Geminin Is Required for the Maintenance of Pluripotency

PLoS ONE

Volumn 8, Issue 9, 2013, Pages

  Tabrizi, Golnaz A ^a   Böse, Kerstin ^a   Reimann, Yvonne ^a   Kessel, Michael ^a  

^a MAX PLANCK INSTITUTE FOR BIOPHYSICAL CHEMISTRY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CRE RECOMBINASE; GEMININ; OCTAMER TRANSCRIPTION FACTOR 4; POLYCOMB REPRESSIVE COMPLEX 2; TAMOXIFEN; TRANSCRIPTION FACTOR SOX2;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL CYCLE REGULATION; CELL DIFFERENTIATION; CELL DIVISION; CELL FATE; CELL LINEAGE; CELL RENEWAL; CHROMATIN; CONTROLLED STUDY; EMBRYO; EMBRYONIC STEM CELL; EPIGENETIC REPRESSION; FIBROBLAST; GEMININ GENE; GENE; GENE DELETION; GENE EXPRESSION; GENE FUNCTION; HISTONE MODIFICATION; MOUSE; NEUROECTODERM; NONHUMAN; NUCLEAR REPROGRAMMING; PLURIPOTENT STEM CELL; PROTEIN EXPRESSION; SOX2 GENE; TOTIPOTENT STEM CELL;

ANIMALS; CELL CYCLE; CELL DIFFERENTIATION; CHROMATIN; DNA REPLICATION; ECTODERM; EMBRYONIC STEM CELLS; ENHANCER ELEMENTS, GENETIC; EPIGENESIS, GENETIC; FIBROBLASTS; GEMININ; GENE DELETION; GENE EXPRESSION REGULATION, DEVELOPMENTAL; MICE; NEURAL STEM CELLS; OCTAMER TRANSCRIPTION FACTOR-3; SOXB1 TRANSCRIPTION FACTORS; STEM CELLS;

EID: 84884405774     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0073826     Document Type: Article

References (59)

