-
1
-
-
84875758730
-
Lessons from the cancer genome
-
Garraway LA, Lander ES (2013) Lessons from the cancer genome. Cell 153(1):17-37.
-
(2013)
Cell
, vol.153
, Issue.1
, pp. 17-37
-
-
Garraway, L.A.1
Lander, E.S.2
-
2
-
-
80054751998
-
Exome sequencing identifies a spectrum of mutation frequencies in advanced and lethal prostate cancers
-
Kumar A, et al. (2011) Exome sequencing identifies a spectrum of mutation frequencies in advanced and lethal prostate cancers. Proc Natl Acad Sci USA 108(41):17087-17092.
-
(2011)
Proc Natl Acad Sci USA
, vol.108
, Issue.41
, pp. 17087-17092
-
-
Kumar, A.1
-
3
-
-
84863922124
-
Comprehensive molecular characterization of human colon and rectal cancer
-
Cancer Genome Atlas Network
-
Cancer Genome Atlas Network (2012) Comprehensive molecular characterization of human colon and rectal cancer. Nature 487(7407):330-337.
-
(2012)
Nature
, vol.487
, Issue.7407
, pp. 330-337
-
-
-
4
-
-
84877028141
-
Comprehensive molecular portraits of human breast tumours
-
Cancer Genome Atlas Network
-
Cancer Genome Atlas Network (2012) Comprehensive molecular portraits of human breast tumours. Nature 490(7418):61-70.
-
(2012)
Nature
, vol.490
, Issue.7418
, pp. 61-70
-
-
-
5
-
-
74449093973
-
A comprehensive catalogue of somatic mutations from a human cancer genome
-
Pleasance ED, et al. (2010) A comprehensive catalogue of somatic mutations from a human cancer genome. Nature 463(7278):191-196.
-
(2010)
Nature
, vol.463
, Issue.7278
, pp. 191-196
-
-
Pleasance, E.D.1
-
6
-
-
85027946522
-
Exome sequencing identifies GRIN2A as frequently mutated in melanoma
-
NISC Comparative Sequencing Program
-
Wei X, et al.; NISC Comparative Sequencing Program (2011) Exome sequencing identifies GRIN2A as frequently mutated in melanoma. Nat Genet 43(5):442-446.
-
(2011)
Nat Genet
, vol.43
, Issue.5
, pp. 442-446
-
-
Wei, X.1
-
7
-
-
84856273432
-
Frequent somatic mutations in MAP3K5 and MAP3K9 in metastatic melanoma identified by exome sequencing
-
Stark MS, et al. (2012) Frequent somatic mutations in MAP3K5 and MAP3K9 in metastatic melanoma identified by exome sequencing. Nat Genet 44(2):165-169.
-
(2012)
Nat Genet
, vol.44
, Issue.2
, pp. 165-169
-
-
Stark, M.S.1
-
8
-
-
84856268319
-
Exome sequencing identifies recurrent somatic MAP2K1 and MAP2K2 mutations in melanoma
-
Nikolaev SI, et al. (2012) Exome sequencing identifies recurrent somatic MAP2K1 and MAP2K2 mutations in melanoma. Nat Genet 44(2):133-139.
-
(2012)
Nat Genet
, vol.44
, Issue.2
, pp. 133-139
-
-
Nikolaev, S.I.1
-
9
-
-
84861427327
-
Melanoma genome sequencing reveals frequent PREX2 mutations
-
Berger MF, et al. (2012) Melanoma genome sequencing reveals frequent PREX2 mutations. Nature 485(7399):502-506.
-
(2012)
Nature
, vol.485
, Issue.7399
, pp. 502-506
-
-
Berger, M.F.1
-
10
-
-
84864258996
-
A landscape of driver mutations in melanoma
-
Hodis E, et al. (2012) A landscape of driver mutations in melanoma. Cell 150(2): 251-263.
-
(2012)
Cell
, vol.150
, Issue.2
, pp. 251-263
-
-
Hodis, E.1
-
11
-
-
84865684161
-
Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma
-
Krauthammer M, et al. (2012) Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma. Nat Genet 44(9):1006-1014.
-
(2012)
Nat Genet
, vol.44
, Issue.9
, pp. 1006-1014
-
-
Krauthammer, M.1
-
12
-
-
84866894408
-
Comprehensive genomic characterization of squamous cell lung cancers
-
Cancer Genome Atlas Research Network
-
Cancer Genome Atlas Research Network (2012) Comprehensive genomic characterization of squamous cell lung cancers. Nature 489(7417):519-525.
