-
1
-
-
74549138787
-
Gilbert-Meulengracht's syndrome and pharmacogenetics: is jaundice just the tip of the iceberg?
-
Strassburg CP. Gilbert-Meulengracht's syndrome and pharmacogenetics: is jaundice just the tip of the iceberg? Drug Metab Rev 2010; 42: 162-175.
-
(2010)
Drug Metab Rev
, vol.42
, pp. 162-175
-
-
Strassburg, C.P.1
-
2
-
-
0028867826
-
The genetic basis of the reduced expression of bilirubin UDP-glucuronosyltransferase 1 in Gilbert's syndrome
-
Bosma PJ, Chowdhury JR, Bakker C, Gantla S, de Boer A, Oostra BA, et al. The genetic basis of the reduced expression of bilirubin UDP-glucuronosyltransferase 1 in Gilbert's syndrome. N Engl J Med 1995; 333: 1171-1175.
-
(1995)
N Engl J Med
, vol.333
, pp. 1171-1175
-
-
Bosma, P.J.1
Chowdhury, J.R.2
Bakker, C.3
Gantla, S.4
de Boer, A.5
Oostra, B.A.6
-
3
-
-
0030030762
-
Genetic variation in bilirubin UPD-glucuronosyltransferase gene promoter and Gilbert's syndrome
-
Monaghan G, Ryan M, Seddon R, Hume R, Burchell B. Genetic variation in bilirubin UPD-glucuronosyltransferase gene promoter and Gilbert's syndrome. Lancet 1996; 347: 578-581.
-
(1996)
Lancet
, vol.347
, pp. 578-581
-
-
Monaghan, G.1
Ryan, M.2
Seddon, R.3
Hume, R.4
Burchell, B.5
-
4
-
-
0028276410
-
Bilirubin UDP-glucuronosyltransferase 1 is the only relevant bilirubin glucuronidating isoform in man
-
erratum, J Biol Chem 1994 Oct 14;269:2542].
-
Bosma PJ, Seppen J, Goldhoorn B, Bakker C, Oude Elferink RP, Chowdhury JR, et al. Bilirubin UDP-glucuronosyltransferase 1 is the only relevant bilirubin glucuronidating isoform in man. J Biol Chem 1994; 269: 17960-17964 [erratum, J Biol Chem 1994 Oct 14;269:2542].
-
(1994)
J Biol Chem
, vol.269
, pp. 17960-17964
-
-
Bosma, P.J.1
Seppen, J.2
Goldhoorn, B.3
Bakker, C.4
Oude Elferink, R.P.5
Chowdhury, J.R.6
-
5
-
-
0031661579
-
UGT1A1 genotypes and glucuronidation of SN-38, the active metabolite of irinotecan
-
Ando Y, Saka H, Asai G, Sugiura S, Shimokata K, Kamataki T. UGT1A1 genotypes and glucuronidation of SN-38, the active metabolite of irinotecan. Ann Oncol 1998; 9: 845-847.
-
(1998)
Ann Oncol
, vol.9
, pp. 845-847
-
-
Ando, Y.1
Saka, H.2
Asai, G.3
Sugiura, S.4
Shimokata, K.5
Kamataki, T.6
-
6
-
-
2342459714
-
Genetic variants in the UDP-glucuronosyltransferase 1A1 gene predict the risk of severe neutropenia of irinotecan
-
Innocenti F, Undevia SD, Iyer L, Chen PX, Das S, Kocherginsky M, et al. Genetic variants in the UDP-glucuronosyltransferase 1A1 gene predict the risk of severe neutropenia of irinotecan. J Clin Oncol 2004; 22: 1382-1388.
