Clostridium perfringens beta-toxin: Characterization and action

Toxin Reviews

Volumn 25, Issue 1, 2006, Pages 89-108

  Sakurai, Jun ^a   Nagahama, Masahiro ^a  

^a TOKUSHIMA BUNRI UNIVERSITY   (Japan)

Author keywords

Beta toxin; Clostridium perfringens; Necrotic enteritis; Oligomer

Indexed keywords

BACTERIAL TOXIN; CLOSTRIDIUM PERFRINGENS BETA TOXIN; LEUKOCIDIN; NOLPITANTIUM; SPANTIDE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTIFICIAL MEMBRANE; CELL STRAIN HL 60; CLOSTRIDIUM PERFRINGENS; HEMOLYSIS; HUMAN; INFLAMMATORY DISEASE; NECROTIZING ENTERITIS; NONHUMAN; OLIGOMERIZATION; REVIEW; SEQUENCE HOMOLOGY; SKIN EDEMA; SKIN NECROSIS; SMALL INTESTINE; STAPHYLOCOCCUS AUREUS; TOXIN ANALYSIS;

ANIMALIA; BACTERIA (MICROORGANISMS); CLOSTRIDIUM PERFRINGENS; STAPHYLOCOCCUS AUREUS;

EID: 32844454443     PISSN: 15569543     EISSN: 15569551     Source Type: Journal    
DOI: 10.1080/15569540500320979     Document Type: Review

References (44)

