-
1
-
-
8644284227
-
A dult Burkitt leukemia and lymphoma
-
Blum KA, Lozanski G, Byrd JC. A dult Burkitt leukemia and lymphoma. Blood 2004; 104: 3009-3020.
-
(2004)
Blood
, vol.104
, pp. 3009-3020
-
-
Blum, K.A.1
Lozanski, G.2
Byrd, J.C.3
-
2
-
-
59449095496
-
AT-101 induces apoptosis in CLL B cells and overcomes stromal cell-mediated Mcl-1 induction and drug resistance
-
Balakrishnan K, Burger JA, Wierda WG, et al. AT-101 induces apoptosis in CLL B cells and overcomes stromal cell-mediated Mcl-1 induction and drug resistance. Blood 2009; 113: 149-153.
-
(2009)
Blood
, vol.113
, pp. 149-153
-
-
Balakrishnan, K.1
Burger, J.A.2
Wierda, W.G.3
-
3
-
-
78651379962
-
Radiosensitization of hormone-refractory prostate cancer cells by gossypol treatment
-
Akagunduz O, Karaca B, Atmaca H, et al. Radiosensitization of hormone-refractory prostate cancer cells by gossypol treatment. J BUON 2010; 15: 763-767.
-
(2010)
J BUON
, vol.15
, pp. 763-767
-
-
Akagunduz, O.1
Karaca, B.2
Atmaca, H.3
-
4
-
-
13944252626
-
Preclinical studies of a nonpeptidic small-molecule inhibitor of Bcl-2 and Bcl-X(L) [(+)-gossypol] against diffuse large cell lymphoma
-
Mohammad RM, Wang S, Aboukameel A, et al. Preclinical studies of a nonpeptidic small-molecule inhibitor of Bcl-2 and Bcl-X(L) [(+)-gossypol] against diffuse large cell lymphoma. Mol Cancer Ther 2005; 4: 13-21.
-
(2005)
Mol Cancer Ther
, vol.4
, pp. 13-21
-
-
Mohammad, R.M.1
Wang, S.2
Aboukameel, A.3
-
5
-
-
56149092147
-
Regulation of antiapoptotic MCL-1 function by gossypol: Mechanistic insights from in vitro reconstituted systems
-
Etxebarria A, Landeta O, Antonsson B, et al. Regulation of antiapoptotic MCL-1 function by gossypol: Mechanistic insights from in vitro reconstituted systems. Biochem Pharmacol 2008; 76: 1563-1576.
-
(2008)
Biochem Pharmacol
, vol.76
, pp. 1563-1576
-
-
Etxebarria, A.1
Landeta, O.2
Antonsson, B.3
-
6
-
-
36048943429
-
Gossypol and its combination with imatinib induce apoptosis in human chronic myeloid leukemic cells
-
Meng Y, Li Y, Li J, et al. ( +) Gossypol and its combination with imatinib induce apoptosis in human chronic myeloid leukemic cells. Leuk Lymphoma 2007; 48: 2204-2212.
-
(2007)
Leuk Lymphoma
, vol.48
, pp. 2204-2212
-
-
Meng, Y.1
Li, Y.2
Li, J.3
-
7
-
-
42249110185
-
R -( + )-gossypol (AT- 101) activates programmed cell death in multiple myeloma cells
-
Kline MP, Rajkumar SV, Timm MM, et al. R -( + )-gossypol (AT- 101) activates programmed cell death in multiple myeloma cells. Exp Hematol 2008; 36: 568-576.
-
(2008)
Exp Hematol
, vol.36
, pp. 568-576
-
-
Kline, M.P.1
Rajkumar, S.V.2
Timm, M.M.3
-
8
-
-
68749112763
-
Small-molecule Bcl-2 antagonists as targeted therapy in oncology
-
Warr MR, Shore GC. Small-molecule Bcl-2 antagonists as targeted therapy in oncology. Curr Oncol 2008; 15: 256-261.
-
(2008)
Curr Oncol
, vol.15
, pp. 256-261
-
-
Warr, M.R.1
Shore, G.C.2
-
9
-
-
13944262237
-
Gossypol acts directly on the mitochondria to overcome Bcl-2- and Bcl-X(L)-mediated apoptosis resistance
-
Oliver CL, Miranda MB, Shangary S, et al. (+ ) -Gossypol acts directly on the mitochondria to overcome Bcl-2- and Bcl-X(L)-mediated apoptosis resistance. Mol Cancer Ther 2005; 4: 23-31.
