메뉴 건너뛰기




Volumn 55, Issue 6, 2012, Pages 1912-1921

Gilbert syndrome redefined: A complex genetic haplotype influences the regulation of glucuronidation

Author keywords

[No Author keywords available]

Indexed keywords

DIOXIN; ENDOTOXIN; GLUCURONOSYLTRANSFERASE 1A1; GLUCURONOSYLTRANSFERASE 1A3; GLUCURONOSYLTRANSFERASE 1A6; GLUCURONOSYLTRANSFERASE 1A7; MESSENGER RNA; PHENOBARBITAL;

EID: 84861574136     PISSN: 02709139     EISSN: 15273350     Source Type: Journal    
DOI: 10.1002/hep.25561     Document Type: Article
Times cited : (48)

References (31)
  • 1
    • 74549138787 scopus 로고    scopus 로고
    • Gilbert-Meulengracht's syndrome and pharmacogenetics: is jaundice just the tip of the iceberg?
    • Strassburg CP. Gilbert-Meulengracht's syndrome and pharmacogenetics: is jaundice just the tip of the iceberg? Drug Metab Rev 2010; 42: 162-175.
    • (2010) Drug Metab Rev , vol.42 , pp. 162-175
    • Strassburg, C.P.1
  • 2
    • 0028867826 scopus 로고
    • The genetic basis of the reduced expression of bilirubin UDP-glucuronosyltransferase 1 in Gilbert's syndrome
    • Bosma PJ, Chowdhury JR, Bakker C, Gantla S, de Boer A, Oostra BA, et al. The genetic basis of the reduced expression of bilirubin UDP-glucuronosyltransferase 1 in Gilbert's syndrome. N Engl J Med 1995; 333: 1171-1175.
    • (1995) N Engl J Med , vol.333 , pp. 1171-1175
    • Bosma, P.J.1    Chowdhury, J.R.2    Bakker, C.3    Gantla, S.4    de Boer, A.5    Oostra, B.A.6
  • 3
    • 0030030762 scopus 로고    scopus 로고
    • Genetic variation in bilirubin UPD-glucuronosyltransferase gene promoter and Gilbert's syndrome
    • Monaghan G, Ryan M, Seddon R, Hume R, Burchell B. Genetic variation in bilirubin UPD-glucuronosyltransferase gene promoter and Gilbert's syndrome. Lancet 1996; 347: 578-581.
    • (1996) Lancet , vol.347 , pp. 578-581
    • Monaghan, G.1    Ryan, M.2    Seddon, R.3    Hume, R.4    Burchell, B.5
  • 4
    • 0028276410 scopus 로고
    • Bilirubin UDP-glucuronosyltransferase 1 is the only relevant bilirubin glucuronidating isoform in man
    • erratum, J Biol Chem 1994 Oct 14;269:2542].
    • Bosma PJ, Seppen J, Goldhoorn B, Bakker C, Oude Elferink RP, Chowdhury JR, et al. Bilirubin UDP-glucuronosyltransferase 1 is the only relevant bilirubin glucuronidating isoform in man. J Biol Chem 1994; 269: 17960-17964 [erratum, J Biol Chem 1994 Oct 14;269:2542].
    • (1994) J Biol Chem , vol.269 , pp. 17960-17964
    • Bosma, P.J.1    Seppen, J.2    Goldhoorn, B.3    Bakker, C.4    Oude Elferink, R.P.5    Chowdhury, J.R.6
  • 5
    • 0031661579 scopus 로고    scopus 로고
    • UGT1A1 genotypes and glucuronidation of SN-38, the active metabolite of irinotecan
    • Ando Y, Saka H, Asai G, Sugiura S, Shimokata K, Kamataki T. UGT1A1 genotypes and glucuronidation of SN-38, the active metabolite of irinotecan. Ann Oncol 1998; 9: 845-847.