1. Costa, S. K. P., De Nucci, G., Antunes, E., Brain, S. D. (2000). Involvement of vanilloid receptors and purinoceptors in the Phoneutria nigriventer spider venom-induced plasma extravasation in rat skin. Eur. J. Pharmacol. 391(3):305-315.
2. Davis, M., Lawrence, G., Shann, F., Walker, P. D. (1982). Longevity of protection by active immunisation against necrotising enteritis in Papua New Guinea. Lancet 320(8294):389-390.
3. Friedrichson, T., Kurzchalia, T. V. (1998). Microdomains of GPI-anchored proteins in living cells revealed by crosslinking. Nature 394(6695):802-805.
4. Gibert, M., Jolivet-Reynaud, C., Popoff, M. R. (1997). Beta2 toxin, a novel toxin produced by Clostridium perfringens. Gene. 203(1):65-73.
5. Gordon, V. M., Nelson, K. L., Buckley, J. T., Stevens, V. L., Tweten, R. K., Elwood, P. C., Leppla, S. H. (1999). Clostridium septicum alpha toxin uses glycosylphosphatidylinositol-anchored protein receptors. J. Biol. Chem. 274(38): 27274-27280.
6. Holzer, P. (1998). Neurogenic vasodilatation and plasma leakage in the skin. Gen. Pharmacol. 30(1):5-11.
7. Hunter, S. E. C., Brown, J. E., Oyston, P. C. F., Sakurai, J., Titball, R. W. Molecular genetic analysis of beta-toxin of Clostridium perfringens reveals sequence homology with alpha-toxin, gamma-toxin, and leukocidin of Staphylococcus aureus. Infect. Immun. 61(9):3958-3965.
8. Johnson, E. M., O'Brien, F. (1976). Evaluation of the permanent sympathectomy produced by the administration of guanethidine to adult rats. J. Pharmacol. Exp. Ther. 196(1):53-61.
9. Johnson, S., Taylor, D. N., Coninx, R., Eampokalap, B., Cooke, R. A., Echeverria, P., Paul, S. R., Sakurai, J., Jimakorn, P., Lawrence, G. W., Walker, P. D. (1987). Enteritis necroticans among Khmer children at an evacuation site in Thailand. Lancet 330(8557):496-500.
10. Kilsdonk, E. P. C., Yancey, P. G., Stoudt, G. W., Bangerter, F. W., Johnson, W. J., Phillips, M. C., Rothbalt, G.H. (1995). Cellular cholesterol efflux mediated by cyclodextrins. J. Biol. Chem. 270(29):17250-17256
11. Kennedy, K. K., Norris, S. J., Beckenhauer, W. H., White, R. G. (1977). Vaccination of cattle and sheep with a combined Clostridium perfringens types C and D toxoid. Am. J. Vet. Res. 38(10):1515-1517.
12. Kvetnansky, R., Weise, V. K., Thoa, N. B., Kopin, I. J. (1979). Effects of chronic guanethidine treatment and adrenal medullectomy on plasma levels of catecholamines and corticosterone in forcibly immobilized rats. J. Pharmacol. Exp. Ther. 209(2):287-291.
13. Lawrence, G., Shann, F., Freestone, D. S., Walker, P. D. (1979). Prevention of necrotising enteritis in Papua New Guinea by active immunisation. Lancet 313(8110):227-230.
14. McDonel, J. L. (1986). Toxins of Clostridium perfringens types A, B, C, D and E. In: Dorner, F., Drews, J., eds., Pharmacology of Bacterial Toxin. Pergamon Press; Oxford, 477-517.
15. Mitchell, T. J., Andrew, P. W., Saunders, F. K., Smith, A. N., Boulnois, G. J. (1991). Complement activation and antibody binding by pneumolysin via a region of the toxin homologous to a human acute-phase protein. Mol. Microbiol. 5(8):1883-1888.
16. Miyata, S., Minami, J., Tamai, E., Matsushita, O., Shimamoto, S., Okabe, A. (2002). Clostridium perfringens epsilon-toxin forms a heptameric pore within the detergent-insoluble microdomains of Madin-Darby canine kidney cells and Rat Synaptosomes. J. Biol. Chem. 277(42):39463-39468.
17. Murrell, T. G. C., Roth, L. (1963). Necrotizing jejunitis: a newly discovered disease in highlands of New Guinea. Med. J. Australia 50(1):61-69.
18. Murrell, T. G. C., Roth, L., Egerton, J., Samels, J., Walker, P. D. (1966). Pigbel: enteritis necroticans: a study in diagnosis and management. Lancet 287(7431):217-222.
19. Nagahama, M., Kihara, A., Miyawaki, T., Mukai, M., Sakaguchi, Y., Ochi, S., Sakurai, J. (1999). Clostridium perfringens beta-toxin is sensitive to thiol-group modification but does not require a thiol group for lethal activity. Biochim. Biophys. Acta 1454(1):97-105.
20. Nagahama, M., Morimitsu, S., Kihara, A., Akita, M., Setsu, K., Sakurai, J. (2003a). Involvement of tachykinin receptors in Clostridium perfringens beta-toxin-induced plasma extravasation. Br. J. Pharmacol. 138(1):23-30.