1. Dejosez M, Zwaka TP, (2012) Pluripotency and nuclear reprogramming. Annu Rev Biochem 81: 737-765.
2. Niwa H, (2007) How is pluripotency determined and maintained? Development 134: 635-646.
3. Thomson M, Liu SJ, Zou LN, Smith Z, Meissner A, et al. (2011) Pluripotency factors in embryonic stem cells regulate differentiation into germ layers. Cell 145: 875-889.
4. Kroll KL, Salic AN, Evans LM, Kirschner MW, (1998) Geminin, a neuralizing molecule that demarcates the future neural plate at the onset of gastrulation. Development 125: 3247-3258.
5. Seo S, Herr A, Lim JW, Richardson GA, Richardson H, et al. (2005) Geminin regulates neuronal differentiation by antagonizing Brg1 activity. Genes Dev 19: 1723-1734.
6. Yellajoshyula D, Patterson ES, Elitt MS, Kroll KL, (2011) Geminin promotes neural fate acquisition of embryonic stem cells by maintaining chromatin in an accessible and hyperacetylated state. Proc Natl Acad Sci U S A 108: 3294-3299.
7. Yellajoshyula D, Lim JW, Thompson DM Jr, Witt JS, Patterson ES, et al. (2012) Geminin regulates the transcriptional and epigenetic status of neuronal fate-promoting genes during mammalian neurogenesis. Mol Cell Biol 32: 4549-4560.
8. Lim JW, Hummert P, Mills JC, Kroll KL, (2011) Geminin cooperates with Polycomb to restrain multi-lineage commitment in the early embryo. Development 138: 33-44.
9. Papanayotou C, Mey A, Birot AM, Saka Y, Boast S, et al. (2008) A mechanism regulating the onset of Sox2 expression in the embryonic neural plate. PLoS Biol 6: e2.
10. Luo L, Yang X, Takihara Y, Knoetgen H, Kessel M, (2004) The cell-cycle regulator geminin inhibits Hox function through direct and polycomb-mediated interactions. Nature 427: 749-753.
11. McGarry TJ, Kirschner MW, (1998) Geminin, an inhibitor of DNA replication, is degraded during mitosis. Cell 93: 1043-1053.
12. Petropoulou C, Kotantaki P, Karamitros D, Taraviras S, (2008) Cdt1 and Geminin in cancer: markers or triggers of malignant transformation? Front Biosci 13: 4485-4494.
13. Arias EE, Walter JC, (2007) Strength in numbers: preventing rereplication via multiple mechanisms in eukaryotic cells. Genes Dev 21: 497-518.
14. Hara K, Nakayama KI, Nakayama K, (2006) Geminin is essential for the development of preimplantation mouse embryos. Genes to cells: devoted to molecular & cellular mechanisms 11: 1281-1293.
15. Gonzalez MA, Tachibana KE, Adams DJ, van der Weyden L, Hemberger M, et al. (2006) Geminin is essential to prevent endoreduplication and to form pluripotent cells during mammalian development. Genes & development 20: 1880-1884.
16. Karamitros D, Kotantaki P, Lygerou Z, Veiga-Fernandes H, Pachnis V, et al. (2010) Differential geminin requirement for proliferation of thymocytes and mature T cells. J Immunol 184: 2432-2441.
17. Shinnick KM, Eklund EA, McGarry TJ, (2010) Geminin deletion from hematopoietic cells causes anemia and thrombocytosis in mice. J Clin Invest 120: 4303-4315.
18. Barry KA, Schultz KM, Payne CJ, McGarry TJ, (2012) Geminin is required for mitotic proliferation of spermatogonia. Dev Biol 371: 35-46.
19. Spella M, Kyrousi C, Kritikou E, Stathopoulou A, Guillemot F, et al. (2011) Geminin regulates cortical progenitor proliferation and differentiation. Stem Cells 29: 1269-1282.
20. Schultz KM, Banisadr G, Lastra RO, McGuire T, Kessler JA, et al. (2011) Geminin-deficient neural stem cells exhibit normal cell division and normal neurogenesis. PLoS One 6: e17736.
21. Gonzalez MA, Tachibana KE, Adams DJ, van der Weyden L, Hemberger M, et al. (2006) Geminin is essential to prevent endoreduplication and to form pluripotent cells during mammalian development. Genes Dev 20: 1880-1884.
22. Yang VS, Carter SA, Hyland SJ, Tachibana-Konwalski K, Laskey RA, et al. (2011) Geminin escapes degradation in G1 of mouse pluripotent cells and mediates the expression of Oct4, Sox2, and Nanog. Curr Biol 21: 692-699.
23. Fujii-Yamamoto H, Kim JM, Arai K, Masai H, (2005) Cell cycle and developmental regulations of replication factors in mouse embryonic stem cells. J Biol Chem 280: 12976-12987.
24. Hayashi S, McMahon AP, (2002) Efficient recombination in diverse tissues by a tamoxifen-inducible form of Cre: a tool for temporally regulated gene activation/inactivation in the mouse. Dev Biol 244: 305-318.
25. Gaspard N, Bouschet T, Herpoel A, Naeije G, van den Ameele J, et al. (2009) Generation of cortical neurons from mouse embryonic stem cells. Nat Protoc 4: 1454-1463.
26. Tomioka M, Nishimoto M, Miyagi S, Katayanagi T, Fukui N, et al. (2002) Identification of Sox-2 regulatory region which is under the control of Oct-3/4-Sox-2 complex. Nucleic Acids Res 30: 3202-3213.
27. Yeom YI, Fuhrmann G, Ovitt CE, Brehm A, Ohbo K, et al. (1996) Germline regulatory element of Oct-4 specific for the totipotent cycle of embryonal cells. Development 122: 881-894.
28. Ho L, Jothi R, Ronan JL, Cui K, Zhao K, et al. (2009) An embryonic stem cell chromatin remodeling complex, esBAF, is an essential component of the core pluripotency transcriptional network. Proc Natl Acad Sci U S A 106: 5187-5191.
29. Takahashi K, Yamanaka S, (2006) Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 126: 663-676.
30. Stadtfeld M, Maherali N, Breault DT, Hochedlinger K, (2008) Defining molecular cornerstones during fibroblast to iPS cell reprogramming in mouse. Cell Stem Cell 2: 230-240.
