Engineering a local microenvironment for pancreatic islet replacement

Current Opinion in Biotechnology

Volumn 24, Issue 5, 2013, Pages 900-908

  Coronel, Maria M ^a,b   Stabler, Cherie L ^a,b  

^a University of Miami College of Engineering   (United States)

^b UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CRITICAL COMPONENT; FUNCTIONALIZATIONS; ISLET TRANSPLANTATION; ISOLATION PROCESS; MICROENVIRONMENTS; NUTRITIONAL PROFILES; PANCREATIC ISLET; TYPE 1 DIABETES MELLITUS;

BIOLOGICAL MATERIALS; SITE SELECTION;

BIOMATERIALS;

HYPOXIA INDUCIBLE FACTOR 1ALPHA; INSULIN; POLYGLACTIN; TISSUE SCAFFOLD; VASCULOTROPIN;

CELL INTERACTION; EXTRACELLULAR MATRIX; HUMAN; INSULIN RELEASE; MATERIAL STATE; MESENCHYMAL STEM CELL; NONHUMAN; OXYGEN TENSION; PANCREAS ISLET CELL FUNCTION; PANCREAS ISLET TRANSPLANTATION; POROSITY; PRIORITY JOURNAL; REVASCULARIZATION; REVIEW; STEM CELL TRANSPLANTATION; TISSUE ENGINEERING; TISSUE REGENERATION;

EID: 84884412705     PISSN: 09581669     EISSN: 18790429     Source Type: Journal    
DOI: 10.1016/j.copbio.2013.05.004     Document Type: Review

References (58)

