Effects of Clostridium perfringens beta-toxin on the rabbit small intestine and colon

Infection and Immunity

Volumn 76, Issue 10, 2008, Pages 4396-4404

  Vidal, Jorge E ^a   McClane, Bruce A ^a   Saputo, Juliann ^b   Parker, Jaquelyn ^b   Uzal, Francisco A ^b  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CLOSTRIDIUM TOXIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CLOSTRIDIUM; CLOSTRIDIUM PERFRINGENS TYPE B; CONTROLLED STUDY; DUODENUM; FEMALE; ILEUM; JEJUNUM; LARGE INTESTINE; NONHUMAN; PRIORITY JOURNAL; PURIFICATION; RABBIT; SMALL INTESTINE; SMALL INTESTINE DISEASE;

ANIMALS; BACTERIAL TOXINS; CLOSTRIDIUM PERFRINGENS; COLON; EXUDATES AND TRANSUDATES; FEMALE; HEMORRHAGE; INTESTINE, SMALL; MALE; RABBITS; TIME FACTORS; TRYPSIN INHIBITORS;

EID: 53649107447     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.00547-08     Document Type: Article

References (30)

1. Bos, J., L. Smithee, B. McClane, R. F. Distefano, F. Uzal, J. G. Songer, S. Mallonee, and J. M. Crutcher. 2005. Fatal necrotizing colitis following a foodborne outbreak of enterotoxigenic Clostridium perfringens type A infection. Clin. Infect. Dis. 40:e78-e83.
2. Farrant, J. M., Z. Traill, C. Conlon, B. Warren, N. Mortensen, F. V. Gleeson, and D. P. Jewell. 1996. Pigbel-like syndrome in a vegetarian in Oxford. Gut 39:336-337.
3. Fernandez-Miyakawa, M. E., D. J. Fisher, R. Poon, S. Sayeed, V. Adams, J. I. Rood, B. A. McClane, and F. A. Uzal. 2007. Both epsilon-toxin and beta-toxin are important for the lethal properties of Clostridium perfringens type B isolates in the mouse intravenous injection model. Infect. Immun. 75:1443-1452.
4. Fernandez-Miyakawa, M. E., V. Pistone-Creydt, F. A. Uzal, B. A. McClane, and C. Ibarra. 2005. Clostridium perfringens enterotoxin damages the human intestine in vitro. Infect. Immun. 73:8407-8410.
5. Fisher, D. J., M. E. Fernandez-Miyakawa, S. Sayeed, R. Poon, V. Adams, J. I. Rood, F. A. Uzal, and B. A. McClane. 2006. Dissecting the contributions of Clostridium perfringens type C toxins to lethality in the mouse intravenous injection model. Infect. Immun. 74:5200-5210.
6. Johnson, S., and D. N. Gerding. 1997. Enterotoxemic infections, p. 117-140. In J. I. Rood, B. A. McClane, J. G. Songer, and R. W. Titball (ed.), The clostridia: molecular biology and pathogenesis. Academic Press, London, United Kingdom.
7. Lawrence, G., and R. Cooke. 1980. Experimental pigbel: the production and pathology of necrotizing enteritis due to Clostridium welchii type C in the guinea pig. Br. J. Exp. Pathol. 61:261-271.
8. Lowry, O. H., N. J. Rosebrough, A. L. Farr, and R. J. Randall. 1951. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193:265-275.
9. Matsuda, T., Y. Okada, E. Inagi, Y. Tanabe, Y. Shimizu, K. Nagashima, J. Sakurai, M. Nagahama, and S. Tanaka. 2007. Enteritis necroticans 'pigbel' in a Japanese diabetic adult. Pathol. Int. 57:622-626.
10. McClane, B. A., F. A. Uzal, M. Fernandez-Miyakawa, D. Lyerly, and T. D. Wilkins. 2004. The enterotoxigenic clostridia, p. 698-752. In S. F. M. Dworkin, E. Rosenburg, K. F. Schleifer, and E. Stackebrandt (ed.), The prokaryotes, vol. 4. Springer-Verlag, New York, NY.
11. McDonel, J. L., and G. W. Demers. 1982. In vivo effects of enterotoxin from Clostridium perfringens type A in the rabbit colon: binding versus biologic activity. J. Infect. Dis. 145:490-494.
