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Volumn 35, Issue 3, 2012, Pages 245-250

Sex-related differences in pharmacokinetics and pharmacodynamics of anti-hypertensive drugs

Author keywords

anti hypertensive drug; pharmacodynamics; pharmacokinetics; sex differences

Indexed keywords

ALPHA HYDROXYMETOPROLOL; AMLODIPINE; ANGIOTENSIN II; ANTIHYPERTENSIVE AGENT; CARVEDILOL; CYTOCHROME P450 2D6; CYTOCHROME P450 3A4; DIGOXIN; DIPHENHYDRAMINE; ENALAPRIL; ENALAPRILAT; ERYTHROMYCIN; ESTROGEN; ESTROGEN RECEPTOR ALPHA; GLYCOPROTEIN P; HYDROCHLOROTHIAZIDE PLUS IRBESARTAN; LISINOPRIL; METOPROLOL; NORVERAPAMIL; PROPRANOLOL; TESTOSTERONE; TORASEMIDE; VALSARTAN; VERAPAMIL;

EID: 84857925482     PISSN: 09169636     EISSN: 13484214     Source Type: Journal    
DOI: 10.1038/hr.2011.189     Document Type: Review
Times cited : (59)

References (50)
  • 1
    • 53249086413 scopus 로고    scopus 로고
    • Gender differences in pharmacological response
    • Anderson GD. Gender differences in pharmacological response. Int Rev Neurobiol 2008; 83: 1-10.
    • (2008) Int Rev Neurobiol , vol.83 , pp. 1-10
    • Anderson, G.D.1
  • 2
    • 38549093710 scopus 로고    scopus 로고
    • Drug metabolism
    • Legato MJ (eds) 2nd edn, Elsevier Academic Press: San Diego
    • Schwartz JB. Drug metabolism. In Legato MJ (eds) Principles of Gender-Specific Medicine 2nd edn, Elsevier Academic Press: San Diego 2004, pp 825-829.
    • (2004) Principles of Gender-Specific Medicine , pp. 825-829
    • Schwartz, J.B.1
  • 3
    • 24344469176 scopus 로고    scopus 로고
    • Biologic and molecular mechanisms for sex differences in pharmacokinetics, pharmacodynamics, and pharmacogenetics: Part I. Workshop held at the National Institute of Health, May 4-6, 1999
    • Anthony M, Berg MJ. Biologic and molecular mechanisms for sex differences in pharmacokinetics, pharmacodynamics, and pharmacogenetics: Part I. Workshop held at the National Institute of Health, May 4-6, 1999. J Womens Health Gend Based Med 2002; 11: 601-615.
    • (2002) J Womens Health Gend Based Med , vol.11 , pp. 601-615
    • Anthony, M.1    Berg, M.J.2
  • 4
    • 33750626722 scopus 로고    scopus 로고
    • The effect of gender on the pharmacokinetics of verapamil and norverapamil in human
    • DOI 10.1002/bdd.512
    • Dadashzadeh S, Javadian B, Sadeghian S. The effect of gender on the pharmacokinetics of verapamil and norverapamil in human. Biopharm Drug Dispos 2006; 27: 329-334. (Pubitemid 44687786)
    • (2006) Biopharmaceutics and Drug Disposition , vol.27 , Issue.7 , pp. 329-334
    • Dadashzadeh, S.1    Javadian, B.2    Sadeghian, S.3
  • 6
    • 0029128788 scopus 로고
    • Age but not gender selectively affects expression of individual cytochrome P450 proteins in human liver
    • George J, Byth K, Farrell GC. Age but not gender selectively affects expression of individual cytochrome P450 proteins in human liver. Biochem Pharmacol 1995; 50: 727-730.