-
(2004)
J Clin Oncol
, vol.22
, pp. 1382-1388
-
-
Innocenti, F.1
Undevia, S.D.2
Iyer, L.3
Chen, P.X.4
Das, S.5
Kocherginsky, M.6
-
7
-
-
41549134617
-
Gilbert's syndrome and irinotecan toxicity: combination with UDP-glucuronosyltransferase 1A7 variants increases risk
-
Lankisch TO, Schulz C, Zwingers T, Erichsen TJ, Manns MP, Heinemann V, et al. Gilbert's syndrome and irinotecan toxicity: combination with UDP-glucuronosyltransferase 1A7 variants increases risk. Cancer Epidemiol Biomarkers Prev 2008; 17: 695-701.
-
(2008)
Cancer Epidemiol Biomarkers Prev
, vol.17
, pp. 695-701
-
-
Lankisch, T.O.1
Schulz, C.2
Zwingers, T.3
Erichsen, T.J.4
Manns, M.P.5
Heinemann, V.6
-
8
-
-
0034128936
-
Human UDP-glucuronosyltransferases: metabolism, expression, and disease
-
Tukey RH, Strassburg CP. Human UDP-glucuronosyltransferases: metabolism, expression, and disease. Annu Rev Pharmacol Toxicol 2000; 40: 581-616.
-
(2000)
Annu Rev Pharmacol Toxicol
, vol.40
, pp. 581-616
-
-
Tukey, R.H.1
Strassburg, C.P.2
-
9
-
-
0842301047
-
Correlation between the UDP-glucuronosyltransferase (UGT1A1) TATAA box polymorphism and carcinogen detoxification phenotype: significantly decreased glucuronidating activity against benzo(a)pyrene-7,8-dihydrodiol(-) in liver microsomes from subjects with the UGT1A1*28 variant
-
Fang JL, Lazarus P. Correlation between the UDP-glucuronosyltransferase (UGT1A1) TATAA box polymorphism and carcinogen detoxification phenotype: significantly decreased glucuronidating activity against benzo(a)pyrene-7, 8-dihydrodiol(-) in liver microsomes from subjects with the UGT1A1*28 variant. Cancer Epidemiol Biomarkers Prev 2004; 13: 102-109.
-
(2004)
Cancer Epidemiol Biomarkers Prev
, vol.13
, pp. 102-109
-
-
Fang, J.L.1
Lazarus, P.2
-
10
-
-
77949654677
-
Regulation of the human bile acid UDP-glucuronosyltransferase 1A3 by the farnesoid X receptor and bile acids
-
Erichsen TJ, Aehlen A, Ehmer U, Kalthoff S, Manns MP, Strassburg CP. Regulation of the human bile acid UDP-glucuronosyltransferase 1A3 by the farnesoid X receptor and bile acids. J Hepatol 2010; 52: 570-578.
-
(2010)
J Hepatol
, vol.52
, pp. 570-578
-
-
Erichsen, T.J.1
Aehlen, A.2
Ehmer, U.3
Kalthoff, S.4
Manns, M.P.5
Strassburg, C.P.6
-
11
-
-
77949901726
-
Interaction between oxidative stress sensor Nrf2 and xenobiotic-activated aryl hydrocarbon receptor in the regulation of the human phase II detoxifying UDP-glucuronosyltransferase 1A10
-
Kalthoff S, Ehmer U, Freiberg N, Manns MP, Strassburg CP. Interaction between oxidative stress sensor Nrf2 and xenobiotic-activated aryl hydrocarbon receptor in the regulation of the human phase II detoxifying UDP-glucuronosyltransferase 1A10. J Biol Chem 2010; 285: 5993-6002.
-
(2010)
J Biol Chem
, vol.285
, pp. 5993-6002
-
-
Kalthoff, S.1
Ehmer, U.2
Freiberg, N.3
Manns, M.P.4
Strassburg, C.P.5
-
12
-
-
50649102122
-
Aryl hydrocarbon receptor (AhR)-mediated regulation of the human estrogen and bile acid UDP-Glucuronosyltransferase 1A3 gene
-
Lankisch TO, Gillman TC, Erichsen TJ, Ehmer U, Kalthoff S, Freiberg N, et al. Aryl hydrocarbon receptor (AhR)-mediated regulation of the human estrogen and bile acid UDP-Glucuronosyltransferase 1A3 gene. Arch Toxicol 2008; 82: 573-582.