-
(2005)
Mol Cancer Ther
, vol.4
, pp. 23-31
-
-
Oliver, C.L.1
Miranda, M.B.2
Shangary, S.3
-
10
-
-
40549146581
-
Preclinical studies of apogossypolone: A new nonpeptidic pan small-molecule inhibitor of Bcl-2, Bcl-XL and Mcl-1 proteins in follicular small cleaved cell lymphoma model
-
Arnold AA, Aboukameel A, Chen J, et al. Preclinical studies of apogossypolone: A new nonpeptidic pan small-molecule inhibitor of Bcl-2, Bcl-XL and Mcl-1 proteins in follicular small cleaved cell lymphoma model. Mol Cancer 2008; 7: 20.
-
(2008)
Mol Cancer
, vol.7
, pp. 20
-
-
Arnold, A.A.1
Aboukameel, A.2
Chen, J.3
-
11
-
-
65249106965
-
Expression of autophagy-related genes Beclin1 and MAPLC3 in non-small cell lung cancer]
-
Liu Q, Wang JJ, Pan YC, et al. [Expression of autophagy-related genes Beclin1 and MAPLC3 in non-small cell lung cancer]. Ai Zheng 2008; 27: 25-29.
-
(2008)
Ai Zheng
, vol.27
, pp. 25-29
-
-
Liu, Q.1
Wang, J.J.2
Pan, Y.C.3
-
12
-
-
56649095807
-
Gossypol promotes the apoptosis of bladder cancer cells in vitro
-
Macoska JA, Adsule S, Tantivejkul K, et al. - (+ )Gossypol promotes the apoptosis of bladder cancer cells in vitro. Pharmacol Res 2008; 58: 323-331.
-
(2008)
Pharmacol Res
, vol.58
, pp. 323-331
-
-
Macoska, J.A.1
Adsule, S.2
Tantivejkul, K.3
-
13
-
-
51049106854
-
Natural BH3 mimetic (+ )-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa
-
Meng Y, Tang W, Dai Y, et al. Natural BH3 mimetic (+ )-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa. Mol Cancer Ther 2008; 7: 2192-2202.
-
(2008)
Mol Cancer Ther
, vol.7
, pp. 2192-2202
-
-
Meng, Y.1
Tang, W.2
Dai, Y.3
-
14
-
-
56149114534
-
Anti-oxidant treatment enhances anti-tumor cytotoxicity of ( + )-gossypol
-
Sikora MJ, Bauer JA, Verhaegen M, et al. Anti-oxidant treatment enhances anti-tumor cytotoxicity of ( + )-gossypol. Cancer Biol Ther 2008; 7: 767-776.
-
(2008)
Cancer Biol Ther
, vol.7
, pp. 767-776
-
-
Sikora, M.J.1
Bauer, J.A.2
Verhaegen, M.3
-
15
-
-
77955485416
-
The Bcl-2 homology domain 3 mimetic gossypol induces both Beclin 1-dependent and Beclin 1-independent cytoprotective autophagy in cancer cells
-
Gao P, Bauvy C, Souquere S, et al. The Bcl-2 homology domain 3 mimetic gossypol induces both Beclin 1-dependent and Beclin 1-independent cytoprotective autophagy in cancer cells. J Biol Chem 2010; 285: 25570-25581.
-
(2010)
J Biol Chem
, vol.285
, pp. 25570-25581
-
-
Gao, P.1
Bauvy, C.2
Souquere, S.3
-
16
-
-
77955432889
-
The pan-Bcl-2 inhibitor ( + )-gossypol triggers autophagic cell death in malignant glioma
-
Voss V CS, Lang V, Ronellenfitsch MW, et al. The pan-Bcl-2 inhibitor ( + )-gossypol triggers autophagic cell death in malignant glioma. Mol Cancer Res 2010; 8: 15-23.
-
(2010)
Mol Cancer Res
, vol.8
, pp. 15-23
-
-
Voss V, C.S.1
Lang, V.2
Ronellenfitsch, M.W.3
-
17
-
-
78650170269
-
A natural BH3 mimetic induces autophagy in apoptosis-resistant prostate cancer via modulating Bcl-2-Beclin1 interaction at endoplasmic reticulum
-
Lian J, W u X, H e F, et al. A natural BH3 mimetic induces autophagy in apoptosis-resistant prostate cancer via modulating Bcl-2-Beclin1 interaction at endoplasmic reticulum. Cell Death Differ 2011; 18: 60-71.
