The p38 MAPK and JNK pathways protect host cells against clostridium perfringens beta-toxin

Infection and Immunity

Volumn 81, Issue 10, 2013, Pages 3703-3708

  Nagahama, Masahiro ^a   Shibutani, Masahiro ^a   Seike, Soshi ^a   Yonezaki, Mami ^a   Takagishi, Teruhisa ^a   Oda, Masataka ^a   Kobayashi, Keiko ^a   Sakurai, Jun ^a  

^a TOKUSHIMA BUNRI UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; CLOSTRIDIUM TOXIN; MITOGEN ACTIVATED PROTEIN KINASE P38; OLIGOMER; POTASSIUM; REACTIVE OXYGEN METABOLITE; STREPTOLYSIN O; STRESS ACTIVATED PROTEIN KINASE;

ARTICLE; BACTERIAL IMMUNITY; CELL DEATH; CLOSTRIDIUM PERFRINGENS; CONTROLLED STUDY; CYTOTOXICITY; ENZYME PHOSPHORYLATION; HOST CELL; HUMAN; HUMAN CELL; LIPID RAFT; NONHUMAN; OLIGOMERIZATION; POTASSIUM TRANSPORT; PRIORITY JOURNAL; PROTEIN FUNCTION;

BACTERIAL TOXINS; CELL LINE, TUMOR; CELL SURVIVAL; CLOSTRIDIUM PERFRINGENS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; P38 MITOGEN-ACTIVATED PROTEIN KINASES;

EID: 84884364713     PISSN: 00199567     EISSN: 10985522     Source Type: Journal    
DOI: 10.1128/IAI.00579-13     Document Type: Article

References (31)