-
(2008)
Arch Toxicol
, vol.82
, pp. 573-582
-
-
Lankisch, T.O.1
Gillman, T.C.2
Erichsen, T.J.3
Ehmer, U.4
Kalthoff, S.5
Freiberg, N.6
-
13
-
-
17844410900
-
Identification and characterization of a functional TATA box polymorphism of the UDP glucuronosyltransferase 1A7 gene
-
Lankisch TO, Vogel A, Eilermann S, Fiebeler A, Krone B, Barut A, et al. Identification and characterization of a functional TATA box polymorphism of the UDP glucuronosyltransferase 1A7 gene. Mol Pharmacol 2005; 67: 1732-1739.
-
(2005)
Mol Pharmacol
, vol.67
, pp. 1732-1739
-
-
Lankisch, T.O.1
Vogel, A.2
Eilermann, S.3
Fiebeler, A.4
Krone, B.5
Barut, A.6
-
14
-
-
64549133772
-
Gilbert's syndrome and hyperbilirubinemia in protease inhibitor therapy-an extended haplotype of genetic variants increases risk in indinavir treatment
-
Lankisch TO, Behrens G, Ehmer U, Mobius U, Rockstroh J, Wehmeier M, et al. Gilbert's syndrome and hyperbilirubinemia in protease inhibitor therapy-an extended haplotype of genetic variants increases risk in indinavir treatment. J Hepatol 2009; 50: 1010-1018.
-
(2009)
J Hepatol
, vol.50
, pp. 1010-1018
-
-
Lankisch, T.O.1
Behrens, G.2
Ehmer, U.3
Mobius, U.4
Rockstroh, J.5
Wehmeier, M.6
-
15
-
-
33751005307
-
Gilbert's disease and atazanavir: from phenotype to UDP-glucuronosyltransferase haplotype
-
Lankisch TO, Moebius U, Wehmeier M, Behrens G, Manns MP, Schmidt RE, et al. Gilbert's disease and atazanavir: from phenotype to UDP-glucuronosyltransferase haplotype. HEPATOLOGY 2006; 44: 1324-1332.
-
(2006)
HEPATOLOGY
, vol.44
, pp. 1324-1332
-
-
Lankisch, T.O.1
Moebius, U.2
Wehmeier, M.3
Behrens, G.4
Manns, M.P.5
Schmidt, R.E.6
-
16
-
-
0036101804
-
Polymorphisms of the UDP-glucuronosyltransferase (UGT) 1A7 gene in colorectal cancer
-
Strassburg CP, Vogel A, Kneip S, Tukey RH, Manns MP. Polymorphisms of the UDP-glucuronosyltransferase (UGT) 1A7 gene in colorectal cancer. Gut 2002; 50: 851-856.
-
(2002)
Gut
, vol.50
, pp. 851-856
-
-
Strassburg, C.P.1
Vogel, A.2
Kneip, S.3
Tukey, R.H.4
Manns, M.P.5
-
18
-
-
0032502764
-
Expression of the UDP-glucuronosyltransferase 1A locus in human colon. Identification and characterization of the novel extrahepatic UGT1A8
-
Strassburg CP, Manns MP, Tukey RH. Expression of the UDP-glucuronosyltransferase 1A locus in human colon. Identification and characterization of the novel extrahepatic UGT1A8. J Biol Chem 1998; 273: 8719-8726.
-
(1998)
J Biol Chem
, vol.273
, pp. 8719-8726
-
-
Strassburg, C.P.1
Manns, M.P.2
Tukey, R.H.3
-
19
-
-
55949120786
-
Variability and function of family 1 uridine-5'-diphosphate glucuronosyltransferases (UGT1A)
-
Strassburg CP, Kalthoff S, Ehmer U. Variability and function of family 1 uridine-5'-diphosphate glucuronosyltransferases (UGT1A). Crit Rev Clin Lab Sci 2008; 45: 485-530.