    • (1995) Biochem Pharmacol , vol.50 , pp. 727-730
    • George, J.1    Byth, K.2    Farrell, G.C.3
  • 8
    • 0028237729 scopus 로고
    • Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: Studies with liver microsomes of 30 Japanese and 30 Caucasians
    • Shimada T, Yamazaki H, Mimura M, Inui Y, Guengerich FP. Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians. J Pharmacol Exp Ther 1994; 270: 414-423. (Pubitemid 24229655)
    • (1994) Journal of Pharmacology and Experimental Therapeutics , vol.270 , Issue.1 , pp. 414-423
    • Shimada, T.1    Yamazaki, H.2    Mimura, M.3    Inui, Y.4    Guengerich, F.P.5
  • 9
    • 0036881095 scopus 로고    scopus 로고
    • Sex-related differences in the clearance of cytochrome P450 3A4 substrates may be caused by P-glycoprotein
    • DOI 10.1067/mcp.2002.128388
    • Cummins CL, Wu C-Y, Benet LZ. Sex-related differences in the clearance of cytochrome P450 3A4 substrates may be caused by P-glycoprotein. Clin Pharmacol Ther 2002; 72: 474-489. (Pubitemid 36237718)
    • (2002) Clinical Pharmacology and Therapeutics , vol.72 , Issue.5 , pp. 474-489
    • Cummins, C.L.1    Wu, C.-Y.2    Benet, L.Z.3
  • 10
    • 0033833913 scopus 로고    scopus 로고
    • Faster clearance of sustained release verapamil in men versus women: Continuing observations on sex-specific differences after oral administration of verapamil
    • Krecic-Shepard ME, Barnas CR, Slimko J, Schwartz JB. Faster clearance of sustained release verapamil in men versus women: continuing observations on sex-specific differences after oral administration of verapamil. Clin Pharmacol Ther 2000; 68: 286-292.
    • (2000) Clin Pharmacol Ther , vol.68 , pp. 286-292
    • Krecic-Shepard, M.E.1    Barnas, C.R.2    Slimko, J.3    Schwartz, J.B.4
  • 12
    • 0030004863 scopus 로고    scopus 로고
    • And age-related antihypertensive effects of amlodipine
    • The Amlodipine Cardiovascular Community Trial Study Group
    • Kloner RA, Sowers JR, DiBona GF, Gaffney M, Wein M. and age-related antihypertensive effects of amlodipine. The Amlodipine Cardiovascular Community Trial Study Group. Am J Cardiol 1996; 77: 713-722.
    • (1996) Am J Cardiol , vol.77 , pp. 713-722
    • Kloner, R.A.1    Sowers, J.R.2    Dibona, G.F.3    Gaffney, M.4    Wein, M.5
  • 13
    • 0024215150 scopus 로고
    • Multicenter placebo-controlled comparison of amlodipine and atenolol in mild to moderate hypertension
    • de Bruijn B, Cocco G, Tyler HM. Multicenter placebo-controlled comparison of amlodipine and atenolol in mild to moderate hypertension. J Cardiovasc Pharmacol 1988; 12 (Suppl 7): S107-S109. (Pubitemid 19014200)
    • (1988) Journal of Cardiovascular Pharmacology , vol.12 , Issue.SUPPL. 7
    • De Bruijn, B.1    Cocco, G.2    Tyler, H.M.3
  • 14
    • 0024234912 scopus 로고
    • Comparison of amlodipine and verapamil in the treatment of mild to moderate hypertension
    • Lorimer AR, Smedsrud T, Walker P, Tyler HM. Comparison of amlodipine and verapamil in the treatment of mild to moderate hypertension. J Cardiovasc Pharmacol 1988; (Suppl 7): S89-S93. (Pubitemid 19014196)
    • (1988) Journal of Cardiovascular Pharmacology , vol.12 , Issue.SUPPL. 7
    • Lorimer, A.R.1    Smedsrud, T.2    Walker, P.3    Tyler, H.M.4
  • 15
    • 30344435923 scopus 로고    scopus 로고
    • Population analyses of amlodipine in patients living in the community and patients living in nursing homes
    • DOI 10.1016/j.clpt.2005.09.007, PII S0009923605004157
    • Kang D, Verotta D, Schwartz JB. Population analyses of amlodipine in patients living in the community and patients living in nursing homes. Clin Pharmacol Ther 2006; 79: 114-124. (Pubitemid 43069583)