-
(2012)
Nature
, vol.489
, Issue.7417
, pp. 519-525
-
-
-
13
-
-
84866410479
-
Mapping the hallmarks of lung adenocarcinoma with massively parallel sequencing
-
Imielinski M, et al. (2012) Mapping the hallmarks of lung adenocarcinoma with massively parallel sequencing. Cell 150(6):1107-1120.
-
(2012)
Cell
, vol.150
, Issue.6
, pp. 1107-1120
-
-
Imielinski, M.1
-
14
-
-
84880507665
-
Mutational heterogeneity in cancer and the search for new cancer-associated genes
-
Lawrence MS, et al. (2013) Mutational heterogeneity in cancer and the search for new cancer-associated genes. Nature 499(7457):214-218.
-
(2013)
Nature
, vol.499
, Issue.7457
, pp. 214-218
-
-
Lawrence, M.S.1
-
15
-
-
0030662074
-
Molecular reconstruction of Sleeping Beauty, a Tc1-like transposon from fish, and its transposition in human cells
-
Ivics Z, Hackett PB, Plasterk RH, Izsvák Z (1997)Molecular reconstruction of Sleeping Beauty, a Tc1-like transposon from fish, and its transposition in human cells. Cell 91(4):501-510.
-
(1997)
Cell
, vol.91
, Issue.4
, pp. 501-510
-
-
Ivics, Z.1
Hackett, P.B.2
Plasterk, R.H.3
Izsvák, Z.4
-
16
-
-
23744479962
-
Efficient transposition of the piggyBac (PB) transposon inmammalian cells and mice
-
Ding S, et al. (2005) Efficient transposition of the piggyBac (PB) transposon inmammalian cells and mice. Cell 122(3):473-483.
-
(2005)
Cell
, vol.122
, Issue.3
, pp. 473-483
-
-
Ding, S.1
-
17
-
-
77957132245
-
Harnessing transposons for cancer gene discovery
-
Copeland NG, Jenkins NA (2010) Harnessing transposons for cancer gene discovery. Nat Rev Cancer 10(10):696-706.
-
(2010)
Nat Rev Cancer
, vol.10
, Issue.10
, pp. 696-706
-
-
Copeland, N.G.1
Jenkins, N.A.2
-
18
-
-
78449294626
-
PiggyBac transposon mutagenesis: A tool for cancer gene discovery in mice
-
Rad R, et al. (2010) PiggyBac transposon mutagenesis: A tool for cancer gene discovery in mice. Science 330(6007):1104-1107.
-
(2010)
Science
, vol.330
, Issue.6007
, pp. 1104-1107
-
-
Rad, R.1
-
19
-
-
80054844707
-
PiggyBac transposon somatic mutagenesis with an activated reporter and tracker (PB-SMART) for genetic screens in mice
-
Landrette SF, Cornett JC, Ni TK, Bosenberg MW, Xu T (2011) piggyBac transposon somatic mutagenesis with an activated reporter and tracker (PB-SMART) for genetic screens in mice. PLoS ONE 6(10):e26650.
-
(2011)
PLoS ONE
, vol.6
, Issue.10
-
-
Landrette, S.F.1
Cornett, J.C.2
Ni, T.K.3
Bosenberg, M.W.4
Xu, T.5
-
20
-
-
82255179056
-
Insertional mutagenesis identifies multiple networks of cooperating genes driving intestinal tumorigenesis
-
March HN, et al. (2011) Insertional mutagenesis identifies multiple networks of cooperating genes driving intestinal tumorigenesis. Nat Genet 43(12):1202-1209.
-
(2011)
Nat Genet
, vol.43
, Issue.12
, pp. 1202-1209
-
-
March, H.N.1
-
21
-
-
84859947197
-
Sleeping Beauty mutagenesis reveals cooperating mutations and pathways in pancreatic adenocarcinoma
-
Australian Pancreatic Cancer Genome Initiative
-
Mann KM, et al.; Australian Pancreatic Cancer Genome Initiative (2012) Sleeping Beauty mutagenesis reveals cooperating mutations and pathways in pancreatic adenocarcinoma. Proc Natl Acad Sci USA 109(16):5934-5941.