-
(2008)
Crit Rev Clin Lab Sci
, vol.45
, pp. 485-530
-
-
Strassburg, C.P.1
Kalthoff, S.2
Ehmer, U.3
-
20
-
-
63749097656
-
Analysis of inherited genetic variations at the UGT1 locus in the French-Canadian population
-
Menard V, Girard H, Harvey M, Perusse L, Guillemette C. Analysis of inherited genetic variations at the UGT1 locus in the French-Canadian population. Hum Mutat 2009; 30: 677-687.
-
(2009)
Hum Mutat
, vol.30
, pp. 677-687
-
-
Menard, V.1
Girard, H.2
Harvey, M.3
Perusse, L.4
Guillemette, C.5
-
21
-
-
0033789766
-
Structural heterogeneity at the UDP-glucuronosyltransferase 1 locus: functional consequences of three novel missense mutations in the human UGT1A7 gene
-
Guillemette C, Ritter JK, Auyeung DJ, Kessler FK, Housman DE. Structural heterogeneity at the UDP-glucuronosyltransferase 1 locus: functional consequences of three novel missense mutations in the human UGT1A7 gene. Pharmacogenetics 2000; 10: 629-644.
-
(2000)
Pharmacogenetics
, vol.10
, pp. 629-644
-
-
Guillemette, C.1
Ritter, J.K.2
Auyeung, D.J.3
Kessler, F.K.4
Housman, D.E.5
-
22
-
-
1842532189
-
Variation of hepatic glucuronidation: Novel functional polymorphisms of the UDP-glucuronosyltransferase UGT1A4
-
Ehmer U, Vogel A, Schutte JK, Krone B, Manns MP, Strassburg CP. Variation of hepatic glucuronidation: Novel functional polymorphisms of the UDP-glucuronosyltransferase UGT1A4. HEPATOLOGY 2004; 39: 970-977.
-
(2004)
HEPATOLOGY
, vol.39
, pp. 970-977
-
-
Ehmer, U.1
Vogel, A.2
Schutte, J.K.3
Krone, B.4
Manns, M.P.5
Strassburg, C.P.6
-
23
-
-
67650753944
-
Genetic polymorphisms of uptake (OATP1B1, 1B3) and efflux (MRP2, BCRP) transporters: implications for inter-individual differences in the pharmacokinetics and pharmacodynamics of statins and other clinically relevant drugs
-
Ieiri I, Higuchi S, Sugiyama Y. Genetic polymorphisms of uptake (OATP1B1, 1B3) and efflux (MRP2, BCRP) transporters: implications for inter-individual differences in the pharmacokinetics and pharmacodynamics of statins and other clinically relevant drugs. Expert Opin Drug Metab Toxicol 2009; 5: 703-729.
-
(2009)
Expert Opin Drug Metab Toxicol
, vol.5
, pp. 703-729
-
-
Ieiri, I.1
Higuchi, S.2
Sugiyama, Y.3
-
24
-
-
49949104757
-
SLCO1B1 variants and statin-induced myopathy-a genomewide study
-
Link E, Parish S, Armitage J, Bowman L, Heath S, Matsuda F, et al. SLCO1B1 variants and statin-induced myopathy-a genomewide study. N Engl J Med 2008; 359: 789-799.
-
(2008)
N Engl J Med
, vol.359
, pp. 789-799
-
-
Link, E.1
Parish, S.2
Armitage, J.3
Bowman, L.4
Heath, S.5
Matsuda, F.6
-
25
-
-
75549088606
-
The influence of SLCO1B1 (OATP1B1) gene polymorphisms on response to statin therapy
-
Romaine SP, Bailey KM, Hall AS, Balmforth AJ. The influence of SLCO1B1 (OATP1B1) gene polymorphisms on response to statin therapy. Pharmacogenomics J 2010; 10: 1-11.