    • (2006) Clinical Pharmacology and Therapeutics , vol.79 , Issue.1 , pp. 114-124
    • Kang, D.1    Verotta, D.2    Schwartz, J.B.3
  • 16
    • 7944235868 scopus 로고    scopus 로고
    • Age and gender effects on the pharmacokinetics and pharmacodynamics of triazolam, a cytochrome P450 3A substrate
    • DOI 10.1016/j.clpt.2004.07.009, PII S0009923604002437
    • Greenblatt DJ, Harmatz JS, von Moltke LL, Wright CE, Shader RI. Age and gender effects on the pharmacokinetics and pharmacodynamics of triazolam, a cytochrome P450 3A substrate. Clin Pharmacol Ther 2004; 76: 467-479. (Pubitemid 39469870)
    • (2004) Clinical Pharmacology and Therapeutics , vol.76 , Issue.5 , pp. 467-479
    • Greenblatt, D.J.1    Harmatz, J.S.2    Von Moltke, L.L.3    Wright, C.E.4    Shader, R.I.5
  • 20
    • 40849120838 scopus 로고    scopus 로고
    • Sex differences in the pressor response to angiotensin II when the endogenous renin-angiotensin system is blocked
    • DOI 10.1161/HYPERTENSIONAHA.107.106922
    • Sartori-Valinotti JC, Iliescu R, Yanes LL, Dorsett-Martin W, Reckelhoff JF. Sex differences in the pressor response to angiotensin II when the endogenous renin-angiotensin system is blocked. Hypertension 2008; 51: 1170-1176. (Pubitemid 351398978)
    • (2008) Hypertension , vol.51 , Issue.4 PART 2 , pp. 1170-1176
    • Sartori-Valinotti, J.C.1    Iliescu, R.2    Yanes, L.L.3    Dorsett-Martin, W.4    Reckelhoff, J.F.5
  • 22
    • 79959357776 scopus 로고    scopus 로고
    • The contribution of ARB to medical treatment
    • Saruta T. The contribution of ARB to medical treatment. Nippon Rinsho 2009; 67: 662-667.
    • (2009) Nippon Rinsho , vol.67 , pp. 662-667
    • Saruta, T.1
  • 23
    • 77955444046 scopus 로고    scopus 로고
    • Cardiovascular outcome of an angiotensin II receptor blocker, candesartan, in Japan
    • Suzuki H, Araki R. Cardiovascular outcome of an angiotensin II receptor blocker, candesartan, in Japan. Drugs Today (Barc) 2010; 46: 427-431.
    • (2010) Drugs Today (Barc) , vol.46 , pp. 427-431
    • Suzuki, H.1    Araki, R.2
  • 24
    • 40049101028 scopus 로고    scopus 로고
    • Predictors of blood pressure response to angiotensin receptor blocker/diuretic combination therapy: A secondary analysis of the irbesartan/hydrochlorothiazide blood pressure reductions in diverse patient populations (INCLUSIVE) study
    • Saunders E, Cable G, Neutel J. Predictors of blood pressure response to angiotensin receptor blocker/diuretic combination therapy: a secondary analysis of the irbesartan/hydrochlorothiazide blood pressure reductions in diverse patient populations (INCLUSIVE) study. J Clin Hypertens (Greenwich) 2008; 10: 27-33.
    • (2008) J Clin Hypertens (Greenwich) , vol.10 , pp. 27-33
    • Saunders, E.1    Cable, G.2    Neutel, J.3
  • 25
    • 29844447525 scopus 로고    scopus 로고
    • Cardiovascular alteration and treatment of hypertension: Do men and women differ?
    • DOI 10.1385/ENDO:28:2:199
    • McBride SM, Flynn FW, Ren J. Cardiovascular alteration and treatment of hypertension: do men and women differ? Endocrine 2005; 28: 199-207. (Pubitemid 43037681)
    • (2005) Endocrine , vol.28 , Issue.2 , pp. 199-207
    • McBride, S.M.1    Flynn, F.W.2    Ren, J.3
  • 26
    • 84871122193 scopus 로고    scopus 로고
    • AVAPRO and AVALIDE: Hypertension treatment. Full Prescribing Information for AVALIDEs (irbesartan-hydrochlorothiazide) (accessed 2 May 2011)
    • Bristol-Myers Squibb. AVAPRO and AVALIDE: Hypertension treatment. Full Prescribing Information for AVALIDEs (irbesartan-hydrochlorothiazide). http://packageinserts.bms. com/pi/pi-avalide.pdf (accessed 2 May 2011).