12. Nagahama, M., S. Hayashi, S. Morimitsu, and J. Sakurai. 2003. Biological activities and pore formation of Clostridium perfringens beta toxin in HL 60 cells. J. Biol. Chem. 278:36934-36941.
13. Niilo, L. 1988. Clostridium perfringens type C Enterotoxemia. Can. Vet. J. 29:658-664.
14. Niilo, L. 1986. Experimental production of hemorrhagic enterotoxemia by Clostridium perfringens type C in maturing lambs. Can. J. Vet. Res. 50:32-35.
15. Petit, L., M. Gibert, and M. R. Popoff. 1999. Clostridium perfringens: toxinotype and genotype. Trends. Microbiol. 7:104-110.
16. Petrillo, T. M., C. M. Beck-Sague, J. G. Songer, C. Abramowsky, J. D. Fortenberry, L. Meacham, A. G. Dean, H. Lee, D. M. Bueschel, and S. R. Nesheim. 2000. Enteritis necroticans (pigbel) in a diabetic child. N. Engl. J. Med. 342:1250-1253.
17. Sakurai, J., and C. L. Duncan. 1978. Some properties of beta-toxin produced by Clostridium perfringens type C. Infect. Immun. 21:678-680.
18. Sarker, M. R., R. J. Carman, and B. A. McClane. 1999. Inactivation of the gene (cpe) encoding Clostridium perfringens enterotoxin eliminates the ability of two cpe-positive C. perfringens type A human gastrointestinal disease isolates to affect rabbit ileal loops. Mol. Microbiol. 33:946-958.
19. Sayeed, S., F. A. Uzal, D. J. Fisher, J. Saputo, J. E. Vidal, Y. Chen, P. Gupta, J. I. Rood, and B. A. McClane. 2008. Beta toxin is essential for the intestinal virulence of Clostridium perfringens type C disease isolate CN3685 in a rabbit ileal loop model. Mol. Microbiol. 67:15-30.
20. Sears, C. L., and J. B. Kaper. 1996. Enteric bacterial toxins: mechanisms of action and linkage to intestinal secretion. Microbiol. Rev. 60:167-215.
21. Severin, W. P., A. A. de la Fuente, and M. F. Stringer. 1984. Clostridium perfringens type C causing necrotizing enteritis. J. Clin. Pathol. 37:942-944.
22. Sherman, S., E. Klein, and B. A. McClane. 1994. Clostridium perfringens type A enterotoxin induces tissue damage and fluid accumulation in rabbit ileum. J. Diarrhoeal. Dis. Res. 12:200-207.
23. Songer, J. G. 1996. Clostridial enteric diseases of domestic animals. Clin. Microbiol. Rev. 9:216-234.
24. Songer, J. G., and F. A. Uzal. 2005. Clostridial enteric infections in pigs. J. Vet. Diagn. Investig. 17:528-536.
25. Steinthorsdottir, V., H. Halldorsson, and O. S. Andresson. 2000. Clostridium perfringens beta-toxin forms multimeric transmembrane pores in human endothelial cells. Microb. Pathog. 28:45-50.
26. Tonnellier, M., E. Maury, J. Guglielminotti, and G. Offenstadt. 2001. A fatal sandwich. Lancet. Infect. Dis. 1:202.
27. Uzal, F. A. 2004. Diagnosis of Clostridium perfringens intestinal infections in sheep and goats. Anaerobe 10:135-143.
28. Walker, P. D., W. H. Foster, P. A. Knight, D. S. Freestone, and G. Lawrence. 1979. Development, preparation and safety testing of a Clostridium welchii type C toxoid. I: preliminary observations in man in Papua New Guinea. J. Biol. Stand. 7:315-323.
29. Walker, P. D., T. G. Murrell, and L. K. Nagy. 1980. Scanning electron microscopy of the jejunum in enteritis necroticans. J. Med. Microbiol. 13: 445-450.
30. Zeitlin, I. J., and W. Sircus. 1974. Factors influencing duodenal trypsin levels following a standard test meal as a test of pancreatic function. Gut 15:173-179.