-
(2010)
Pharmacogenomics J
, vol.10
, pp. 1-11
-
-
Romaine, S.P.1
Bailey, K.M.2
Hall, A.S.3
Balmforth, A.J.4
-
26
-
-
0036233667
-
Glucuronidation of statins in animals and humans: a novel mechanism of statin lactonization
-
Prueksaritanont T, Subramanian R, Fang X, Ma B, Qiu Y, Lin JH, et al. Glucuronidation of statins in animals and humans: a novel mechanism of statin lactonization. Drug Metab Dispos 2002; 30: 505-512.
-
(2002)
Drug Metab Dispos
, vol.30
, pp. 505-512
-
-
Prueksaritanont, T.1
Subramanian, R.2
Fang, X.3
Ma, B.4
Qiu, Y.5
Lin, J.H.6
-
27
-
-
27844536927
-
Tissue-specific, inducible, and hormonal control of the human UDP-glucuronosyltransferase-1 (UGT1) locus
-
Chen S, Beaton D, Nguyen N, Senekeo-Effenberger K, Brace-Sinnokrak E, Argikar U, et al. Tissue-specific, inducible, and hormonal control of the human UDP-glucuronosyltransferase-1 (UGT1) locus. J Biol Chem 2005; 280: 37547-37557.
-
(2005)
J Biol Chem
, vol.280
, pp. 37547-37557
-
-
Chen, S.1
Beaton, D.2
Nguyen, N.3
Senekeo-Effenberger, K.4
Brace-Sinnokrak, E.5
Argikar, U.6
-
28
-
-
45049084272
-
Genetic variability of aryl hydrocarbon receptor (AhR)-mediated regulation of the human UDP glucuronosyltransferase (UGT) 1A4 gene
-
Erichsen TJ, Ehmer U, Kalthoff S, Lankisch TO, Müller TM, Munzel PA, et al. Genetic variability of aryl hydrocarbon receptor (AhR)-mediated regulation of the human UDP glucuronosyltransferase (UGT) 1A4 gene. Toxicol Appl Pharmacol 2008; 230: 252-260.
-
(2008)
Toxicol Appl Pharmacol
, vol.230
, pp. 252-260
-
-
Erichsen, T.J.1
Ehmer, U.2
Kalthoff, S.3
Lankisch, T.O.4
Müller, T.M.5
Munzel, P.A.6
-
29
-
-
34247869082
-
Nrf2-Keap1 signaling pathway regulates human UGT1A1 expression in vitro and in transgenic UGT1 mice
-
Yueh MF, Tukey RH. Nrf2-Keap1 signaling pathway regulates human UGT1A1 expression in vitro and in transgenic UGT1 mice. J Biol Chem 2007; 282: 8749-8758.
-
(2007)
J Biol Chem
, vol.282
, pp. 8749-8758
-
-
Yueh, M.F.1
Tukey, R.H.2
-
30
-
-
0035029401
-
The phenobarbital response enhancer module in the human bilirubin UDP-glucuronosyltransferase UGT1A1 gene and regulation by the nuclear receptor CAR
-
Sugatani J, Kojima H, Ueda A, Kakizaki S, Yoshinari K, Gong QH, et al. The phenobarbital response enhancer module in the human bilirubin UDP-glucuronosyltransferase UGT1A1 gene and regulation by the nuclear receptor CAR. HEPATOLOGY 2001; 33: 1232-1238.
-
(2001)
HEPATOLOGY
, vol.33
, pp. 1232-1238
-
-
Sugatani, J.1
Kojima, H.2
Ueda, A.3
Kakizaki, S.4
Yoshinari, K.5
Gong, Q.H.6
-
31
-
-
77953126166
-
Combined effect of regulatory polymorphisms on transcription of UGT1A1 as a cause of Gilbert syndrome
-
Matsui K, Maruo Y, Sato H, Takeuchi Y. Combined effect of regulatory polymorphisms on transcription of UGT1A1 as a cause of Gilbert syndrome. BMC Gastroenterol 2010; 10: 57.
-
(2010)
BMC Gastroenterol
, vol.10
, pp. 57
-
-
Matsui, K.1
Maruo, Y.2
Sato, H.3
Takeuchi, Y.4
|