    • Bristol-Myers Squibb
  • 28
    • 43549096857 scopus 로고    scopus 로고
    • Combination therapy versus monotherapy as initial treatment for stage 2 hypertension: A prespecified subgroup analysis of a community-based, randomized, open-label trial
    • DOI 10.1016/j.clinthera.2008.04.013, PII S0149291808001525
    • Everett BM, Glynn RJ, Danielson E, Ridker PM. Combination therapy versus monotherapy as initial treatment for stage 2 hypertension: a prespecified subgroup analysis of a community-based, randomized, open-label trial. Clin Ther 2008; 30: 661-672. (Pubitemid 351680499)
    • (2008) Clinical Therapeutics , vol.30 , Issue.4 , pp. 661-672
    • Everett, B.M.1    Glynn, R.J.2    Danielson, E.3    Ridker, P.M.4
  • 29
    • 2042419003 scopus 로고    scopus 로고
    • Gender Differences in Angiotensin-Converting Enzyme (ACE) Activity and Inhibition by Enalaprilat in Healthy Volunteers
    • DOI 10.1097/00005344-200405000-00018
    • Zapater P, Novalbos J, Gallego-Sandín S, Hernández FT, Abad-Santos F. Gender differences in angiotensin-converting enzyme (ACE) activity and inhibition by enalaprilat in healthy volunteers. J Cardiovasc Pharmacol 2004; 43: 737-744. (Pubitemid 38534076)
    • (2004) Journal of Cardiovascular Pharmacology , vol.43 , Issue.5 , pp. 737-744
    • Zapater, P.1    Novalbos, J.2    Gallego-Sandin, S.3    Hernandez, F.T.4    Abad-Santos, F.5
  • 30
    • 2642513916 scopus 로고    scopus 로고
    • Gender difference in the response to an angiotensin-converting enzyme inhibitor and a diuretic in hypertensive patients of African descent
    • DOI 10.1097/00004872-200406000-00023
    • lconnet C, Bochud M, Bovet P, Maillard M, Burnier M. Gender difference in the response to an angiotensin-converting enzyme inhibitor and a diuretic in hypertensive patients of African descent. J Hypertens 2004; 22: 1213-1220. (Pubitemid 38721013)
    • (2004) Journal of Hypertension , vol.22 , Issue.6 , pp. 1213-1220
    • Falconnet, C.1    Bochud, M.2    Bovet, P.3    Maillard, M.4    Burnier, M.5
  • 31
    • 41749092325 scopus 로고    scopus 로고
    • Sex and the renin-angiotensin system: Inequality between the sexes in response to RAS stimulation and inhibition
    • DOI 10.1152/ajpregu.00864.2007
    • Sullivan JC. Sex and the renin-angiotensin system: inequality between the sexes in response to RAS stimulation and inhibition. Am J Physiol Regul Integr Comp Physiol 2008; 294: R1220-R1226. (Pubitemid 351490641)
    • (2008) American Journal of Physiology - Regulatory Integrative and Comparative Physiology , vol.294 , Issue.4
    • Sullivan, J.C.1
  • 32
    • 27644579447 scopus 로고    scopus 로고
    • Angiotensin-converting enzyme inhibition increases basal vascular tissue plasminogen activator release in women but not in men
    • DOI 10.1161/01.ATV.0000186185.13977.94
    • Pretorius M, Luther JM, Murphey LJ, Vaughan DE, Brown NJ. Angiotensin-converting enzyme inhibition increases basal vascular tissue plasminogen activator release in women but not in men. Arterioscler Thromb Vasc Biol 2005; 25: 2435-2440. (Pubitemid 41552667)
    • (2005) Arteriosclerosis, Thrombosis, and Vascular Biology , vol.25 , Issue.11 , pp. 2435-2440
    • Pretorius, M.1    Luther, J.M.2    Murphey, L.J.3    Vaughan, D.E.4    Brown, N.J.5
  • 33
    • 41949120397 scopus 로고    scopus 로고
    • Determinants of steady-state torasemide pharmacokinetics: Impact of pharmacogenetic factors, gender and angiotensin II receptor blockers
    • DOI 10.2165/00003088-200847050-00003
    • Werner D, Werner U, Meybaum A, Schmidt B, Umbreen S, Grosch A, Lestin HG, Graf B, Zolk O, Fromm MF. Determinants of steady-state torasemide pharmacokinetics: impact of pharmacogenetic factors, gender and angiotensin II receptor blockers. Clin Pharmacokinet 2008; 47: 323-332. (Pubitemid 351508118)
