Modeling the mechanism of action of a DGAT1 inhibitor using a causal reasoning platform

PLoS ONE

Volumn 6, Issue 11, 2011, Pages

  Enayetallah, Ahmed E ^a   Ziemek, Daniel ^a   Leininger, Michael T ^a   Randhawa, Ranjit ^a   Yang, Jianxin ^a   Manion, Tara B ^a   Mather, Dawn E ^a   Zavadoski, William J ^a   Kuhn, Max ^a   Treadway, Judith L ^a   des Etages, Shelly Ann G ^a   Gibbs, E Michael ^a   Greene, Nigel ^a   Steppan, Claire M ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACYLTRANSFERASE INHIBITOR; HEPATOCYTE NUCLEAR FACTOR 4ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PF 04620110; STEROL REGULATORY ELEMENT BINDING PROTEIN; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; DGAT1 PROTEIN, RAT; DIACYLGLYCEROL ACYLTRANSFERASE; ENZYME INHIBITOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CAUSAL REASONING ENGINE; CHEMICAL MODEL; CONTROLLED STUDY; DECISION SUPPORT SYSTEM; DRUG DOSE COMPARISON; DRUG MECHANISM; DRUG MEGADOSE; FOOD INTAKE; GENE EXPRESSION; GENETIC ANALYSIS; HYPOTHESIS; INSULIN SENSITIVITY; LOW DRUG DOSE; MALE; NONHUMAN; RAT; TRANSCRIPTION REGULATION; TRIACYLGLYCEROL BLOOD LEVEL; ALGORITHM; ANIMAL; BLOOD; DNA MICROARRAY; DRUG ANTAGONISM; FEEDING BEHAVIOR; POLYMERASE CHAIN REACTION; SPRAGUE DAWLEY RAT; THEORETICAL MODEL;

MUS; RATTUS;

ALGORITHMS; ANIMALS; DIACYLGLYCEROL O-ACYLTRANSFERASE; ENZYME INHIBITORS; FEEDING BEHAVIOR; MODELS, THEORETICAL; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; POLYMERASE CHAIN REACTION; RATS; RATS, SPRAGUE-DAWLEY; TRIGLYCERIDES;

EID: 80455150233     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0027009     Document Type: Article

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