21. Nagahama, M., Hayashi, S., Morimitstu, S., Sakurai, J. (2003b). Biological activities and pore-formation of Clostridium perfringens beta-toxin in HL 60 cells. J. Biol. Chem. 278 (38):36934-36941.
22. Pinkney, M., Beachey, E., Kehoe, M. (1989). The thiol-activated toxin streptolysin O does not require a thiol group for cytolytic activity. Infect. Immun. 57(8):2553-2558.
23. Sakurai, J. (1995). Toxins of Clostridium perfringens. Rev. Medical. Microbiol. 6(3):175-185.
24. Sakurai, J., Duncan, C. L. (1977). Purification of beta-toxin from Clostridium perfringens type C. Infect. Immun. 18(3):741-745.
25. Sakurai, J., Duncan, C. L. (1978). Some properties of beta-toxin produced by Clostridium perfringens type C. Infect. Immun. 21 (2):678-680.
26. Sakurai, J., Fujii, Y., Matsuura, M. (1980). Effect of oxidizing agents and sulfhydryl group reagents on beta toxin from Clostridium perfringens type C. Microbiol. Immunol. 24(7):595-601.
27. Sakurai, J., Fujii, Y., Matsuura, M., Endo, K. (1981). Pharmacological effect of beta toxin of Clostridium perfringens type C on rats. Microbiol. Immunol. 25(5):423-432.
28. Sakurai, J., Fujii, Y., Dezaki, K., Endo, K. (1984). Effect of Clostridium perfringens beta toxin on blood pressure of rats. Microbiol. Immunol. 28(1):23-31.
29. Sakurai, J., Fujii, Y. (1987). Purification and characterization of Clostridium perfringens beta toxin. Toxicon. 25(12):1301-1310.
30. Sakurai, J., Nagahama, M. (2003). Mechanism of action of Clostridium perfringens beta-toxin. Recent Res. Devel. Infect. Immun. 1:433-449.
31. Sakurai, J., Fujii, Y., Nagahama, M. (1992). Effect of p-chloromercuribenzoate on Clostridium perfringens beta toxin. Toxicon. 30(3):323-330.
32. Sakurai, J., Nagahama, M., Ochi, S. (1997). Major toxins of Clostridium perfringens. J. Toxicol. Toxin Rev. 16(4):195-214.
33. Schraw, W., Li, Y., McClain, M. S., van der Goot, F. G., Cover, T. L. (2002). Association of Helicobacter pylori Vacuolating Toxin (VacA) with Lipid Rafts. J. Biol. Chem. 277(37):34642-34650.
34. Sekino-Suzuki, N., Nakamura, M., Mitsui, K., Ohno-Iwashita, Y. (1996). Contribution of individual tryptophan residues to the structure and activity of θ-toxin (perfringolysin O), a cholesterol-binding cytolysin. Eur. J. Biochem. 241(3):941-947.
35. Shatursky, O., Bayles, R., Rogers, M., Jost, B. H., Songer, J. G., Tweten R.K. (2000). Clostridium perfringens beta-toxin forms potential-dependent, cation-selective channels in lipid bilayers. Infect. Immun. 68(10):5546-5551.
36. Simons, K., Toomre, D. (2000). Lipid rafts and signal transduction. Nat. Rev. Mol. Cell Biol. 1(1):31-39.
37. Siney, L., Brain, S. D. (1996). Involvement of sensory neuropeptides in the development of plasma extravasation in rat dorsal skin following thermal injury. Br. J. Pharmacol. 117(6):1065-1070.
38. Song, L., Hobaugh, M. R., Shustak, C., Cheley, S., Bayley, H., Gouaux, J. E. (1996). Structure of staphylococcal alpha-hemolysin, a heptameric transmembrane pore. Science 274(5294):1859-1866.
39. Songer, J. G. (1996). Clostridial enteric diseases of domestic animals. Clin. Microbiol. Rev. 9(2):216-234.
40. Steinthorsdottir, V., Fridriksdottir, V., Gunnarsson, E., Andresson, O. S. (1998). Site-directed mutagenesis of Clostridium perfringens beta-toxin: expression of wild-type and mutant toxins in Bacillus subtilis. FEMS Microbiol. Lett. 158(1):17-23.
41. Steinthorsdottir, V., Halldorsson, H., Andresson, O. S. (2000). Clostridium perfringens beta-toxin forms multimeric transmembrane pores in human endothelial cells. Microb. Pathog. 28(1):45-50.
42. Waheed, A. A., Shimada, Y., Heijnen, H. F., Nakamura, M., Inomata, M., Hayashi, M., Iwashita, S., Slot, J. W., Ohno-Iwashita, Y. (2001). Selective binding of perfringolysin O derivative to cholesterol-rich membrane microdomains (rafts). Proc. Natl. Acad. Sci. USA 98(9):4926-4931.
43. Walker, B., Bayley, H. (1995). Key residues for membrane binding, oligomerization, and pore forming activity of staphylococcal alpha-hemolysin identified by cysteine scanning mutagenesis and targeted chemical modification. J. Biol. Chem. 270(39):23065-23071.
44. Ziessler, J., Rassfeld-Sternberg, L. (1949). Enteritis necroticans due to Clostridium welchi type F. Br. Med. J. 1:267.