    • (2008) Clinical Pharmacokinetics , vol.47 , Issue.5 , pp. 323-332
    • Werner, D.1    Werner, U.2    Meybaum, A.3    Schmidt, B.4    Umbreen, S.5    Grosch, A.6    Lestin, H.G.7    Graf, B.8    Zolk, O.9    Fromm, M.F.10
  • 34
    • 0036446611 scopus 로고    scopus 로고
    • Effects of gender on the pharmacokinetics of drugs secreted by the renal organic anions transport systems in the rat
    • DOI 10.1006/phrs.2001.0912
    • Cerrutti JA, Quaglia NB, Brandoni A, Torres AM. Effects of gender on the pharmacokinetics of drugs secreted by the renal organic anions transport systems in the rat. Pharmacol Res 2002; 45: 107-112. (Pubitemid 35428844)
    • (2002) Pharmacological Research , vol.45 , Issue.2 , pp. 107-112
    • Cerrutti, J.A.1    Quaglia, N.B.2    Brandoni, A.3    Torres, A.M.4
  • 35
    • 0037275143 scopus 로고    scopus 로고
    • The influence of sex on pharmacokinetics
    • DOI 10.2165/00003088-200342020-00001
    • Schwartz JB. The influence of sex on pharmacokinetics. Clin Pharmacokinet 2003; 42: 107-121. (Pubitemid 36188552)
    • (2003) Clinical Pharmacokinetics , vol.42 , Issue.2 , pp. 107-121
    • Schwartz, J.B.1
  • 37
    • 0020078179 scopus 로고
    • A randomized trial of propranolol in patients with acute myocardial infarction. I. Mortality results
    • b-Blocker Heart Attack Trial Research Group
    • b-Blocker Heart Attack Trial Research Group. A randomized trial of propranolol in patients with acute myocardial infarction. I. Mortality results. JAMA 1982; 247: 1707-1714.
    • (1982) JAMA , vol.247 , pp. 1707-1714
  • 39
    • 33749184189 scopus 로고    scopus 로고
    • The anti-ischemic effect of metoprolol in patients with chronic angina pectoris is gender-specific
    • DOI 10.1159/000092769
    • Cocco G, Chu D. The anti-ischemic effect of metoprolol in patients with chronic angina pectoris is gender-specific. Cardiology 2006; 106: 147-153. (Pubitemid 44474982)
    • (2006) Cardiology , vol.106 , Issue.3 , pp. 147-153
    • Cocco, G.1    Chu, D.2
  • 40
    • 0021082394 scopus 로고
    • Differential stereoselective metabolism of metoprolol in extensive and poor debrisoquin metabolizers
    • Lennard MS, Tucker GT, Silas JH, Freestone S, Ramsay LE, Woods HF. Differential stereoselective metabolism of metoprolol in extensive and poor debrisoquin metabolizers. Clin Pharmacol Ther 1983; 34: 732-737. (Pubitemid 14219918)
    • (1983) Clinical Pharmacology and Therapeutics , vol.34 , Issue.6 , pp. 732-737
    • Lennard, M.S.1    Tucker, G.T.2    Silas, J.H.3
  • 41
    • 0034074170 scopus 로고    scopus 로고
    • Significant interaction between the nonprescription antihistamine diphenhydramine and the CYP2D6 substrate metoprolol in healthy men with high or low CYP2D6 activity
    • Hamelin BA, Bouayad A, Méthot J, Jobin J, Desgagnés P, Poirier P, Allaire J, Dumesnil J, Turgeon J. Significant interaction between the nonprescription antihistamine diphenhydramine and the CYP2D6 substrate metoprolol in healthy men with high or low CYP2D6 activity. Clin Pharmacol Ther 2000; 67: 466-477. (Pubitemid 30327485)
    • (2000) Clinical Pharmacology and Therapeutics , vol.67 , Issue.5 , pp. 466-477
    • Hamelin, B.A.1    Bouayad, A.2    Methot, J.3    Jobin, J.4    Desgagnes, P.5    Poirier, P.6    Allaire, J.7    Dumesnil, J.8    Turgeon, J.9
  • 44
    • 0029121788 scopus 로고
    • Sex differences in pharmacokinetics of oral propranolol in healthy Chinese volunteers
    • Xie HG, Chen X. Sex differences in pharmacokinetics of oral propranolol in healthy Chinese volunteers. Zhongguo Yao Li Xue Bao 1995; 16: 468-470.
