Posttrauma cotreatment with lithium and valproate: Reduction of lesion volume, attenuation of blood-brain barrier disruption and improvement in motor coordination in mice with traumatic brain injury Laboratory investigation

Journal of Neurosurgery

Volumn 119, Issue 3, 2013, Pages 766-773

  Yu, Fengshan ^a,b,c   Wang, Zhifei ^a   Tanaka, Mikiei ^c   Chiu, Chi Tso ^a   Leeds, Peter ^a   Zhang, Yumin ^b,c   Chuang, De Maw ^a,b  

^a NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

^b Center for Neuroscience and Regenerative Medicine   (United States)

^c UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES   (United States)

Author keywords

Acetylhistone H3; Lithium; Mouse; Neuroprotection; Traumatic brain injury; Valproate

Indexed keywords

HISTONE DEACETYLASE; HISTONE H3; IMMUNOGLOBULIN G; LITHIUM; VALPROIC ACID;

ACETYLATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD BRAIN BARRIER; COMBINATION CHEMOTHERAPY; CONTROLLED STUDY; DRUG POTENTIATION; ENZYME INHIBITION; MALE; MOTOR COORDINATION; MOUSE; NERVE DEGENERATION; NONHUMAN; PRIORITY JOURNAL; TRAUMATIC BRAIN INJURY;

ANIMALS; ANTIMANIC AGENTS; BLOOD-BRAIN BARRIER; BRAIN INJURIES; DISEASE MODELS, ANIMAL; DRUG THERAPY, COMBINATION; LITHIUM; MALE; MICE; MICE, INBRED C57BL; MOVEMENT DISORDERS; VALPROIC ACID;

EID: 84884397376     PISSN: 00223085     EISSN: 19330693     Source Type: Journal    
DOI: 10.3171/2013.6.JNS13135     Document Type: Article

References (28)

