In-vitro maintenance and functionality of primary renal tubules and their application in the study of relative renal toxicity of nephrotoxic drugs

Journal of Pharmacological and Toxicological Methods

Volumn 68, Issue 2, 2013, Pages 269-274

  Xu, Jinsheng ^a   Patton, David ^a   Jackson, Simon K ^b   Purcell, Wendy M ^b  

^a UNIVERSITY OF THE WEST OF ENGLAND   (United Kingdom)

^b UNIVERSITY OF PLYMOUTH   (United Kingdom)

Author keywords

CSIT; Cytochrome P450 1A1; Galactose; Kidney glucose; Pyruvate; Renal tubule aggregate

Indexed keywords

CYTOCHROME P450 1A1; GALACTOSE; GLUCOSE; PYRUVIC ACID;

ANIMAL TISSUE; ARTICLE; CELL SPREADING; CONTROLLED STUDY; ENZYME ACTIVITY; IN VITRO STUDY; KIDNEY FUNCTION; KIDNEY METABOLISM; KIDNEY TUBULE; KIDNEY TUBULE CELL; MALE; MIGRATION INHIBITION; NEPHROTOXICITY; NONHUMAN; ORGAN CULTURE TECHNIQUE; RAT;

RATTUS;

CSIT; CYTOCHROME P450 1A1; GALACTOSE; KIDNEY GLUCOSE; PYRUVATE; RENAL TUBULE AGGREGATE;

ANIMALS; CYTOCHROME P-450 CYP1A1; GALACTOSE; GLUCOSE; KIDNEY TUBULES; MALE; PYRUVIC ACID; RATS; RATS, WISTAR; TIME FACTORS; TOXICITY TESTS;

EID: 84884416299     PISSN: 10568719     EISSN: 1873488X     Source Type: Journal    
DOI: 10.1016/j.vascn.2013.02.007     Document Type: Article

References (31)