    • (1998) Ann Oncol , vol.9 , pp. 845-847
    • Ando, Y.1    Saka, H.2    Asai, G.3    Sugiura, S.4    Shimokata, K.5    Kamataki, T.6
  • 6
    • 2342459714 scopus 로고    scopus 로고
    • Genetic variants in the UDP-glucuronosyltransferase 1A1 gene predict the risk of severe neutropenia of irinotecan
    • Innocenti F, Undevia SD, Iyer L, Chen PX, Das S, Kocherginsky M, et al. Genetic variants in the UDP-glucuronosyltransferase 1A1 gene predict the risk of severe neutropenia of irinotecan. J Clin Oncol 2004; 22: 1382-1388.
    • (2004) J Clin Oncol , vol.22 , pp. 1382-1388
    • Innocenti, F.1    Undevia, S.D.2    Iyer, L.3    Chen, P.X.4    Das, S.5    Kocherginsky, M.6
  • 8
    • 0034128936 scopus 로고    scopus 로고
    • Human UDP-glucuronosyltransferases: metabolism, expression, and disease
    • Tukey RH, Strassburg CP. Human UDP-glucuronosyltransferases: metabolism, expression, and disease. Annu Rev Pharmacol Toxicol 2000; 40: 581-616.
    • (2000) Annu Rev Pharmacol Toxicol , vol.40 , pp. 581-616
    • Tukey, R.H.1    Strassburg, C.P.2
  • 9
    • 0842301047 scopus 로고    scopus 로고
    • Correlation between the UDP-glucuronosyltransferase (UGT1A1) TATAA box polymorphism and carcinogen detoxification phenotype: significantly decreased glucuronidating activity against benzo(a)pyrene-7,8-dihydrodiol(-) in liver microsomes from subjects with the UGT1A1*28 variant
    • Fang JL, Lazarus P. Correlation between the UDP-glucuronosyltransferase (UGT1A1) TATAA box polymorphism and carcinogen detoxification phenotype: significantly decreased glucuronidating activity against benzo(a)pyrene-7, 8-dihydrodiol(-) in liver microsomes from subjects with the UGT1A1*28 variant. Cancer Epidemiol Biomarkers Prev 2004; 13: 102-109.
    • (2004) Cancer Epidemiol Biomarkers Prev , vol.13 , pp. 102-109
    • Fang, J.L.1    Lazarus, P.2
  • 10
    • 77949654677 scopus 로고    scopus 로고
    • Regulation of the human bile acid UDP-glucuronosyltransferase 1A3 by the farnesoid X receptor and bile acids
    • Erichsen TJ, Aehlen A, Ehmer U, Kalthoff S, Manns MP, Strassburg CP. Regulation of the human bile acid UDP-glucuronosyltransferase 1A3 by the farnesoid X receptor and bile acids. J Hepatol 2010; 52: 570-578.
    • (2010) J Hepatol , vol.52 , pp. 570-578
    • Erichsen, T.J.1    Aehlen, A.2    Ehmer, U.3    Kalthoff, S.4    Manns, M.P.5    Strassburg, C.P.6
  • 11
    • 77949901726 scopus 로고    scopus 로고
    • Interaction between oxidative stress sensor Nrf2 and xenobiotic-activated aryl hydrocarbon receptor in the regulation of the human phase II detoxifying UDP-glucuronosyltransferase 1A10
    • Kalthoff S, Ehmer U, Freiberg N, Manns MP, Strassburg CP. Interaction between oxidative stress sensor Nrf2 and xenobiotic-activated aryl hydrocarbon receptor in the regulation of the human phase II detoxifying UDP-glucuronosyltransferase 1A10. J Biol Chem 2010; 285: 5993-6002.
    • (2010) J Biol Chem , vol.285 , pp. 5993-6002
    • Kalthoff, S.1    Ehmer, U.2    Freiberg, N.3    Manns, M.P.4    Strassburg, C.P.5
  • 12
    • 50649102122 scopus 로고    scopus 로고
    • Aryl hydrocarbon receptor (AhR)-mediated regulation of the human estrogen and bile acid UDP-Glucuronosyltransferase 1A3 gene
    • Lankisch TO, Gillman TC, Erichsen TJ, Ehmer U, Kalthoff S, Freiberg N, et al. Aryl hydrocarbon receptor (AhR)-mediated regulation of the human estrogen and bile acid UDP-Glucuronosyltransferase 1A3 gene. Arch Toxicol 2008; 82: 573-582.