-
(2011)
Cell Death Differ
, vol.18
, pp. 60-71
-
-
Lian, J.1
Wu, X.2
He, F.3
-
18
-
-
78149256773
-
Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL
-
Sung B, Ravindran J, Prasad S, et al. Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL. J Biol Chem 2010; 285: 35418-35427.
-
(2010)
J Biol Chem
, vol.285
, pp. 35418-35427
-
-
Sung, B.1
Ravindran, J.2
Prasad, S.3
-
19
-
-
52649179285
-
Gossypol, a BH3 mimetic, induces apoptosis in chronic lymphocytic leukemia cells
-
Balakrishnan K, Wierda WG, Keating MJ, et al. Gossypol, a BH3 mimetic, induces apoptosis in chronic lymphocytic leukemia cells. Blood 2008; 112: 1971-1980.
-
(2008)
Blood
, vol.112
, pp. 1971-1980
-
-
Balakrishnan, K.1
Wierda, W.G.2
Keating, M.J.3
-
20
-
-
84863116789
-
Sorafenib sensitizes (+ )-gossypolinduced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation
-
Lian J, N i Z, Dai X, et al. Sorafenib sensitizes (+ )-gossypolinduced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation. Mol Cancer Ther 2012; 11: 416-426.
-
(2012)
Mol Cancer Ther
, vol.11
, pp. 416-426
-
-
Lian, J.1
Ni, Z.2
Dai, X.3
-
21
-
-
77950886468
-
Methods for detecting autophagy and determining autophagy-induced cell death
-
Chen Y, Azad MB, Gibson SB. Methods for detecting autophagy and determining autophagy-induced cell death. Can J Physiol Pharmacol 2010; 88: 285-295.
-
(2010)
Can J Physiol Pharmacol
, vol.88
, pp. 285-295
-
-
Chen, Y.1
Azad, M.B.2
Gibson, S.B.3
-
22
-
-
78649251524
-
Roles of autophagy in cetuximab-mediated cancer therapy against EGFR
-
Li X, Lu Y, Pan T, et al. Roles of autophagy in cetuximab-mediated cancer therapy against EGFR. Autophagy 2010; 6: 1066-1077.
-
(2010)
Autophagy
, vol.6
, pp. 1066-1077
-
-
Li, X.1
Lu, Y.2
Pan, T.3
-
23
-
-
70349220767
-
Repression of the miR-17-92 cluster by p53 has an important function in hypoxia-induced apoptosis
-
Yan HL, Xue G, Mei Q, et al. Repression of the miR-17-92 cluster by p53 has an important function in hypoxia-induced apoptosis. EMBO J 2009; 28: 2719-2732.
-
(2009)
EMBO J
, vol.28
, pp. 2719-2732
-
-
Yan, H.L.1
Xue, G.2
Mei, Q.3
-
24
-
-
53249140333
-
Silencing alpha-fetoprotein expression induces growth arrest and apoptosis in human hepatocellular cancer cell
-
Yang X, Zhang Y, Zhang L, et al. Silencing alpha-fetoprotein expression induces growth arrest and apoptosis in human hepatocellular cancer cell. Cancer Lett 2008; 271: 281-293.
-
(2008)
Cancer Lett
, vol.271
, pp. 281-293
-
-
Yang, X.1
Zhang, Y.2
Zhang, L.3
-
25
-
-
0035863399
-
A novel response of cancer cells to radiation involves autophagy and formation of acidic vesicles
-
Paglin, H ollister T, Delohery T, et al. A novel response of cancer cells to radiation involves autophagy and formation of acidic vesicles. Cancer Res 2001; 61: 439-444.
-
(2001)
Cancer Res
, vol.61
, pp. 439-444
-
-
Paglin, H.1
Ollister, T.2
Delohery, T.3
-
26
-
-
79961120130
-
HMGB1 as an autophagy sensor in oxidative stress
-
Kang R, Livesey KM, Zeh HJ 3rd, et al. HMGB1 as an autophagy sensor in oxidative stress. Autophagy 2011; 7: 904-908.
-
(2011)
Autophagy
, vol.7
, pp. 904-908
-
-
Kang, R.1
Livesey, K.M.2
Zeh III, H.J.3
-
27
-
-
77953699668
-
Targeting the prodeath and prosurvival functions of autophagy as novel therapeutic strategies in cancer
-
Dalby KN, Tekedereli I, Lopez-Berestein G, et al. Targeting the prodeath and prosurvival functions of autophagy as novel therapeutic strategies in cancer. Autophagy 2010; 6: 322-329.
