • 41
    • 0022560339 scopus 로고
    • Pharmacokinetics of ( + /+)-, ( + )+, and ( + )-gossypol in humans and dogs
    • Wu DF, Yu YW, Tang ZM, et al. Pharmacokinetics of ( + /+)-, ( + )+, and ( + )-gossypol in humans and dogs. Clin Pharmacol Ther 1986; 39: 613-618.
    • (1986) Clin Pharmacol Ther , vol.39 , pp. 613-618
    • Wu, D.F.1    Yu, Y.W.2    Tang, Z.M.3
  • 42
    • 0036562428 scopus 로고    scopus 로고
    • The effect of N-acetyl-L-cysteine on the viscosity of ileal neobladder mucus
    • Schrier BP, Lichtendonk WJ, Witjes JA. The effect of N-acetyl-L-cysteine on the viscosity of ileal neobladder mucus. World J Urol 2002; 20: 64-67.
    • (2002) World J Urol , vol.20 , pp. 64-67
    • Schrier, B.P.1    Lichtendonk, W.J.2    Witjes, J.A.3
  • 43
    • 0034819436 scopus 로고    scopus 로고
    • N-acetyl-L-cysteine improves renal medullary hypoperfusion in acute renal failure
    • Conesa EL, Valero F, Nadal JC, et al. N-acetyl-L-cysteine improves renal medullary hypoperfusion in acute renal failure. Am J Physiol Regul Integr Comp Physiol 2001; 281: R730-R737.
    • (2001) Am J Physiol Regul Integr Comp Physiol , vol.281
    • Conesa, E.L.1    Valero, F.2    Nadal, J.C.3
  • 44
    • 82855176141 scopus 로고    scopus 로고
    • Antioxidant N-acetyl-L-cysteine (NAC) supplementation reduces reactive oxygen species (ROS)-mediated hepatocellular tumor promotion of indole-3-carbinol (I3C) in rats
    • Shimamoto K, Hayashi H, Taniai E, et al. Antioxidant N-acetyl-L-cysteine (NAC) supplementation reduces reactive oxygen species (ROS)-mediated hepatocellular tumor promotion of indole-3-carbinol (I3C) in rats. J Toxicol Sci 2011; 36: 775-786.
    • (2011) J Toxicol Sci , vol.36 , pp. 775-786
    • Shimamoto, K.1    Hayashi, H.2    Taniai, E.3
  • 45
    • 43849084504 scopus 로고    scopus 로고
    • A prospective randomized study using N-acetyl-L-cysteine for early liver toxicity after allogeneic hematopoietic stem cell transplantation
    • Barkholt L, Remberger M, Hassan Z, et al. A prospective randomized study using N-acetyl-L-cysteine for early liver toxicity after allogeneic hematopoietic stem cell transplantation. Bone Marrow Transplant 2008; 41: 785-790.
    • (2008) Bone Marrow Transplant , vol.41 , pp. 785-790
    • Barkholt, L.1    Remberger, M.2    Hassan, Z.3


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