-
1
-
-
48249125791
-
Malignant Gliomas in Adults
-
doi:10.1056/NEJMra0708126
-
Wen PY, Kesari S, (2008) Malignant Gliomas in Adults. N Engl J Med 359: 492-507. doi:10.1056/NEJMra0708126. PubMed: 18669428.
-
(2008)
N Engl J Med
, vol.359
, pp. 492-507
-
-
Wen, P.Y.1
Kesari, S.2
-
2
-
-
34547122001
-
The 2007 WHO Classification of Tumours of the Central Nervous System
-
doi:10.1007/s00401-007-0243-4
-
Louis DN, Ohgaki H, Wiestler OD, Cavenee WK, Burger PC, et al. (2007) The 2007 WHO Classification of Tumours of the Central Nervous System. Acta Neuropathol 114: 97-109. doi:10.1007/s00401-007-0243-4. PubMed: 17618441.
-
(2007)
Acta Neuropathol
, vol.114
, pp. 97-109
-
-
Louis, D.N.1
Ohgaki, H.2
Wiestler, O.D.3
Cavenee, W.K.4
Burger, P.C.5
-
3
-
-
84873411117
-
Brain cancer in 2012: Molecular characterization leads the way
-
doi:10.1038/nrclinonc.2012.240
-
Stupp R, Hegi ME, (2013) Brain cancer in 2012: Molecular characterization leads the way. Nat Rev Clin Oncol 10: 69-70. doi:10.1038/nrclinonc.2012.240. PubMed: 23296110.
-
(2013)
Nat Rev Clin Oncol
, vol.10
, pp. 69-70
-
-
Stupp, R.1
Hegi, M.E.2
-
4
-
-
20044366163
-
Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma
-
doi:10.1056/NEJMoa043330
-
Stupp R, Mason WP, van den Bent MJ, Weller M, Fisher B, et al. (2005) Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med 352: 987-996. doi:10.1056/NEJMoa043330. PubMed: 15758009.
-
(2005)
N Engl J Med
, vol.352
, pp. 987-996
-
-
Stupp, R.1
Mason, W.P.2
van den Bent, M.J.3
Weller, M.4
Fisher, B.5
-
5
-
-
65349121788
-
Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial
-
doi:10.1016/S1470-2045(09)70025-7
-
Stupp R, Hegi ME, Mason WP, van den Bent MJ, Taphoorn MJB, et al. (2009) Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial. Lancet Oncol 10: 459-466. doi:10.1016/S1470-2045(09)70025-7. PubMed: 19269895.
-
(2009)
Lancet Oncol
, vol.10
, pp. 459-466
-
-
Stupp, R.1
Hegi, M.E.2
Mason, W.P.3
van den Bent, M.J.4
Taphoorn, M.J.B.5
-
6
-
-
48649086682
-
Mechanisms of Disease: temozolomide and glioblastoma-look to the future
-
doi:10.1038/ncpgasthep1210
-
Mrugala MM, Chamberlain MC, (2008) Mechanisms of Disease: temozolomide and glioblastoma-look to the future. Nat Clin Pract Oncol 5: 476-486. doi:10.1038/ncpgasthep1210. PubMed: 18542116.
-
(2008)
Nat Clin Pract Oncol
, vol.5
, pp. 476-486
-
-
Mrugala, M.M.1
Chamberlain, M.C.2
-
7
-
-
33846252663
-
Apoptosis in malignant glioma cells triggered by the temozolomide-induced DNA lesion O6-methylguanine
-
Roos WP, Batista LFZ, Naumann SC, Wick W, Weller M, et al. (2006) Apoptosis in malignant glioma cells triggered by the temozolomide-induced DNA lesion O6-methylguanine. Oncogene 26: 186-197. PubMed: 16819506.
-
(2006)
Oncogene
, vol.26
, pp. 186-197
-
-
Roos, W.P.1
Batista, L.F.Z.2
Naumann, S.C.3
Wick, W.4
Weller, M.5
-
8
-
-
0034027358
-
Unmasking a killer. DNA O6-methylguanine and the cytotoxicity of methylating agents
-
Bignami M, O'Driscoll M, Aquilina G, Karran P, (2000) Unmasking a killer. DNA O6-methylguanine and the cytotoxicity of methylating agents. Mutat Res 462: 71-82.