-
(2010)
Autophagy
, vol.6
, pp. 322-329
-
-
Dalby, K.N.1
Tekedereli, I.2
Lopez-Berestein, G.3
-
28
-
-
20344387475
-
Autophagy: Dual roles in life and death?
-
Baehrecke EH. Autophagy: Dual roles in life and death? Nat Rev Mol Cell Biol 2005; 6: 505-510.
-
(2005)
Nat Rev Mol Cell Biol
, vol.6
, pp. 505-510
-
-
Baehrecke, E.H.1
-
29
-
-
33645944960
-
Autophagy and cancer therapy
-
Kondo Y, Kondo S. Autophagy and cancer therapy. Autophagy 2006; 2: 85-90.
-
(2006)
Autophagy
, vol.2
, pp. 85-90
-
-
Kondo, Y.1
Kondo, S.2
-
30
-
-
78649308481
-
The Bcl-2-Beclin 1 interaction in (+ )-gossypol-induced autophagy versus apoptosis in prostate cancer cells
-
Lian J, Karnak D, Xu L. The Bcl-2-Beclin 1 interaction in (+ )-gossypol-induced autophagy versus apoptosis in prostate cancer cells. Autophagy 2010; 6: 1201-1203.
-
(2010)
Autophagy
, vol.6
, pp. 1201-1203
-
-
Lian, J.1
Karnak, D.2
Xu, L.3
-
31
-
-
34250894388
-
BH3-only proteins and BH3 mimetics induce autophagy by competitively disrupting the interaction between Beclin 1 and Bcl-2/Bcl-X(L)
-
Maiuri MC, Criollo A, Tasdemir E, et al. BH3-only proteins and BH3 mimetics induce autophagy by competitively disrupting the interaction between Beclin 1 and Bcl-2/Bcl-X(L). Autophagy 2007; 3: 374-376.
-
(2007)
Autophagy
, vol.3
, pp. 374-376
-
-
Maiuri, M.C.1
Criollo, A.2
Tasdemir, E.3
-
32
-
-
77957681100
-
ROS-mediated mechanisms of autophagy stimulation and their relevance in cancer therapy
-
Dewaele M, Maes H, Agostinis P. ROS-mediated mechanisms of autophagy stimulation and their relevance in cancer therapy. Autophagy 2010; 6: 838-854.
-
(2010)
Autophagy
, vol.6
, pp. 838-854
-
-
Dewaele, M.1
Maes, H.2
Agostinis, P.3
-
33
-
-
34848920863
-
ROS, mitochondria and the regulation of autophagy
-
Scherz-Shouval R, Elazar Z. ROS, mitochondria and the regulation of autophagy. Trends Cell Biol 2007; 17: 422-427.
-
(2007)
Trends Cell Biol
, vol.17
, pp. 422-427
-
-
Scherz-Shouval, R.1
Elazar, Z.2
-
34
-
-
80155199811
-
Bcl-2: A prime regulator of mitochondrial redox metabolism in cancer cells
-
Low ICC, Kang J, Pervaiz S. Bcl-2: A prime regulator of mitochondrial redox metabolism in cancer cells. Antioxid Redox Signal 2011; 15: 2975-2987.
-
(2011)
Antioxid Redox Signal
, vol.15
, pp. 2975-2987
-
-
Low, I.C.C.1
Kang, J.2
Pervaiz, S.3
-
35
-
-
84859509849
-
Gossypol inhibits electron transport and stimulates ROS generation in Yarrowia lipolytica mitochondria
-
Arinbasarova AY, Medentsev AG, Krupyanko VI. Gossypol inhibits electron transport and stimulates ROS generation in Yarrowia lipolytica mitochondria. Open Biochem J 2012; 6: 11-15.
-
(2012)
Open Biochem J
, vol.6
, pp. 11-15
-
-
Arinbasarova, A.Y.1
Medentsev, A.G.2
Krupyanko, V.I.3
-
36
-
-
77955423341
-
Simultaneous induction of non-canonical autophagy and apoptosis in cancer cells by ROSdependent ERK and JNK activation
-
Wong CH, Iskandar KB, Yadav SK, et al. Simultaneous induction of non-canonical autophagy and apoptosis in cancer cells by ROSdependent ERK and JNK activation. PLoS One 2010; 5: E9996.