31. Ichida JK, Blanchard J, Lam K, Son EY, Chung JE, et al. (2009) A small-molecule inhibitor of tgf-Beta signaling replaces sox2 in reprogramming by inducing nanog. Cell Stem Cell 5: 491-503.
32. Zhu W, Depamphilis ML, (2009) Selective killing of cancer cells by suppression of geminin activity. Cancer Res 69: 4870-4877.
33. Ballabeni A, Park IH, Zhao R, Wang W, Lerou PH, et al. (2011) Cell cycle adaptations of embryonic stem cells. Proc Natl Acad Sci U S A 108: 19252-19257.
34. Kalaszczynska I, Geng Y, Iino T, Mizuno S, Choi Y, et al. (2009) Cyclin A is redundant in fibroblasts but essential in hematopoietic and embryonic stem cells. Cell 138: 352-365.
35. Menchon C, Edel MJ, Izpisua Belmonte JC, (2011) The cell cycle inhibitor p27Kip(1) controls self-renewal and pluripotency of human embryonic stem cells by regulating the cell cycle, Brachyury and Twist. Cell Cycle 10: 1435-1447.
36. Ruiz S, Panopoulos AD, Herrerias A, Bissig KD, Lutz M, et al. (2011) A high proliferation rate is required for cell reprogramming and maintenance of human embryonic stem cell identity. Curr Biol 21: 45-52.
37. Li VC, Ballabeni A, Kirschner MW, (2012) Gap 1 phase length and mouse embryonic stem cell self-renewal. Proc Natl Acad Sci U S A 109: 12550-12555.
38. Filipczyk AA, Laslett AL, Mummery C, Pera MF, (2007) Differentiation is coupled to changes in the cell cycle regulatory apparatus of human embryonic stem cells. Stem Cell Res 1: 45-60.
39. White J, Stead E, Faast R, Conn S, Cartwright P, et al. (2005) Developmental activation of the Rb-E2F pathway and establishment of cell cycle-regulated cyclin-dependent kinase activity during embryonic stem cell differentiation. Mol Biol Cell 16: 2018-2027.
40. Lessard J, Wu JI, Ranish JA, Wan M, Winslow MM, et al. (2007) An essential switch in subunit composition of a chromatin remodeling complex during neural development. Neuron 55: 201-215.
41. Pasini D, Cloos PA, Walfridsson J, Olsson L, Bukowski JP, et al. (2010) JARID2 regulates binding of the Polycomb repressive complex 2 to target genes in ES cells. Nature 464: 306-310.
42. Gao Z, Zhang J, Bonasio R, Strino F, Sawai A, et al. (2012) PCGF homologs, CBX proteins, and RYBP define functionally distinct PRC1 family complexes. Mol Cell 45: 344-356.
43. Ho L, Ronan JL, Wu J, Staahl BT, Chen L, et al. (2009) An embryonic stem cell chromatin remodeling complex, esBAF, is essential for embryonic stem cell self-renewal and pluripotency. Proc Natl Acad Sci U S A 106: 5181-5186.
44. Luo L, Uerlings Y, Happel N, Asli NS, Knoetgen H, et al. (2007) Regulation of geminin functions by cell cycle-dependent nuclear-cytoplasmic shuttling. Mol Cell Biol 27: 4737-4744.
45. Boos A, Lee A, Thompson DM, Kroll KL, (2006) Subcellular translocation signals regulate Geminin activity during embryonic development. Biol Cell 98: 363-375.
46. Kulartz M, Knippers R, (2004) The replicative regulator protein geminin on chromatin in the HeLa cell cycle. J Biol Chem 279: 41686-41694.
47. Pitulescu ME, Teichmann M, Luo L, Kessel M, (2009) TIPT2 and geminin interact with basal transcription factors to synergize in transcriptional regulation. BMC Biochem 10: 16.
48. Ho L, Miller EL, Ronan JL, Ho WQ, Jothi R, et al. (2011) esBAF facilitates pluripotency by conditioning the genome for LIF/STAT3 signalling and by regulating polycomb function. Nat Cell Biol 13: 903-913.
49. Avilion AA, Nicolis SK, Pevny LH, Perez L, Vivian N, et al. (2003) Multipotent cell lineages in early mouse development depend on SOX2 function. Genes Dev 17: 126-140.
50. Masui S, Nakatake Y, Toyooka Y, Shimosato D, Yagi R, et al. (2007) Pluripotency governed by Sox2 via regulation of Oct3/4 expression in mouse embryonic stem cells. Nat Cell Biol 9: 625-635.
51. Bergsland M, Ramskold D, Zaouter C, Klum S, Sandberg R, et al. (2011) Sequentially acting Sox transcription factors in neural lineage development. Genes Dev 25: 2453-2464.
52. Bylund M, Andersson E, Novitch BG, Muhr J, (2003) Vertebrate neurogenesis is counteracted by Sox1-3 activity. Nat Neurosci 6: 1162-1168.
53. Wang Z, Oron E, Nelson B, Razis S, Ivanova N, (2012) Distinct lineage specification roles for NANOG, OCT4, and SOX2 in human embryonic stem cells. Cell Stem Cell 10: 440-454.
54. Buganim Y, Faddah DA, Cheng AW, Itskovich E, Markoulaki S, et al. (2012) Single-cell expression analyses during cellular reprogramming reveal an early stochastic and a late hierarchic phase. Cell 150: 1209-1222.
55. Kopp JL, Ormsbee BD, Desler M, Rizzino A, (2008) Small increases in the level of Sox2 trigger the differentiation of mouse embryonic stem cells. Stem Cells 26: 903-911.
56. Uerlings Y (2008) Die Funktion von Geminin beim Übergang von Neuro- zu Gliogenese in der Maus. der Georg-August-Universität zu Göttingen: der Georg-August-Universität zu Göttingen.
57. Liu P, Jenkins NA, Copeland NG, (2003) A highly efficient recombineering-based method for generating conditional knockout mutations. Genome Res 13: 476-484.
58. Voss AK, Thomas T, Gruss P, (1997) Germ line chimeras from female ES cells. Exp Cell Res 230: 45-49.
59. Wiese C, Kania G, Rolletschek A, Blyszczuk P, Wobus AM, (2006) Pluripotency: capacity for in vitro differentiation of undifferentiated embryonic stem cells. Methods Mol Biol 325: 181-205.