1. Boogaard P.J., Zoetewer J.P., van Berkel T.J.C., Noordende J.M.V., Mulder G.J., Nagelkerke J.F. Primary culture of proximal tubular cells from normal rat kidney as in vitro model to study mechanisms of nephrotoxicicity: Toxicity of nephrotoxicants at low concentrations during prolonged exposure. Biochemistry and Pharmacology 1990, 39:1335-1345.
2. Bruggeman I.M., Mertens W.M., Temmink J.H.M., Lans M.C., Vos R.M.E., van Bladeren P.J. Use of monolayers of primary rat kidney cortex cells for nephrotoxicity studies. Toxicology in Vitro 1989, 3:261-269.
3. Burke M.D., Richard T.M. Ethoxyresorufin: Direct fluorimetric assay of a microsomal O-dealkylation which is preferentially inducible by 3-methylcholanthrene. Drug Metabolism and Disposition 1974, 2:583-588.
4. Chahwala S.B., Harpur E.S. The use of renal tubule fragments isolated from the rat to investigate aspects of gentamicin nephrotoxicity. Journal of Pharmacological Methods 1986, 15:21-34.
5. Chen J., Meyerhof D.P., Tracy B.L. Model results of kidney burdens from uranium intakes. Health Physics 2004, 86:3-11.
6. Giorgi M., Marini S., Longo V., Mazzaccaro A., Amato G., Gervasi P.G. Cytochrome P450-dependent monooxygenase activities and their inducibility by classic P450 inducers in the liver, kidney, and nasal mucosa of male adult ring-necked pheasants. Toxicology and Applied Pharmacology 2000, 167:237-245.
7. Gonzalez R.J., Tarloff J.B. Expression and activities of several drug-metabolizing enzymes in LLC-PK1 cells. Toxicology In Vitro 2004, 18:887-894.
8. Heidenreich R.A., Mallee J., Rogers S., Segal S. Developmental and tissue-specific modulation of rat galactose-1-phosphate uridyltransferase steady state messenger RNA and specific activity levels. Pediatric Research 1994, 34:416-419.
9. Junqueira L.C., Carneiro J., Kelley R.O. Basic histology 1989, Prentice-Hall International (UK) Ltd., London. 6th ed.
10. Khatsenko O.G., Barteneva N.S., De La Maza L.M., Kikkawa Y. Role of nitric oxide in the inhibition of cytochrome P450 in the liver of mice infected with Chlamydia trachomatis. Biochemistry and Pharmacology 1998, 55:1835-1842.
11. Kintzel P.E., Dorrt R.T. Anticancer drug renal toxicity and elimination: dosing guidelines for altered renal function. Cancer Treatment Reviews 1995, 21:33-64.
12. Königs M., Lenczyk M., Schwerdt G., Holzinger H., Gekle M., Humpf H.-U. Cytotoxicity, metabolism and cellular uptake of the mycotoxin deoxynivalenol in human proximal tubule cells and lung fibroblasts in primary culture. Toxicology 2007, 240:48-59.
13. L'Azou B., Henge-Napoli M.H., Minaro L., Mirto H., Barrouillet M.P., Cambar J. Effects of cadmium and uranium on some in vitro renal targets. Cell Biology and Toxicology 2002, 18:329-340.
14. López-García M.P. Endogenous nitric oxide is responsible for the early loss of P450 in cultured rat hepatocytes. FEBS Letters 1998, 438:145-149.
15. Ma M., Xu J., Purcell W.M. Biochemical and functional changes of rat liver spheroids during spheroid formation and maintenance in culture: I. Morphological maturation and kinetic changes of energy metabolism, albumin synthesis and activities of some enzymes. Journal of Cellular Biochemistry 2003, 90:1166-1175.
16. McGuinness S., Gandolfi A.J., Brendel K. Use of renal tubule suspensions for in vitro toxicity studies. Toxicology in Vitro 1993, 6:1-24.
17. Raza H., John A., Lakhani M.S., Ahmed I., Montague W. Multiplicity and tissue specific expression of camel cytochrome P450(s). Comparative Biochemistry and Physiology. C 1998, 121:205-211.
18. Schwartzman M.L., McGiff J.C. Renal cytochrome P450. Journal of Lipid Mediators and Cell Signalling 1995, 12:229-242.
19. Stevens A., Lowe J. Human histology 1998, Mosby, London. 2nd ed.
20. Stumvoll M., Meyer C., Gerich J.E. Important role of the kidney in human carbohydrate metabolism. Medical Hypotheses 1999, 52:363-366.
21. Stumvoll M., Meyer C., Mitrakou, Nadkarni V., Gerich J.E. Renal glucose production and utilization: New aspects in humans. Diabetologia 1997, 40:749-757.
22. Stumvoll M., Welle S., Chintalapudi U., Perriello G., Gutierrez O., Gerich J. Uptake and release of glucose by the human kidney: Postabsorptive rates and responses to epinephrine. Journal of Clinical Investigation 1995, 96:2528-2533.
23. Tang M., Odejinmi S.I., Vankayalapati H., Wierenga K.J., Lai K. Innovative therapy for classic galactosemia - Tale of two HTS. Molecular Genetics and Metabolism 2012, 105:44-55.
24. Xu J., Jackson S.K. Current considerations in model and high throughput drug safety screening testing. Mini-Review in Medical Chemistry 2009, 9:861-868.
25. Xu J., Ma M., Purcell W.M. Optimising the enzymatic determination of galactose in the culture media of rat liver and Hepg2 cell spheroids. Analytical Biochemistry 2002, 311:179-181.
26. Xu J., Ma M., Purcell W.M. Biochemical and functional changes of rat liver spheroids during spheroid formation and maintenance in culture: II. Nitric oxide synthesis and related changes. Journal of Cellular Biochemistry 2003, 90:1176-1185.
27. Xu J., Ma M., Purcell W.M. Characterisation of some cytotoxic endpoints using rat liver and Hepg2 spheroids as in vitro models and their application in hepatotoxicity studies: I. glucose metabolism and enzyme release as cytotoxic markers. Toxicology and Applied Pharmacology 2003, 189:100-111.
28. Xu J., Ma M., Purcell W.M. Characterisation of some cytotoxic endpoints using rat liver and Hepg2 spheroids as in vitro models and their application in hepatotoxicity studies: II. Spheroid cell spreading inhibition as a new cytotoxic marker. Toxicology and Applied Pharmacology 2003, 189:112-119.
29. Xu J., Purcell M.W. Energy metabolism and transformation as endpoints to screen hepatotoxicity using a liver spheroid model. Toxicology and Applied Pharmacology 2006, 216:293-302.
30. Zhang H., Tasnim F., Ying J.Y., Zink D. The impact of extracellular matrix coatings on the performance of human renal cells applied in bioartificial kidneys. Biomaterials 2009, 30:2899-2911.
31. Zorzoli A. Gluconeogenesis in mouse kidney cortex: II. Glucose production and enzyme activities in newborn and early postnatal animals. Developmental Biology 1968, 17:400-441.