1. Barton F.B., Rickels M.R., Alejandro R., Hering B.J., Wease S., Naziruddin B., Oberholzer J., Odorico J.S., Garfinkel M.R., Levy M., et al. Improvement in outcomes of clinical islet transplantation: 1999-2010. Diabetes Care 2012, 35:1436-1445.
2. Zhang N., Su D., Qu S., Tse T., Bottino R., Balamurugan A.N., Xu J., Bromberg J.S., Dong H.H. Sirolimus is associated with reduced islet engraftment and impaired beta-cell function. Diabetes 2006, 55:2429-2436.
3. McCall M., Pawlick R., Kin T., Shapiro A.M.J. Anakinra potentiates the protective effects of etanercept in transplantation of marginal mass human islets in immunodeficient mice. Am J Transplant 2012, 12:322-329.
4. Koulmanda M., Bhasin M., Fan Z., Hanidziar D., Goel N., Putheti P., Movahedi B., Libermann T.A., Strom T.B. Alpha 1-antitrypsin reduces inflammation and enhances mouse pancreatic islet transplant survival. Proc Natl Acad Sci 2012, 109:15443-15448.
5. Merani S., Toso C., Emamaullee J., Shapiro A.M. Optimal implantation site for pancreatic islet transplantation. Br J Surg 2008, 95:1449-1461.
6. Christoffersson G., Henriksnäs J., Johansson L., Rolny C., Ahlström H., Caballero-Corbalan J., Segersvärd R., Permert J., Korsgren O., Carlsson P.-O., et al. Clinical and experimental pancreatic islet transplantation to striated muscle: establishment of a vascular system similar to that in native islets. Diabetes 2010, 59:2569-2578.
7. Scharp D.W., Swanson C.J., Olack B.J., Latta P.P., Hegre O.D., Doherty E.J., Gentile F.T., Flavin K.S., Ansara M.F., Lacy P.E. Protection of encapsulated human islets implanted without immunosuppression in patients with type I or type II diabetes and in nondiabetic control subjects. Diabetes 1994, 43:1167-1170.
8. Pileggi A., Molano R.D., Ricordi C., Zahr E., Collins J., Valdes R., Inverardi L. Reversal of diabetes by pancreatic islet transplantation into a subcutaneous, neovascularized device. Transplantation 2006, 81:1318-1324.
9. Hussey A.J., Winardi M., Han X.L., Thomas G.P., Penington A.J., Morrison W.A., Knight K.R., Feeney S.J. Seeding of pancreatic islets into prevascularized tissue engineering chambers. Tissue Eng Part A 2009, 15:3823-3833.
10. Berman D.M., O'Neil J.J., Coffey L.C., Chaffanjon P.C., Kenyon N.M., Ruiz P., Pileggi A., Ricordi C., Kenyon N.S. Long-term survival of nonhuman primate islets implanted in an omental pouch on a biodegradable scaffold. Am J Transplant 2009, 9:91-104.
11. Hefty T.R., Kuhr C.S., Chong K.T., Guinee D.G., Wang W., Reems J.A., Greenbaum C.J. Omental roll-up: a technique for islet engraftment in a large animal model. J Surg Res 2010, 161:134-138.
12. Shah S., Lowery E., Braun R.K., Martin A., Huang N., Medina M., Sethupathi P., Seki Y., Takami M., Byrne K., et al. Cellular basis of tissue regeneration by omentum. PLoS ONE 2012, 7:e38368.
13. Kakabadze Z., Shanava K., Ricordi C., Shapiro A.M., Gupta S., Berishvili E. An isolated venous sac as a novel site for cell therapy in diabetes mellitus. Transplantation 2012, 94:319-324.
14. Komori J., Boone L., DeWard A., Hoppo T., Lagasse E. The mouse lymph node as an ectopic transplantation site for multiple tissues. Nat Biotechnol 2012, 30:976-983.
15. Perez V., Caicedo A., Berman D., Arrieta E., Abdulreda M., Rodriguez-Diaz R., Pileggi A., Hernandez E., Dubovy S., Parel J., et al. The anterior chamber of the eye as a clinical transplantation site for the treatment of diabetes: a study in a baboon model of diabetes. Diabetologia 2011, 54:1121-1126.
16. Stendahl J.C., Kaufman D.B., Stupp S.I. Extracellular matrix in pancreatic islets: relevance to scaffold design and transplantation. Cell Transplant 2009, 18:1-12.
17. Tak P.P., Firestein G.S. NF-κB: a key role in inflammatory diseases. J Clin Invest 2001, 107:7-11.
18. Nikolova G., Jabs N., Konstantinova I., Domogatskaya A., Tryggvason K., Sorokin L., Fässler R., Gu G., Gerber H.-P., Ferrara N., et al. The vascular basement membrane: a niche for insulin gene expression and Beta cell proliferation. Dev Cell 2006, 10:397-405.
19. Thomas F., Wu J., Contreras J.L., Smyth C., Bilbao G., He J., Thomas J. A tripartite anoikis-like mechanism causes early isolated islet apoptosis. Surgery 2001, 130:333-338.
