Clostridium perfringens β-toxin binding to vascular endothelial cells in a human case of enteritis necroticans

Journal of Medical Microbiology

Volumn 58, Issue 6, 2009, Pages 826-828

  Miclard, Julien ^a   Van Baarlen, Joop ^b   Wyder, Marianne ^a   Grabscheid, Benno ^a   Posthaus, Horst ^a  

^a UNIVERSITY OF BERN   (Switzerland)

^b Laboratorium Pathologie Oost Nederland   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL TOXIN; BETA TOXIN; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CASE REPORT; CLOSTRIDIUM PERFRINGENS; DIABETES MELLITUS; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; NECROTIZING ENTERITIS; PRIORITY JOURNAL;

ADULT; BACTERIAL TOXINS; CLOSTRIDIUM INFECTIONS; CLOSTRIDIUM PERFRINGENS; ENDOTHELIAL CELLS; ENTERITIS; FATAL OUTCOME; HUMANS; IMMUNOHISTOCHEMISTRY; INTESTINE, SMALL; MALE; NECROSIS; YOUNG ADULT;

EID: 66449126569     PISSN: 00222615     EISSN: None     Source Type: Journal    
DOI: 10.1099/jmm.0.008060-0     Document Type: Article

References (12)

1. Albini, S., Brodard, I., Jaussi, A., Wollschlaeger, N., Frey, J., Miserez, R. & Abril, C. (2008). Real-time multiplex PCR assays for reliable detection of Clostridium perfringens toxin genes in animal isolates. Vet Microbiol 127, 179-185. (Pubitemid 350267032)
2. Johnson, S. & Gerding, D. N. (1997). Enterotoxemic infections. In The Clostridia: Molecular Biology and Pathogenesis, pp. 117-140. Edited by J. I. Rood, B. A. McClaine, J. G. Songer & R. W. Titball. San Diego: Academic Press.
3. Lawrence, G. & Walker, P. D. (1976). Pathogenesis of enteritis necroticans in Papua New Guinea. Lancet 1, 125-126.
4. Matsuda, T., Okada, Y., Inagi, E., Tanabe, Y., Shimizu, Y., Nagashima, K., Sakurai, J., Nagahama, M. & Tanaka, S. (2007). Enteritis necroticans 'pigbel' in a Japanese diabetic adult. Pathol Int 57, 622-626.
5. Miclard, J., Jäggi, M., Sutter, E., Wyder, M., Grabscheid, B. & Posthaus, H. (2009). Clostridium perfringens beta-toxin targets endothelial cells in necrotizing enteritis in piglets. Vet Microbiol 134, (in press). doi:10.1016/j.vetmic.2009.01.025
6. Nagahama, M., Hayashi, S., Morimitsu, S. & Sakurai, J. (2003). Biological activities and pore formation of Clostridium perfringens beta toxin in HL 60 cells. J Biol Chem 278, 36934-36941. (Pubitemid 37140028)
7. Sayeed, S., Uzal, F. A., Fisher, D. J., Saputo, J., Vidal, J. E., Chen, Y., Gupta, P., Rood, J. I. & McClane, B. A. (2008). Beta toxin is essential for the intestinal virulence of Clostridium perfringens type C disease isolate CN3685 in a rabbit ileal loop model. Mol Microbiol 67, 15-30. (Pubitemid 350231133)
8. Severin, W. P., de la Fuente, A. A. & Stringer, M. F. (1984). Clostridium perfringens type C causing necrotising enteritis. J Clin Pathol 37, 942-944. (Pubitemid 14065070)
9. Smedley, J. G., Fisher, D. J., Sayeed, S., Chakrabarti, G. & McClane, B. A. (2004). The enteric toxins of Clostridium perfringens. Rev Physiol Biochem Pharmacol 152, 183-204.
10. Songer, J. G. (1996). Clostridial enteric diseases of domestic animals. Clin Microbiol Rev 9, 216-234. (Pubitemid 26124457)
11. Steinthorsdottir, V., Halldorsson, H. & Andresson, O. S. (2000). Clostridium perfringens beta-toxin forms multimeric transmembrane pores in human endothelial cells. Microb Pathog 28, 45-50. (Pubitemid 30037815)
12. Vidal, J. E., McClane, B. A., Saputo, J., Parker, J. & Uzal, F. A. (2008). Effects of Clostridium perfringens beta-toxin on the rabbit small intestine and colon. Infect Immun 76, 4396-4404.