The use of an approved biodegradable polymer scaffold as a solid support system for improvement of islet engraftment

Artificial Organs

Volumn 32, Issue 12, 2008, Pages 990-993

  Kin, Tatsuya ^a,b   O'Neil, John J ^c   Pawlick, Rena ^b   Korbutt, Gregory S ^b   Shapiro, A M James ^b   Lakey, Jonathan R T ^d  

^a 210 College Plaza   (Canada)

^b UNIVERSITY OF ALBERTA   (Canada)

^c JOHNSON AND JOHNSON   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Biopolymers; Diabetes; Islet transplantation; Omentum; Scaffold

Indexed keywords

ANIMALS; BIODEGRADABLE POLYMERS; GRAFTING (CHEMICAL); GRAFTS; SCAFFOLDS (BIOLOGY);

ANIMAL MODEL; BEAGLE DOG; BIODEGRADABLE POLYMER SCAFFOLDS; BIODEGRADABLE SCAFFOLD; ENGRAFTMENT; INSULIN INJECTIONS; ISLET TRANSPLANTATION; METABOLIC STATE; OMENTUM; SOLID-SUPPORT SYSTEM;

INSULIN;

GLUCAGON; POLYMER;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTOTRANSPLANTATION; BIODEGRADABLE IMPLANT; CONTROLLED STUDY; DOG; GLUCOSE BLOOD LEVEL; GRAFT SURVIVAL; HISTOLOGY; MALE; METABOLISM; MICROENVIRONMENT; NONHUMAN; PANCREAS FUNCTION; PANCREAS ISLET TRANSPLANTATION; PANCREAS RESECTION; PRIORITY JOURNAL;

ANIMALIA; CANIS FAMILIARIS;

EID: 58149203692     PISSN: 0160564X     EISSN: 15251594     Source Type: Journal    
DOI: 10.1111/j.1525-1594.2008.00688.x     Document Type: Article

References (23)

1. Ryan EA, Paty BW, Senior PA, et al. Five-year follow-up after clinical islet transplantation. Diabetes 2005 54 : 2060 9.
2. Oberholzer J, Triponez F, Mage R, et al. Human islet transplantation: lessons from 13 autologous and 13 allogeneic transplantations. Transplantation 2000 69 : 1115 23.
3. Robertson RP, Lanz KJ, Sutherland DE, Kendall DM. Prevention of diabetes for up to 13 years by autoislet transplantation after pancreatectomy for chronic pancreatitis. Diabetes 2001 50 : 47 50.
4. Gray DW, Warnock GL, Sutton R, Peters M, McShane P, Morris PJ. Successful autotransplantation of isolated islets of Langerhans in the cynomolgus monkey. Br J Surg 1986 73 : 850 3.
5. Koulmanda M, Smith RN, Qipo A, Weir G, Auchincloss H, Strom TB. Prolonged survival of allogeneic islets in cynomolgus monkeys after short-term anti-CD154-based therapy: nonimmunologic graft failure? Am J Transplant 2006 6 : 687 96.
6. Alejandro R, Cutfield RG, Shienvold FL, et al. Natural history of intrahepatic canine islet cell autografts. J Clin Invest 1986 78 : 1339 48.
7. Kaufman DB, Morel P, Field MJ, Munn SR, Sutherland DE. Purified canine islet autografts. Functional outcome as influenced by islet number and implantation site. Transplantation 1990 50 : 385 91.
8. Hiller WF, Klempnauer J, Luck R, Steiniger B. Progressive deterioration of endocrine function after intraportal but not kidney subcapsular rat islet transplantation. Diabetes 1991 40 : 134 40.
9. Keymeulen B, Anselmo J, Pipeleers D. Length of metabolic normalization after rat islet cell transplantation depends on endocrine cell composition of graft and on donor age. Diabetologia 1997 40 : 1152 8.
10. Van Deijnen JH, Van Suylichem PT, Wolters GH, Van Schilfgaarde R. Distribution of collagens type I, type III and type V in the pancreas of rat, dog, pig and man. Cell Tissue Res 1994 277 : 115 21.
11. Wang RN, Rosenberg L. Maintenance of beta-cell function and survival following islet isolation requires re-establishment of the islet-matrix relationship. J Endocrinol 1999 163 : 181 90.
12. Pinkse GG, Bouwman WP, Jiawan-Lalai R, Terpstra OT, Bruijn JA, de Heer E. Integrin signaling via RGD peptides and anti-beta1 antibodies confers resistance to apoptosis in islets of Langerhans. Diabetes 2006 55 : 312 7.
13. Rosenberg L, Wang R, Paraskevas S, Maysinger D. Structural and functional changes resulting from islet isolation lead to islet cell death. Surgery 1999 126 : 393 8.
14. Bosco D, Meda P, Halban PA, Rouiller DG. Importance of cell-matrix interactions in rat islet beta-cell secretion in vitro: role of alpha6beta1 integrin. Diabetes 2000 49 : 233 43.
15. Dufour JM, Rajotte RV, Zimmerman M, et al. Development of an ectopic site for islet transplantation, using biodegradable scaffolds. Tissue Eng 2005 11 : 1323 31.
16. Blomeier H, Zhang X, Rives C, et al. Polymer scaffolds as synthetic microenvironments for extrahepatic islet transplantation. Transplantation 2006 82 : 452 9.
17. Kin T, Iwata H, Aomatsu Y, et al. Xenotransplantation of pig islets in diabetic dogs with use of a microcapsule composed of agarose and polystyrene sulfonic acid mixed gel. Pancreas 2002 25 : 94 100.
18. Barnett MJ, McGhee-Wilson D, Shapiro AM, Lakey JR. Variation in human islet viability based on different membrane integrity stains. Cell Transplant 2004 13 : 481 8.
19. Korbutt GS, Elliott JF, Ao Z, Smith DK, Warnock GL, Rajotte RV. Large scale isolation, growth, and function of porcine neonatal islet cells. J Clin Invest 1996 97 : 2119 29.
20. Gustavson SM, Rajotte RV, Hunkeler D, et al. Islet auto-transplantation into an omental or splenic site results in a normal beta cell but abnormal alpha cell response to mild non-insulin-induced hypoglycemia. Am J Transplant 2005 5 : 2368 77.
21. Ao Z, Matayoshi K, Lakey JR, Rajotte RV, Warnock GL. Survival and function of purified islets in the omental pouch site of outbred dogs. Transplantation 1993 56 : 524 9.
22. Shapiro L, Cohen S. Novel alginate sponges for cell culture and transplantation. Biomaterials 1997 18 : 583 90.
23. Rucker M, Laschke MW, Junker D, et al. Angiogenic and inflammatory response to biodegradable scaffolds in dorsal skinfold chambers of mice. Biomaterials 2006 27 : 5027 38.