1. Autry AE, Monteggia LM: Brain-derived neurotrophic factor and neuropsychiatric disorders. Pharmacol Rev 64:238-258, 2012
2. Chiu CT, Chuang DM: Molecular actions and therapeutic potential of lithium in preclinical and clinical studies of CNS disorders. Pharmacol Ther 128:281-304, 2010
3. Chiu CT, Liu G, Leeds P, Chuang DM: Combined treatment with the mood stabilizers lithium and valproate produces multiple beneficial effects in transgenic mouse models of Huntington's disease. Neuropsychopharmacology 36:2406-2421, 2011
4. Chiu CT, Wang Z, Hunsberger JG, Chuang DM: Therapeutic potential of mood stabilizers lithium and valproic acid: beyond bipolar disorder. Pharmacol Rev 65:105-142, 2013
5. Chuang DM, Leng Y, Marinova Z, Kim HJ, Chiu CT: Multiple roles of HDAC inhibition in neurodegenerative conditions. Trends Neurosci 32:591-601, 2009
6. Dash PK, Johnson D, Clark J, Orsi SA, Zhang M, Zhao J, et al: Involvement of the glycogen synthase kinase-3 signaling pathway in TBI pathology and neurocognitive outcome. PLoS ONE 6:e24648, 2011
7. Dash PK, Orsi SA, Moore AN: Histone deactylase inhibition combined with behavioral therapy enhances learning and memory following traumatic brain injury. Neuroscience 163: 1-8, 2009
8. Dash PK, Orsi SA, Zhang M, Grill RJ, Pati S, Zhao J, et al: Valproate administered after traumatic brain injury provides neuroprotection and improves cognitive function in rats. PLoS ONE 5:e11383, 2010
9. Faul M, Xu L, Wald MM, Coronado VG: Traumatic Brain Injury in the United States: Emergency Department Visits, Hospitalizations and Deaths. Atlanta: Centers for Disease Control and Prevention, National Center for Injury Prevention and Control, 2010
10. Feng HL, Leng Y, Ma CH, Zhang J, Ren M, Chuang DM: Combined lithium and valproate treatment delays disease onset, reduces neurological deficits and prolongs survival in an amyotrophic lateral sclerosis mouse model. Neuroscience 155:567-572, 2008
11. Fox GB, Fan L, Levasseur RA, Faden AI: Sustained sensory/motor and cognitive deficits with neuronal apoptosis following controlled cortical impact brain injury in the mouse. J Neurotrauma 15:599-614, 1998 (Pubitemid 28413053)
12. Hall ED, Bryant YD, Cho W, Sullivan PG: Evolution of posttraumatic neurodegeneration after controlled cortical impact traumatic brain injury in mice and rats as assessed by the de Olmos silver and fluorojade staining methods. J Neurotrauma 25:235-247, 2008 (Pubitemid 351416738)
13. Leng Y, Liang MH, Ren M, Marinova Z, Leeds P, Chuang DM: Synergistic neuroprotective effects of lithium and valproic acid or other histone deacetylase inhibitors in neurons: roles of glycogen synthase kinase-3 inhibition. J Neurosci 28:2576-2588, 2008 (Pubitemid 351348211)
14. Lin D, Mok H, Yatham LN: Polytherapy in bipolar disorder. CNS Drugs 20:29-42, 2006 (Pubitemid 43061720)
15. Loane DJ, Faden AI: Neuroprotection for traumatic brain injury: translational challenges and emerging therapeutic strategies. Trends Pharmacol Sci 31:596-604, 2010
16. Loane DJ, Pocivavsek A, Moussa CE, Thompson R, Matsuoka Y, Faden AI, et al: Amyloid precursor protein secretases as therapeutic targets for traumatic brain injury. Nat Med 15: 377-379, 2009
17. Maas AI, Stocchetti N, Bullock R: Moderate and severe traumatic brain injury in adults. Lancet Neurol 7:728-741, 2008 (Pubitemid 351957931)
18. Margulies S, Hicks R: Combination therapies for traumatic brain injury: prospective considerations. J Neurotrauma 26: 925-939, 2009
19. Shapira M, Licht A, Milman A, Pick CG, Shohami E, Eldar- Finkelman H: Role of glycogen synthase kinase-3beta in early depressive behavior induced by mild traumatic brain injury. Mol Cell Neurosci 34:571-577, 2007 (Pubitemid 46483079)
20. Shein NA, Grigoriadis N, Alexandrovich AG, Simeonidou C, Lourbopoulos A, Polyzoidou E, et al: Histone deacetylase inhibitor ITF2357 is neuroprotective, improves functional recovery, and induces glial apoptosis following experimental traumatic brain injury. FASEB J 23:4266-4275, 2009
21. Tsai LK, Leng Y, Wang Z, Leeds P, Chuang DM: The mood stabilizers valproic acid and lithium enhance mesenchymal stem cell migration via distinct mechanisms. Neuropsychopharmacology 35:2225-2237, 2010
22. Tsai LK, Wang Z, Munasinghe J, Leng Y, Leeds P, Chuang DM: Mesenchymal stem cells primed with valproate and lithium robustly migrate to infarcted regions and facilitate recovery in a stroke model. Stroke 42:2932-2939, 2011
23. Wang Z, Leng Y, Tsai LK, Leeds P, Chuang DM: Valproic acid attenuates blood-brain barrier disruption in a rat model of transient focal cerebral ischemia: the roles of HDAC and MMP-9 inhibition. J Cereb Blood Flow Metab 31:52-57, 2011
24. Wang ZF, Fessler EB, Chuang DM: Beneficial effects of mood stabilizers lithium, valproate and lamotrigine in experimental stroke models. Acta Pharmacol Sin 32:1433-1445, 2011
25. Yu F, Wang Z, Tchantchou F, Chiu CT, Zhang Y, Chuang DM: Lithium ameliorates neurodegeneration, suppresses neuroinflammation, and improves behavioral performance in a mouse model of traumatic brain injury. J Neurotrauma 29:362-374, 2012
26. Yu F, Zhang Y, Chuang DM: Lithium reduces BACE1 overexpression, beta amyloid accumulation, and spatial learning deficits in mice with traumatic brain injury. J Neurotrauma 29:2342-2351, 2012
27. Zhang B, West EJ, Van KC, Gurkoff GG, Zhou J, Zhang XM, et al: HDAC inhibitor increases histone H3 acetylation and reduces microglia inflammatory Response following traumatic brain injury in rats. Brain Res 1226:181-191, 2008
28. Zhu ZF, Wang QG, Han BJ, William CP: Neuroprotective effect and cognitive outcome of chronic lithium on traumatic brain injury in mice. Brain Res Bull 83:272-277, 2010