-
(2012)
Proc Natl Acad Sci USA
, vol.109
, Issue.16
, pp. 5934-5941
-
-
Mann, K.M.1
-
22
-
-
84861990162
-
The deubiquitinase USP9X suppresses pancreatic ductal adenocarcinoma
-
Australian Pancreatic Cancer Genome Initiative
-
Pérez-Mancera PA, et al.; Australian Pancreatic Cancer Genome Initiative (2012) The deubiquitinase USP9X suppresses pancreatic ductal adenocarcinoma. Nature 486(7402):266-270.
-
(2012)
Nature
, vol.486
, Issue.7402
, pp. 266-270
-
-
Pérez-Mancera, P.A.1
-
23
-
-
84860214530
-
From genes to drugs: Targeted strategies for melanoma
-
Flaherty KT, Hodi FS, Fisher DE (2012) From genes to drugs: Targeted strategies for melanoma. Nat Rev Cancer 12(5):349-361.
-
(2012)
Nat Rev Cancer
, vol.12
, Issue.5
, pp. 349-361
-
-
Flaherty, K.T.1
Hodi, F.S.2
Fisher, D.E.3
-
24
-
-
18444374405
-
Mutations of the BRAF gene in human cancer
-
Davies H, et al. (2002) Mutations of the BRAF gene in human cancer. Nature 417(6892):949-954.
-
(2002)
Nature
, vol.417
, Issue.6892
, pp. 949-954
-
-
Davies, H.1
-
25
-
-
0037228055
-
High frequency of BRAF mutations in nevi
-
Pollock PM, et al. (2003) High frequency of BRAF mutations in nevi. Nat Genet 33(1): 19-20.
-
(2003)
Nat Genet
, vol.33
, Issue.1
, pp. 19-20
-
-
Pollock, P.M.1
-
26
-
-
65649147543
-
Braf(V600E) cooperates with Pten loss to induce metastatic melanoma
-
Dankort D, et al. (2009) Braf(V600E) cooperates with Pten loss to induce metastatic melanoma. Nat Genet 41(5):544-552.
-
(2009)
Nat Genet
, vol.41
, Issue.5
, pp. 544-552
-
-
Dankort, D.1
-
27
-
-
33847201454
-
A new mouse model to explore the initiation, progression, and therapy of BRAFV600E-induced lung tumors
-
Dankort D, et al. (2007) A new mouse model to explore the initiation, progression, and therapy of BRAFV600E-induced lung tumors. Genes Dev 21(4):379-384.
-
(2007)
Genes Dev
, vol.21
, Issue.4
, pp. 379-384
-
-
Dankort, D.1
-
28
-
-
33745015018
-
Characterization of melanocyte-specific inducible Cre recombinase transgenic mice
-
Bosenberg M, et al. (2006) Characterization of melanocyte-specific inducible Cre recombinase transgenic mice. Genesis 44(5):262-267.
-
(2006)
Genesis
, vol.44
, Issue.5
, pp. 262-267
-
-
Bosenberg, M.1
-
29
-
-
0029913457
-
Molecular cloning of mitogen-activated protein/ERK kinase kinases (MEKK) 2 and 3. Regulation of sequential phosphorylation pathways involving mitogen-activated protein kinase and c-Jun kinase
-
Blank JL, Gerwins P, Elliott EM, Sather S, Johnson GL (1996) Molecular cloning of mitogen-activated protein/ERK kinase kinases (MEKK) 2 and 3. Regulation of sequential phosphorylation pathways involving mitogen-activated protein kinase and c-Jun kinase. J Biol Chem 271(10):5361-5368. 30. Karandikar M, Xu S, Cobb MH (2000) MEKK1 binds raf-1 and the ERK2 cascade components. J Biol Chem 275(51):40120-40127.
-
(1996)
J Biol Chem
, vol.271
, Issue.10
, pp. 5361-5368
-
-
Blank, J.L.1
Gerwins, P.2
Elliott, E.M.3
Sather, S.4
Johnson, G.L.5
-
30
-
-
0036279167
-
The PHD domain of MEKK1 acts as an E3 ubiquitin ligase and mediates ubiquitination and degradation of ERK1/2
-
Lu Z, Xu S, Joazeiro C, Cobb MH, Hunter T (2002) The PHD domain of MEKK1 acts as an E3 ubiquitin ligase and mediates ubiquitination and degradation of ERK1/2. Mol Cell 9(5):945-956.
