Assessing the translatability of In vivo cardiotoxicity mechanisms to In vitro models using causal reasoning

BMC Pharmacology and Toxicology

Volumn 14, Issue , 2013, Pages

  Enayetallah, Ahmed E ^a   Puppala, Dinesh ^a   Ziemek, Daniel ^a   Fischer, James E ^a   Kantesaria, Sheila ^a   Pletcher, Mathew T ^a  

^a PFIZER INC   (United States)

Author keywords

Cardiotoxicity; Causal reasoning; In vitro screening; Preclinical safety; Translatability

Indexed keywords

AMIODARONE; AMITRIPTYLINE; CYCLOSPORIN; DEXAMETHASONE; DOBUTAMINE; DOXORUBICIN; KRUPPEL LIKE FACTOR 4; LORATADINE; MITOXANTRONE; TERBUTALINE; TRANSFORMING GROWTH FACTOR BETA1; ADENOSINE TRIPHOSPHATE; DRUG; KRUPPEL LIKE FACTOR;

ANIMAL TISSUE; ARTICLE; CARDIOTOXICITY; CYTOTOXICITY TEST; GENE EXPRESSION; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; ADVERSE DRUG REACTION; ANIMAL; BIOLOGICAL MODEL; BIOLOGY; DRUG EFFECT; DRUG SCREENING; EPIDEMIOLOGY; GENETICS; HEART; HEART MUSCLE CELL; HEK293 CELL LINE; HUMAN; METABOLISM; METHODOLOGY; PREDICTIVE VALUE; RAT; STATISTICS;

ADENOSINE TRIPHOSPHATE; ANIMALS; CAUSALITY; COMPUTATIONAL BIOLOGY; DRUG EVALUATION, PRECLINICAL; DRUG-RELATED SIDE EFFECTS AND ADVERSE REACTIONS; GENE EXPRESSION; HEART; HEK293 CELLS; HUMANS; KRUPPEL-LIKE TRANSCRIPTION FACTORS; MODELS, CARDIOVASCULAR; MYOCYTES, CARDIAC; PHARMACEUTICAL PREPARATIONS; PREDICTIVE VALUE OF TESTS; RATS; TRANSFORMING GROWTH FACTOR BETA1;

EID: 84884336291     PISSN: 20506511     EISSN: None     Source Type: Journal    
DOI: 10.1186/2050-6511-14-46     Document Type: Article

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