1. Songer JG. 1996. Clostridial enteric diseases of domestic animals. Clin. Microbiol. Rev. 9:216-234.
2. Sakurai J, Nagahama M. 2006. Clostridium perfringens beta-toxin: characterization and action. Toxin Rev. 25:89-108.
3. Sakurai J, Fujii Y, Matsuura M. 1980. Effect of oxidizing agents and sulfhydryl group reagents on beta toxin from Clostridium perfringens type C. Microbiol. Immunol. 24:595-601.
4. Sakurai J, Fujii Y, Dezaki K, Endo K. 1984. Effect of Clostridium perfringens beta toxin on blood pressure of rats. Microbiol. Immunol. 28:23-31.
5. Nagahama M, Morimitsu S, Kihara A, Akita M, Setsu K, Sakurai J. 2003. Involvement of tachykinin receptors in Clostridium perfringens betatoxin- induced plasma extravasation. Br. J. Pharmacol. 138:23-30.
6. Nagahama M, Kihara A, Kintoh H, Oda M, Sakurai J. 2008. Involvement of tumor necrosis factor-alpha in Clostridium perfringens betatoxin-induced plasma extravasation in mice. Br. J. Pharmacol. 153:1296-1302.
7. Sayeed S, Uzal FA, Fisher DJ, Saputo J, Vidal JE, Chen Y, Gupta P, Rood JI, McClane BA. 2008. Beta toxin is essential for the intestinal virulence of Clostridium perfringens type C disease isolate CN3685 in a rabbit ileal loop model. Mol. Microbiol. 67:15-30.
8. Vidal JE, McClane BA, Saputo J, Parker J, Uzal FA. 2008. Effects of Clostridium perfringens beta-toxin on the rabbit small intestine and colon. Infect. Immun. 76:4396-4404.
9. Vidal JE, Ma M, Saputo J, Garcia J, Uzal FA, McClane BA. 2012. Evidence that the Agr-like quorum sensing system regulates the toxin production, cytotoxicity and pathogenicity of Clostridium perfringens type C isolate CN3685. Mol. Microbiol. 83:179-194.
10. Miclard J, Jäggi Sutter ME, Wyder M, Grabscheid B, Posthaus H. 2009. Clostridium perfringens beta-toxin targets endothelial cells in necrotizing enteritis in piglets. Vet. Microbiol. 137:320-325.
11. Miclard J, van Baarlen J, Wyder M, Grabscheid B, Posthaus H. 2009. Clostridium perfringens beta-toxin binding to vascular endothelial cells in a human case of enteritis necroticans. J. Med. Microbiol. 58:826-828.
12. Gurtner C, Popescu F, Wyder M, Sutter E, Zeeh F, Frey J, von Schubert C, Posthaus H. 2010. Rapid cytopathic effects of Clostridium perfringens beta-toxin on porcine endothelial cells. Infect. Immun. 78:2966-2973.
13. Popescu F, Wyder M, Gurtner C, Frey J, Cooke RA, Greenhill AR, Posthaus H. 2011. Susceptibility of primary human endothelial cells to C. perfringens beta-toxin suggesting similar pathogenesis in human and porcine necrotizing enteritis. Vet. Microbiol. 153:173-177.
14. Hunter SE, Brown JE, Oyston PC, Sakurai J, Titball RW. 1993. Molecular genetic analysis of beta-toxin of Clostridium perfringens reveals sequence homology with alpha-toxin, gamma-toxin, and leukocidin of Staphylococcus aureus. Infect. Immun. 61:3958-3965.
15. Shatursky O, Bayles R, Rogers M, Jost BH, Songer JG, Tweten RK. 2000. Clostridium perfringens beta-toxin forms potential-dependent, cation-selective channels in lipid bilayers. Infect. Immun. 68:5546-5551.
16. Tweten RK. 2001. Clostridium perfringens beta-toxin and Clostridium septicum alpha-toxin: their mechanisms and possible role in pathogenesis. Vet. Microbiol. 82:1-9.
17. Nagahama M, Hayashi S, Morimitsu S, Sakurai J. 2003. Biological activities and pore formation of Clostridium perfringens beta-toxin in HL 60 cells. J. Biol. Chem. 278:36934-36941.
18. Steinthorsdottir V, Halldórsson H, Andrésson OS. 2000. Clostridium perfringens beta-toxin forms multimeric transmembrane pores in human endothelial cells. Microb. Pathog. 28:45-50.
19. Huffman DL, Abrami L, Sasik R, Corbeil J, van der Goot FG, Aroian RV. 2004. Mitogen-activated protein kinase pathways defend against bacterial pore-forming toxins. Proc. Natl. Acad. Sci. U. S. A. 101:10995-11000.
20. Husmann M, Dersch K, Bobkiewicz W, Beckmann E, Veerachato G, Bhakdi S. 2006. Differential role of p38 mitogen activated protein kinase for cellular recovery from attack by pore-forming S. aureus alpha-toxin or streptolysin O. Biochem. Biophys. Res. Commun. 344:1128-1134.
21. Ratner AJ, Hippe KR, Aguilar JL, Bender MH, Nelson AL, Weiser JN. 2006. Epithelial cells are sensitive detectors of bacterial pore-forming toxins. J. Biol. Chem. 281:12994-12998.
22. Kloft N, Busch T, Neukirch C, Weis S, Boukhallouk F, Bobkiewicz W, Cibis I, Bhakdi S, Husmann M. 2009. Pore-forming toxins activate MAPK p38 by causing loss of cellular potassium. Biochem. Biophys. Res. Commun. 385:503-506.
23. Bebien M, Hensler ME, Davanture S, Hsu LC, Karin M, Park JM, Alexopoulou L, Liu GY, Nizet V, Lawrence T. 2012. The pore-forming toxin β hemolysin/cytolysin triggers p38 MAPK-dependent IL-10 production in macrophages and inhibits innate immunity. PLoS Pathog. 8:e1002812. doi:10.1371/journal.ppat.1002812.
24. Porta H, Cancino-Rodezno A, Soberón M, Bravo A. 2011. Role of MAPK p38 in the cellular responses to pore-forming toxins. Peptides 32: 601-606.
25. Sakurai J, Fujii Y. 1987. Purification and characterization of Clostridium perfringens beta toxin. Toxicon 25:1301-1310.
26. Sakurai J, Fujii Y, Matsuura M, Endo K. 1981. Pharmacological effect of beta toxin of Clostridium perfringens type C on rats. Microbiol. Immunol. 25:423-432.
27. Nagahama M, Umezaki M, Oda M, Kobayashi K, Tone S, Suda T, Ishidoh K, Sakurai J. 2011. Clostridium perfringens iota-toxin b induces rapid cell necrosis. Infect. Immun. 79:4353-4360.
28. Nagahama M, Nagayasu K, Kobayashi K, Sakurai J. 2002. Binding component of Clostridium perfringens iota-toxin induces endocytosis in Vero cells. Infect. Immun. 70:1909-1914.
29. Nagahama M, Hagiyama T, Kojima T, Aoyanagi K, Takahashi C, Oda M, Sakaguchi Y, Oguma K, Sakurai J. 2009. Binding and internalization of Clostridium botulinum C2 toxin. Infect. Immun. 77:5139-5148.
30. Gonzalez MR, Bischofberger M, Frêche B, Ho S, Parton RG, van der Goot FG. 2011. Pore-forming toxins induce multiple cellular responses promoting survival. Cell. Microbiol. 13:1026-1043.
31. Imre G, Heering J, Takeda AN, Husmann M, Thiede B, zu Heringdorf DM, Green DR, van der Goot FG, Sinha B, Dötsch V, Rajalingam K. 2012. Caspase-2 is an initiator caspase responsible for pore-forming toxinmediated apoptosis. EMBO J. 31:2615-2628.