-
(2000)
Mutat Res
, vol.462
, pp. 71-82
-
-
Bignami, M.1
O'Driscoll, M.2
Aquilina, G.3
Karran, P.4
-
9
-
-
0036570062
-
Clinical Relevance of MGMT in the Treatment of Cancer
-
doi:10.1200/JCO.2002.06.110
-
Gerson SL, (2002) Clinical Relevance of MGMT in the Treatment of Cancer. J Clin Oncol 20: 2388-2399. doi:10.1200/JCO.2002.06.110. PubMed: 11981013.
-
(2002)
J Clin Oncol
, vol.20
, pp. 2388-2399
-
-
Gerson, S.L.1
-
10
-
-
1942469956
-
MGMT: its role in cancer aetiology and cancer therapeutics
-
doi:10.1038/nrc1319
-
Gerson SL, (2004) MGMT: its role in cancer aetiology and cancer therapeutics. Nat Rev Cancer 4: 296-307. doi:10.1038/nrc1319. PubMed: 15057289.
-
(2004)
Nat Rev Cancer
, vol.4
, pp. 296-307
-
-
Gerson, S.L.1
-
11
-
-
51649117107
-
Correlation of O6-Methylguanine Methyltransferase (MGMT) Promoter Methylation With Clinical Outcomes in Glioblastoma and Clinical Strategies to Modulate MGMT Activity
-
doi:10.1200/JCO.2007.11.5964
-
Hegi ME, Liu L, Herman JG, Stupp R, Wick W, et al. (2008) Correlation of O6-Methylguanine Methyltransferase (MGMT) Promoter Methylation With Clinical Outcomes in Glioblastoma and Clinical Strategies to Modulate MGMT Activity. J Clin Oncol 26: 4189-4199. doi:10.1200/JCO.2007.11.5964. PubMed: 18757334.
-
(2008)
J Clin Oncol
, vol.26
, pp. 4189-4199
-
-
Hegi, M.E.1
Liu, L.2
Herman, J.G.3
Stupp, R.4
Wick, W.5
-
12
-
-
67649873216
-
Extent of MGMT promoter methylation correlates with outcome in glioblastomas given temozolomide and radiotherapy
-
doi:10.1038/sj.bjc.6605127
-
Dunn J, Baborie A, Alam F, Joyce K, Moxham M, et al. (2009) Extent of MGMT promoter methylation correlates with outcome in glioblastomas given temozolomide and radiotherapy. Br J Cancer 101: 124-131. doi:10.1038/sj.bjc.6605127. PubMed: 19536096.
-
(2009)
Br J Cancer
, vol.101
, pp. 124-131
-
-
Dunn, J.1
Baborie, A.2
Alam, F.3
Joyce, K.4
Moxham, M.5
-
13
-
-
34848824363
-
Long-term survival with glioblastoma multiforme
-
doi:10.1093/brain/awm204
-
Krex D, Klink B, Hartmann C, von Deimling A, Pietsch T, et al. (2007) Long-term survival with glioblastoma multiforme. Brain 130: 2596-2606. doi:10.1093/brain/awm204. PubMed: 17785346.
-
(2007)
Brain
, vol.130
, pp. 2596-2606
-
-
Krex, D.1
Klink, B.2
Hartmann, C.3
von Deimling, A.4
Pietsch, T.5
-
14
-
-
75149166496
-
MGMT promoter methylation in malignant gliomas: ready for personalized medicine?
-
doi:10.1038/nrneurol.2009.197
-
Weller M, Stupp R, Reifenberger G, Brandes AA, van den Bent MJ, et al. (2010) MGMT promoter methylation in malignant gliomas: ready for personalized medicine? Nat. Rev Neurol 6: 39-51. doi:10.1038/nrneurol.2009.197.
