Multiplicity and tissue specific expression of camel cytochrome P450(s)

Comparative Biochemistry and Physiology - C Pharmacology Toxicology and Endocrinology

Volumn 121, Issue 1-3, 1998, Pages 205-211

  Raza, Haider ^a   John, Annie ^a   Lakhani, Mohammad S ^a   Ahmed, Ijaz ^a   Montague, William ^a  

^a UNITED ARAB EMIRATES UNIVERSITY   (United Arab Emirates)

Author keywords

Camel tissues; Cytochrome P450 isoenzymes; Xenobiotic metabolism

Indexed keywords

AMINOPHENAZONE; ANILINE; ANTIBODY; BENZO[A]PYRENE; CYTOCHROME P450; ETHOXYCOUMARIN; ETHOXYRESORUFIN; LAURIC ACID; UNSPECIFIC MONOOXYGENASE; XENOBIOTIC AGENT;

ANIMAL TISSUE; ARTICLE; BRAIN; CAMEL; CENTRAL VEIN; ENZYME ACTIVITY; HYDROXYLATION; IMMUNOCHEMISTRY; INTESTINE; KIDNEY; LIVER MICROSOME; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANIMALS; BRAIN; CAMELS; CATALYSIS; CYTOCHROME P-450 ENZYME SYSTEM; HUMANS; IMMUNOHISTOCHEMISTRY; KIDNEY; LIVER; RATS;

EID: 0031738747     PISSN: 07428413     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0742-8413(98)10041-5     Document Type: Article

References (27)

1. Baron J., Redick J.A., Guengerich F.P. An immunohistochemical study on the localizations and distribution of phenobarbital and 3-methylcholanthrene-inducible cytochromes P450 within the livers of untreated rats. J Biol Chem. 256:1981;5931-5937.
2. Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem. 72:1976;248-254.
3. Buhler R., Lindros K.O., Nordling A., Johansson I., Ingelman-Sundberg M. Zonation of cytochrome P450 isoenzyme expression and induction in rat liver. Eur J Biochem. 204:1992;407-412.
4. Cochin J., Axelrod J.J. Biochemical pharmacological changes in the rat following chronic administration of morphine, nalorphine and morphine. J Pharmacol Exp Ther. 125:1959;105-110.
5. Debri K., Boobis A.R., Davies D.S., Edwards R.J. Distribution and induction of CYP3A1 and 3 A2 in rat liver and extrahepatic tissues. Biochem Pharmacol. 50:1995;2047-2056.
6. Dignam J.D., Strobel H.W. NADPH-cytochrome P450 reductase from rat liver. Purification by affinity chromatography and characterization. Biochemistry. 17:1977;1116-1123.
7. Elsheikh H.A., Ali B.H., Homeida A.M., Hapke H.J. Activities of glutathione S-transferase and ethoxy coumarin-O-deethylase in tissues of camels, sheep goats and rats. Comp Biochem Physiol. 98C:1991;293-297.
8. Foster J.R., Elcombe C.R., Boobis A.R., Davis D.S., Sesardic D., McQuade J., Robson R.T., Hayward C., Lock E.A. Immunocytochemical localization of cytochrome P450 in hepatic and extrahepatic tissues of the rat with a monoclonal antibody against cytochrome P450c. Biochem Pharmacol. 35:1986;4543-4554.
9. Gonzalez F.J. Human cytochrome P450: problems and prospects. TIPS. 13:1992;346-352.
10. Greenlee W.F., Poland A. An improved assay of 7-ethoxycoumarin-O-deethylase activity. Induction of hepatic enzyme by phenobarbital, 3-methylcholanthrene and 2,3,7,8-tetrachlorodibenzo-p-dioxin. J Pharmacol Exp Ther. 205:1978;596-605.
11. Guarino A.M., Gram T.E., Gigon P.L., Greene F.E., Gillette J.R. Changes in Mechaelis and spectral constants for aniline in hepatic microsomes from phenobarbital-treated rats. Mol Pharmacol. 5:1969;131-136.
12. Guengerich F.P. Enzymatic oxidation of xenobiotic chemical. Crit Rev Biochem Mol Biol. 25:1990;97-153.
13. Guengerich F.P. Reactions and significance of cytochrome P450 enzymes. J Biol Chem. 26:1991;10019-10022.
14. Guengerich F.P. Bioactivation and detoxification of toxic and carcinogenic chemicals. The 1992 B.B. Brodie award lecture. Drug Metabol Dispos. 21:1993;1-6.
15. Laemmli U.K. Cleavage of structural protein during the assembly of the head bacteriophage T4. Nature. 227:1970;680-685.
16. Murray G.I., Burke M.D. Immunohistochemistry of drug metabolizing enzymes. Biochem Pharmacol. 50:1995;895-903.
17. Nebert D.W., Gelboin H.V. Substrate-inducible microsomal aryl hydroxylase in mammalian cell culture. I. Assay and properties of induced enzyme. J Biol Chem. 243:1968;6242-6249.
18. Okey A.B. Enzyme induction in the cytochrome P450 system. Pharmacol Ther. 45:1990;241-298.
19. Omura T., Sato R. The carbon monoxide binding pigment of liver microsomes I Evidence for its hemoprotein nature. J Biol Chem. 239:1964;2370-2378.
20. Parker GL, Orton TC Induction by oxyisobutyrates of hepatic and kidney microsomal cytochrome P450 with specificity towards hydroxylation of fatty acids. In: Gustafsson JA, Duke J-C, Mode A, Rafter J, editors. Biochemistry, Biophysics and Regulation of Cytochrome P450, Amsterdam: Elsevier, 1980: 373-377.
21. Pohl R.J., Fouts J.R. A rapid method for assaying the metabolism of 7-ethoxyresorufin by microsomal subcellular fraction. Anal Biochem. 107:1980;150-155.
22. Raza H., Montague W. Drug and xenobiotic metabolising enzymes in camel liver. Multiple forms and species specific expression. Comp Biochem Physiol. 104C:1993;137-145.
23. Raza H., Montague W. Metabolism of benzo(a)pyrene, dimethylbenzanthracene and aflotoxin B1 by camel liver microsomes. Comp Biochem Physiol. 107C:1994;379-386.
24. Ryan D.E., Levin W. Purification and characterization of hepatic cytochrome P450. Pharmacol Ther. 45:1990;153-239.
25. Towbin H., Staehelin R., Gordon J. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets. Procedure and some applications. Proc Natl Acad Sci USA. 76:1970;4350-4354.
26. Yang CS, Smith TJ, Hong JY. Cytochrome P450 enzyme as targets for chemoprevention against chemical carcinogenesis and toxicity: opportunities and limitations. Cancer Res (suppl) 54: 1994: 1982-1986.
27. Zamboni L., Demartino C. Buffered picric acid-formaldehyde: a new, rapid fixative for electron microscopy. J Cell Biol. 35:1967;148A.