Quantitative analysis of tenuifolin concentrations in rat plasma and tissue using LC-MS/MS: Application to pharmacokinetic and tissue distribution study

Journal of Pharmaceutical and Biomedical Analysis

Volumn 88, Issue , 2014, Pages 191-200

  Ma, Bo ^a   Li, Xiaotian ^b   Li, Jing ^a   Zhang, Qi ^a   Liu, Yinhui ^a   Yang, Xiaojing ^a   Sun, Jingjing ^a   Yao, Di ^a   Liu, Lei ^a   Liu, Xiaoxin ^a   Ying, Hanjie ^a  

^a NANJING TECH UNIVERSITY   (China)

^b ZHENGZHOU UNIVERSITY   (China)

Author keywords

Absolute bioavailability; LC MS MS; Pharmacokinetics; Tenuifolin; Tissue distribution

Indexed keywords

ACETONITRILE; FORMIC ACID; HERBACEOUS AGENT; METHANOL; SAPONIN; TENUIFOLIN; UNCLASSIFIED DRUG; WATER;

AMNESIA; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN; CALIBRATION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG STRUCTURE; ELECTROSPRAY; FLOW RATE; HEART; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; KIDNEY; LIMIT OF QUANTITATION; LIQUID CHROMATOGRAPHY; LIVER; LUNG; MALE; MASS SPECTROMETRY; NONHUMAN; PLASMA; PRECIPITATION; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RAT; RUNNING; SPLEEN; SYSTEMIC CIRCULATION; TISSUE DISTRIBUTION; TISSUE HOMOGENATE;

ABSOLUTE BIOAVAILABILITY; LCMS/MS; PHARMACOKINETICS; TENUIFOLIN; TISSUE DISTRIBUTION;

ABSORPTION; ANIMALS; BIOLOGICAL AVAILABILITY; BLOOD-BRAIN BARRIER; CALIBRATION; CHROMATOGRAPHY, REVERSE-PHASE; DITERPENES, KAURANE; FEMALE; MALE; MEMORY DISORDERS; PLANT EXTRACTS; QUALITY CONTROL; RATS; RATS, SPRAGUE-DAWLEY; REPRODUCIBILITY OF RESULTS; TANDEM MASS SPECTROMETRY; TISSUE DISTRIBUTION;

EID: 84884304235     PISSN: 07317085     EISSN: 1873264X     Source Type: Journal    
DOI: 10.1016/j.jpba.2013.07.012     Document Type: Article

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