-
(2002)
Mol Cell
, vol.9
, Issue.5
, pp. 945-956
-
-
Lu, Z.1
Xu, S.2
Joazeiro, C.3
Cobb, M.H.4
Hunter, T.5
-
31
-
-
77949354563
-
PLX4032, a selective BRAF(V600E) kinase inhibitor, activates the ERK pathway and enhances cell migration and proliferation of BRAF melanoma cells
-
Halaban R, et al. (2010) PLX4032, a selective BRAF(V600E) kinase inhibitor, activates the ERK pathway and enhances cell migration and proliferation of BRAF melanoma cells. Pigment Cell Melanoma Res 23(2):190-200.
-
(2010)
Pigment Cell Melanoma Res
, vol.23
, Issue.2
, pp. 190-200
-
-
Halaban, R.1
-
32
-
-
21844478747
-
Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma
-
Garraway LA, et al. (2005) Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma. Nature 436(7047):117-122.
-
(2005)
Nature
, vol.436
, Issue.7047
, pp. 117-122
-
-
Garraway, L.A.1
-
33
-
-
0033547353
-
NRap GEP: A novel neural GDP/GTP exchange protein for rap1 small G protein that interacts with synaptic scaffolding molecule (S-SCAM)
-
Ohtsuka T, et al. (1999) nRap GEP: A novel neural GDP/GTP exchange protein for rap1 small G protein that interacts with synaptic scaffolding molecule (S-SCAM). Biochem Biophys Res Commun 265(1):38-44.
-
(1999)
Biochem Biophys Res Commun
, vol.265
, Issue.1
, pp. 38-44
-
-
Ohtsuka, T.1
-
34
-
-
0036470661
-
Interaction of synaptic scaffolding molecule and β-catenin
-
NishimuraW, Yao I, Iida J, Tanaka N, Hata Y (2002) Interaction of synaptic scaffolding molecule and β-catenin. J Neurosci 22(3):757-765.
-
(2002)
J Neurosci
, vol.22
, Issue.3
, pp. 757-765
-
-
Nishimura, W.1
Yao, I.2
Iida, J.3
Tanaka, N.4
Hata, Y.5
-
35
-
-
0035394373
-
Regulation of PTEN binding to MAGI-2 by two putative phosphorylation sites at threonine 382 and 383
-
Tolkacheva T, et al. (2001) Regulation of PTEN binding to MAGI-2 by two putative phosphorylation sites at threonine 382 and 383. Cancer Res 61(13):4985-4989.
-
(2001)
Cancer Res
, vol.61
, Issue.13
, pp. 4985-4989
-
-
Tolkacheva, T.1
-
36
-
-
79951497419
-
The genomic complexity of primary human prostate cancer
-
Berger MF, et al. (2011) The genomic complexity of primary human prostate cancer. Nature 470(7333):214-220.
-
(2011)
Nature
, vol.470
, Issue.7333
, pp. 214-220
-
-
Berger, M.F.1
-
37
-
-
84862523863
-
Sequence analysis of mutations and translocations across breast cancer subtypes
-
Banerji S, et al. (2012) Sequence analysis of mutations and translocations across breast cancer subtypes. Nature 486(7403):405-409.
-
(2012)
Nature
, vol.486
, Issue.7403
, pp. 405-409
-
-
Banerji, S.1
-
38
-
-
3843084078
-
The COSMIC (Catalogue of Somatic Mutations in Cancer) database and website
-
Bamford S, et al. (2004) The COSMIC (Catalogue of Somatic Mutations in Cancer) database and website. Br J Cancer 91(2):355-358.
-
(2004)
Br J Cancer
, vol.91
, Issue.2
, pp. 355-358
-
-
Bamford, S.1
-
39
-
-
3442894137
-
Expression profiling reveals novel pathways in the transformation of melanocytes to melanomas
-
Hoek K, et al. (2004) Expression profiling reveals novel pathways in the transformation of melanocytes to melanomas. Cancer Res 64(15):5270-5282.
-
(2004)
Cancer Res
, vol.64
, Issue.15
, pp. 5270-5282
-
-
Hoek, K.1
-
40
-
-
33745753404
-
Metastatic potential of melanomas defined by specific gene expression profiles with no BRAF signature
-
Hoek KS, et al. (2006) Metastatic potential of melanomas defined by specific gene expression profiles with no BRAF signature. Pigment Cell Res 19(4):290-302.