-
(2010)
PLoS One
, vol.5
-
-
Wong, C.H.1
Iskandar, K.B.2
Yadav, S.K.3
-
37
-
-
84863516150
-
Resveratrol enhances the antitumor effects of temozolomide in glioblastoma via ROSdependent AMPK-TSC-mTOR signaling pathway
-
Yuan Y, Xue X, Guo R-B, et al. Resveratrol enhances the antitumor effects of temozolomide in glioblastoma via ROSdependent AMPK-TSC-mTOR signaling pathway. CNS Neurosci Ther 2012; 18: 536-546.
-
(2012)
CNS Neurosci Ther
, vol.18
, pp. 536-546
-
-
Yuan, Y.1
Xue, X.2
Guo, R.-B.3
-
38
-
-
67650831206
-
Sorafenib and vorinostat kill colon cancer cells by CD95-dependent and -independent mechanisms
-
Walker T, Mitchell C, Park MA, et al. Sorafenib and vorinostat kill colon cancer cells by CD95-dependent and -independent mechanisms. Mol Pharmacol 2009; 76: 342-355.
-
(2009)
Mol Pharmacol
, vol.76
, pp. 342-355
-
-
Walker, T.1
Mitchell, C.2
Park, M.A.3
-
39
-
-
48249123422
-
M 867, a novel selective inhibitor of caspase-3 enhances cell death and extends tumor growth delay in irradiated lung cancer models
-
Kim KW, Moretti L, L u B. M 867, a novel selective inhibitor of caspase-3 enhances cell death and extends tumor growth delay in irradiated lung cancer models. PLoS One 2008; 3: E2275.
-
(2008)
PLoS One
, vol.3
-
-
Kim, K.W.1
Moretti, L.2
Lu, B.3
-
40
-
-
34848909873
-
Comparison of pharmacokinetic and metabolic profiling among gossypol, apogossypol and apogossypol hexaacetate
-
Jia L, Coward LC, Kerstner-Wood CD, et al. Comparison of pharmacokinetic and metabolic profiling among gossypol, apogossypol and apogossypol hexaacetate. Cancer Chemother Pharmacol 2008; 61: 63-73.
-
(2008)
Cancer Chemother Pharmacol
, vol.61
, pp. 63-73
-
-
Jia, L.1
Coward, L.C.2
Kerstner-Wood, C.D.3
-
41
-
-
0022560339
-
Pharmacokinetics of ( + /+)-, ( + )+, and ( + )-gossypol in humans and dogs
-
Wu DF, Yu YW, Tang ZM, et al. Pharmacokinetics of ( + /+)-, ( + )+, and ( + )-gossypol in humans and dogs. Clin Pharmacol Ther 1986; 39: 613-618.
-
(1986)
Clin Pharmacol Ther
, vol.39
, pp. 613-618
-
-
Wu, D.F.1
Yu, Y.W.2
Tang, Z.M.3
-
42
-
-
0036562428
-
The effect of N-acetyl-L-cysteine on the viscosity of ileal neobladder mucus
-
Schrier BP, Lichtendonk WJ, Witjes JA. The effect of N-acetyl-L-cysteine on the viscosity of ileal neobladder mucus. World J Urol 2002; 20: 64-67.
-
(2002)
World J Urol
, vol.20
, pp. 64-67
-
-
Schrier, B.P.1
Lichtendonk, W.J.2
Witjes, J.A.3
-
44
-
-
82855176141
-
Antioxidant N-acetyl-L-cysteine (NAC) supplementation reduces reactive oxygen species (ROS)-mediated hepatocellular tumor promotion of indole-3-carbinol (I3C) in rats
-
Shimamoto K, Hayashi H, Taniai E, et al. Antioxidant N-acetyl-L-cysteine (NAC) supplementation reduces reactive oxygen species (ROS)-mediated hepatocellular tumor promotion of indole-3-carbinol (I3C) in rats. J Toxicol Sci 2011; 36: 775-786.
-
(2011)
J Toxicol Sci
, vol.36
, pp. 775-786
-
-
Shimamoto, K.1
Hayashi, H.2
Taniai, E.3
-
45
-
-
43849084504
-
A prospective randomized study using N-acetyl-L-cysteine for early liver toxicity after allogeneic hematopoietic stem cell transplantation
-
Barkholt L, Remberger M, Hassan Z, et al. A prospective randomized study using N-acetyl-L-cysteine for early liver toxicity after allogeneic hematopoietic stem cell transplantation. Bone Marrow Transplant 2008; 41: 785-790.
-
(2008)
Bone Marrow Transplant
, vol.41
, pp. 785-790
-
-
Barkholt, L.1
Remberger, M.2
Hassan, Z.3
|