    • (2008) Arch Toxicol , vol.82 , pp. 573-582
    • Lankisch, T.O.1    Gillman, T.C.2    Erichsen, T.J.3    Ehmer, U.4    Kalthoff, S.5    Freiberg, N.6
  • 13
    • 17844410900 scopus 로고    scopus 로고
    • Identification and characterization of a functional TATA box polymorphism of the UDP glucuronosyltransferase 1A7 gene
    • Lankisch TO, Vogel A, Eilermann S, Fiebeler A, Krone B, Barut A, et al. Identification and characterization of a functional TATA box polymorphism of the UDP glucuronosyltransferase 1A7 gene. Mol Pharmacol 2005; 67: 1732-1739.
    • (2005) Mol Pharmacol , vol.67 , pp. 1732-1739
    • Lankisch, T.O.1    Vogel, A.2    Eilermann, S.3    Fiebeler, A.4    Krone, B.5    Barut, A.6
  • 14
    • 64549133772 scopus 로고    scopus 로고
    • Gilbert's syndrome and hyperbilirubinemia in protease inhibitor therapy-an extended haplotype of genetic variants increases risk in indinavir treatment
    • Lankisch TO, Behrens G, Ehmer U, Mobius U, Rockstroh J, Wehmeier M, et al. Gilbert's syndrome and hyperbilirubinemia in protease inhibitor therapy-an extended haplotype of genetic variants increases risk in indinavir treatment. J Hepatol 2009; 50: 1010-1018.
    • (2009) J Hepatol , vol.50 , pp. 1010-1018
    • Lankisch, T.O.1    Behrens, G.2    Ehmer, U.3    Mobius, U.4    Rockstroh, J.5    Wehmeier, M.6
  • 15
    • 33751005307 scopus 로고    scopus 로고
    • Gilbert's disease and atazanavir: from phenotype to UDP-glucuronosyltransferase haplotype
    • Lankisch TO, Moebius U, Wehmeier M, Behrens G, Manns MP, Schmidt RE, et al. Gilbert's disease and atazanavir: from phenotype to UDP-glucuronosyltransferase haplotype. HEPATOLOGY 2006; 44: 1324-1332.
    • (2006) HEPATOLOGY , vol.44 , pp. 1324-1332
    • Lankisch, T.O.1    Moebius, U.2    Wehmeier, M.3    Behrens, G.4    Manns, M.P.5    Schmidt, R.E.6
  • 16
    • 0036101804 scopus 로고    scopus 로고
    • Polymorphisms of the UDP-glucuronosyltransferase (UGT) 1A7 gene in colorectal cancer
    • Strassburg CP, Vogel A, Kneip S, Tukey RH, Manns MP. Polymorphisms of the UDP-glucuronosyltransferase (UGT) 1A7 gene in colorectal cancer. Gut 2002; 50: 851-856.
    • (2002) Gut , vol.50 , pp. 851-856
    • Strassburg, C.P.1    Vogel, A.2    Kneip, S.3    Tukey, R.H.4    Manns, M.P.5
  • 18
    • 0032502764 scopus 로고    scopus 로고
    • Expression of the UDP-glucuronosyltransferase 1A locus in human colon. Identification and characterization of the novel extrahepatic UGT1A8
    • Strassburg CP, Manns MP, Tukey RH. Expression of the UDP-glucuronosyltransferase 1A locus in human colon. Identification and characterization of the novel extrahepatic UGT1A8. J Biol Chem 1998; 273: 8719-8726.
