A flexible approach for optimising in silico ADME/Tox characterisation of lead candidates

Expert Opinion on Drug Metabolism and Toxicology

Volumn 2, Issue 1, 2006, Pages 157-168

  Bidault, Yann ^a  

^a Micropolis   (France)

Author keywords

ADME Tox; Cheminformatics; Consensus model; Cytochrome P450; hERG channel; in silico prediction; Lead optimisation; Mutagenicity; Pharmacokinetics; Support vector machine; SVM

Indexed keywords

CYTOCHROME P450 2D6; POTASSIUM CHANNEL HERG;

COMPUTER MODEL; DRUG INDUSTRY; DRUG RESEARCH; HUMAN; INFORMATION SCIENCE; MEDICAL TECHNOLOGY; MUTAGENICITY; PREDICTION; REVIEW; SUPPORT VECTOR MACHINE;

ANIMALS; CELL LINE; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; DRUG TOXICITY; HUMANS; MODELS, CHEMICAL; PREDICTIVE VALUE OF TESTS;

EID: 33845799670     PISSN: 17425255     EISSN: None     Source Type: Journal    
DOI: 10.1517/17425255.2.1.157     Document Type: Review

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