-
(2010)
Nat Rev Neurol
, vol.6
, pp. 39-51
-
-
Weller, M.1
Stupp, R.2
Reifenberger, G.3
Brandes, A.A.4
van den Bent, M.J.5
-
15
-
-
33750370444
-
MicroRNA signatures in human cancers
-
doi:10.1038/nrc1997
-
Calin GA, Croce CM, (2006) MicroRNA signatures in human cancers. Nat Rev Cancer 6: 857-866. doi:10.1038/nrc1997. PubMed: 17060945.
-
(2006)
Nat Rev Cancer
, vol.6
, pp. 857-866
-
-
Calin, G.A.1
Croce, C.M.2
-
16
-
-
18144365478
-
MicroRNA biogenesis and cancer
-
doi:10.1158/0008-5472.CAN-05-0298
-
Gregory RI, Shiekhattar R, (2005) MicroRNA biogenesis and cancer. Cancer Res 65: 3509-3512. doi:10.1158/0008-5472.CAN-05-0298. PubMed: 15867338.
-
(2005)
Cancer Res
, vol.65
, pp. 3509-3512
-
-
Gregory, R.I.1
Shiekhattar, R.2
-
17
-
-
54949158061
-
MicroRNAs in diseases and drug response
-
doi:10.1016/j.coph.2008.06.005
-
Garofalo M, Condorelli G, Croce CM, (2008) MicroRNAs in diseases and drug response. Curr Opin Pharmacol 8: 661-667. doi:10.1016/j.coph.2008.06.005. PubMed: 18619557.
-
(2008)
Curr Opin Pharmacol
, vol.8
, pp. 661-667
-
-
Garofalo, M.1
Condorelli, G.2
Croce, C.M.3
-
18
-
-
34250841756
-
MicroRNAs in human cancer: from research to therapy
-
doi:10.1242/jcs.03450
-
Negrini M, Ferracin M, Sabbioni S, Croce CM, (2007) MicroRNAs in human cancer: from research to therapy. J Cell Sci 120: 1833-1840. doi:10.1242/jcs.03450. PubMed: 17515481.
-
(2007)
J Cell Sci
, vol.120
, pp. 1833-1840
-
-
Negrini, M.1
Ferracin, M.2
Sabbioni, S.3
Croce, C.M.4
-
19
-
-
84857109002
-
miR-221/222 overexpession in human glioblastoma increases invasiveness by targeting the protein phosphate PTPmu
-
doi:10.1038/onc.2011.280
-
Quintavalle C, Garofalo M, Zanca C, Romano G, Iaboni M, et al. (2012) miR-221/222 overexpession in human glioblastoma increases invasiveness by targeting the protein phosphate PTPmu. Oncogene 31: 858-868. doi:10.1038/onc.2011.280. PubMed: 21743492.
-
(2012)
Oncogene
, vol.31
, pp. 858-868
-
-
Quintavalle, C.1
Garofalo, M.2
Zanca, C.3
Romano, G.4
Iaboni, M.5
-
20
-
-
67349247040
-
miR-21 and 221 upregulation and miR-181b downregulation in human grade II-IV astrocytic tumors
-
doi:10.1007/s11060-009-9797-4
-
Conti A, Aguennouz MH, Torre D, Tomasello C, Cardali S, et al. (2009) miR-21 and 221 upregulation and miR-181b downregulation in human grade II-IV astrocytic tumors. J Neuro Oncol 93: 325-332. doi:10.1007/s11060-009-9797-4. PubMed: 19159078.
-
(2009)
J Neuro Oncol
, vol.93
, pp. 325-332
-
-
Conti, A.1
Aguennouz, M.H.2
Torre, D.3
Tomasello, C.4
Cardali, S.5
-
21
-
-
23044464236
-
Extensive modulation of a set of microRNAs in primary glioblastoma
-
doi:10.1016/j.bbrc.2005.07.030
-
Ciafrè SA, Galardi S, Mangiola A, Ferracin M, Liu CG, et al. (2005) Extensive modulation of a set of microRNAs in primary glioblastoma. Biochem Biophys Res Commun 334: 1351-1358. doi:10.1016/j.bbrc.2005.07.030. PubMed: 16039986.