    • (1995) Zhongguo Yao Li Xue Bao , vol.16 , pp. 468-470
    • Xie, H.G.1    Chen, X.2
  • 45
    • 0024325077 scopus 로고
    • Pathway-selective sex differences in the metabolic clearance of propranolol in human subjects
    • Walle T, Walle UK, Cowart TD, Conradi EC. Pathway-selective sex differences in the metabolic clearance of propranolol in human subjects. Clin Pharmacol Ther 1989; 46: 257-263. (Pubitemid 19254757)
    • (1989) Clinical Pharmacology and Therapeutics , vol.46 , Issue.3 , pp. 257-263
    • Walle, T.1    Walle, U.K.2    Cowart, T.D.3    Conradi, E.C.4
  • 47
    • 33745684838 scopus 로고    scopus 로고
    • Influence of carvedilol on serum digoxin levels in heart failure: Is there any gender difference?
    • Baris N, Kalkan S, Güneri S, Bozdemir V, Guven H. Influence of carvedilol on serum digoxin levels in heart failure: is there any gender difference? Eur J Clin Pharmacol 2006; 62: 535-538.
    • (2006) Eur J Clin Pharmacol , vol.62 , pp. 535-538
    • Baris, N.1    Kalkan, S.2    Güneri, S.3    Bozdemir, V.4    Guven, H.5
  • 48
    • 0036290013 scopus 로고    scopus 로고
    • How important are gender differences in pharmacokinetics?
    • Meibohm B, Beierle I, Derendorf H. How important are gender differences in pharmacokinetics? Clin Pharmacokinet 2002; 41: 329-342. (Pubitemid 34713088)
    • (2002) Clinical Pharmacokinetics , vol.41 , Issue.5 , pp. 329-342
    • Meibohm, B.1    Beierle, I.2    Derendorf, H.3
  • 49
    • 18444414855 scopus 로고    scopus 로고
    • Pharmacokinetic characterization of transcellular transport and drug interaction of digoxin in Caco-2 cell monolayers
    • DOI 10.1248/bpb.28.114
    • Aiba T, Ishida K, Yoshinaga M, Okuno M, Hashimoto Y. Pharmacokinetic characterization of transcellular transport and drug interaction of digoxin in Caco-2 cell monolayers. Biol Pharm Bull 2005; 28: 114-119. (Pubitemid 40879794)
    • (2005) Biological and Pharmaceutical Bulletin , vol.28 , Issue.1 , pp. 114-119
    • Aiba, T.1    Ishida, K.2    Yoshinaga, M.3    Okuno, M.4    Hashimoto, Y.5
  • 50
    • 0037083941 scopus 로고    scopus 로고
    • Interaction of digoxin with antihypertensive drugs via MDR1
    • DOI 10.1016/S0024-3205(01)01494-1, PII S0024320501014941
    • Takara K, Kakumoto M, Tanigawara Y, Funakoshi J, Sakaeda T, Okumura K. Interaction of digoxin with antihypertensive drugs via MDR1. Life Sci 2002; 70: 1491-1500. (Pubitemid 34164543)
    • (2002) Life Sciences , vol.70 , Issue.13 , pp. 1491-1500
    • Takara, K.1    Kakumoto, M.2    Tanigawara, Y.3    Funakoshi, J.4    Sakaeda, T.5    Okumura, K.6


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