20. Borg D., Bonifacio E. The use of biomaterials in islet transplantation. Curr Diabetes Rep 2011, 11:434-444.
21. Gibly R.F., Zhang X., Graham M.L., Hering B.J., Kaufman D.B., Lowe W.L., Shea L.D. Extrahepatic islet transplantation with microporous polymer scaffolds in syngeneic mouse and allogeneic porcine models. Biomaterials 2011, 32:9677-9684.
22. Berman D.M., O'Neil J.J., Coffey L.C.K., Chaffanjon P.C.J., Kenyon N.M., Ruiz P., Pileggi A., Ricordi C., Kenyon N.S. Long-term survival of nonhuman primate islets implanted in an omental pouch on a biodegradable scaffold. Am J Transplant 2009, 9:91-104.
23. Kin T., O'Neil J.J., Pawlick R., Korbutt G.S., Shapiro A.M., Lakey J.R. The use of an approved biodegradable polymer scaffold as a solid support system for improvement of islet engraftment. Artif Organs 2008, 32:990-993.
24. Pedraza E., Brady A., Fraker C., Molano R., Sukert S., Kenyon N., Pileggi A., Ricordi C., Stabler C. Macro-porous PDMS scaffolds for extrahepatic islet transplantation. Cell Transplant 2012, in press.
25. Kenyon N., Pedraza E., Berman D.M., Willman M., Kenyon N., Margolles-Clark E., Buchwald P., Latta P., Ricordi C., Stabler C. Scaffolds within an omental pouch site support long term survival of allogeneic, nonhuman primate islets. Am J Transplant 2011, 11:117.
26. Daoud J., Petropavlovskaia M., Rosenberg L., Tabrizian M. The effect of extracellular matrix components on the preservation of human islet function in vitro. Biomaterials 2010, 31:1676-1682.
27. Daoud J.T., Petropavlovskaia M.S., Patapas J.M., Degrandpre C.E., Diraddo R.W., Rosenberg L., Tabrizian M. Long-term in vitro human pancreatic islet culture using three-dimensional microfabricated scaffolds. Biomaterials 2011, 32:1536-1542.
28. Weber L.M., Anseth K.S. Hydrogel encapsulation environments functionalized with extracellular matrix interactions increase islet insulin secretion. Matrix Biol 2008, 27:667-673.
29. Weber L.M., Hayda K.N., Anseth K.S. Cell-matrix interactions improve beta-cell survival and insulin secretion in three-dimensional culture. Tissue Eng Part A 2008, 14:1959-1968.
30. Salvay D., Rives C., Zhang X., Chen F., Kaufman D.B., Lowe W.L., Shea L.D. Extracellular matrix protein-coated scaffolds promote the reversal of diabetes after extrahepatic islet transplantation. Transplantation 2008, 85:1456-1464.
31. Lin C.-C., Anseth K.S. Cell-cell communication mimicry with poly(ethylene glycol) hydrogels for enhancing β-cell function. Proc Natl Acad Sci 2011, 108:6380-6385.
32. Lim D.J., Antipenko S.V., Anderson J.M., Jaimes K.F., Viera L., Stephen B.R., Bryant S.M., Yancey B.D., Hughes K.J., Cui W., et al. Enhanced rat islet function and survival in vitro using a biomimetic self-assembled nanomatrix gel. Tissue Eng Part A 2011, 17:399-406.
33. Kheradmand T., Wang S., Gibly R.F., Zhang X., Holland S., Tasch J., Graham J.G., Kaufman D.B., Miller S.D., Shea L.D., et al. Permanent protection of PLG scaffold transplanted allogeneic islet grafts in diabetic mice treated with ECDI-fixed donor splenocyte infusions. Biomaterials 2011, 32:4517-4524.
34. Su J., Hu B.-H., Lowe W.L., Kaufman D.B., Messersmith P.B. Anti-inflammatory peptide-functionalized hydrogels for insulin-secreting cell encapsulation. Biomaterials 2010, 31:308-314.
35. Lifson N., Lassa C.V., Dixit P.K. Relation between blood flow and morphology in islet organ of rat pancreas. Am J Physiol Endocrinol Metab 1985, 249:E43-E48.
36. Dionne K.E., Colton C.K., Yarmush M.L. Effect of hypoxia on insulin secretion by isolated rat and canine islets of Langerhans. Diabetes 1993, 42:12-21.
37. Moritz W., Meier F., Stroka D.M., Giuliani M., Kugelmeier P., Nett P.C., Lehmann R., Candinas D., Gassmann M., Weber M. Apoptosis in hypoxic human pancreatic islets correlates with HIF-1alpha expression. FASEB J 2002, 16:745-747.
38. Cheng K., Ho K., Stokes R., Scott C., Lau S.M., Hawthorne W.J., O'Connell P.J., Loudovaris T., Kay T.W., Kulkarni R.N., et al. Hypoxia-inducible factor-1alpha regulates beta cell function in mouse and human islets. J Clin Invest 2010, 120:2171-2183.
39. Cantley J., Grey S.T., Maxwell P.H., Withers D.J. The hypoxia response pathway and beta-cell function. Diabetes Obes Metab 2010, 12(Suppl 2):159-167.