-
(2005)
Biochem Biophys Res Commun
, vol.334
, pp. 1351-1358
-
-
Ciafrè, S.A.1
Galardi, S.2
Mangiola, A.3
Ferracin, M.4
Liu, C.G.5
-
22
-
-
83455236760
-
miR221/222 in Cancer: Their Role in Tumor Progression and Response to Therapy
-
doi:10.2174/156652412798376170
-
Garofalo M, Quintavalle C, Romano G, Croce CM, Condorelli G, (2012) miR221/222 in Cancer: Their Role in Tumor Progression and Response to Therapy. Curr Mol Med 12: 27-33. doi:10.2174/156652412798376170. PubMed: 22082479.
-
(2012)
Curr Mol Med
, vol.12
, pp. 27-33
-
-
Garofalo, M.1
Quintavalle, C.2
Romano, G.3
Croce, C.M.4
Condorelli, G.5
-
23
-
-
70949104622
-
miR-221&222 regulate TRAIL resistance and enhance tumorigenicity through PTEN and TIMP3 downregulation
-
doi:10.1016/j.ccr.2009.10.014
-
Garofalo M, Di Leva G, Romano G, Nuovo G, Suh SS, et al. (2009) miR-221&222 regulate TRAIL resistance and enhance tumorigenicity through PTEN and TIMP3 downregulation. Cancer Cell 16: 498-509. doi:10.1016/j.ccr.2009.10.014. PubMed: 19962668.
-
(2009)
Cancer Cell
, vol.16
, pp. 498-509
-
-
Garofalo, M.1
Di Leva, G.2
Romano, G.3
Nuovo, G.4
Suh, S.S.5
-
24
-
-
74249112785
-
MicroRNAs as regulators of death receptors signaling
-
Garofalo M, Condorelli GL, Croce CM, Condorelli G, (2010) MicroRNAs as regulators of death receptors signaling. Cell Death Differ: 2: 200-8. PubMed: 19644509.
-
(2010)
Cell Death Differ
, vol.2
, pp. 200-208
-
-
Garofalo, M.1
Condorelli, G.L.2
Croce, C.M.3
Condorelli, G.4
-
25
-
-
84855543629
-
EGFR and MET receptor tyrosine kinase-altered microRNA expression induces tumorigenesis and gefitinib resistance in lung cancers
-
doi:10.1038/nm.2577
-
Garofalo M, Romano G, Di Leva G, Nuovo G, Jeon Y-J, et al. (2011) EGFR and MET receptor tyrosine kinase-altered microRNA expression induces tumorigenesis and gefitinib resistance in lung cancers. Nat Med 18: 74-82. doi:10.1038/nm.2577. PubMed: 22157681.
-
(2011)
Nat Med
, vol.18
, pp. 74-82
-
-
Garofalo, M.1
Romano, G.2
Di Leva, G.3
Nuovo, G.4
Jeon, Y.-J.5
-
26
-
-
0035710746
-
Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method
-
doi:10.1006/meth.2001.1262
-
Livak KJ, Schmittgen TD, (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 25: 402-408. doi:10.1006/meth.2001.1262. PubMed: 11846609.
-
(2001)
Methods
, vol.25
, pp. 402-408
-
-
Livak, K.J.1
Schmittgen, T.D.2
-
27
-
-
0033557903
-
Inactivation of the DNA Repair. Gene O6-Methylguanine-DNA Methyltransferase by Promoter Hypermethylation is a Common Event in Primary Human Neoplasia
-
Esteller M, Hamilton SR, Burger PC, Baylin SB, Herman JG, (1999) Inactivation of the DNA Repair. Gene O6-Methylguanine-DNA Methyltransferase by Promoter Hypermethylation is a Common Event in Primary Human Neoplasia. Cancer Res 59: 793-797.