-
(2006)
Pigment Cell Res
, vol.19
, Issue.4
, pp. 290-302
-
-
Hoek, K.S.1
-
41
-
-
49649103221
-
The gene expression profiles of primary and metastatic melanoma yields a transition point of tumor progression and metastasis
-
Riker AI, et al. (2008) The gene expression profiles of primary and metastatic melanoma yields a transition point of tumor progression and metastasis. BMC Med Genomics 1:13.
-
(2008)
BMC Med Genomics
, vol.1
, pp. 13
-
-
Riker, A.I.1
-
42
-
-
0033566323
-
The receptor protein tyrosine phosphatase, PTP-RO, is upregulated during megakaryocyte differentiation and Is associated with the c-Kit receptor
-
Taniguchi Y, London R, Schinkmann K, Jiang S, Avraham H (1999) The receptor protein tyrosine phosphatase, PTP-RO, is upregulated during megakaryocyte differentiation and Is associated with the c-Kit receptor. Blood 94(2):539-549.
-
(1999)
Blood
, vol.94
, Issue.2
, pp. 539-549
-
-
Taniguchi, Y.1
London, R.2
Schinkmann, K.3
Jiang, S.4
Avraham, H.5
-
43
-
-
83455254767
-
RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E)
-
Poulikakos PI, et al. (2011) RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E). Nature 480(7377):387-390.
-
(2011)
Nature
, vol.480
, Issue.7377
, pp. 387-390
-
-
Poulikakos, P.I.1
-
44
-
-
0029942952
-
Cloning of rat MEK kinase 1 cDNA reveals an endogenous membrane-associated 195-kDa protein with a large regulatory domain
-
Xu S, et al. (1996) Cloning of rat MEK kinase 1 cDNA reveals an endogenous membrane-associated 195-kDa protein with a large regulatory domain. Proc Natl Acad Sci USA 93(11):5291-5295.
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, Issue.11
, pp. 5291-5295
-
-
Xu, S.1
-
45
-
-
78149278589
-
A molecular network for de novo generation of the apical surface and lumen
-
Bryant DM, et al. (2010) A molecular network for de novo generation of the apical surface and lumen. Nat Cell Biol 12(11):1035-1045.
-
(2010)
Nat Cell Biol
, vol.12
, Issue.11
, pp. 1035-1045
-
-
Bryant, D.M.1
-
46
-
-
0031666744
-
Development of a selfinactivating lentivirus vector
-
Miyoshi H, Blömer U, Takahashi M, Gage FH, Verma IM (1998) Development of a selfinactivating lentivirus vector. J Virol 72(10):8150-8157.
-
(1998)
J Virol
, vol.72
, Issue.10
, pp. 8150-8157
-
-
Miyoshi, H.1
Blömer, U.2
Takahashi, M.3
Gage, F.H.4
Verma, I.M.5
-
47
-
-
78651324347
-
The STRING database in 2011: Functional interaction networks of proteins, globally integrated and scored
-
Szklarczyk D, et al. (2011) The STRING database in 2011: Functional interaction networks of proteins, globally integrated and scored. Nucleic Acids Res 39(Database issue):D561-D568.
-
(2011)
Nucleic Acids Res
, vol.39
, Issue.DATABASE ISSUE
-
-
Szklarczyk, D.1
-
48
-
-
84866002291
-
The cBio cancer genomics portal: An open platform for exploring multidimensional cancer genomics data
-
Cerami E, et al. (2012) The cBio cancer genomics portal: An open platform for exploring multidimensional cancer genomics data. Cancer Discov 2(5):401-404.
-
(2012)
Cancer Discov
, vol.2
, Issue.5
, pp. 401-404
-
-
Cerami, E.1
-
49
-
-
84875740314
-
Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal
-
Gao J, et al. (2013) Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal. Sci Signal 6(269):pl1.
-
(2013)
Sci Signal
, vol.6
, Issue.269
-
-
Gao, J.1
-
50
-
-
33847246805
-
Oncomine 3. 0: Genes, pathways, and networks in a collection of 18,000 cancer gene expression profiles
-
Rhodes DR, et al. (2007) Oncomine 3.0: Genes, pathways, and networks in a collection of 18,000 cancer gene expression profiles. Neoplasia 9(2):166-180.
-
(2007)
Neoplasia
, vol.9
, Issue.2
, pp. 166-180
-
-
Rhodes, D.R.1
|