40. Dubois S., Madec A.M., Mesnier A., Armanet M., Chikh K., Berney T., Thivolet C. Glucose inhibits angiogenesis of isolated human pancreatic islets. J Mol Endocrinol 2010, 45:99-105.
41. Ludwig B., Zimerman B., Steffen A., Yavriants K., Azarov D., Reichel A., Vardi P., German T., Shabtay N., Rotem A., et al. A novel device for islet transplantation providing immune protection and oxygen supply. Horm Metab Res 2010, 42:918-922.
42. Ludwig B., Rotem A., Schmid J., Weir G.C., Colton C.K., Brendel M.D., Neufeld T., Block N.L., Yavriyants K., Steffen A., et al. Improvement of islet function in a bioartificial pancreas by enhanced oxygen supply and growth hormone releasing hormone agonist. Proc Natl Acad Sci 2012, 109:5022-5027.
43. Pedraza E., Coronel M.M., Fraker C.A., Ricordi C., Stabler C.L. Preventing hypoxia-induced cell death in beta cells and islets via hydrolytically activated, oxygen-generating biomaterials. Proc Natl Acad Sci 2012, 109:4245-4250.
44. Shimoda M., Chen S., Noguchi H., Matsumoto S., Grayburn P. In vivo non-viral gene delivery of human vascular endothelial growth factor improves revascularisation and restoration of euglycaemia after human islet transplantation into mouse liver. Diabetologia 2010, 53:1669-1679.
45. Davis N.E., Beenken-Rothkopf L.N., Mirsoian A., Kojic N., Kaplan D.L., Barron A.E., Fontaine M.J. Enhanced function of pancreatic islets co-encapsulated with ECM proteins and mesenchymal stromal cells in a silk hydrogel. Biomaterials 2012, 33:6691-6697.
46. Ito T., Itakura S., Todorov I., Rawson J., Asari S., Shintaku J., Nair I., Ferreri K., Kandeel F., Mullen Y. Mesenchymal stem cell and islet co-transplantation promotes graft revascularization and function. Transplantation 2010, 89:1438-1445. 1410.1097/TP.1430b1013e3181db1409c1434.
47. Ding Y., Xu D., Feng G., Bushell A., Muschel R.J., Wood K.J. Mesenchymal stem cells prevent the rejection of fully allogenic islet grafts by the immunosuppressive activity of matrix metalloproteinase-2 and -9. Diabetes 2009, 58:1797-1806.
48. Yeung T.Y., Seeberger K.L., Kin T., Adesida A., Jomha N., Shapiro A.M., Korbutt G.S. Human mesenchymal stem cells protect human islets from pro-inflammatory cytokines. PLoS ONE 2012, 7:e38189.
49. Berman D.M., Willman M.A., Han D., Kleiner G., Kenyon N.M., Cabrera O., Karl J.A., Wiseman R.W., O'Connor D.H., Bartholomew A.M., et al. Diabetes 2010, 59:2558-2568.
50. Phelps E.A., Garcia A.J. Update on therapeutic vascularization strategies. Regen Med 2009, 4:65-80.
51. Martino M.M., Tortelli F., Mochizuki M., Traub S., Ben-David D., Kuhn G.A., Muller R., Livne E., Eming S.A., Hubbell J.A. Engineering the growth factor microenvironment with fibronectin domains to promote wound and bone tissue healing. Sci Transl Med 2011, 3. 100ra189.
52. Phelps E.A., Landázuri N., Thulé P.M., Taylor W.R., García A.J. Bioartificial matrices for therapeutic vascularization. Proc Natl Acad Sci 2010, 107:3323-3328.
53. Phelps E.A., Headen D.M., Taylor W.R., Thulé P.M., García A.J. Vasculogenic bio-synthetic hydrogel for enhancement of pancreatic islet engraftment and function in type 1 diabetes. Biomaterials 2013, 34:4602-4611.
54. Chow L.W., Wang L-j, Kaufman D.B., Stupp S.I. Self-assembling nanostructures to deliver angiogenic factors to pancreatic islets. Biomaterials 2010, 31:6154-6161.
55. Stendahl J.C., Wang L.J., Chow L.W., Kaufman D.B., Stupp S.I. Growth factor delivery from self-assembling nanofibers to facilitate islet transplantation. Transplantation 2008, 86:478-481.
56. Burke G., Vendrame F., Pileggi A., Ciancio G., Reijonen H., Pugliese A. Recurrence of autoimmunity following pancreas transplantation. Curr Diabetes Rep 2011, 11:413-419.
57. Kontos S., Kourtis I.C., Dane K.Y., Hubbell J.A. Engineering antigens for in situ erythrocyte binding induces T-cell deletion. Proc Natl Acad Sci U S A 2013, 110:E60-E68.
58. Getts D.R., Martin A.J., McCarthy D.P., Terry R.L., Hunter Z.N., Yap W.T., et al. Microparticles bearing encephalitogenic peptides induce T-cell tolerance and ameliorate experimental autoimmune encephalomyelitis. Nat Biotechnol 2012, 30:1217-1224.