-
(1999)
Cancer Res
, vol.59
, pp. 793-797
-
-
Esteller, M.1
Hamilton, S.R.2
Burger, P.C.3
Baylin, S.B.4
Herman, J.G.5
-
28
-
-
84862192642
-
miR-181d: a predictive glioblastoma biomarker that downregulates MGMT expression
-
doi:10.1093/neuonc/nos089
-
Zhang W, Zhang J, Hoadley K, Kushwaha D, Ramakrishnan V, et al. (2012) miR-181d: a predictive glioblastoma biomarker that downregulates MGMT expression. Neuro Oncol 14: 712-719. doi:10.1093/neuonc/nos089. PubMed: 22570426.
-
(2012)
Neuro Oncol
, vol.14
, pp. 712-719
-
-
Zhang, W.1
Zhang, J.2
Hoadley, K.3
Kushwaha, D.4
Ramakrishnan, V.5
-
29
-
-
33846695481
-
O6-Methylguanine-DNA Methyltransferase Regulation by p53 in Astrocytic Cells
-
doi:10.1158/0008-5472.CAN-06-2782
-
Blough MD, Zlatescu MC, Cairncross JG, (2007) O6-Methylguanine-DNA Methyltransferase Regulation by p53 in Astrocytic Cells. Cancer Res 67: 580-584. doi:10.1158/0008-5472.CAN-06-2782. PubMed: 17234766.
-
(2007)
Cancer Res
, vol.67
, pp. 580-584
-
-
Blough, M.D.1
Zlatescu, M.C.2
Cairncross, J.G.3
-
30
-
-
33745077330
-
MicroRNA deregulation in human thyroid papillary carcinomas
-
doi:10.1677/erc.1.01209
-
Pallante P, Visone R, Ferracin M, Ferraro A, Berlingieri MT, et al. (2006) MicroRNA deregulation in human thyroid papillary carcinomas. Endocr Relat Cancer 13: 497-508. doi:10.1677/erc.1.01209. PubMed: 16728577.
-
(2006)
Endocr Relat Cancer
, vol.13
, pp. 497-508
-
-
Pallante, P.1
Visone, R.2
Ferracin, M.3
Ferraro, A.4
Berlingieri, M.T.5
-
31
-
-
67349247040
-
miR-21 and 221 upregulation and miR-181b downregulation in human grade II-IV astrocytic tumors
-
doi:10.1007/s11060-009-9797-4
-
Conti A, Aguennouz M, La Torre D, Tomasello C, Cardali S, et al. (2009) miR-21 and 221 upregulation and miR-181b downregulation in human grade II-IV astrocytic tumors. J Neuro Oncol 93: 325-332. doi:10.1007/s11060-009-9797-4. PubMed: 19159078.
-
(2009)
J Neuro Oncol
, vol.93
, pp. 325-332
-
-
Conti, A.1
Aguennouz, M.2
La Torre, D.3
Tomasello, C.4
Cardali, S.5
-
32
-
-
76249128792
-
miR-221 overexpression contributes to liver tumorigenesis
-
doi:10.1073/pnas.0907904107
-
Pineau P, Volinia S, McJunkin K, Marchio A, Battiston C, et al. (2010) miR-221 overexpression contributes to liver tumorigenesis. Proc Natl Acad Sci U S A 107: 264-269. doi:10.1073/pnas.0907904107. PubMed: 20018759.
-
(2010)
Proc Natl Acad Sci U S A
, vol.107
, pp. 264-269
-
-
Pineau, P.1
Volinia, S.2
McJunkin, K.3
Marchio, A.4
Battiston, C.5
-
33
-
-
23044464236
-
Extensive modulation of a set of microRNAs in primary glioblastoma
-
doi:10.1016/j.bbrc.2005.07.030
-
Ciafrè SA, Galardi S, Mangiola A, Ferracin M, Liu CG, et al. (2005) Extensive modulation of a set of microRNAs in primary glioblastoma. Biochem Biophys Res Commun 334: 1351-1358. doi:10.1016/j.bbrc.2005.07.030. PubMed: 16039986.