    • (1998) J Biol Chem , vol.273 , pp. 8719-8726
    • Strassburg, C.P.1    Manns, M.P.2    Tukey, R.H.3
  • 19
    • 55949120786 scopus 로고    scopus 로고
    • Variability and function of family 1 uridine-5'-diphosphate glucuronosyltransferases (UGT1A)
    • Strassburg CP, Kalthoff S, Ehmer U. Variability and function of family 1 uridine-5'-diphosphate glucuronosyltransferases (UGT1A). Crit Rev Clin Lab Sci 2008; 45: 485-530.
    • (2008) Crit Rev Clin Lab Sci , vol.45 , pp. 485-530
    • Strassburg, C.P.1    Kalthoff, S.2    Ehmer, U.3
  • 20
    • 63749097656 scopus 로고    scopus 로고
    • Analysis of inherited genetic variations at the UGT1 locus in the French-Canadian population
    • Menard V, Girard H, Harvey M, Perusse L, Guillemette C. Analysis of inherited genetic variations at the UGT1 locus in the French-Canadian population. Hum Mutat 2009; 30: 677-687.
    • (2009) Hum Mutat , vol.30 , pp. 677-687
    • Menard, V.1    Girard, H.2    Harvey, M.3    Perusse, L.4    Guillemette, C.5
  • 21
    • 0033789766 scopus 로고    scopus 로고
    • Structural heterogeneity at the UDP-glucuronosyltransferase 1 locus: functional consequences of three novel missense mutations in the human UGT1A7 gene
    • Guillemette C, Ritter JK, Auyeung DJ, Kessler FK, Housman DE. Structural heterogeneity at the UDP-glucuronosyltransferase 1 locus: functional consequences of three novel missense mutations in the human UGT1A7 gene. Pharmacogenetics 2000; 10: 629-644.
    • (2000) Pharmacogenetics , vol.10 , pp. 629-644
    • Guillemette, C.1    Ritter, J.K.2    Auyeung, D.J.3    Kessler, F.K.4    Housman, D.E.5
  • 22
    • 1842532189 scopus 로고    scopus 로고
    • Variation of hepatic glucuronidation: Novel functional polymorphisms of the UDP-glucuronosyltransferase UGT1A4
    • Ehmer U, Vogel A, Schutte JK, Krone B, Manns MP, Strassburg CP. Variation of hepatic glucuronidation: Novel functional polymorphisms of the UDP-glucuronosyltransferase UGT1A4. HEPATOLOGY 2004; 39: 970-977.
    • (2004) HEPATOLOGY , vol.39 , pp. 970-977
    • Ehmer, U.1    Vogel, A.2    Schutte, J.K.3    Krone, B.4    Manns, M.P.5    Strassburg, C.P.6
  • 23
    • 67650753944 scopus 로고    scopus 로고
    • Genetic polymorphisms of uptake (OATP1B1, 1B3) and efflux (MRP2, BCRP) transporters: implications for inter-individual differences in the pharmacokinetics and pharmacodynamics of statins and other clinically relevant drugs
    • Ieiri I, Higuchi S, Sugiyama Y. Genetic polymorphisms of uptake (OATP1B1, 1B3) and efflux (MRP2, BCRP) transporters: implications for inter-individual differences in the pharmacokinetics and pharmacodynamics of statins and other clinically relevant drugs. Expert Opin Drug Metab Toxicol 2009; 5: 703-729.
    • (2009) Expert Opin Drug Metab Toxicol , vol.5 , pp. 703-729
    • Ieiri, I.1    Higuchi, S.2    Sugiyama, Y.3
  • 25
    • 75549088606 scopus 로고    scopus 로고
    • The influence of SLCO1B1 (OATP1B1) gene polymorphisms on response to statin therapy
    • Romaine SP, Bailey KM, Hall AS, Balmforth AJ. The influence of SLCO1B1 (OATP1B1) gene polymorphisms on response to statin therapy. Pharmacogenomics J 2010; 10: 1-11.
    • (2010) Pharmacogenomics J , vol.10 , pp. 1-11
    • Romaine, S.P.1    Bailey, K.M.2    Hall, A.S.3    Balmforth, A.J.4
  • 26
    • 0036233667 scopus 로고    scopus 로고
    • Glucuronidation of statins in animals and humans: a novel mechanism of statin lactonization
    • Prueksaritanont T, Subramanian R, Fang X, Ma B, Qiu Y, Lin JH, et al. Glucuronidation of statins in animals and humans: a novel mechanism of statin lactonization. Drug Metab Dispos 2002; 30: 505-512.