-
(2005)
Biochem Biophys Res Commun
, vol.334
, pp. 1351-1358
-
-
Ciafrè, S.A.1
Galardi, S.2
Mangiola, A.3
Ferracin, M.4
Liu, C.G.5
-
34
-
-
0030972856
-
Methylnitrosourea-induced Tumorigenesis in MGMT Gene Knockout Mice
-
Sakumi K, Shiraishi A, Shimizu S, Tsuzuki T, Ishikawa T, et al. (1997) Methylnitrosourea-induced Tumorigenesis in MGMT Gene Knockout Mice. Cancer Res 57: 2415-2418. PubMed: 9192819.
-
(1997)
Cancer Res
, vol.57
, pp. 2415-2418
-
-
Sakumi, K.1
Shiraishi, A.2
Shimizu, S.3
Tsuzuki, T.4
Ishikawa, T.5
-
35
-
-
41949114939
-
Mgmt deficiency alters the in vivo mutational spectrum of tissues exposed to the tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)
-
doi:10.1093/carcin/bgn030
-
Sandercock LE, Hahn JN, Li L, Luchman HA, Giesbrecht JL, et al. (2008) Mgmt deficiency alters the in vivo mutational spectrum of tissues exposed to the tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). Carcinogenesis 29: 866-874. doi:10.1093/carcin/bgn030. PubMed: 18281247.
-
(2008)
Carcinogenesis
, vol.29
, pp. 866-874
-
-
Sandercock, L.E.1
Hahn, J.N.2
Li, L.3
Luchman, H.A.4
Giesbrecht, J.L.5
-
36
-
-
1542366109
-
Roles of MGMT and MLH1 proteins in alkylation-induced apoptosis and mutagenesis
-
doi:10.1016/S1568-7864(03)00134-4
-
Takagi Y, Takahashi M, Sanada M, Ito R, Yamaizumi M, et al. (2003) Roles of MGMT and MLH1 proteins in alkylation-induced apoptosis and mutagenesis. DNA Repair (Amst) 2: 1135-1146. doi:10.1016/S1568-7864(03)00134-4. PubMed: 13679151.
-
(2003)
DNA Repair (Amst)
, vol.2
, pp. 1135-1146
-
-
Takagi, Y.1
Takahashi, M.2
Sanada, M.3
Ito, R.4
Yamaizumi, M.5
-
37
-
-
0027250179
-
Brain and liver targeted overexpression of O6-methylguanine DNA methyltransferase in transgenic mice
-
doi:10.1093/carcin/14.8.1537
-
Walter CA, Lu J, Bhakta M, Mitra S, Dunn W, et al. (1993) Brain and liver targeted overexpression of O6-methylguanine DNA methyltransferase in transgenic mice. Carcinogenesis 14: 1537-1543. doi:10.1093/carcin/14.8.1537. PubMed: 8353838.
-
(1993)
Carcinogenesis
, vol.14
, pp. 1537-1543
-
-
Walter, C.A.1
Lu, J.2
Bhakta, M.3
Mitra, S.4
Dunn, W.5
-
38
-
-
0035974625
-
Overexpression of human O6-alkylguanine DNA alkyltransferase(AGT) prevents MNU induced lymphomas in heterozygous p53 deficient mice
-
Reese JS, Allay E, Gerson SL, (2001) Overexpression of human O6-alkylguanine DNA alkyltransferase(AGT) prevents MNU induced lymphomas in heterozygous p53 deficient mice. Oncogene 20: 5258-5263.
-
(2001)
Oncogene
, vol.20
, pp. 5258-5263
-
-
Reese, J.S.1
Allay, E.2
Gerson, S.L.3
-
39
-
-
0033600130
-
Mice over-expressing human O6 alkylguanine-DNA alkyltransferase selectively reduce O6 methylguanine mediated carcinogenic mutations to threshold levels after N-methyl-N-nitrosourea
-
Allay E, Veigl M, Gerson SL, (1999) Mice over-expressing human O6 alkylguanine-DNA alkyltransferase selectively reduce O6 methylguanine mediated carcinogenic mutations to threshold levels after N-methyl-N-nitrosourea. Oncogene 18: 3783-3787.
-
(1999)
Oncogene
, vol.18
, pp. 3783-3787
-
-
Allay, E.1
Veigl, M.2
Gerson, S.L.3
|