    • (2002) Drug Metab Dispos , vol.30 , pp. 505-512
    • Prueksaritanont, T.1    Subramanian, R.2    Fang, X.3    Ma, B.4    Qiu, Y.5    Lin, J.H.6
  • 27
    • 27844536927 scopus 로고    scopus 로고
    • Tissue-specific, inducible, and hormonal control of the human UDP-glucuronosyltransferase-1 (UGT1) locus
    • Chen S, Beaton D, Nguyen N, Senekeo-Effenberger K, Brace-Sinnokrak E, Argikar U, et al. Tissue-specific, inducible, and hormonal control of the human UDP-glucuronosyltransferase-1 (UGT1) locus. J Biol Chem 2005; 280: 37547-37557.
    • (2005) J Biol Chem , vol.280 , pp. 37547-37557
    • Chen, S.1    Beaton, D.2    Nguyen, N.3    Senekeo-Effenberger, K.4    Brace-Sinnokrak, E.5    Argikar, U.6
  • 28
    • 45049084272 scopus 로고    scopus 로고
    • Genetic variability of aryl hydrocarbon receptor (AhR)-mediated regulation of the human UDP glucuronosyltransferase (UGT) 1A4 gene
    • Erichsen TJ, Ehmer U, Kalthoff S, Lankisch TO, Müller TM, Munzel PA, et al. Genetic variability of aryl hydrocarbon receptor (AhR)-mediated regulation of the human UDP glucuronosyltransferase (UGT) 1A4 gene. Toxicol Appl Pharmacol 2008; 230: 252-260.
    • (2008) Toxicol Appl Pharmacol , vol.230 , pp. 252-260
    • Erichsen, T.J.1    Ehmer, U.2    Kalthoff, S.3    Lankisch, T.O.4    Müller, T.M.5    Munzel, P.A.6
  • 29
    • 34247869082 scopus 로고    scopus 로고
    • Nrf2-Keap1 signaling pathway regulates human UGT1A1 expression in vitro and in transgenic UGT1 mice
    • Yueh MF, Tukey RH. Nrf2-Keap1 signaling pathway regulates human UGT1A1 expression in vitro and in transgenic UGT1 mice. J Biol Chem 2007; 282: 8749-8758.
    • (2007) J Biol Chem , vol.282 , pp. 8749-8758
    • Yueh, M.F.1    Tukey, R.H.2
  • 30
    • 0035029401 scopus 로고    scopus 로고
    • The phenobarbital response enhancer module in the human bilirubin UDP-glucuronosyltransferase UGT1A1 gene and regulation by the nuclear receptor CAR
    • Sugatani J, Kojima H, Ueda A, Kakizaki S, Yoshinari K, Gong QH, et al. The phenobarbital response enhancer module in the human bilirubin UDP-glucuronosyltransferase UGT1A1 gene and regulation by the nuclear receptor CAR. HEPATOLOGY 2001; 33: 1232-1238.
    • (2001) HEPATOLOGY , vol.33 , pp. 1232-1238
    • Sugatani, J.1    Kojima, H.2    Ueda, A.3    Kakizaki, S.4    Yoshinari, K.5    Gong, Q.H.6
  • 31
    • 77953126166 scopus 로고    scopus 로고
    • Combined effect of regulatory polymorphisms on transcription of UGT1A1 as a cause of Gilbert syndrome
    • Matsui K, Maruo Y, Sato H, Takeuchi Y. Combined effect of regulatory polymorphisms on transcription of UGT1A1 as a cause of Gilbert syndrome. BMC Gastroenterol 2010; 10: 57.
    • (2010) BMC Gastroenterol , vol.10 , pp. 57
    • Matsui, K.1    Maruo, Y.2    Sato, H.3    Takeuchi, Y.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.